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Pharmacy staff profile

Dr Dorothy Saville

PositionSenior Lecturer in Pharmaceutical Science
QualificationsBPharm(Hons) MSc PhD
Research summarySolid state pharmaceutics; formulation and drug delivery; pharmacokinetics and drug metabolism
Teaching

Physical pharmacy; pharmacokinetics

Clinical

I have good knowledge of the grapefruit–medicines interaction and also an interest in clinical pharmacokinetics, particularly of drugs acting in CNS.

Research

In order to improve oral bioavailability of drugs with poor aqueous solubility, an amorphous form or a metastable polymorph may be used. These forms, however, have a risk of either crystallising (amorphous) or changing to a more stable polymorph with loss of oral bioavailability. Research focuses on factors influencing the stability of the amorphous form or the metastable polymorphic form. Current projects in this area include:

  • The stability of amorphous drug upon milling
  • The formulation of amorphous suspensions

In addition, the effect of storage conditions on release from enteric coated tablets is under study.

Additional details

  • Review of papers for publication International Journal of Pharmaceutics (1998–present)

Publications

Surwase, S. A., Itkonen, L., Aaltonen, J., Saville, D., Rades, T., Peltonen, L., & Strachan, C. J. (2015). Polymer incorporation method affects the physical stability of amorphous indomethacin in aqueous suspension. European Journal of Pharmaceutics & Biopharmaceutics, 96, 32-43. doi: 10.1016/j.ejpb.2015.06.005

Surwase, S. A., Boetker, J. P., Saville, D., Boyd, B. J., Gordon, K. C., Peltonen, L., & Strachan, C. J. (2013). Indomethacin: New polymorphs of an old drug. Molecular Pharmaceutics, 10(12), 4472-4480. doi: 10.1021/mp400299a

Zhang, F., Aaltonen, J., Tian, F., Saville, D. J., & Rades, T. (2009). Influence of particle size and preparation methods on the physical and chemical stability of amorphous simvastatin. European Journal of Pharmaceutics & Biopharmaceutics, 71(1), 64-70. doi: 10.1016/j.ejpb.2008.07.010

Chieng, N., Rehder, S., Saville, D., Rades, T., & Aaltonen, J. (2009). Quantitative solid-state analysis of three solid forms of ranitidine hydrochloride in ternary mixtures using Raman spectroscopy and X-ray powder diffraction. Journal of Pharmaceutical & Biomedical Analysis, 49(1), 18-25. doi: 10.1016/j.jpba.2008.09.054

Chieng, N., Hubert, M., Saville, D., Rades, T., & Aaltonen, J. (2009). Formation kinetics and stability of carbamazepine-nicotinamide cocrystals prepared by mechanical activation. Crystal Growth & Design, 9(5), 2377-2386. doi: 10.1021/cg801253f

Journal - Research Article

Surwase, S. A., Itkonen, L., Aaltonen, J., Saville, D., Rades, T., Peltonen, L., & Strachan, C. J. (2015). Polymer incorporation method affects the physical stability of amorphous indomethacin in aqueous suspension. European Journal of Pharmaceutics & Biopharmaceutics, 96, 32-43. doi: 10.1016/j.ejpb.2015.06.005

Surwase, S. A., Boetker, J. P., Saville, D., Boyd, B. J., Gordon, K. C., Peltonen, L., & Strachan, C. J. (2013). Indomethacin: New polymorphs of an old drug. Molecular Pharmaceutics, 10(12), 4472-4480. doi: 10.1021/mp400299a

Zhang, F., Aaltonen, J., Tian, F., Saville, D. J., & Rades, T. (2009). Influence of particle size and preparation methods on the physical and chemical stability of amorphous simvastatin. European Journal of Pharmaceutics & Biopharmaceutics, 71(1), 64-70. doi: 10.1016/j.ejpb.2008.07.010

Chieng, N., Hubert, M., Saville, D., Rades, T., & Aaltonen, J. (2009). Formation kinetics and stability of carbamazepine-nicotinamide cocrystals prepared by mechanical activation. Crystal Growth & Design, 9(5), 2377-2386. doi: 10.1021/cg801253f

Chieng, N., Rehder, S., Saville, D., Rades, T., & Aaltonen, J. (2009). Quantitative solid-state analysis of three solid forms of ranitidine hydrochloride in ternary mixtures using Raman spectroscopy and X-ray powder diffraction. Journal of Pharmaceutical & Biomedical Analysis, 49(1), 18-25. doi: 10.1016/j.jpba.2008.09.054

Chieng, N., Aaltonen, J., Saville, D., & Rades, T. (2009). Physical characterization and stability of amorphous indomethacin and ranitidine hydrochloride binary systems prepared by mechanical activation. European Journal of Pharmaceutics & Biopharmaceutics, 71(1), 47-54. doi: 10.1016/j.ejpb.2008.06.022

Chieng, N., Rades, T., & Saville, D. (2008). Formation and physical stability of the amorphous phase of ranitidine hydrochloride polymorphs prepared by cryo-milling. European Journal of Pharmaceutics & Biopharmaceutics, 68, 771-780. doi: 10.1016/j.ejpb.2007.09.001

Numata, M., Fawcett, J. P., Saville, D. J., & Rosengren, R. J. (2008). Hepatic cytochrome P450 activity and pollutant concentrations in paradise shelducks and southern black-backed gulls in the South Island of New Zealand. Ecotoxicology, 17, 697-708. doi: 10.1007/s10646-008-0218-9

Mukhopadhyay, D., Saville, D., & Tucker, I. G. (2008). Crosslinking of drug-alginate granules: Part 2: Effect of granule preparation and composition on granule properties. International Journal of Pharmaceutics, 356, 193-199. doi: 10.1016/j.ijpharm.2008.01.022

Tian, F., Zhang, F., Sandler, N., Gordon, K. C., McGoverin, C. M., Strachan, C. J., Saville, D. J., & Rades, T. (2007). Influence of sample characteristics on quantification of carbamazepine hydrate formation by X-ray powder diffraction and Raman spectroscopy. European Journal of Pharmaceutics & Biopharmaceutics, 66, 466-474.

