Contact Details
- Phone
- 64 3 479 7296
- ian.tucker@otago.ac.nz
University Links
- Position
- Emeritus Professor
- Qualifications
- BPharm(Hons) PhD(Qld) MPS
- Research summary
- Drug formulation and delivery
- Teaching
Pharmaceutics, formulation and drug delivery to undergraduate and postgraduate students.
Research
My general research area is in formulation and delivery of bioactives for human and veterinary applications. This can be divided into two broad areas: research on delivery systems for optimal delivery of bioactives (drugs); research on absorption processes in order to achieve optimal delivery of bioactives to target organs/cells
Current research on delivery systems is focussed on sustained release polymer matrix tablets. We are trying to understand the mechanisms involved in the coalescence of polymer particles in such tablets and how this leads to sustained release properties. The aim is to understand how the physico-chemical properties of drug, excipients and polymer affect the formation of stable polymer matrices in order to design tablets with predictable and stable release profiles. Other delivery systems include: nanosystems including bilosomes and polymeric nanoparticles decorated with cell penetrating peptides; oil-based systems for intramuscular injection. Techniques used include: release studies, kinetic studies, thermal analytical methods, particle sizing (PCS, laser diffraction), electron microscopy, helium pycnometry, texture analysis, analytical methods particularly HPLC, factorial-designed studies and statistical analysis, regression methods for modelling release data.
The research on absorption processes is trying to understand how bioactives cross biological membranes, the role of transporters, stereoselectivity of transporters, how bile salts affect permeation through effects on membrane fluidity and transporter function. We have been concentrating on the blood brain barrier but given our active research programme on mastitis in dairy cattle, we are also interested in the blood–milk barrier. Techniques used include: cell culture studies, electron miscroscopy, in vivo studies including microdialysis, analytical methods (LCMS, radiotracer).
Publications
Yang, L., Zhang, H., Mikov, M., & Tucker, I. G. (2009). Physicochemical and biological characterization of monoketocholic acid, a novel permeability enhancer. Molecular Pharmaceutics, 6(2), 448-456. doi: 10.1021/mp800143w
Yang, L., Fawcett, J. P., Zhang, H., & Tucker, I. G. (2013). Effect of 12-oxochenodeoxycholate on the pharmacokinetics and pharmacodynamics of morphine 6-glucuronide in Wistar rats. Journal of Pharmacy & Pharmacology, 65(4), 561-566. doi: 10.1111/jphp.12020
Yang, L., Zhang, H., Fawcett, J. P., Mikov, M., & Tucker, I. G. (2011). Effect of bile salts on the transport of morphine-6-glucuronide in rat brain endothelial cells. Journal of Pharmaceutical Sciences, 100(4), 1516-1524. doi: 10.1002/jps.22390
Pirayavaraporn, C., Rades, T., & Tucker, I. G. (2012). Determination of moisture content in relation to thermal behaviour and plasticization of Eudragit RLPO. International Journal of Pharmaceutics, 422(1-2), 68-74. doi: 10.1016/j.ijpharm.2011.10.028
Petrovski, K. R., Caicedo-Caldas, A., Williamson, N. B., Lopez-Villalobos, N., Grinberg, A., Parkinson, T. J., & Tucker, I. G. (2011). Efficacy of a novel internal dry period teat sealant containing 0.5% chlorhexidine against experimental challenge with Streptococcus uberis in dairy cattle. Journal of Dairy Science, 94(7), 3366-3375. doi: 10.3168/jds.2010-3744
