Dr Greg Giles

2022

Journal - Research Article

Giles, G. I., Erickson, J. R., & Bussey, C. T. (2022). Photoactivation of tDodSNO induces localized vasodilation in rats: Metabolically stable S-nitrosothiols can act as targeted nitric oxide donors in vivo. Nitric Oxide, 129, 53-62. doi: 10.1016/j.niox.2022.10.001

Alimoradi, H., Thomas, A., Lyth, D. D. B., Barzegar-Fallah, A., Matikonda, S. S., Gamble, A. B., & Giles, G. I. (2022). SMA-BmobaSNO: An intelligent photoresponsive nitric oxide releasing polymer for drug nanoencapsulation and targeted delivery. Nanotechnology, 33, 195101. doi: 10.1088/1361-6528/ac4eb0

2021

Intellectual Property

Sammut, I. A., Harrison, J. C., Hewitt, R. J., Read, M. I., Stanley, N. J., Woods, L. M., Kueh, J. T. B., … Smith, R. A. J., Giles, G., … Larsen, D. S. (2021). Carbon monoxide releasing norbornenone compounds. (11072584). United States.

2020

Journal - Research Article

McNeill, S., Giles, N. M., Preston, D., Jones, P. P., Crowley, J. D., & Giles, G. I. (2020). The quadruply stranded metallo-supramolecular helicate [Pd₂ (hextrz)₄]⁴⁺ acts as a molecular mimic of cytolytic peptides. Chemical Research in Toxicology, 33, 1822-1834. doi: 10.1021/acs.chemrestox.0c00061

2019

Journal - Research Article

van Hilst, Q. V. C., Vasdev, R. A. S., Preston, D., Findlay, J. A., Scottwell, S. Ø., Giles, G. I., Brooks, H. J. L., & Crowley, J. D. (2019). Synthesis, characterisation and antimicrobial studies of some 2,6-bis(1,2,3-triazol-4-yl)pyridine ruthenium(II) “click” complexes. Asian Journal of Organic Chemistry, 8, 496-505. doi: 10.1002/ajoc.201900088

Alimoradi, H., Barzegar-Fallah, A., Sammut, I. A., Griesh, K., & Giles, G. I. (2019). Encapsulation of tDodSNO generates a photoactivated nitric oxide releasing nanoparticle for localized control of vasodilation and vascular hyperpermeability. Free Radical Biology & Medicine, 130, 297-305. doi: 10.1016/j.freeradbiomed.2018.10.433

Journal - Research Other

Alimoradi, H., Greish, K., Gamble, A. B., & Giles, G. I. (2019). Controlled delivery of nitric oxide for cancer therapy. Pharmaceutical Nanotechnology, 7(4), 279-303. doi: 10.2174/2211738507666190429111306

Conference Contribution - Published proceedings: Abstract

Giles, N., & Giles, G. (2019). Nanostring analysis of the effect of nitric oxide on cancer gene expression. Free Radical Biology & Medicine, 145(Suppl. 1), (pp. S64). doi: 10.1016/j.freeradbiomed.2019.10.169

2018

Journal - Research Article

Vasdev, R. A. S., Gaudin, L. F., Preston, D., Jogy, J. P., Giles, G. I., & Crowley, J. D. (2018). Anticancer activity and cisplatin binding ability of bis-quinoline and bis-isoquinoline derived Pd₂L₄⁴⁺ metallosupramolecular cages. Frontiers in Chemistry, 6, 563. doi: 10.3389/fchem.2018.00563

Journal - Research Other

Alimoradi, H., Barzegar-Fallah, A., Sammut, I. A., Griesh, K., & Giles, G. I. (2018). Data characterizing the biophysical and nitric oxide release properties of the tDodSNO: Styrene maleic anhydride nanoparticle SMA-tDodSNO [Data article]. Data in Brief, 21, 1771-1775. doi: 10.1016/j.dib.2018.10.149

