Dr Christine Jasoni
University Position
Senior Lecturer
Department
Department of Anatomy Tel 64 3 479 7254 Fax 64 3 479 7254 Email
Lab web page http://anatomy.otago.ac.nz/research/devel_neuroendo/index.html
Interests
The focus of our research is on discovering how the maternal environment during pregnancy affects the formation of the fetal brain. With conditions such as obesity and diabetes on the rise in Western society, it is critical that we fully understand the health implications of these disorders for future generations. We seek:
- to discover epigenetic changes in the brains of the offspring of obese or diabetic mothers
- to establish specifically how these changes bring about altered development of axon tracts in the offspring hypothalamus
Keywords
development, axon guidance, epigenetics, maternal nutrition
Clinical conditions
childhood obesity
Technical expertise
explant brain culture, live imaging, in situ hybridization, confocal microscopy
Laboratory Staff
Research Fellows/Post-docs |
Research Technicians |
PhD Students |
Postgraduate Students |
Representative Publications
Constantin, S., Jasoni, C.L., Wadas, B., Herbison, A.E. GABA and glutamate differentially regulate intracellular calcium concentrations in mouse GnRH neurons. (2010) Endocrinology, 151(1), pp. 262-270. View abstract
Jasoni, C.L., Porteous, R.W., Herbison, A.E. The anatomical location of mature GnRH neurons corresponds with their birthdate in the developing mouse. (2009) Developmental Dynamics, 238(3), pp. 524-531. DOI: 10.1002/dvdy.21869 View abstract
Romano, N., Lee, K., Ábrahám, I.M., Jasoni, C.L., Herbison, A.E. Nonclassical estrogen modulation of presynaptic GABA terminals modulates calcium dynamics in gonadotropin-releasing hormone neurons. (2008) Endocrinology, 149 (11), pp. 5335-5344.
DOI: 10.1210/en.2008-0424 View abstract
Grattan, D.R., Jasoni, C.L., Liu, X., Anderson, G.M., Herbison, A.E. Prolactin regulation of gonadotropin-releasing hormone neurons to suppress luteinizing hormone secretion in mice. (2007) Endocrinology, 148 (9), pp. 4344-4351.
DOI: 10.1210/en.2007-0403 View abstract
Jasoni, C.L., Todman, M.G., Strumia, M.M., Herbison, A.E. Cell type-specific expression of a genetically encoded calcium indicator reveals intrinsic calcium oscillations in adult gonadotropin-releasing hormone neurons. (2007) Journal of Neuroscience, 27 (4), pp. 860-867. DOI: 10.1523/JNEUROSCI.3579-06.2007 View abstract
Jasoni, C.L., Todman, M.G., Han, S.-K., Herbison, A.E. Expression of mRNAs encoding receptors that mediate stress signals in gonadotropin-releasing hormone neurons of the mouse. (2005) Neuroendocrinology, 82 (5-6), pp. 320-328.
DOI: 10.1159/000093155 View abstract