Red X iconGreen tick iconYellow tick icon

Contact Details

Phone
+64 3 479 3040
Email
john.ashton@otago.ac.nz
Position
Associate Professor
Department
Department of Pharmacology and Toxicology
Qualifications
BSc(Hons)(Well) PhD(Massey)
Research summary
Non-small cell lung cancer, focus on ALK+ lung cancer
Teaching
Pharmacology teaching to Science, Medical, Dental and Physiotherapy students
Memberships
  • ASCEPT
  • Lung Foundation NZ

Research

Lung Cancer

Non-small cell lung cancer is difficult to treat and causes more cancer-related mortality than any other cancer in the developed world. Although lung cancer has been associated with smoking, the majority people with lung cancer are now non-smokers. Treatment has been revolutionised in recent years by the introduction of targeted therapies - such that life expectancy has been doubled for a sub-population of patients. My research is focused on lung cancer driven by mutations to the ALK protein, the mechanisms of action of drugs that target ALK, and mechanisms of cancer drug resistance.

Publications

Rivers-Auty, J. R., Smith, P. F., & Ashton, J. C. (2014). The cannabinoid CB2 receptor agonist GW405833 does not ameliorate brain damage induced by hypoxia-ischemia in rats. Neuroscience Letters, 569, 104-109. doi: 10.1016/j.neulet.2014.03.077 Journal - Research Article

Maggo, S., & Ashton, J. C. (2014). Effects of HMG-CoA reductase inhibitors on learning and memory in the guinea pig. European Journal of Pharmacology, 723, 294-304. doi: 10.1016/j.ejphar.2013.11.018 Journal - Research Article

Ashton, J. C., Zheng, Y., Darlington, C., Baek, J.-H., & Smith, P. F. (2014). Cannabinoid CB2 receptor immunolabelling in the healthy brain—still a live possibility. Naunyn-Schmiedeberg's Archives of Pharmacology, 387(3), 301. doi: 10.1007/s00210-013-0948-y Journal - Professional & Other Non-Research Articles

Rivers-Auty, J., & Ashton, J. C. (2014). Neuroinflammation in ischemic brain injury as an adaptive process. Medical Hypotheses, 82(2), 151-158. doi: 10.1016/j.mehy.2013.11.024 Journal - Research Other

Linsell, O., & Ashton, J. C. (2014). Cerebral hypoxia-ischemia causes cardiac damage in a rat model. NeuroReport, 25(10), 796-800. doi: 10.1097/wnr.0000000000000190 Journal - Research Article

Back to top