Yang, L., Zhang, H., Mikov, M., & Tucker, I. G. (2009). Physicochemical and biological characterization of monoketocholic acid, a novel permeability enhancer. Molecular Pharmaceutics, 6(2), 448-456. doi: 10.1021/mp800143w
Journal - Research Article
Yang, L., Fawcett, J. P., Zhang, H., & Tucker, I. G. (2013). Effect of 12-oxochenodeoxycholate on the pharmacokinetics and pharmacodynamics of morphine 6-glucuronide in Wistar rats. Journal of Pharmacy & Pharmacology, 65(4), 561-566. doi: 10.1111/jphp.12020
Journal - Research Article
Yang, L., Zhang, H., Fawcett, J. P., Mikov, M., & Tucker, I. G. (2011). Effect of bile salts on the transport of morphine-6-glucuronide in rat brain endothelial cells. Journal of Pharmaceutical Sciences, 100(4), 1516-1524. doi: 10.1002/jps.22390
Journal - Research Article
Pirayavaraporn, C., Rades, T., & Tucker, I. G. (2012). Determination of moisture content in relation to thermal behaviour and plasticization of Eudragit RLPO. International Journal of Pharmaceutics, 422(1-2), 68-74. doi: 10.1016/j.ijpharm.2011.10.028
Journal - Research Article
Petrovski, K. R., Caicedo-Caldas, A., Williamson, N. B., Lopez-Villalobos, N., Grinberg, A., Parkinson, T. J., & Tucker, I. G. (2011). Efficacy of a novel internal dry period teat sealant containing 0.5% chlorhexidine against experimental challenge with Streptococcus uberis in dairy cattle. Journal of Dairy Science, 94(7), 3366-3375. doi: 10.3168/jds.2010-3744
Journal - Research Article
Tucker, I. G. (2011). Drug delivery to the brain via the blood-brain barrier: A review of the literature and some recent patent disclosures. Therapeutic Delivery, 2(3), 311-327. doi: 10.4155/tde.11.3
Journal - Research Article
Chen, G., Fawcett, J. P., Mikov, M., & Tucker, I. G. (2009). Simultaneous determination of methotrexate and its polyglutamate metabolites in Caco-2 cells by liquid chromatography-tandem mass spectrometry. Journal of Pharmaceutical & Biomedical Analysis, 50(2), 262-266. doi: 10.1016/j.jpba.2009.04.025
Journal - Research Article
Yang, L., Tucker, I. G., & Østergaard, J. (2011). Effects of bile salts on propranolol distribution into liposomes studied by capillary electrophoresis. Journal of Pharmaceutical & Biomedical Analysis, 56(3), 553-559. doi: 10.1016/j.jpba.2011.06.020
Journal - Research Article
Jain, R., Wu, Z., Bork, O., & Tucker, I. G. (2012). Pre-formulation and chemical stability studies of penethamate, a benzylpenicillin ester prodrug, in aqueous vehicles. Drug Development & Industrial Pharmacy, 38(1), 55-63. doi: 10.3109/03639045.2011.590497
Journal - Research Article
Wu, Z., Tucker, I. G., Razzak, M., Yang, L., McSporran, K., & Medlicott, N. J. (2010). Absorption and tissue tolerance of ricobendazole in the presence of hydroxypropyl-β-cyclodextrin following subcutaneous injection in sheep. International Journal of Pharmaceutics, 397, 96-102. doi: 10.1016/j.ijpharm.2010.07.002
Journal - Research Article
Glaessl, B., Siepmann, F., Tucker, I., Rades, T., & Siepmann, J. (2010). Deeper insight into the drug release mechanisms in Eudragit RL-based delivery systems. International Journal of Pharmaceutics, 389, 139-146. doi: 10.1016/j.ijpharm.2010.01.031
Journal - Research Article
Li, Y., Zhang, H., Fawcett, J. P., & Tucker, I. G. (2010). Effect of cyclosporin A on the pharmacokinetics of mitoquinone (MitoQ10), a mitochondria-targeted antioxidant, in rat. Asian Journal of Pharmaceutical Sciences, 5(3), 106-113.
