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Health Sciences profile

Dr Sean Coffey

PositionSenior Lecturer
DepartmentDepartment of Medicine (DSM)
QualificationsMB BS FRACP Phd
Research summaryCardiovascular medicine
Clinical
  • Clinical cardiology
  • Cardiovascular imaging – echocardiography, cardiac CT, and cardiac MRI

Research

I am interested in many aspects of cardiovascular medicine, especially valvular heart disease, but also ischaemic heart disease, cardiomyopathies, and atrial fibrillation.

To tackle these, I, along with collaborators, use basic science techniques in molecular biology and genomics, population based approaches, and advanced phenotyping techniques using echocardiography, cardiac CT, and cardiac MRI. We have started running clinical trials in-house, with the aim of developing therapies for testing in wider clinical settings.

Publications

Coffey, S., Harper, A. R., Cairns, B. J., Roberts, I. S. D., & Prendergast, B. D. (2017). Clinical information has low sensitivity for postmortem diagnosis of heart valve disease. Heart. Advance online publication. doi: 10.1136/heartjnl-2016-310718

Coffey, S., Lewandowski, A. J., Garratt, S., Meijer, R., Lynum, S., Bedi, R., … Leeson, P. (2017). Protocol and quality assurance for carotid imaging in 100,000 participants of UK Biobank: Development and assessment. European Journal of Preventive Cardiology. Advance online publication. doi: 10.1177/2047487317732273

Vernon, S. T., Coffey, S., Bhindi, R., Hoo, S. Y. S., Nelson, G. I., Ward, M. A., … Figtree, G. A. (2017). Increasing proportion of ST elevation myocardial infarction patients with coronary atherosclerosis poorly explained by standard modifiable risk factors. European Journal of Preventive Cardiology. Advance online publication. doi: 10.1177/2047487317720287

Cairns, B. J., Coffey, S., Travis, R. C., Prendergast, B., Green, J., Engert, J. C., … Clarke, R. (2017). A replicated, genome-wide significant association of aortic stenosis with a genetic variant for lipoprotein(a): Meta-analysis of published and novel data. Circulation, 135(12), 1181-1183. doi: 10.1161/CIRCULATIONAHA.116.026103

Ram, T. P., Fomison-Nurse, I., Gandhi, S., Coffey, S., Saxena, P., Galvin, I., Bunton, R., Williams, M. J. A., Lamberts, R. R., & Katare, R. (2017). The diagnostic sensitivity of circulating cardio-enriched microRNAs is increased after normalization of high-density lipoprotein levels [Short communication]. International Journal of Cardiology, 236, 498-500. doi: 10.1016/j.ijcard.2017.01.119

Journal - Research Article

Coffey, S., Harper, A. R., Cairns, B. J., Roberts, I. S. D., & Prendergast, B. D. (2017). Clinical information has low sensitivity for postmortem diagnosis of heart valve disease. Heart. Advance online publication. doi: 10.1136/heartjnl-2016-310718

Vernon, S. T., Coffey, S., Bhindi, R., Hoo, S. Y. S., Nelson, G. I., Ward, M. A., … Figtree, G. A. (2017). Increasing proportion of ST elevation myocardial infarction patients with coronary atherosclerosis poorly explained by standard modifiable risk factors. European Journal of Preventive Cardiology. Advance online publication. doi: 10.1177/2047487317720287

Coffey, S., Lewandowski, A. J., Garratt, S., Meijer, R., Lynum, S., Bedi, R., … Leeson, P. (2017). Protocol and quality assurance for carotid imaging in 100,000 participants of UK Biobank: Development and assessment. European Journal of Preventive Cardiology. Advance online publication. doi: 10.1177/2047487317732273

Coffey, S., Williams, M. J. A., Phillips, L. V., Galvin, I. F., Bunton, R. W., & Jones, G. T. (2016). Integrated microRNA and messenger RNA analysis in aortic stenosis. Scientific Reports, 6, 36904. doi: 10.1038/srep36904

Coffey, S., Cox, B., & Williams, M. J. A. (2016). Changing causes of heart valve disease mortality in New Zealand from 1988 to 2007. New Zealand Medical Journal, 129(1428), 55-64. Retrieved from https://www.nzma.org.nz/journal

Rawal, S., Parshu Ram, T., Coffey, S., Williams, M. J. A., Saxena, P., Bunton, R. W., Galvin, I. F., & Katare, R. (2016). Differential expression pattern of cardiovascular microRNAs in the human type-2 diabetic heart with normal ejection fraction. International Journal of Cardiology, 202, 40-43. doi: 10.1016/j.ijcard.2015.08.161

d'Arcy, J. L., Coffey, S., Loudon, M. A., Kennedy, A., Pearson-Stuttard, J., Birks, J., … Prendergast, B. D. (2016). Large-scale community echocardiographic screening reveals a major burden of undiagnosed valvular heart disease in older people: The OxVALVE Population Cohort Study. European Heart Journal, 37, 3515-3522. doi: 10.1093/eurheartj/ehw229

Bussey, C. T., Hughes, G., Saxena, P., Galvin, I. F., Bunton, R. W., Noye, M. K., Coffey, S., Williams, M. J. A., Baldi, J. C., Jones, P. P., & Lamberts, R. R. (2015). Chamber-specific changes in calcium-handling proteins in the type 2 diabetic human heart with preserved ejection fraction. International Journal of Cardiology, 193, 53-55. doi: 10.1016/j.ijcard.2015.05.053

