Dr Stephen Bunn
University Position
Senior Lecturer
Department
Department of Anatomy Tel 64 3 479 7366 Fax 64 3 479 7254 Email
Interests
Our research activities are directed at understanding intracellular signalling events within neuroendocrine cells, with a particular interest in the mechanisms by which multiple inputs interact within a single cell. We are pursuing these research aims through the use of isolated neuroendocrine cells maintained in culture. In recent years our major investigations have used adrenal medullary chromaffin cells and hypothalamic neuronal cultures to examine the integration of signals with respect to catecholamine and peptide synthesis and secretion.
Keywords
signal transduction, catecholamines, chromaffin cells, protein kinases, hypothalamic neurons
Clinical conditions
stress
Technical expertise
neuronal cell culture, immunocytochemistry, confocal microscopy, immunoblotting
Laboratory Staff
Research Technician |
PhD StudentsJoe Yip (with Dave Grattan) |
Masters Students |
Undergraduate Students |
Representative Publications
Knowles PJ, Douglas SA, Bunn SJ. (2011). Nicotinic stimulation of catecholamine synthesis and tyrosine hydroxylase phosphorylation in cervine adrenal medullary chromaffin cells. J Neuroendocrinol, 23, pp. 224-231. View abstract
Douglas SA, Sreenivasan D, Carman FH, Bunn SJ. (2010). Cytokine interactions with adrenal medullary chromaffin cells. Cell Mol Neurobiol, 30, pp. 1467-1475. View abstract
Grattan, D.R., Steyn, F.J., Kokay, I.C., Anderson, G.M., Bunn, S.J. Pregnancy-induced adaptation in the neuroendocrine control of prolactin secretion. (2008) Journal of Neuroendocrinology, 20 (4), pp. 497-507. doi: 10.1111/j.1365-2826.2008.01661.x View abstract
O'Sullivan, K.M. and Bunn, S.J. Phospholipase C isozymes are differentially distributed in the rat adrenal medulla. (2006) Neuroscience Letters, 396, pp. 212-216. doi: 10.1016/j.neulet.2005.11.033 View abstract
Ma, F.Y., Anderson, G.M., Gunn, T.D., Goffin, V., Grattan, D.R., Bunn, S.J. Prolactin specifically activates signal transducer and activator of transcription 5b in neuroendocrine dopaminergic neurons. (2005) Endocrinology, 146 (12), pp. 5112-5119. doi: 10.1210/en.2005-0770 View abstract
Ma, F.Y., Grattan, D.R., Goffin, V., Bunn, S.J. Prolactin-regulated tyrosine hydroxylase activity and messenger ribonucleic acid expression in mediobasal hypothalamic cultures: The differential role of specific protein kinases. (2005) Endocrinology, 146 (1), pp. 93-102. doi: 10.1210/en.2004-0800 View abstract