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Health Sciences profile

Associate Professor Roland Broadbent

PositionAssociate Professor
DepartmentDepartment of Women's and Children's Health (DSM)
QualificationsMB ChB(Otago) FRACP
Research summaryNeonatal medicine, neonatal pharmacology

Research

Dr Broadbent is active in neonatal research, focussing on neonatal pharmacology, with a special interest in drug infusion kinetics. He is the Clinical Director of the Newborn Intensive Care Unit at Dunedin Hospital, and has been involved in several multicentre research collaborations. He maintains research interests in the following areas:

  • Neonatology
  • Neonatal jaundice
  • Neonatal pharmacology
  • Necrotising enterocolitis
  • Neonatal probiotics

Publications

Koller-Smith, L. I. M., Shah, P. S., Ye, X. Y., Sjörs, G., Wang, Y. A., Chow, S. S. W., Darlow, B. A., … on behalf of the Australian and New Zealand Neonatal Network, Canadian Neonatal Network, Swedish Neonatal Quality Register, and also Broadbent, R. (2017). Comparing very low birth weight versus very low gestation cohort methods for outcome analysis of high risk preterm infants. BMC Pediatrics, 17, 166. doi: 10.1186/s12887-017-0921-x

Salis, E. R., Reith, D. M., Wheeler, B. J., Broadbent, R. S., & Medlicott, N. J. (2017). Insulin resistance, glucagon-like peptide-1 and factors influencing glucose homeostasis in neonates. Archives of Disease in Childhood: Fetal & Neonatal Edition, 102(2), F162-F166. doi: 10.1136/archdischild-2015-309174

Poller, B., Strachan, C., Broadbent, R., & Walker, G. F. (2017). A minitablet formulation made from electrospun nanofibers. European Journal of Pharmaceutics & Biopharmaceutics, 114, 213-220. doi: 10.1016/j.ejpb.2017.01.022

Shah, P. S., Lui, K., Sjörs, G., Mirea, L., Reichman, B., Adams, M., … Darlow, B. A., … for the for the International Network for Evaluating Outcomes (iNeo) of Neonates including, including Broadbent, R. (2016). Neonatal outcomes of very low birth weight and very preterm neonates: An international comparison. Journal of Pediatrics, 177, 144-152. doi: 10.1016/j.jpeds.2016.04.083

Harris, S. L., Austin, N. C., Battin, M., Broadbent, R., Horwood, J., Keenan, R., … Graham, P., Woodward, L. J., & Darlow, B. A. (2016). In-hospital morbidity and brain metrics of preterm neonates born 1998–2009. New Zealand Medical Journal, 129(1440), 94-107. Retrieved from https://www.nzma.org.nz/journal

Chapter in Book - Research

Brooks, H. J. L., McConnell, M. A., & Broadbent, R. S. (2013). Microbes and the inflammatory response in necrotising enterocolitis. In O. Erez (Ed.), Preterm birth. InTech. doi: 10.5772/55039

Dore, G. M., Broadbent, R. S., & Walker, J. (1998). Managing the pregnant opioid user and her infant. In J. D. Sellman, G. Robinson, R. McCormick & G. Dore (Eds.), The Long and the Short of Treatment for Alcohol and Drug Disorders. (pp. 116-122). Christchurch, New Zealand: Department of Psychological Medicine.

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Journal - Research Article

Koller-Smith, L. I. M., Shah, P. S., Ye, X. Y., Sjörs, G., Wang, Y. A., Chow, S. S. W., Darlow, B. A., … on behalf of the Australian and New Zealand Neonatal Network, Canadian Neonatal Network, Swedish Neonatal Quality Register, and also Broadbent, R. (2017). Comparing very low birth weight versus very low gestation cohort methods for outcome analysis of high risk preterm infants. BMC Pediatrics, 17, 166. doi: 10.1186/s12887-017-0921-x

Poller, B., Strachan, C., Broadbent, R., & Walker, G. F. (2017). A minitablet formulation made from electrospun nanofibers. European Journal of Pharmaceutics & Biopharmaceutics, 114, 213-220. doi: 10.1016/j.ejpb.2017.01.022

Salis, E. R., Reith, D. M., Wheeler, B. J., Broadbent, R. S., & Medlicott, N. J. (2017). Insulin resistance, glucagon-like peptide-1 and factors influencing glucose homeostasis in neonates. Archives of Disease in Childhood: Fetal & Neonatal Edition, 102(2), F162-F166. doi: 10.1136/archdischild-2015-309174