Coffey, S., Williams, M. J. A., Phillips, L. V., & Jones, G. T. (2015). Circulating microRNA profiling needs further refinement before clinical use in patients with aortic stenosis. Journal of the American Heart Association, 4(8), e002150. doi: 10.1161/jaha.115.002150

Coffey, S., Cox, B., & Williams, M. J. A. (2014). Lack of progress in valvular heart disease in the pre—transcatheter aortic valve replacement era: Increasing deaths and minimal change in mortality rate over the past three decades. American Heart Journal, 167(4), 562-567. doi: 10.1016/j.ahj.2013.12.030

Coffey, S., Rayner, J., Newton, J., & Prendergast, B. D. (2014). Right-sided valve disease. International Journal of Clinical Practice, 68(10), 1221-1226. doi: 10.1111/ijcp.12485

Moore, A., Shindikar, A., Fomison-Nurse, I., Riu, F., Munasinghe, P., Parshu Ram, T., Saxena, P., Coffey, S., Bunton, R. W., Galvin, I. F., Williams, M. J. A., … Katare, R. (2014). Rapid onset of cardiomyopathy in STZ-induced female diabetic mice involves the downregulation of pro-survival Pim-1. Cardiovascular Diabetology, 13, 68. doi: 10.1186/1475-2840-13-68

Coffey, S., & Jones, G. T. (2014). MicroRNAs are central to osteogenesis: A review with a focus on cardiovascular calcification. microRNA Diagnostics & Therapeutics, 1, 113-125. doi: 10.2478/micrnat-2014-0005

Coffey, S., Cox, B., & Williams, M. J. A. (2014). The prevalence, incidence, progression, and risks of aortic valve sclerosis: A systematic review and meta-analysis. JACC, 63(25 (Part A)), 2852-2861. doi: 10.1016/j.jacc.2014.04.018

Rayner, J., Coffey, S., Newton, J., & Prendergast, B. D. (2014). Aortic valve disease. International Journal of Clinical Practice, 68(10), 1209-1215. doi: 10.1111/ijcp.12471

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Journal - Research Other

Cairns, B. J., Coffey, S., Travis, R. C., Prendergast, B., Green, J., Engert, J. C., … Clarke, R. (2017). A replicated, genome-wide significant association of aortic stenosis with a genetic variant for lipoprotein(a): Meta-analysis of published and novel data. Circulation, 135(12), 1181-1183. doi: 10.1161/CIRCULATIONAHA.116.026103

Ram, T. P., Fomison-Nurse, I., Gandhi, S., Coffey, S., Saxena, P., Galvin, I., Bunton, R., Williams, M. J. A., Lamberts, R. R., & Katare, R. (2017). The diagnostic sensitivity of circulating cardio-enriched microRNAs is increased after normalization of high-density lipoprotein levels [Short communication]. International Journal of Cardiology, 236, 498-500. doi: 10.1016/j.ijcard.2017.01.119

Coffey, S., & Prendergast, B. (2017). Valvular heart disease in the elderly: More questions than answers. Journal of Thoracic Disease, 9(1), E97-E98. doi: 10.21037/jtd.2017.01.28

Yong, M. S., Coffey, S., Prendergast, B. D., Marasco, S. F., Zimmet, A. D., McGiffin, D. C., & Saxena, P. (2016). Surgical management of tricuspid valve endocarditis in the current era: A review. International Journal of Cardiology, 202, 44-48. doi: 10.1016/j.ijcard.2015.08.211

Coffey, S., Cairns, B. J., & Lung, B. (2016). The modern epidemiology of heart valve disease. Heart, 102(1), 75-85. doi: 10.1136/heartjnl-2014-307020

Dona, A. C., Coffey, S., & Figtree, G. (2016). Translational and emerging clinical applications of metabolomics in cardiovascular disease diagnosis and treatment. European Journal of Preventive Cardiology, 23(15), 1578-1589. doi: 10.1177/2047487316645469

Yong, M. S., Saxena, P., Killu, A. M., Coffey, S., Burkhart, H. M., Wan, S.-H., & Malouf, J. F. (2015). The preoperative evaluation of infective endocarditis via 3-dimensional transesophageal echocardiography. Texas Heart Institute Journal, 42(4), 372-376. doi: 10.14503/THIJ-14-4375

Coffey, S., & Prendergast, B. D. (2015). Public healthcare systems should not pay for private profit. BMJ, 350, g7773. doi: 10.1136/bmj.g7774

Coffey, S., d'Arcy, J. L., Loudon, M. A., Mant, D., Farmer, A. J., Prendergast, B. D., for the OxVALVE-PCS Group. (2014). The OxVALVE population cohort study (OxVALVE-PCS): Population screening for undiagnosed valvular heart disease in the elderly: Study design and objectives. Open Heart, 1(1), e000043. doi: 10.1136/openhrt-2014-000043

Coffey, S., Williams, M. J. A., & Cox, B. (2013). Letter by Coffey et al regarding article, Estimating deaths from cardiovascular disease: A review of global methodologies of mortality measurement. Circulation, 128(6), e84. doi: 10.1161/CIRCULATIONAHA.113.002123

Coffey, S., Nadarasa, K., Pan, A., van der Linden, A., Chu, J., & Schultz, M. (2012). The increasing incidence of Streptococcus bovis endocarditis and bacteraemia: A case series from 1997 to 2010. International Journal of Cardiology, 161(2), 111-113. doi: 10.1016/j.ijcard.2012.06.031

Coffey, S., & Williams, M. (2011). Quetiapine-associated cardiomyopathy [Clinical correspondence]. New Zealand Medical Journal, 124(1337). Retrieved from http://journal.nzma.org.nz/journal/124-1337/4744/content.pdf

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