Professor Dave Grattan
University Position
Professor
Department
Department of Anatomy Tel 64 3 479 7442 Fax 64 3 479 7254 Email
Interests
My group is interested in the neuroendocrine functions of the hormone prolactin, and in particular, the role of prolactin in the neuroendocrine and neurobiological adaptations of the maternal brain. Specific interests include the control of appetite and body weight during pregnancy and obesity, plasticity in oxytocin neurons during late pregnancy and lactation, and role of prolactin in changes in mood and behaviour in the post partum period.
Keywords
prolactin, leptin, hypothalamus, JAK/STAT pathway, SOCS
Clinical conditions
hyperprolactinaemia, infertility, post-partum anxiety, post-partum depression
Technical expertise
Neuroanatomy, immunohistochemistry, in situ hybridisation, neurochemistry, radioimmunoassay, signal transduction
Laboratory Staff
Research Fellows/Post-docs
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Assistant Research Fellows/
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PhD Students
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Undergraduate Students
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Representative Publications
Grattan, D.R., Kokay, I.C. Prolactin: A pleiotropic neuroendocrine hormone. (2008) Journal of Neuroendocrinology, 20 (6), pp. 752-763. DOI: 10.1111/j.1365-2826.2008.01736.x View abstract
Steyn, F.J., Anderson, G.M., Grattan, D.R. Hormonal regulation of suppressors of cytokine signaling (SOCS) messenger ribonucleic acid in the arcuate nucleus during late pregnancy. (2008) Endocrinology, 149 (6), pp. 3206-3214.
DOI: 10.1210/en.2007-1623 View abstract
Larsen, C.M., Kokay, I.C., Grattan, D.R. Male pheromones initiate prolactin-induced neurogenesis and advance maternal behavior in female mice. (2008) Hormones and Behavior, 53 (4), pp. 509-517. DOI: 10.1016/j.yhbeh.2007.11.020
View abstract
Augustine, R.A., Grattan, D.R. Induction of central leptin resistance in hyperphagic pseudopregnant rats by chronic prolactin infusion. (2008) Endocrinology, 149 (3), pp. 1049-1055. DOI: 10.1210/en.2007-1018 View abstract
Grattan, D.R., Jasoni, C.L., Liu, X., Anderson, G.M., Herbison, A.E. Prolactin regulation of gonadotropin-releasing hormone neurons to suppress luteinizing hormone secretion in mice. (2007) Endocrinology, 148 (9), pp. 4344-4351.
DOI: 10.1210/en.2007-0403 View abstract