Associate Professor Christine Jasoni

Dr Christine Jasoni
University Position

Associate Professor

Department

Department of Anatomy Tel 64 3 479 3071 Fax 64 3 479 7254 Email christine.jasoni@otago.ac.nz

Lab web page http://develneuro.otago.ac.nz/

Interests

The focus of our research is on discovering how the maternal environment during pregnancy affects the formation of the fetal brain. With conditions such as obesity and diabetes on the rise in Western society, it is critical that we fully understand the health implications of these disorders for future generations. We seek:

  1. to discover epigenetic changes in the brains of the offspring of obese or diabetic mothers
  2. to establish specifically how these changes bring about altered development of axon tracts in the offspring hypothalamus
Clinical conditions

Pregnancy complications, childhood obesity and mental illness

Technical expertise

Molecular biology (including RNA-seq, qPCR, methylation analysis, in situ hybridization), in vitro neuronal culture, live imaging, confocal microscopy, transgenic technologies

Biography

 

Laboratory Staff
Research Fellows/Post-doc

Kelly Glendining

Assistant Research Fellows

Lorryn Fisher

PhD Student

Hannah Twigg

Selected Recent Publications

Kim DW, Glendining KA, Grattan DR, Jasoni CL.(2016) Maternal obesity leads to increased proliferation and numbers of astrocytes in the developing fetal and neonatal mouse hypothalamus. Int J Dev Neurosci. Oct;53:18-25. View abstract

Prescott SL, Allen K, Armstrong K, Collins C, Dickinson H, Gardiner K, Jacka F, Jasoni C, Moore T, Moritz KM, Muhlhausler B, Siero W, Sim K,
Nanan R, Saffery R, Singh G, Vickers MH, Craig JM. (2016) The establishment of DOHaD working groups in Australia and New Zealand. J Dev Orig Health Dis. Oct;7(5):433-439. View abstract

Kim DW, Glendining KA, Grattan DR, Jasoni CL.(2016) Maternal obesity in the mouse compromises the blood-brain barrier in the arcuate nucleus of offspring. Endocrinology. Jun;157(6):2229-42. View abstract

Jasoni CL, Sanders TR, Kim DW. (2015) Do all roads lead to Rome? The role of neuro-immune interactions before birth in the programming of offspring obesity. Front Neurosci.  3;8:455. doi: 10.3389/fnins.2014.00455. (IF, 3.7). View abstract

Hale MW, Spencer SJ, Conti B, Jasoni CL, Kent S, Radler ME, Reyes TM, Sominsky L. (2015) Diet, behavior and immunity across the lifespan. Neurosci Biobehav Rev. 58:46-62. doi: 10.1016/j.neubiorev.2014.12.009. (IF, 8.8). View abstract

Sanders TR, Kim DW, Jasoni CL (2014) Maternal obesity and IL-6 lead to aberrant developmental gene expression and deregulated neurite growth in the fetal arcuate nucleus. Endocrinology 155(7): 2566-77 (IF, 4.7). View abstract

Kim DW, Young SL, Grattan DR, Jasoni CL (2014) Obesity during pregnancy disrupts placental morphology, lipid accumulation, proliferation, and inflammation in a sex-specific manner across gestation the mouse. Biol Reprod, Published online ahead of print 14 May 2014; doi: 10.1095/ biolreprod.113.117259 (IF, 4.1). View abstract

Wyatt AK, Zavodna M, Viljoen JL, Stanton JL, Gemmell N, and Jasoni CL (2013) Changes in methylation patterns of Kiss1 and Kiss1r gene promoters across puberty. Genetics and Epigenetics, 5: 51-62. doi: 10.4137/GEG.S12897. View abstract

Centre for Neuroendocrinology Centre for Neuroendocrinology University of Otago