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Health Sciences profile

Dr Zoe Ashley

PositionResearch Fellow
DepartmentDepartment of Physiology
QualificationsPhD
Research summaryRole of ENaC in vascular biology
MembershipsEuropean Society of Hypertension

Research

Currently research active investigating the role of the Epithelial Sodium Channel (ENaC) as a potential 'new player' in the regulation of vascular tone and flow-mediated responses. Shear-sensation by ENaC is dependent on the interaction with the glycocalyx. Our research is investigating the molecular aspects of ENaC-matrix action and the functional role of vascular ENaC under both normal and pathophysiological (diabetes and hypertension) states.

Publications

Ashley, Z., Schwenke, D. O., & Cragg, P. A. (2015). Hyperventilation in normoxia following myocardial infarction in rats: A shift in the set point of the hypoxic ventilatory response. Acta Physiologica, 214, 415-425. doi: 10.1111/apha.12527

Bussey, C. T., de Leeuw, A. E., Cook, R. F., Ashley, Z., Schofield, J., & Lamberts, R. R. (2014). Dual implantation of a radio-telemeter and vascular access port allows repeated hemodynamic and pharmacological measures in conscious lean and obese rats. Laboratory Animals, 48(3), 250-260. doi: 10.1177/0023677214530687

Russold, M. F., Ramnarine, I., Ashley, Z., Sutherland, H., Salmons, S., & Jarvis, J. C. (2010). Practical and effective stomal sphincter creation: Evaluation in pigs. Diseases of the Colon & Rectum, 53(4), 467-474. doi: 10.1007/DCR.0b013e3181bdbe91

Ashley, Z., Sutherland, H., Russold, M. F., Lanmüller, H., Mayr, W., Jarvis, J. C., & Salmons, S. (2008). Therapeutic stimulation of denervated muscles: The influence of pattern. Muscle & Nerve, 38, 875-886. doi: 10.1002/mus.21020

Ashley, Z., Salmons, S., Boncompagni, S., Protasi, F., Russold, M., Lanmuller, H., … Jarvis, J. C. (2007). Effects of chronic electrical stimulation on long-term denervated muscles of the rabbit hind limb. Journal of Muscle Research & Cell Motility, 28, 203-217. doi: 10.1007/s10974-007-9119-4

Journal - Research Article

Ashley, Z., Schwenke, D. O., & Cragg, P. A. (2015). Hyperventilation in normoxia following myocardial infarction in rats: A shift in the set point of the hypoxic ventilatory response. Acta Physiologica, 214, 415-425. doi: 10.1111/apha.12527

Bussey, C. T., de Leeuw, A. E., Cook, R. F., Ashley, Z., Schofield, J., & Lamberts, R. R. (2014). Dual implantation of a radio-telemeter and vascular access port allows repeated hemodynamic and pharmacological measures in conscious lean and obese rats. Laboratory Animals, 48(3), 250-260. doi: 10.1177/0023677214530687

Russold, M. F., Ramnarine, I., Ashley, Z., Sutherland, H., Salmons, S., & Jarvis, J. C. (2010). Practical and effective stomal sphincter creation: Evaluation in pigs. Diseases of the Colon & Rectum, 53(4), 467-474. doi: 10.1007/DCR.0b013e3181bdbe91

Ashley, Z., Sutherland, H., Russold, M. F., Lanmüller, H., Mayr, W., Jarvis, J. C., & Salmons, S. (2008). Therapeutic stimulation of denervated muscles: The influence of pattern. Muscle & Nerve, 38, 875-886. doi: 10.1002/mus.21020

Ashley, Z., Salmons, S., Boncompagni, S., Protasi, F., Russold, M., Lanmuller, H., … Jarvis, J. C. (2007). Effects of chronic electrical stimulation on long-term denervated muscles of the rabbit hind limb. Journal of Muscle Research & Cell Motility, 28, 203-217. doi: 10.1007/s10974-007-9119-4

Ashley, Z., Sutherland, H., Lanmüller, H., Russold, M. F., Unger, E., Bijak, M., … Jarvis, J. C. (2007). Atrophy, but not necrosis, in rabbit skeletal muscle denervated for periods up to one year. American Journal of Physiology: Cell Physiology, 292, C440-C451. doi: 10.1152/ajpcell.00085.2006

Chilcott, R. P., Dalton, C. H., Ashley, Z., Allen, C. E., Bradley, S. T., ..., & Rice, P. (2007). Evaluation of barrier creams against sulphur mustard: (II) in vivo and in vitro studies using the domestic white pig. Cutaneous & Ocular Toxicology, 26, 235-247. doi: 10.1080/15569520701212373

Ramnarine, I. R., Capoccia, M., Ashley, Z., Sutherland, H., Russold, M., Summerfield, N., … Jarvis, J. C. (2006). Counterpulsation from the skeletal muscle ventricle and the intraaortic balloon pump in the normal and failing circulations. Circulation, 114(Suppl. I), I-10-I-15. doi: 10.1161/CIRCULATIONAHA.105.000372

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