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Health Sciences profile

Associate Professor Grant Butt

PositionAssociate Professor
DepartmentDepartment of Physiology
QualificationsBSc (Hons) PhD (Cant)
Research summaryMechanisms and regulation of intestinal epithelial transport

Research

  • Cellular mechanisms and regulation of ion transport in the mammalian intestine.
  • Intestinal secretion of mucus and bicarbonate
  • The role of NOD2 mutations in Crohn's disease.
  • the interaction of bacteria with the intestinal epithelium.

Publications

Chao, P.-C., & Butt, A. G. (2017). cAMP-dependent secretagogues stimulate the NaHCO3 cotransporter in the villous epithelium of the brushtail possum, Trichosurus vulpecula. Journal of Comparative Physiology B. Advance online publication. doi: 10.1007/s00360-017-1063-z

Alsop, T.-A., McLeod, B. J., & Butt, A. G. (2016). Variations in epithelial Na+ transport and epithelial sodium channel localisation in the vaginal cul-de-sac of the brushtail possum, Trichosurus vulpecula, during the oestrous cycle. Reproduction, Fertility & Development, 28(3), 328-336. doi: 10.1071/RD13277

Dunn, E. T. J., Taylor, E. S., Stebbings, S., Schultz, M., Butt, A. G., & Kemp, R. A. (2016). Distinct immune signatures in the colon of Crohn's disease and ankylosing spondylitis patients in the absence of inflammation. Immunology & Cell Biology, 94(5), 421-429. doi: 10.1038/icb.2015.112

Schultz, M., Lai, C. C., Lindstrom, A. L., Stein, K., Donaldson, G., Thompson-Fawcett, M., & Butt, A. G. (2015). Aggravation of established colitis in specific pathogen-free IL-10 knockout mice by restraint stress is not mediated by increased colonic permeability. Journal of Crohn's & Colitis, 9(9), 754-762. doi: 10.1093/ecco-jcc/jjv098

Schultz, M., Dunn, E., Taylor, E., Butt, G. A., & Kemp, R. (2013). The Gut Map Project: T cell distribution in inflammation of the gut. Journal of Gastroenterology & Hepatology, 28(Suppl. 3), 588. doi: 10.1111/jgh.12363_2

Chapter in Book - Research

Butt, A. G., Mills, R. G., & Macknight, A. (1999). Digestive System. In J. J. Bray, P. A. Cragg, A. D. C. Macknight & R. G. Mills (Eds.), Lecture Notes on Human Physiology. (pp. 468-511). London: Blackwell Science.

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Journal - Research Article

Chao, P.-C., & Butt, A. G. (2017). cAMP-dependent secretagogues stimulate the NaHCO3 cotransporter in the villous epithelium of the brushtail possum, Trichosurus vulpecula. Journal of Comparative Physiology B. Advance online publication. doi: 10.1007/s00360-017-1063-z

Alsop, T.-A., McLeod, B. J., & Butt, A. G. (2016). Variations in epithelial Na+ transport and epithelial sodium channel localisation in the vaginal cul-de-sac of the brushtail possum, Trichosurus vulpecula, during the oestrous cycle. Reproduction, Fertility & Development, 28(3), 328-336. doi: 10.1071/RD13277

Dunn, E. T. J., Taylor, E. S., Stebbings, S., Schultz, M., Butt, A. G., & Kemp, R. A. (2016). Distinct immune signatures in the colon of Crohn's disease and ankylosing spondylitis patients in the absence of inflammation. Immunology & Cell Biology, 94(5), 421-429. doi: 10.1038/icb.2015.112

Schultz, M., Lai, C. C., Lindstrom, A. L., Stein, K., Donaldson, G., Thompson-Fawcett, M., & Butt, A. G. (2015). Aggravation of established colitis in specific pathogen-free IL-10 knockout mice by restraint stress is not mediated by increased colonic permeability. Journal of Crohn's & Colitis, 9(9), 754-762. doi: 10.1093/ecco-jcc/jjv098