Tian, F., Sandler, N., Aaltonen, J., Lang, C., Saville, D. J., Gordon, K. C., Strachan, C. J., … Rades, T. (2007). Influence of polymorphic form, morphology, and excipient interactions on the dissolution of carbamazepine compacts. Journal of Pharmaceutical Sciences, 96(3), 584-594.

Tian, F., Saville, D. J., Gordon, K. C., Strachan, C. J., Zeitler, J. A., Sandler, N., & Rades, T. (2007). The influence of various excipients on the conversion kinetics of carbamazepine polymorphs in aqueous suspension. Journal of Pharmacy & Pharmacology, 59, 193-201.

Tian, F., Sandler, N., Gordon, K. C., McGoverin, C. M., Reay, A., Strachan, C. J., Saville, D. J., & Rades, T. (2006). Visualizing the conversion of carbamazepine in aqueous suspension with and without the presence of excipients: A single crystal study using SEM and Raman microscopy. European Journal of Pharmaceutics & Biopharmaceutics, 64, 326-335.

Tian, F., Zeitler, J. A., Strachan, C. J., Saville, D. J., Gordon, K. C., & Rades, T. (2006). Characterizing the conversion kinetics of carbamazepine polymorphs to the dihydrate in aqueous suspension using Raman spectroscopy. Journal of Pharmaceutical & Biomedical Analysis, 40, 271-280.

Chieng, N., Zujovic, Z., Bowmaker, G., Rades, T., & Saville, D. (2006). Effect of milling conditions on the solid-state conversion of ranitidine hydrochloride form 1. International Journal of Pharmaceutics, 327, 36-44.

Mukhopadhyay, D., Reid, M., Saville, D., & Tucker, I. G. (2005). Cross-linking of dried paracetamol alginate granules Part 1: The effect of the cross-linking process variables. International Journal of Pharmaceutics, 299(1-2), 134-145.

Gardiner, S. J., Kirkpatrick, C., Begg, E. J., Zhang, M., Moore, M. P., & Saville, D. J. (2003). Transfer of metformin into human milk. Clinical Pharmacology & Therapeutics, 73, 71-77.

Agatonovic-Kustrin, S., Rades, T., Wu, V., Saville, D. J., & Tucker, I. G. (2001). Determination of polymorphic forms of ranitidine - HCl by DRIFTS and XRPD. Journal of Pharmaceutical & Biomedical Analysis, 25, 741-750.

Ho, P.-C., Saville, D. J., & Wanwimolruk, S. (2001). Inhibition of CYP3A4 activity in human liver microsomes by flavonoids and furanocoumarins found in grapefruit. Journal of Pharmacy & Pharmaceutical Sciences, 4(3), 217-227.

Saville, D. J. (2001). Influence of storage on in-vitro release of ibuprofen from sugar coated tablets. International Journal of Pharmaceutics, 224, 39-49.

Ho, P.-C., Saville, D. J., & Wanwimolruk, S. (2000). Simultaneous HPLC analysis of verapamil and norverapamil enantiomers in human plasma and urine. Journal of Liquid Chromatography & Related Technologies, 23, 1711-1724.

Ho, P.-C., Saville, D. J., Coville, P., & Wanwimolruk, S. (2000). Content of CYP3A4 inhibitors, naringin, naringenin and bergapten in grapefruit and grapefruit juice products. Pharmaceutica Acta Helvetiae, 74, 379-385.

Ho, P.-C., Ghose, K., Saville, D. J., Coville, P., & Wanwimolruk, S. (2000). Effect of grapefruit juice on pharmacokinetics and pharmacodynamics of verapamil enantiomers in healthy volunteers. European Journal of Clinical Pharmacology, 56, 693-698.

Wu, V., Rades, T., & Saville, D. J. (2000). Stability of polymorphic forms of ranitidine hydrochloride. Pharmazie, 55(7), 508-512.

Agatonovic-Kustrin, S., Wu, V., Rades, T., Saville, D. J., & Tucker, I. G. (2000). Ranitidine hydrochloride X-ray assay using a neural network. Journal of Pharmaceutical & Biomedical Analysis, 22(6), 985-992.

Agatonovic-Kustrin, S., Wu, V., Rades, T., Saville, D. J., & Tucker, I. G. (1999). Powder diffractometric assay of two polymorphic forms of ranitidine hydrochloride. International Journal of Pharmaceutics, 184(1), 107-114. doi: 10.1016/S0378-5173(99)00104-0

Wanwimolruk, S., Zhang, H., Coville, P., Saville, D. J., & Davis, L. S. (1999). In vitro hepatic metabolism of a CYP3A-mediated drug, quinine, in Adélie penguins. Comparative Biochemistry & Physiology Part C, 124(3), 301-307.

Ho, P.-C., Saville, D. J., & Wanwimolruk, S. (1998). Improved High Performance Liquide Chromatographic (HPLC) method for the analysis of naringin in grapefruit juice without extraction. Pharmacy & Pharmacology Communications, 4, 473-476.

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