2017

Chapter in Book - Research

Alimoradi, H., Matikonda, S. S., Gamble, A. B., Giles, G. I., & Greish, K. (2017). Redox activated polymeric nanoparticles in tumor therapy. In E. Andronescu & A. M. Grumezescu (Eds.), Nanostructures for drug delivery. (pp. 327-354). Amsterdam, Netherlands: Elsevier. doi: 10.1016/B978-0-323-46143-6.00010-5

Journal - Research Article

Giles, G. I., Nasim, M. J., Ali, W., & Jacob, C. (2017). The Reactive Sulfur Species concept: 15 Years On. Antioxidants, 6(2), 38. doi: 10.3390/antiox6020038

Conference Contribution - Published proceedings: Abstract

Alimoradi, H., Greish, K., Sammut, I., Barzegar-Fallah, A., & Giles, G. I. (2017). Induction of localized vasodilation and hyperpermeability using a novel nitric oxide donor nanoparticle. Proceedings of the Australasian Pharmaceutical Science Association and the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (APSA-ASCEPT) Joint Scientific Meeting. (pp. 85). Retrieved from http://www.asceptasm.com/

Puthoor Jogy, J., & Giles, G. I. (2017). Induction of apoptosis in triple negative breast cancer cells by selenium derivatives. Proceedings of the Australasian Pharmaceutical Science Association and the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (APSA-ASCEPT) Joint Scientific Meeting. (pp. 24). Retrieved from http://www.asceptasm.com/

Puthoor Jogy, J., & Giles, G. (2017). Structural variations in selenium drugs determine selective toxicity towards triple negative breast cancer. Free Radical Biology & Medicine, 112(Suppl. 1), (pp. 98-99). doi: 10.1016/j.freeradbiomed.2017.10.147

2016

Journal - Research Article

Preston, D., McNeill, S. M., Lewis, J. E. M., Giles, G. I., & Crowley, J. D. (2016). Enhanced kinetic stability of [Pd₂L₄] ⁴⁺ cages through ligand substitution. Dalton Transactions, 45, 8050-8060. doi: 10.1039/c6dt00133e

McKay, A. P., Lo, W. K. C., Preston, D., Giles, G. I., Crowley, J. D., Barnsley, J. E., Gordon, K. C., & McMorran, D. A. (2016). Palladium(II) and platinum(II) complexes of ((2-pyridyl)pyrazol-1-ylmethyl)benzoic acids: Synthesis, solid state characterisation and biological cytotoxicity. Inorganica Chimica Acta, 446, 41-53. doi: 10.1016/j.ica.2016.02.038

Alimoradi, H., Matikonda, S. S., Gamble, A. B., Giles, G. I., & Greish, K. (2016). Hypoxia responsive drug delivery systems in tumor therapy. Current Pharmaceutical Design, 22(19), 2808-2820.

Zadehvakili, B., McNeill, S. M., Fawcett, J. P., & Giles, G. I. (2016). The design of redox active thiol peroxidase mimics: Dihydrolipoic acid recognition correlates with cytotoxicity and prooxidant action. Biochemical Pharmacology, 104, 19-28. doi: 10.1016/j.bcp.2016.01.012

Journal - Research Other

Zadehvakili, B., Giles, N. M., Fawcett, J. P., & Giles, G. I. (2016). Data on the catalytic mechanism of thiol peroxidase mimics [Data article]. Data in Brief, 8, 207-210. doi: 10.1016/j.dib.2016.05.037

Conference Contribution - Published proceedings: Abstract

McNeill, S. M., Hewitt, E. F., Preston, D., Crowley, J. D., & Giles, G. (2016). Cytotoxic mechanism of supramolecular helicates. Free Radical Biology & Medicine, 100(Suppl.), (pp. S23-S24). doi: 10.1016/j.freeradbiomed.2016.10.056

Preston, D., McNeill, S. M., Lewis, J. E. M., Giles, G. I., & Crowley, J. D. (2016). Assessing the biological stability of metallosupramolecular architectures. Proceedings of the Diagnostics, Drugs, Devices, Discovery (D4) Conference. Retrieved from http://www.otago.ac.nz/d4/index.html