Schultz, M., Dunn, E., Taylor, E., Butt, G. A., & Kemp, R. (2013). The Gut Map Project: T cell distribution in inflammation of the gut. Journal of Gastroenterology & Hepatology, 28(Suppl. 3), 588. doi: 10.1111/jgh.12363_2

Hamilton, K. L., & Butt, A. G. (2013). Glucose transport into everted sacs of the small intestine of mice. Advances in Physiology Education, 37(4), 415-426. doi: 10.1152/advan.00017.2013

Al-Salami, H., Butt, G., Tucker, I., Golocorbin-Kon, S., & Mikov, M. (2012). Probiotics decreased the bioavailability of the bile acid analog, monoketocholic acid, when coadministered with gliclazide, in healthy but not diabetic rats. European Journal of Drug Metabolism & Pharmacokinetics, 37(2), 99-108. doi: 10.1007/s13318-011-0060-y

Fan, S., Harfoot, N., Bartolo, R. C., & Butt, A. G. (2012). CFTR is restricted to a small population of high expresser cells that provide a forskolin-sensitive transepithelial Cl- conductance in the proximal colon of the possum, Trichosurus vulpecula. Journal of Experimental Biology, 215, 1218-1230. doi: 10.1242/jeb.061176

Gill, M., Bartolo, R. C., Demmers, K., Harfoot, N., Fan, S., & Butt, G. (2011). The distribution and expression of CFTR restricts electrogenic anion secretion to the ileum of the brushtail possum, Trichosurus vulpecula. Journal of Experimental Biology, 214(Pt 11), 1943-1954. doi: 10.1242/jeb.053371

Demmers, K., Carter, D., Fan, S., Mao, P., Maqbool, N. J., McLeod, B. J., Bartolo, R. C., & Butt, A. G. (2010). Molecular and functional characterization of the cystic fibrosis transmembrane conductance regulator from the Australian common brushtail possum, Trichosurus vulpecula. Journal of Comparative Physiology B, 180(4), 545-561. doi: 10.1007/s00360-009-0433-6

Ke, Y., Butt, A. G., Swart, M., Liu, Y.-f., & McDonald, F. J. (2010). COMMD1 down-regulates the epithelial sodium channel through Nedd4-2. American Journal of Physiology: Renal Physiology, 298, F1445-F1456. doi: 10.1152/ajprenal.00257.2009

Schultz, M., & Butt, G. (2010). E. coli Nissle 1917 in the treatment of inflammatory bowel disease. Practical Gastroenterology, 34(3), 11-19.

Bartolo, R. C., Harfoot, N., Gill, M., Demmers, K., McLeod, B., & Butt, A. G. (2009). Electrogenic Cl secretion does not occur in the ileum of the Australian common brushtail possum, Trichosurus vulpecula, due to low levels of expression of the NaK2CL cotransporter, NKCC1. Journal of Comparative Physiology B, 179(8), 997-1010. doi: 10.1007/s00360-009-0379-8

Schep, L. J., Temple, W. A., Butt, G. A., & Beasley, D. M. (2009). Ricin as a weapon of mass terror: Separating fact from fiction. Environment International, 35(8), 1267-1271. doi: 10.1016/j.envint.2009.08.004

Bartolo, R. C., Harfoot, N., Gill, M., McLeod, B. J., & Butt, A. G. (2009). Secretagogues stimulate electrogenic HCO3- secretion in the ileum of the brushtail possum, Trichosurus vulpecula: Evidence for the role of a Na+/HCO3- cotransporter. Journal of Experimental Biology, 212, 2645-2655. doi: 10.1242/jeb.028928

Al-Salami, H., Butt, G., Tucker, I., Fawcett, J. P., Golocorbin-Kon, S., Mikov, I., & Mikov, M. (2009). Gliclazide reduces MKC intestinal transport in healthy but not diabetic rats. European Journal of Drug Metabolism & Pharmacokinetics, 34(1), 43-50.

