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Health Sciences profile

Professor Colin Brown

PositionProfessor
DepartmentDepartment of Physiology
QualificationsBSc(Hons) PhD
Research summaryNeuroendocrinology

Research

Our research group principally uses electrophysiology and immunohistochemistry to determine how the brain controls birth, lactation, food intake and water balance. We currently focus on the control of the secretion of the hormone, oxytocin, which is necessary for birth and lactation, and is involved in driving increased food intake during pregnancy. We are also investigating how vasopressin (anti-diuretic hormone) neurons prevent water loss in the urine to protect from dehydration and how malfunction of vasopressin neurons might contribute to the development of hypertension.

Publications

Seymour, A. J., Scott, V., Augustine, R. A., Bouwer, G. T., Campbell, R. E., & Brown, C. H. (2017). Development of an excitatory kisspeptin projection to the oxytocin system in late pregnancy. Journal of Physiology, 595(3), 825-838. doi: 10.1113/jp273051

Augustine, R. A., Bouwer, G. T., Seymour, A. J., Grattan, D. R., & Brown, C. H. (2016). Reproductive regulation of gene expression in the hypothalamic supraoptic and paraventricular nuclei. Journal of Neuroendocrinology, 28(4). doi: 10.1111/jne.12350

Choe, K. Y., Han, S. Y., Gaub, P., Shell, B., Voisin, D. L., Knapp, B. A., … Brown, C. H., … Bourque, C. W. (2015). High salt intake increases blood pressure via BDNF-mediated downregulation of KCC2 and impaired baroreflex inhibition of vasopressin neurons. Neuron, 85(3), 549-560. doi: 10.1016/j.neuron.2014.12.048

Han, S. Y., Bouwer, G. T., Seymour, A. J., Korpal, A. K., Schwenke, D. O., & Brown, C. H. (2015). Induction of hypertension blunts baroreflex inhibition of vasopressin neurons in the rat. European Journal of Neuroscience, 42(9), 2690-2698. doi: 10.1111/ejn.13062

Moaddab, M., Hyland, B. I., & Brown, C. H. (2015). Oxytocin enhances the expression of morphine-induced conditioned place preference in rats. Psychoneuroendocrinology, 53, 159-169. doi: 10.1016/j.psyneuen.2015.01.003

Journal - Research Article

Seymour, A. J., Scott, V., Augustine, R. A., Bouwer, G. T., Campbell, R. E., & Brown, C. H. (2017). Development of an excitatory kisspeptin projection to the oxytocin system in late pregnancy. Journal of Physiology, 595(3), 825-838. doi: 10.1113/jp273051

Augustine, R. A., Bouwer, G. T., Seymour, A. J., Grattan, D. R., & Brown, C. H. (2016). Reproductive regulation of gene expression in the hypothalamic supraoptic and paraventricular nuclei. Journal of Neuroendocrinology, 28(4). doi: 10.1111/jne.12350

Royo, J. M., Brown, C. H., Leng, G., & MacGregor, D. J. (2016). Oxytocin neurones: Intrinsic mechanisms governing the regularity of spiking activity. Journal of Neuroendocrinology, 28(4). doi: 10.1111/jne.12358

Ladyman, S. R., Augustine, R. A., Scherf, E., Phillipps, H. R., Brown, C. H., & Grattan, D. R. (2016). Attenuated hypothalamic responses to α-melanocyte stimulating hormone during pregnancy in the rat. Journal of Physiology, 594(4), 1087-1101. doi: 10.1113/jp271605

Choe, K. Y., Han, S. Y., Gaub, P., Shell, B., Voisin, D. L., Knapp, B. A., … Brown, C. H., … Bourque, C. W. (2015). High salt intake increases blood pressure via BDNF-mediated downregulation of KCC2 and impaired baroreflex inhibition of vasopressin neurons. Neuron, 85(3), 549-560. doi: 10.1016/j.neuron.2014.12.048

Han, S. Y., Bouwer, G. T., Seymour, A. J., Korpal, A. K., Schwenke, D. O., & Brown, C. H. (2015). Induction of hypertension blunts baroreflex inhibition of vasopressin neurons in the rat. European Journal of Neuroscience, 42(9), 2690-2698. doi: 10.1111/ejn.13062

Moaddab, M., Hyland, B. I., & Brown, C. H. (2015). Oxytocin enhances the expression of morphine-induced conditioned place preference in rats. Psychoneuroendocrinology, 53, 159-169. doi: 10.1016/j.psyneuen.2015.01.003

