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Dissecting hippocampal dentate circuitry with molecular and neurophysiological tools

Speaker

Dr Calvin Young, Kavli Institute of Systems Neuroscience and the Centre for the Biology of Memory, NTNU

Calvin received his honours and Masters degrees from Otago University, where he mostly engaged in hippocampal oscillation research with Professor Neil McNaughton. In 2006, he joined Professor Brian Bland at the University of Calgary for his PhD training, where he continued to work in brain oscillation research and characterised the posterior hypothalamic nucleus as a novel deep brain stimulation target for Parkinson’s Disease. He has recently completed his postdoctoral fellowship at the Kavli Institute of Systems Neuroscience and the Centre for the Biology of Memory at NTNU, Norway and is set to join Dr Marie Carlen’s laboratory at Karolinska Institute, Sweden.

Abstract

Dentate gyrus in the hippocampal formation is an enigmatic structure. As one of the areas in rodent brain that undergoes continued neurogenesis, the dynamics of information processing in the dentate has remained elusive. To address the functional significance of principle cells found in the dentate (dentate granule cells), we employed advanced molecular biology and neurophysiology techniques to develop novel methodology for in vivo identification of dentate granule cells by simultaneous optogenetic stimulation and tetrode recordings, and examine the role of adult neurogenesis in hippocampal spatial representation. In this talk, the focus will be on the application of viral vectors and the use of channelrhodopsin-2 in the rodent hippocampus.

Date Tuesday, 5 June 2012
Time 1:00pm - 2:00am
Audience Public
Event Category Sciences
Event Type Seminar
CampusDunedin
DepartmentPsychology
LocationWilliam James Seminar Room - 103
Contact NameCara Duffy
Contact Phone64 3 479 7645
Contact Emailcduffy@psy.otago.ac.nz

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