Vasdev, R. A. S., Preston, D., Scottwell, S. Ø., Schramm, M. P., Giles, G. I., Brooks, H. J. L., & Crowley, J. D. (2016). Oxidatively locked [Co₂L₃]⁶⁺ cylinders derived from bis(bidentate) 2-pyridyl-1,2,3-triazole "click" ligands: Synthesis, stability and cytotoxicity. Proceedings of the New Zealand Institute of Chemistry (NZIC) Conference. Retrieved from http://www.nzic16.org/

2015

Journal - Research Article

Lo, W. K. C., Huff, G. S., Preston, D., McMorran, D. A., Giles, G. I., Gordon, K. C., & Crowley, J. D. (2015). A dinuclear platinum(II) N4Py complex: An unexpected coordination mode for N4Py. Inorganic Chemistry, 54(14), 6671-6673. doi: 10.1021/acs.inorgchem.5b01032

McNeill, S. M., Preston, D., Lewis, J. E. M., Robert, A., Knerr-Rupp, K., Graham, D. O., Wright, J. R., Giles, G. I., & Crowley, J. D. (2015). Biologically active [Pd₂L₄]⁴⁺ quadruply-stranded helicates: Stability and cytotoxicity. Dalton Transactions, 44, 11129-11136. doi: 10.1039/c5dt01259g

2014

Journal - Research Article

Kumari, S., Sammut, I. A., & Giles, G. I. (2014). The design of nitric oxide donor drugs: S-nitrosothiol tDodSNO is a superior photoactivated donor in comparison to GSNO and SNAP. European Journal of Pharmacology, 737, 168-176. doi: 10.1016/j.ejphar.2014.05.012

Conference Contribution - Published proceedings: Abstract

Giles, G. I., Nield-Patterson, A. F., & Deuss, F. A. (2014). Characterization of the mechanism of action of the novel photoactivated NO donor drug tDodSNO by cellular infrared microscopy. Free Radical Biology & Medicine, 76(Suppl. 1), (pp. S81). doi: 10.1016/j.freeradbiomed.2014.10.286

Conference Contribution - Poster Presentation (not in published proceedings)

Kumari, S., Sammut, I., & Giles, G. (2014, September). Characterization of tDodSNO, a novel photoactivated nitric oxide donor drug. Poster session presented at the Division of Health Sciences Research Forum: Learning Different Research Languages, Dunedin, New Zealand.

2013

Journal - Research Article

Aitken, J. B., Shearer, E. L., Giles, N. M., Lai, B., Vogt, B., Reboucas, J. S., … Giles, G. I. (2013). Intracellular targeting and pharmacological activity of the superoxide dismutase mimics MnTE-2-PyP⁵⁺ and MnTnHex-2-PyP⁵⁺ regulated by their porphyrin ring substituents. Inorganic Chemistry, 52(8), 4121-4123. doi: 10.1021/ic300700g

Conference Contribution - Poster Presentation (not in published proceedings)

Ejje, N., Deuss, F. A., Puskar, L., Hampton, M. B., & Giles, G. I. (2013, August). Analysis of the intracellular targets of auranofin drug action by Synchrotron Radiation Fourier Transform Infrared Spectroscopy. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Shearer, E. L., & Giles, G. I. (2013, August). Novel advances in the radical drugs tert-dodecane S-nitrosothiol and menadione: Evidence for additivity or synergism. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

McNeill, S. M., Robert, A., Knerr, K., Lewis, J., Crowley, J. D., & Giles, G. I. (2013, August). The potential use of palladium metallosupramolecular cages as drug targeting agents for cancer therapy. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Shearer, E. L., Aitken, J. B., Giles, N. M., Reboucas, J. S., Batinic-Haberle, I., Lay, P. A., & Giles, G. I. (2013, August). The activity of superoxide dismutase mimetics is regulated by intracellular location. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2012

Journal - Research Article

Ang, A. D., Konigstorfer, A., Giles, G. I., & Bhatia, M. (2012). Measuring free tissue sulfide. Advances in Biological Chemistry, 2(4), 360-365. doi: 10.4236/abc.2012.24044