Moaddab, M., Hyland, B. I., & Brown, C. H. (2015). Oxytocin excites nucleus accumbens shell neurons in vivo. Molecular & Cellular Neuroscience, 68, 323-330. doi: 10.1016/j.mcn.2015.08.013

Han, S. Y., Gray, E., Hughes, G., Brown, C. H., & Schwenke, D. O. (2014). Increased sympathetic drive during the onset of hypertension in conscious Cyp1a1-Ren2 rats. Pflügers Archiv: European Journal of Physiology, 466(3), 459-466. doi: 10.1007/s00424-013-1338-5

Joe, N., Scott, V., & Brown, C. H. (2014). Glial regulation of extrasynaptic NMDA receptor-mediated excitation of supraoptic nucleus neurons during dehydration. Journal of Neuroendocrinology, 26(1), 35-42. doi: 10.1111/jne.12121

Brown, C. H., Bains, J. S., Ludwig, M., & Stern, J. E. (2013). Physiological regulation of magnocellular neurosecretory cell activity: Integration of intrinsic, local and afferent mechanisms. Journal of Neuroendocrinology, 25(8), 678-710. doi: 10.1111/jne.12051

Scott, V., & Brown, C. H. (2013). Beyond the GnRH axis: Kisspeptin regulation of the oxytocin system in pregnancy and lactation. Advances in Experimental Medicine & Biology, 784, 201-218. doi: 10.1007/978-1-4614-6199-9_10

Tasker, J. G., Oliet, S. H. R., Bains, J. S., Brown, C. H., & Stern, J. E. (2012). Glial regulation of neuronal function: From synapse to systems physiology. Journal of Neuroendocrinology, 24(4), 566-576. doi: 10.1111/j.1365-2826.2011.02259.x

Ruan, M., Russell, J. A., & Brown, C. H. (2011). Acute morphine administration and withdrawal from chronic morphine increase afterdepolarization amplitude in rat supraoptic nucleus neurons in hypothalamic explants. Neuropharmacology, 61, 789-797. doi: 10.1016/j.neuropharm.2011.05.025

Scott, V., & Brown, C. H. (2011). Kisspeptin activation of supraoptic nucleus neurons in Vivo. Endocrinology, 152(10), 3862-3870. doi: 10.1210/en.2011-1181

Fleming, T. M., Scott, V., Naskar, K., Joe, N., Brown, C. H., & Stern, J. E. (2011). State-dependent changes in astrocyte regulation of extrasynaptic NMDA receptor signalling in neurosecretory neurons. Journal of Physiology, 589(16), 3929-3941. doi: 10.1113/jphysiol.2011.207340

Bull, P. M., Russell, J. A., Scott, V., & Brown, C. H. (2011). Apamin increases post-spike excitability of supraoptic nucleus neurons in anaesthetized morphine-naïve rats and morphine-dependent rats: Consequences for morphine withdrawal excitation. Experimental Brain Research, 212(4), 517-528. doi: 10.1007/s00221-011-2759-z

Scott, V., & Brown, C. H. (2010). State-dependent plasticity in vasopressin neurones: Dehydration-induced changes inactivity patterning. Journal of Neuroendocrinology, 22(5), 343-354. doi: 10.1111/j.1365-2826.2010.01961.x

Scott, V., Bishop, V. R., Leng, G., & Brown, C. H. (2009). Dehydration-induced modulation of κ-opioid inhibition of vasopressin neurone activity. Journal of Physiology, 587(23), 5679-5689. doi: 10.1113/jphysiol.2009.180232

Ruan, M., & Brown, C. H. (2009). Feedback inhibition of action potential discharge by endogenous adenosine enhancement of the medium afterhyperpolarization. Journal of Physiology, 587(Pt 5), 1043-1056. doi: 10.1113/jphysiol.2008.167239

Leng, G., Brown, C., Sabatier, N., & Scott, V. (2008). Population dynamics in vasopressin cells. Neuroendocrinology, 88(3), 160-172.

Brown, C. H., Ruan, M., Scott, V., Tobin, V. A., & Ludwig, M. (2008). Multi-factorial somato-dendritic regulation of phasic spike discharge in vasopressin neurons. Progress in Brain Research, 170, 219-228.

Brown, C. H., & Grattan, D. R. (2007). Does maternal oxytocin protect the fetal brain? Trends in Endocrinology & Metabolism, 18(6), 225-226.

Brown, C. H., Scott, V., Ludwig, M., Leng, G., & Bourque, C. W. (2007). Somatodendritic dynorphin release: Orchestrating activity patterns of vasopressin neurons. Biochemical Society Transactions, 35(5), 1236-1242.

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