Shah, P. S., Lui, K., Sjörs, G., Mirea, L., Reichman, B., Adams, M., … Darlow, B. A., … for the for the International Network for Evaluating Outcomes (iNeo) of Neonates including, including Broadbent, R. (2016). Neonatal outcomes of very low birth weight and very preterm neonates: An international comparison. Journal of Pediatrics, 177, 144-152. doi: 10.1016/j.jpeds.2016.04.083

Harris, S. L., Austin, N. C., Battin, M., Broadbent, R., Horwood, J., Keenan, R., … Graham, P., Woodward, L. J., & Darlow, B. A. (2016). In-hospital morbidity and brain metrics of preterm neonates born 1998–2009. New Zealand Medical Journal, 129(1440), 94-107. Retrieved from https://www.nzma.org.nz/journal

Miller, H., Kerruish, N., Broadbent, R. S., Barker, D., & Wheeler, B. J. (2016). Why do parents decline newborn intramuscular vitamin K prophylaxis? Journal of Medical Ethics, 42(10), 643-648. doi: 10.1136/medethics-2016-103534

Salis, E. R., Soelbeck, M. K., Reith, D. M., Wheeler, B. J., Broadbent, R. S., & Medlicott, N. J. (2016). Effect of gestational age and blood glucose on C-peptide excretion rate and clearance in neonates. Journal of Paediatrics & Child Health, 52(1), 60-66. doi: 10.1111/jpc.12977

Salis, E. R., Reith, D. M., Broadbent, R. S., & Medlicott, N. J. (2016). Haematocrit influences insulin concentration measurements in dried blood spots. Journal of Maternal-Fetal & Neonatal Medicine, 29(19), 3208-3211. doi: 10.3109/14767058.2015.1119116

Burke, M., Bernhardt, H., Reith, D. M., Barker, D., Broadbent, R. S., & Wheeler, B. J. (2015). Perinatal influences on the uptake of newborn vitamin K prophylaxis: A retrospective cohort study. Australian & New Zealand Journal of Public Health, 39(6), 573-576. doi: 10.1111/1753-6405.12399

Bernhardt, H., Barker, D., Reith, D. M., Broadbent, R. S., Jackson, P. M., & Wheeler, B. J. (2015). Declining newborn intramuscular vitamin K prophylaxis predicts subsequent immunisation refusal: A retrospective cohort study. Journal of Paediatrics & Child Health, 51(9), 889-894. doi: 10.1111/jpc.12887

Gosai, S., Broadbent, R. S., Barker, D. P., Jackson, P. M., & Wheeler, B. J. (2014). Medical and midwifery attitudes towards vitamin K prophylaxis in New Zealand neonates. Journal of Paediatrics & Child Health, 50(7), 536-539. doi: 10.1111/jpc.12490

Darlow, B. A., Marschner, S. L., Donoghoe, M., Battin, M. R., Broadbent, R. S., Elder, M. J., Hewson, M. P., … Graham, P., McNeill, N. J., … on behalf of the Benefits Of Oxygen Saturation Targeting-New Zealand (BOOST-NZ) Collaborative Group. (2014). Randomized controlled trial of oxygen saturation targets in very preterm infants: Two year outcomes. Journal of Pediatrics, 165(1), 30-35. doi: 10.1016/j.jpeds.2014.01.017

Sherwin, C. M. T., Medlicott, N. J., Reith, D. M., & Broadbent, R. S. (2014). Intravenous drug delivery in neonates: Lessons learnt. Archives of Disease in Childhood, 99, 590-594. doi: 10.1136/archdischild-2013-304887

Restieaux, M., Maw, A., Broadbent, R., Jackson, P., Barker, D., & Wheeler, B. (2013). Neonatal extravasation injury: Prevention and management in Australia and New Zealand: A survey of current practice. BMC Pediatrics, 13, 34. doi: 10.1186/1471-2431-13-34

Medlicott, N. J., Reith, D. M., McCaffrey, F., Krittaphol, W., & Broadbent, R. S. (2013). Delayed delivery of intravenous gentamicin in neonates: Impact of infusion variables. Journal of Pharmacy & Pharmacology, 65(3), 370-378. doi: 10.1111/jphp.12000

Boost II United Kingdom, Australia, and New Zealand Collaborative Groups, including Darlow, B. A., Broadbent, R., & Hewson, M. (2013). Oxygen saturation and outcomes in preterm infants. New England Journal of Medicine, 368, 2094-2104. doi: 10.1056/NEJMoa1302298