Al-Salami, H., Butt, G., Fawcett, J. P., Tucker, I. G., Golocorbin-Kon, S., & Mikov, M. (2008). Probiotic treatment reduces blood glucose levels and increases systemic absorption of gliclazide in diabetic rats. European Journal of Drug Metabolism & Pharmacokinetics, 33(2), 101-106.

Al-Salami, H., Butt, G., Tucker, I., & Mikov, M. (2008). Influence of the semisynthetic bile acid MKC on the ileal permeation of gliclazide in vitro in healthy and diabetic rats treated with probiotics. Methods & Findings in Experimental & Clinical Pharmacology, 30(2), 107-113.

Al-Salami, H., Butt, G., Tucker, I., Skrbic, R., Golocorbin-Kon, S., & Mikov, M. (2008). Probiotic pre-treatment reduces gliclazide permeation (ex vivo) in healthy rats but increases it in diabetic rats to the level seen in untreated healthy rats. Archives of Drug Information, 1, 35-41. doi: 10.1111/j.1753-5174.2008.00006.x

Al-Salami, H., Butt, G., Tucker, I., Skrbic, R., Golocorbin-Kon, S., & Mikov, M. (2008). Probiotic treatment proceeded by a single dose of bile acid and gliclazide exert the most hypoglycemic effect in type 1 diabetic rats. Medical Hypotheses & Research, 4(2), 93-101.

Al-Salami, H., Butt, G., Tucker, I., & Mikov, M. (2008). Influence of the semisynthetic bile acid (MKC) on the ileal permeation of gliclazide in healthy and diabetic rats. Pharmacological Reports, 60, 532-541.

Schultz, M., & Butt, A. G. (2007). Methodological aspects in probiotic research: A brief review with an emphasis on epithelial barrier function. International Journal of Probiotics & Prebiotics, 2(2/3), 85-96.

Wen, J. Y., McLeod, B. J., Tucker, I. G., Davies, N. M., Ledger, R., & Butt, A. G. (2007). Enhancing absorption of fluorescein and LHRH across hindgut epithelia in a marsupial, the common brushtail possum Trichosurus Vulpecula. Journal of Pharmaceutical Sciences, 96(9), 2262-2273.

McLeod, B. J., Zhang, H., Huang, L., Thompson, E. G., Butt, A. G., & Tucker, I. G. (2005). An in situ single-pass perfusion model for assessing absorption across the intestinal mucosa of the brushtail possum. New Zealand Veterinary Journal, 53(4), 234-241.

Clunes, M. T., Butt, A. G., & Wilson, S. M. (2004). A glucocorticoid-induced Na+ conductance in human airway epithelial cells identified by perforated patch recording. Journal of Physiology, 557(3), 809-819.

Butt, A. G., Mathieson, S., & McLeod, B. (2002). Aldosterone does not regulate amiloride-sensitive Na+ transport in the colon of the Australian common brushtail possum, Trichosurus vulpecula. Journal of Comparative Physiology B, 172, 519-527.

Wen, J., Ledger, R., Butt, A. G., McLeod, B., Davies, N. M., & Tucker, I. G. (2002). Inhibition of proteolysis in luminal extracts from the intestine of the brushtail possum. Journal of Pharmacy & Pharmacology, 54, 1365-1372.

Wen, J., Ledger, R., McLeod, B. J., Davies, N. M., Butt, A. G., & Tucker, I. G. (2002). Enzymatic degradation of luteinizing hormone releasing hormone (LHRH) by mucosal homogenates from the intestine of the common brushtail possum (Trichosurus vulpecula). Life Sciences, 71, 3019-3030.

Wen, J., Ledger, R., McLeod, B. J., Davies, N. M., Butt, A. G., & Tucker, I. G. (2002). Protein and peptide degradation in the intestine of the common brushtail possum (Trichosurus vulpecula). Journal of Comparative Physiology B, 172, 553-559.

