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Health Sciences profile

Professor Andrew Day

PositionHead of Department
DepartmentDepartment of Paediatrics (UOC)
QualificationsMB ChB, MD, FRACP, AGAF
Research summaryGastrointestinal disorders in children

Research

Andrew Day trained in paediatrics in Christchurch and undertook further subspeciality training in Toronto, Canada. After completing clinical and research training in Canada, Dr Day took up a clinical academic position at University of New South Wales, Sydney, Australia. He returned to the department in 2009 and was appointed to Head of Department in 2010.

Professor Day is a paediatric gastroenterologist. His research interests include Inflammatory Bowel disease, Crohn’s disease and Coeliac disease, with projects focusing upon host-pathogen interactions in the gut (and how these relate to chronic gut diseases), intestinal inflammatory biomarkers, and nutritional aspects of gut diseases.

Publications

Turner, D., Leach, S. T., Mack, D., Uusoue, K., McLernon, R., Hyams, J., … Day, A. S. (2010). Faecal calprotectin, lactoferrin, M2-pyruvate kinase and S100A12 in severe ulcerative colitis: A prospective multicentre comparison of predicting outcomes and monitoring response. Gut, 59, 1207-1212. doi: 10.1136/gut.2010.211755

Kaakoush, N. O., Day, A. S., Leach, S. T., Lemberg, D. A., Nielsen, S., & Mitchell, H. M. (2015). Effect of exclusive enteral nutrition on the microbiota of children with newly diagnosed Crohn's disease. Clinical & Translational Gastroenterology, 6, e71. doi: 10.1038/ctg.2014.21

Kaakoush, N. O., Deshpande, N. P., Wilkins, M. R., Tan, C. G., Burgos-Portugal, J. A., Raftery, M. J., Day, A. S., … Mitchell, H. (2011). The pathogenic potential of Campylobacter concisus strains associated with chronic intestinal diseases. PLoS ONE, 6(12), e29045. doi: 10.1371/journal.pone.0029045

Wright, E. K., Kamm, M. A., De Cruz, P., Hamilton, A. L., Ritchie, K. J., Krejany, E. O., … Day, A. S., … Gearry, R. B. (2015). Measurement of fecal calprotectin improves monitoring and detection of recurrence of Crohn's disease following surgery. Gastroenterology, 148, 938-947. doi: 10.1053/j.gastro.2015.01.026

Leach, S. T., Mitchell, H. M., Eng, W. R., Zhang, L., & Day, A. S. (2008). Sustained modulation of intestinal bacteria by exclusive enteral nutrition used to treat children with Crohn's disease. Alimentary Pharmacology & Therapeutics, 28, 724-733. doi: 10.1111/j.1365-2036.2008.03796.x

Journal - Research Article

Kaakoush, N. O., Castaño-Rodríguez, N., Day, A. S., Lemberg, D. A., Leach, S. T., & Mitchell, H. M. (2015). Faecal levels of zonula occludens toxin in paediatric patients with Crohn's disease and their association with the intestinal microbiota. Journal of Medical Microbiology, 64(3), 303-306. doi: 10.1099/jmm.0.000005

Kaakoush, N. O., Day, A. S., Leach, S. T., Lemberg, D. A., Nielsen, S., & Mitchell, H. M. (2015). Effect of exclusive enteral nutrition on the microbiota of children with newly diagnosed Crohn's disease. Clinical & Translational Gastroenterology, 6, e71. doi: 10.1038/ctg.2014.21

Wright, E. K., Kamm, M. A., De Cruz, P., Hamilton, A. L., Ritchie, K. J., Krejany, E. O., … Day, A. S., … Gearry, R. B. (2015). Measurement of fecal calprotectin improves monitoring and detection of recurrence of Crohn's disease following surgery. Gastroenterology, 148, 938-947. doi: 10.1053/j.gastro.2015.01.026

Falvey, J. D., Hoskin, T., Meijer, B., Ashcroft, A., Walmsley, R., Day, A. S., & Gearry, R. B. (2015). Disease activity assessment in IBD: Clinical indices and biomarkers fail to predict endoscopic remission. Inflammatory Bowel Diseases, 21, 824-831. doi: 10.1097/mib.0000000000000341