Wheeler, B., Broadbent, R., & Reith, D. (2012). Premedication for neonatal intubation in Australia and New Zealand: A survey of current practice. Journal of Paediatrics & Child Health, 48(11), 997-1000. doi: 10.1111/j.1440-1754.2012.02589.x

Sherwin, C. M. T., Kostan, E., Broadbent, R. S., Medlicott, N. J., & Reith, D. M. (2009). Evaluation of the effect of intravenous volume expanders upon the volume of distribution of gentamicin in septic neonates. Biopharmaceutics & Drug Disposition, 30(5), 276-280. doi: 10.1002/bdd.666

Sherwin, C. M. T., McCaffrey, F., Broadbent, R. S., Reith, D. M., & Medlicott, N. J. (2009). Discrepancies between predicted and observed rates of intravenous gentamicin delivery for neonates. Journal of Pharmacy & Pharmacology, 61(4), 465-471. doi: 10.1211/jpp/61.04.0008

Gabbett, M. T., Robertson, S. P., Broadbent, R., Aftimos, S., Sachdev, R., & Nezarati, M. N. (2008). Characterizing the oculoauriculofrontonasal syndrome. Clinical Dysmorphology, 17, 79-85. doi: 10.1097/MCD.0b013e3282f449c8

Sherwin, C., Broadbent, R., Young, S., Worth, J., McCaffrey, F., Medlicott, N. J., & Reith, D. (2008). Utility of interleukin-12 and interleukin-10 in comparison with other cytokines and acute-phase reactants in the diagnosis of neonatal sepsis. American Journal of Perinatology, 25, 629-636. doi: 10.1055/s-0028-1090585

Sherwin, C. M. T., Broadbent, R. S., Medlicott, N. J., & Reith, D. M. (2008). Individualising netilmicin dosing in neonates. European Journal of Clinical Pharmacology, 64, 1201-1208. doi: 10.1007/s00228-008-0536-0

Evans, N., Hutchinson, J., Simpson, J. M., Donoghue, D., Darlow, B., Henderson-Smart, D., on behalf of the Australian and New Zealand Neonatal Network, including Austin, N., Broadbent, R., & Richardson, V. (2007). Prenatal predictors of mortality in very preterm infants cared for in the Australian and New Zealand Neonatal Network. Archives of Disease in Childhood: Fetal & Neonatal Edition, 92, F34-F40. doi: 10.1136/adc.2006.094169

Broadbent, R. S. (2007). Recipient twin limb ischemia with postnatal onset. Journal of Pediatrics, 150, 207-209. doi: 10.1016/j.jpeds.2006.11.033

Crowther, C. A., Doyle, L. W., Haslam, R. R., Hiller, J. E., Harding, J. E., Robinson, J. S., for the ACTORDS Study Group, including Reid, R., Austin, N., Darlow, B., Poad, D., Broadbent, R., Wilson, D., Sangalli, M., Elder, D., & Richardson, V. (2007). Outcomes at 2 years of age after repeat doses of antenatal corticosteroids. New England Journal of Medicine, 357(12), 1179-1189.

Henderson-Smart, D. J., Hutchinson, J. L., Donoghue, D. A., Evans, N. J., Simpson, J. M., Wright, I., for the Australian and New Zealand Neonatal Network, including Darlow, B., & Broadbent, R. (2006). Prenatal predictors of chronic lung disease in very preterm infants. Archives of Disease in Childhood: Fetal & Neonatal Edition, 91, F40-F45.

Brooks, H. J. L., McConnell, M. A., Corbett, J., Buchan, G. S., Fitzpatrick, C. E., & Broadbent, R. S. (2006). Potential prophylactic value of bovine colostrum in necrotizing enterocolitis in neonates: An in vitro study on bacterial attachment, antibody levels and cytokine production. FEMS Immunology & Medical Microbiology, 48(3), 347-354.

Ellyett, K. M., Cragg, P. A., & Broadbent, R. S. (2006). Effect of surfactant deficiency and surfactant replacement on airway patency in the piglet lung. Respiratory Physiology & Neurobiology, 150, 173-181.