Journal - Research Article
Chatterjee, L., Rades, T., & Tucker, I. G. (2010). Mechanical properties of excipients do not affect polymer matrix formation. International Journal of Pharmaceutics, 384(1/2), 87-92. doi: 10.1016/j.ijpharm.2009.09.047
Journal - Research Article
Wu, Z., Tucker, I. G., Razzak, M., McSporran, K., & Medlicott, N. J. (2010). Tissue compatibility and pharmacokinetics of three potential subcutaneous injectables for low-pH drug solutions. Journal of Pharmacy & Pharmacology, 62(7), 873-882. doi: 10.1211/jpp.62.07.0008
Journal - Research Article
Jain, R., Wu, Z., & Tucker, I. G. (2009). A stability-indicating HPLC assay with diode array detection for the determination of a benzylpenicillin prodrug in aqueous solutions. Journal of Pharmaceutical & Biomedical Analysis, 50(5), 841-846. doi: 10.1016/j.jpba.2009.06.046
Journal - Research Article
Krittaphol, W., McDowell, A., Thomson, C. D., Tucker, I. G., Fawcett, J. P., & Mikov, M. (2009). An improved HPLC method for the investigation of L-selenomethionine metabolism in rat gut contents. Biomedical Chromatography, 23, 1169-1174. doi: 10.1002/bmc.1239
Journal - Research Article
Glaessl, B., Siepmann, F., Tucker, I., Siepmann, J., & Rades, T. (2009). Characterisation of quaternary polymethacrylate films containing tartaric acid, metoprolol free base or metoprolol tartrate. European Journal of Pharmaceutics & Biopharmaceutics, 73, 36-372. doi: 10.1016/j.ejpb.2009.07.010
Journal - Research Article
Chen, G., Fawcett, J. P., Mikov, M., & Tucker, I. G. (2009). Monoketocholate can decrease transcellular permeation of methotrexate across Caco-2 cell monolayers and reduce its intestinal absorption in rat. Journal of Pharmacy & Pharmacology, 61(7), 953-959. doi: 10.1211/jpp/61.07.0016
Journal - Research Article
McDowell, A., McLeod, B. J., Rades, T., & Tucker, I. G. (2009). Polymeric nanoparticles as an oral delivery system for biocontrol agents for the brushtail possum (Trichosurus vulpecula). New Zealand Veterinary Journal, 57(6), 370-377.
Journal - Research Article
Baeumer, B., Chatterjee, L., Hinow, P., Rades, T., Radunskaya, A., & Tucker, I. (2009). Predicting the drug release kinetics of matrix tablets. Discrete & Continuous Dynamical Systems Series B, 12(2), 261-277. doi: 10.3934/dcdsb.2009.12.261
Journal - Research Article
Wu, Z., Tucker, I. G., Razzak, M., & Medlicott, N. J. (2009). Stability of ricobendazole in aqueous solutions. Journal of Pharmaceutical & Biomedical Analysis, 49(5), 1282-1286. doi: 10.1016/j.jpba.2009.02.032
Journal - Research Article
Mukhopadhyay, D., Saville, D., & Tucker, I. G. (2008). Crosslinking of drug-alginate granules: Part 2: Effect of granule preparation and composition on granule properties. International Journal of Pharmaceutics, 356, 193-199. doi: 10.1016/j.ijpharm.2008.01.022
Journal - Research Article
Yang, L., Broom, M. F., & Tucker, I. G. (2012). Characterization of a nanoparticulate drug delivery system using scanning ion occlusion sensing. Pharmaceutical Research, 29(9), 2578-2586. doi: 10.1007/s11095-012-0788-3
Journal - Research Article
Tucker, I. G., Yang, L., & Mujoo, H. (2012). Delivery of drugs to the brain via the blood brain barrier using colloidal carriers. Journal of Microencapsulation, 29(5), 475-486. doi: 10.3109/02652048.2012.658445
Journal - Research Article
Chen, G., Yang, L., Zhang, H., Tucker, I. G., & Fawcett, J. P. (2012). Effect of ketocholate derivatives on methotrexate uptake in Caco-2 cell monolayers. International Journal of Pharmaceutics, 433, 89-93. doi: 10.1016/j.ijpharm.2012.04.077
Journal - Research Article