Wen, J., Davies, N. M., Ledger, R., Butt, A. G., McLeod, B., & Tucker, I. G. (2002). Isocratic liquid chromatographic assay for monitoring the degradation of luteinizing hormone releasing hormone by extracts from the gastrointestinal tract of possums. Journal of Chromatography B, 779, 221-227.

Butt, A. G., Mathieson, S., & McLeod, B. (2002). Electrogenic ion transport in the intestine of the Australian common brushtail possum, Trichosurus vulpecula: Indications of novel transport patterns in a marsupial. Journal of Comparative Physiology B, 172, 495-502.

Hamilton, K. L., Butt, A. G., Cheng, S., & Carter, D. J. (2002). Methoxsalen stimulates electrogenic Cl- secretion in the mouse jejunum. Experimental Physiology, 87(4), 437-445.

Hope, N. M., Butt, A. G., Ross, I., Warhurst, G., Arn, M., Grigor, M. R., Lubcke, R., & Barbezat, G. O. (2001). Somatostatin (SST) enhances cAMP-dependent short-circuit current in human colon via somatostatin receptor subtype-2 (SSTR-2). Digestive Diseases & Sciences, 46(11), 2499-2503.

Taylor, J., Hamilton, K. L., & Butt, A. G. (2001). HCO3- potentiates the cAMP-dependent secretory response of the human distal colon through a DIDS-sensitive pathway. Pflügers Archiv: European Journal of Physiology, 442(2), 256-262.

Arn, M., Butt, A. G., Lubcke, R., Ross, I., Grigor, M. R., Warhurst, G., & Barbezat, G. O. (2000). Somatostatin and octreotide stimulate short-circuit current in human colonic epithelium. Digestive Diseases & Sciences, 45(11), 2100-2107.

Samson, A., Hamilton, K. L., & Butt, A. G. (2000). Effect of somatostatin on electrogenic ion transport in the duodenum and colon of the mouse, Mus domesticus. Comparative Biochemistry & Physiology Part A, 125A, 459-468.

Hamilton, K. L., & Butt, A. G. (2000). The molecular basis of renal tubular transport disorders. Comparative Biochemistry & Physiology Part A, 126A, 305-321.

Hamilton, K. L., Meads, L., & Butt, A. G. (1999). 1-EBIO stimulates C1 secretion by activating a basolateral K channel in the mouse jejunum. Pflügers Archiv: European Journal of Physiology, 439, 158-166.

Schep, L., Tucker, I. G., Young, G., Ledger, R., & Butt, A. G. (1998). Permeability of the salmon (Oncorhynchus tshawytscha) posterior intestine in vivo to two hydrophilic markers. Journal of Comparative Physiology B, 168, 562-568.

Butt, A. G., Bowler, J. M., & McLaughlin, C. W. (1998). Villus and crypt cell composition in the secreting mouse jejunum measured with x-ray microanalysis. Journal of Membrane Biology, 162, 17-29.

Butt, A. G., & Hamilton, K. L. (1998). Ion channels in isolated mouse jejunal crypts. Pflügers Archiv: European Journal of Physiology, 435, 528-538.

Schep, L., Tucker, I. G., Young, G., & Butt, A. G. (1997). Regional permeability differences between the proximal and distal portions of the isolated salmonid posterior intestine. Journal of Comparative Physiology B, 167(5), 370-377.

Schep, L., Tucker, I., Young, G., Ledger, R., & Butt, A. G. (1996). Proteolytic activity in the gastrointestinal tract of salmon. Australian Journal of Hospital Pharmacy, 26.

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Journal - Research Other

Schultz, M., & Butt, A. G. (2012). Is the north to south gradient in inflammatory bowel disease a global phenomenon? Expert Review of Gastroenterology & Hepatology, 6(4), 445-447. doi: 10.1586/egh.12.31

Schultz, M., Roberts, R. L., & Butt, A. G. (2010). Understanding probiotic treatment strategies in inflammatory bowel disease, with a special emphasis on the intestinal barrier. European Gastroenterology & Hepatology Review, 6(1), 58-65.

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