Crowther, C. A., Haslam, R. R., Hiller, J. E., Doyle, L. W., Robinson, J. S., for the Australasian Collaborative Trial of Repeat Doses of Steroids (ACTORDS) Study Group, including Reid, R., Austin, N., Darlow, B., Mogridge, N., Broadbent, R., Patel, F., Tout, S., Wilson, D., Sangalli, M., & Elder, D. (2006). Neonatal respiratory distress syndrome after repeat exposure to antenatal corticosteroids: A randomised controlled trial. Lancet, 367, 1913-1919. doi: 10.1016/S0140-6736(06)68846-6

Lingvall, M., Reith, D., & Broadbent, R. (2005). The effect of sepsis upon gentamicin pharmacokinetics in neonates. British Journal of Clinical Pharmacology, 59(1), 54-61.

Thom, R., Parnell, W. R., Broadbent, R. S., & Heath, A.-L. M. (2003). Predicting iron status in low birthweight infants. Journal of Paediatrics & Child Health, 39, 173-176.

Vogel, A. M., Lennon, D. R., Broadbent, R. S., Byrnes, C. A., Grimwood, K., Mildenhall, L., Richardson, V. F., & Rowley, S. (2002). Pailvizumab prophylaxis of respiratory syncitial virus infection in high-risk infants. Journal of Paediatrics & Child Health, 38(6), 550-554.

Bourchier, D., Darlow, B. A., Corban, J., Mildenhall, R., Broadbent, R. S., Doran, J., … Elder, D. E., & Knight, D. (2000). Routine examination of the newborn. Position statement of the Fetus and Newborn Committee of the Paediatric Society of New Zealand. New Zealand Medical Journal, 113, 361-363.

Kunac, D., Ball, P. A., & Broadbent, R. S. (1999). Study of the use of in-line intravenous filtration in neonates: Help or hindrance? Australian Journal of Hospital Pharmacy, 29(6), 321-327.

Chen, J. W., Broadbent, R. S., & Thomson, I. A. (1998). Staphylococcal neonatal necrotising fasciitis: Survival without radical debridement. New Zealand Medical Journal, 111, 251-253.

Elder, D. E., Bolton, D. P., Dempster, A. G., Taylor, B. J., & Broadbent, R. S. (1996). Pathophysiology of overheating in a piglet model: findings compared with sudden infant death syndrome. Journal of Paediatrics & Child Health, 32, 281-284.

Ellyett, K. M., Broadbent, R. S., Fawcett, E. R., & Campbell, A. (1996). Surfactant aerosol treatment of Respiratory Distress Syndrome in the spontaneously breathing premature rabbit. Pediatric Research, 39, 953-957.

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Journal - Research Other

Amer, A., Broadbent, R. S., Edmonds, L., & Wheeler, B. J. (2016). Central venous catheter-related tachycardia in the newborn: Case report and literature review. Case Reports in Medicine, 2016, 6206358. doi: 10.1155/2016/6206358

Lala, A. C., Broadbent, R. S., Medlicott, N. J., Sherwin, C. M. T., & Reith, D. M. (2015). Illustrative neonatal cases regarding drug delivery issues. Journal of Paediatrics & Child Health, 51, 478-481. doi: 10.1111/jpc.12764

Sherwin, C. M. T., Svahn, S., Van Der Linden, A., Broadbent, R. S., Medlicott, N. J., & Reith, D. M. (2009). Individualised dosing of amikacin in neonates: A pharmacokinetic/pharmacodynamic analysis. European Journal of Clinical Pharmacology, 65(7), 705-713. doi: 10.1007/s00228-009-0637-4

Sherwin, C. M. T., Broadbent, R. S., Medlicott, N. J., & Reith, D. M. (2009). Individualised dosing of amikacin in neonates [Letter to the editor]. European Journal of Clinical Pharmacology, 65(12), 1267-1268. doi: 10.1007/s00228-009-0691-y

Donoghue, D. A., Henderson-Smart, D. J., on behalf of the Australian and New Zealand Neonatal Network, including Austin, N., Darlow, B., Broadbent, R., & Richardson, V. (2009). The establishment of the Australian and New Zealand Neonatal Network. Journal of Paediatrics & Child Health, 45(7-8), 400-404. doi: 10.1111/j.1440-1754.2009.01527.x

Sherwin, C. M. T., Svahn, S., Broadbent, R. S., Van Der Linden, A., Medlicott, N. J., & Reith, D. M. (2008). Netilmicin withdrawal: Impact on neonates [Letter]. New Zealand Medical Journal, 121(1284). Retrieved from http://journal.nzma.org.nz/journal/121-1284/3328/content.pdf

Broadbent, R. (2007). [Reply to letter to the editor On the pathogenesis of recipient twin limb ischemia]. Journal of Pediatrics, 151(1), e4-e5.

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