Aurangzeb, B., Whitten, K. E., Harrison, B., Mitchell, M., Kepreotes, H., Sidler, M., … Day, A. S. (2012). Prevalence of malnutrition and risk of under-nutrition in hospitalized children. Clinical Nutrition, 31(1), 35-40. doi: 10.1016/j.clnu.2011.08.011

Ramsden, L., & Day, A. S. (2012). Paediatric growth charts: How do we use them and can we use them better? Journal of Paediatrics & Child Health, 48(1), 22-25. doi: 10.1111/j.1440-1754.2011.02185.x

Critch, J., Day, A. S., Otley, A., King-Moore, C., Teitelbaum, J. E., & Shashidhar, H. (2012). Use of enteral nutrition for the control of intestinal inflammation in pediatric Crohn disease. Journal of Pediatric Gastroenterology & Nutrition, 54(2), 298-305. doi: 10.1097/MPG.0b013e318235b397

Nahidi, L., Day, A. S., Lemberg, D. A., & Leach, S. T. (2012). Differential effects of nutritional and non-nutritional therapies on intestinal barrier function in an in vitro model. Journal of Gastroenterology, 47(2), 107-117. doi: 10.1007/s00535-011-0471-1

Baumgart, D. C., Bernstein, C. N., Abbas, Z., Colombel, J. F., Day, A. S., D'Haens, G., … Yamamoto-Furusho, J. K. (2011). IBD around the world: Comparing the epidemiology, diagnosis, and treatment: Proceedings of the World Digestive Health Day 2010: Inflammatory bowel disease task force meeting. Inflammatory Bowel Diseases, 17(2), 639-644. doi: 10.1002/ibd.21409

Wadhera, V., Lemberg, D. A., Leach, S. T., & Day, A. S. (2011). Complementary and alternative medicine in children attending gastroenterology clinics: Usage patterns and reasons for use. Journal of Paediatrics & Child Health, 47(12), 904-910. doi: 10.1111/j.1440-1754.2011.02100.x

Nahidi, L., Leach, S. T., Sidler, M. A., Levin, A., Lemberg, D. A., & Day, A. S. (2011). Osteoprotegerin in pediatric Crohn's disease and the effects of exclusive enteral nutrition. Inflammatory Bowel Diseases, 17(2), 516-523. doi: 10.1002/ibd.21361

Loughran-Fowlds, A., Leach, S., Lin, J., Oei, J., Henry, R., Day, A. S., & Lui, K. (2011). Respiratory disease and early serum S100A12 changes in very premature infants. Acta Paediatrica, 20, 1538-1543. doi: 10.1111/j.1651-2227.2011.02384.x

Li-Kim-Moy, J. P., Tobias, V., Day, A. S., Leach, S., & Lemberg, D. A. (2011). Esophageal subepithelial fibrosis and hyalinization are features of eosinophilic esophagitis. Journal of Pediatric Gastroenterology & Nutrition, 52(2), 147-153. doi: 10.1097/MPG.0b013e3181ef37a1

Judd, T. A., Day, A. S., Lemberg, D. A., Turner, D., & Leach, S. T. (2011). Update of fecal markers of inflammation in inflammatory bowel disease. Journal of Gastroenterology & Hepatology, 26(10), 1493-1499. doi: 10.1111/j.1440-1746.2011.06846.x

Levin, A. D., Wadhera, V., Leach, S. T., Woodhead, H. J., Lemberg, D. A., Mendoza-Cruz, A. C., & Day, A. S. (2011). Vitamin D deficiency in children with inflammatory bowel disease. Digestive Diseases & Sciences, 56(3), 830-836. doi: 10.1007/s10620-010-1544-3

Kaakoush, N. O., Deshpande, N. P., Wilkins, M. R., Tan, C. G., Burgos-Portugal, J. A., Raftery, M. J., Day, A. S., … Mitchell, H. (2011). The pathogenic potential of Campylobacter concisus strains associated with chronic intestinal diseases. PLoS ONE, 6(12), e29045. doi: 10.1371/journal.pone.0029045