Zadehvakili, B., Fawcett, J. P., & Giles, G. I. (2012). Synthesis, structure activity relationship studies and antioxidant activity evaluation of some organochalcogen catalysts as novel GPx mimics. Free Radical Biology & Medicine, 53(Suppl. 1), S99. doi: 10.1016/j.freeradbiomed.2012.08.206

Giles, N. M., Kumari, S., Stamm, R., Patel, S., & Giles, G. I. (2012). A hydrogen peroxide electrode assay to measure thiol peroxidase activity for organoselenium and organotellurium drugs. Analytical Biochemistry, 429(2), 103-107. doi: 10.1016/j.ab.2012.07.013

Aitken, J. B., Lay, P. A., Duong, T. T. H., Aran, R., Witting, P. K., Harris, H. H., … Giles, G. I. (2012). Synchrotron radiation induced X-ray emission studies of the antioxidant mechanism of the organoselenium drug ebselen. Journal of Biological Inorganic Chemistry, 17(4), 589-598. doi: 10.1007/s00775-012-0879-y

Giles, N. M., Kumari, S., Gang, B. P., Yuen, C. W. W., Billaud, E. M. F., & Giles, G. I. (2012). The molecular design of S-nitrosothiols as photodynamic agents for controlled nitric oxide release. Chemical Biology & Drug Design, 80(3), 471-478. doi: 10.1111/j.1747-0285.2012.01420.x

Stadler, N., Heeneman, S., Vöö, S., Stanley, N., Giles, G. I., Gang, B. P., … Davies, M. J. (2012). Reduced metal ion concentrations in atherosclerotic plaques from subjects with Type 2 diabetes mellitus. Atherosclerosis, 222(2), 512-518. doi: 10.1016/j.atherosclerosis.2012.03.015

Conference Contribution - Published proceedings: Abstract

Zadehvakili, B., Fawcett, J. P., & Giles, G. I. (2012). Synthesis, structure activity relationship studies and antioxidant activity evaluation of some organochalcogen catalysts as novel GPx mimics. Proceedings of the Oxygen Theme Meeting. (pp. 22). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf

Kumari, S., Giles, N. M., & Giles, G. I. (2012). Development of photoactivated nitric oxide donors as anticancer drugs. Proceedings of the Oxygen Theme Meeting. (pp. 20). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf

Jupp, L. J., & Giles, G. I. (2012). Ebselen as a redox based therapeutic for triple negative breast cancer. Free Radical Biology & Medicine, 53(Suppl. 1), (pp. S98-S99). doi: 10.1016/j.freeradbiomed.2012.08.205

Kumari, S., Giles, N., Billaud, E., & Giles, G. (2012). Development of photoactivated nitric oxide donors as anticancer drugs. Protein Science, 21(S1), (pp. 76). doi: 10.1002/pro.2113

Conference Contribution - Poster Presentation (not in published proceedings)

Kumari, S., Giles, N. M., & Giles, G. I. (2012, September). Development of photoactivated nitric oxide donors as anticancer drugs. Poster session presented at the Division of Health Sciences Research Forum: Health Matters: Research Excellence at Otago, Dunedin, New Zealand.

2011

Conference Contribution - Verbal presentation and other Conference outputs

Giles, G. I., Gang, B., Stadler, N., & Davies, M. J. (2011, September). Mapping elemental distribution in human atherosclerotic lesions using a hard x-ray microprobe at the Australian Synchrotron. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Other Research Output

Giles, G. (2011, May). S-nitrosothiols: A new paradigm in nitric oxide signalling. University of Otago Department of Pharmacology & Toxicology Seminar, Dunedin, New Zealand. [Department Seminar].

