Dr Greg Anderson
University Position
Lecturer
Department
Department of Anatomy Tel 64 3 479 7320 Fax 64 3 479 7254 Email
Lab web page http://anatomy.otago.ac.nz/research/andersongroup
Interests
The neural pathways by which the hormones leptin, insulin and ghrelin modulate GnRH neurons, the central drivers of fertility, in order to respond to the animal's nutritional status. The mechanisms by which the recently-discovered brain peptide RFRP-3 (the mammalian homologue of avian gonadotrophin inhibitory hormone) regulates GnRH and LH secretion in mammals. The hypothalamic actions and signaling pathways of prolactin, and the effects of reproductive experience on these.
Keywords
GnRH, RFRP-3, GnIH, leptin, insulin, ghrelin
Clinical conditions
infertility, nutritional disorders
Technical expertise
Immunohistochemistry, western blotting, radioimmunoassay, in situ hybridisation, RT-PCR, in vivo rodent techniques.
Laboratory Staff
Research Fellows/Post-docs |
Research Technicians |
PhD Students |
Masters Students |
Undergraduate Students |
Representative Publications
Rizwan MZ, Porteous R, Herbison AE, Anderson GM. Cells expressing RFRP-1/3, the mammalian GnIH orthologs, are not hypophysiotropic neuroendocrine neurons in the rat. Endocrinology in press. DOI: 10.1210/en.2008-1287 View abstract
Anderson GM, Relf HL, Rizwan MZ, Evans JJ. (2008) Central and peripheral effects of RFamide-related peptide-3 on LH and prolactin secretion in rats. Endocrinology in press. DOI:10.1210/en.2008-1359 View abstract
Anderson, G.M., Kieser, D.C., Steyn, F.J., Grattan, D.R. Hypothalamic prolactin receptor messenger ribonucleic acid levels, prolactin signaling, and hyperprolactinemic inhibition of pulsatile luteinizing hormone secretion are dependent on estradiol. (2008) Endocrinology, 149 (4), pp. 1562-1570. DOI: 10.1210/en.2007-0867 View abstract
Anderson, G.M., Beijer, P., Bang, A.S., Fenwick, M.A., Bunn, S.J., Grattan, D.R. Suppression of prolactin-induced signal transducer and activator of transcription 5b signaling and induction of suppressors of cytokine signaling messenger ribonucleic acid in the hypothalamic arcuate nucleus of the rat during late pregnancy and lactation. (2006) Endocrinology, 147 (10), pp. 4996-5005. DOI: 10.1210/en.2005-0755 View abstract
Anderson, G.M., Grattan, D.R., Van Den Ancker, W., Bridges, R.S. Reproductive experience increases prolactin responsiveness in the medial preoptic area and arcuate nucleus of female rats. (2006) Endocrinology, 147 (10), pp. 4688-4694.
DOI: 10.1210/en.2006-0600 View abstract