Stewart, M., Day, A. S., & Otley, A. (2011). Physician attitudes and practices of enteral nutrition as primary treatment of paediatric Crohn disease in North America. Journal of Pediatric Gastroenterology & Nutrition, 52(1), 38-42. doi: 10.1097/MPG.0b013e3181e2c724

Wong, S., Lemberg, D. A., & Day, A. S. (2010). Exclusive enteral nutrition in the management of perianal Crohn's disease in children. Journal of Digestive Diseases, 11(3), 185-188. doi: 10.1111/j.1751-2980.2010.00434.x

Zhang, L., Budiman, V., Day, A. S., Mitchell, H., Lemberg, D. A., Riordan, S. M., … Ismail, Y. (2010). Isolation and detection of Campylobacter concisus from saliva of healthy individuals and patients with inflammatory bowel disease. Journal of Clinical Microbiology, 48(8), 2965-2967. doi: 10.1128/JCM.02391-09

Man, S. M., Kaakoush, N. O., Leach, S. T., Nahidi, L., Lu, H. K., Norman, J., Day, A. S., … Mitchell, H. M. (2010). Host attachment, invasion, and stimulation of proinflammatory cytokines by Campylobacter concisus and other non-Campylobacter jejuni Campylobacter species. Journal of Infectious Diseases, 202(12), 1855-1865. doi: 10.1086/657316

Turner, D., Leach, S. T., Mack, D., Uusoue, K., McLernon, R., Hyams, J., … Day, A. S. (2010). Faecal calprotectin, lactoferrin, M2-pyruvate kinase and S100A12 in severe ulcerative colitis: A prospective multicentre comparison of predicting outcomes and monitoring response. Gut, 59, 1207-1212. doi: 10.1136/gut.2010.211755

Kaakoush, N. O., Holmes, J., Octavia, S., Man, S. M., Zhang, L., Castaño-Rodríguez, N. M., … Day, A. S., … Mitchell, H. (2010). Detection of Helicobacteraceae in intestinal biopsies of children with Crohn's disease. Helicobacter, 15(6), 549-557. doi: 10.1111/j.1523-5378.2010.00792.x

Stewart, L. C., Day, A. S., Pearson, J., Barclay, M. L., Gearry, R. B., Roberts, R. L., & Bentley, R. W. (2010). SLC11A1 polymorphisms in inflammatory bowel disease and Mycobacterium avium subspecies paratuberculosis status. World Journal of Gastroenterology, 16(45), 5727-5731. doi: 10.3748/wjg.v16.i45.5727

Leach, S. T., Nahidi, L., Tilakaratne, S., Day, A. S., & Lemberg, D. A. (2010). Development and assessment of a modified pediatric Crohn disease Activity Index. Journal of Pediatric Gastroenterology & Nutrition, 51(2), 232-236. doi: 10.1097/MPG.0b013e3181d13609

Man, S. M., Zhang, L., Day, A. S., Leach, S. T., Lemberg, D. A., & Mitchell, H. (2010). Campylobacter concisus and other Campylobacter species in children with newly diagnosed Crohn’s disease. Inflammatory Bowel Diseases, 16(6), 1008-1016. doi: 10.1002/ibd.21157

Leach, S. T., Mitchell, H. M., Eng, W. R., Zhang, L., & Day, A. S. (2008). Sustained modulation of intestinal bacteria by exclusive enteral nutrition used to treat children with Crohn's disease. Alimentary Pharmacology & Therapeutics, 28, 724-733. doi: 10.1111/j.1365-2036.2008.03796.x

Sidler, M. A., Leach, S. T., & Day, A. S. (2008). Fecal S100A12 and fecal calprotectin as noninvasive markers for inflammatory bowel disease in children. Inflammatory Bowel Diseases, 14(3), 359-366. doi: 10.1002/ibd.20336

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Journal - Research Other

Keenan, J. I., Mitchell, H. M., & Day, A. S. (2011). Interactions between gastric and enteric infections: Clues to the pathogenesis of inflammatory bowel disease? [Viewpoint]. New Zealand Medical Journal, 124(1332). Retrieved from http://journal.nzma.org.nz/journal/124-1332/4606/content.pdf

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