2010

Conference Contribution - Published proceedings: Full paper

Eason, C., Murphy, E., Ogilvie, S., Blackie, H., Ross, J., Kaveramann, M., … Harrison, J., Giles, G., Sammut, I., … Brimble, M. (2010). Trends in vetebrate pesticide use and new developments: New Zealand initiatives and international implications. In R. M. Timm & K. A. Fagerstone (Eds.), Proceedings of the 24th Vertebrate Pest Conference. (pp. 91-96). [Full Paper]

Conference Contribution - Published proceedings: Abstract

Giles, G. I., Arya, S., Patel, S., & Giles, N. M. (2010). Electrochemical evaluation of molecular mimics of glutathione peroxidase. Free Radical Biology and Medicine. 49(Suppl. 1), (pp. S210). doi: 10.1016/j.freeradbiomed.2010.10.609

Conference Contribution - Verbal presentation and other Conference outputs

Giles, G. I., Aitken, J. B., & Lay, P. (2010, February). X-ray microprobe analysis of the structure-activity relationships that determine the efficacy of Superoxide Dismutase mimetic drugs. Verbal presentation at the 10th International Conference on Biology and Synchrotron Radiation and 6th International Workshop on Medical Applications of Synchrotron Radiation, Melbourne, Australia.

2009

Chapter in Book - Research

Giles, G. I. (2009). Redox-controlled transcription factors and gene expression. In C. Jacob & P. G. Winyard (Eds.), Redox signaling and regulation in biology and medicine. (pp. 245-270). Weinheim, Germany: Wiley-VCH.

Conference Contribution - Published proceedings: Abstract

Giles, G. I., & Giles, N. M. (2009). Organochalcogenides as redox activated anti cancer drugs. Free Radical Biology and Medicine. 47(Suppl. 1), (pp. S143). [Abstract]

Conference Contribution - Verbal presentation and other Conference outputs

Giles, G. (2009, December). Srixe cellular imaging of manganese metalloporphyrin based superoxide dismutase mimetics. Verbal presentation at the 5th Joint Meeting of The Societies for Free Radical Research Australasia and Japan & Mutagenesis and Experimental Pathology Society of Australia, Sydney, Australia.

Giles, G. I., Aitken, J. B., & Lay, P. (2009, September). Evaluation of the structure-activity relationships that determine the cellular distribution of superoxide dismutase mimetics. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting, Dunedin, New Zealand.

2008

Chapter in Book - Research

Teng, X., Isbell, T. S., Crawford, J. H., Bosworth, C. A., Giles, G. I., Koenitzer, J. R., … Patel, R. P. (2008). Novel method for measuring S-nitrosothiols using hydrogen sulfide. In Methods in enzymology (Volo. 441: Nitric oxide, part G oxidative and nitrasative stress in redox regulation of cell signaling). (pp. 161-172). San Diego, CA: Academic Press. doi: 10.1016/s0076-6879(08)01209-3

Conference Contribution - Published proceedings: Abstract

Giles, G. I., Billaud, E., & Giles, N. M. (2008). Synthetic S-nitrosothiols as anti cancer agents. Free Radical Biology and Medicine. 45(Suppl. 1), (pp. S82-S83). [Abstract]

Giles, N. M., & Giles, G. I. (2008). A cytotoxic analysis of Thiol Oxidation Catalysts (TOCS) towards human lung carcinoma cell line A549. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting. ASCEPT. Retrieved from http://phal.otago.ac.nz/ascept_docos/programme%202008.pdf

Billaud, E., Giles, N. M., & Giles, G. I. (2008). Tert-dodecane-S-nitrosothiol as a nitric oxide donor. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting. ASCEPT. Retrieved from http://phal.otago.ac.nz/ascept_docos/programme%202008.pdf

Giles, G. I., Aitken, J., & Lay, P. A. (2008). SRIXE imaging of drug uptake and cellular distribution. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting. ASCEPT. Retrieved from http://phal.otago.ac.nz/ascept_docos/programme%202008.pdf

Conference Contribution - Verbal presentation and other Conference outputs

Giles, G. (2008, November). Thiol oxidation catalysts as anti-cancer agents. Verbal presentation at the Society for Free Radical Research Australasia Conference, Melbourne, Australia.

2007

Journal - Research Article

Singh, A., Guidry, L., Narasimhulu, K. V., Mai, D., Trombley, J., Redding, K. E., Giles, G. I., … Steyn, A. J. C. (2007). Mycobacterium tuberculosis WhiB3 responds to O₂ and nitric oxide via its [4Fe-4S] cluster and is essential for nutrient starvation survival. PNAS, 104(28), 11562-11567. doi: 10.1073/pnas.0700490104

Conference Contribution - Published proceedings: Abstract

Giles, G. I., Aitken, J., & Lay, P. (2007). SRIXE cellular imaging of the antioxidant agent Ebselen. Free Radical Biology and Medicine. 43(Suppl. 1), (pp. S176-S177). [Abstract]

2006

Journal - Research Article

Griguer, C. E., Oliva, C. R., Kelley, E. E., Giles, G. I., Lancaster, Jr, J. R., & Gillespie, G. Y. (2006). Xanthine oxidase-dependent regulation of hypoxia-inducible factor in cancer cells. Cancer Research, 66(4), 2257-2263. doi: 10.1158/0008-5472.CAN-05-3364

Kelley, E. E., Hock, T., Khoo, N. K. H., Richardson, G. R., Johnson, K. K., Powell, P. C., Giles, G. I., … Tarpey, M. M. (2006). Moderate hypoxia induces xanthine oxidoreductase activity in arterial endothelial cells. Free Radical Biology & Medicine, 40(6), 952-959. doi: 10.1016/j.freeradbiomed.2005.11.008

Giles, G. I. (2006). The redox regulation of thiol dependent signaling pathways in cancer. Current Pharmaceutical Design, 12, 4427-4443.

2005

Journal - Research Article

Fry, F. H., Holme, A. L., Giles, N. M., Giles, G. I., Collins, C., Holt, K., … Jacob, C. (2005). Multifunctional redox catalysts as selective enhancers of oxidative stress. Organic & Biomolecular Chemistry, 3(14), 2579-2587. doi: 10.1039/b502197a

2003

Journal - Research Article

Giles, N. M., Giles, G. I., Holley, J. E., Gutowski, N. J., & Jacob, C. (2003). Targeting oxidative stress-related diseases: Organochalcogen catalysts as redox sensitizers. Biochemical Pharmacology, 66(10), 2021-2028. doi: 10.1016/S0006-2952(03)00544-6

Jacob, C., Giles, G. I., Giles, N. M., & Sies, H. (2003). Sulfur and selenium: The role of oxidation state in protein structure and function. Angewandte Chemie International Edition, 42(39), 4742-4758. doi: 10.1002/anie.200300573

Giles, N. M., Gutowski, N. J., Giles, G. I., & Jacob, C. (2003). Redox catalysts as sensitisers towards oxidative stress. FEBS Letters, 535, 179-182. doi: 10.1016/S0014-5793(02)03890-5

Giles, N. M., Giles, G. I., & Jacob, C. (2003). Multiple roles of cysteine in biocatalysis. Biochemical & Biophysical Research Communications, (1), 1-4. doi: 10.1016/S0006-291X(02)02770-5

Giles, N. M., Watts, A. B., Giles, G. I., Fry, F. H., Littlechild, J. A., & Jacob, C. (2003). Metal and redox modulation of cysteine protein function. Chemistry & Biology, 10(8), 677-693. doi: 10.1016/S1074-5521(03)00174-1

Journal - Research Other

Giles, G. I., Giles, N. M., Collins, C. A., Holt, K., Fry, F. H., Lowden, P. A. S., … Jacob, C. (2003). Electrochemical, in vitro and cell culture analysis of integrated redox catalysts: Implications for cancer therapy. Chemical Communications, 2030-2031. doi: 10.1039/b302877a

2002

Journal - Research Article

Giles, G. I., Tasker, K. M., Collins, C., Giles, N. M., O'Rourke, E., & Jacob, C. (2002). Reactive sulphur species: An in vitro investigation of the oxidation properties of disulphide S-oxides. Biochemical Journal, 364, 579-585.