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Pharmacy staff profile

Associate Professor Paul Fawcett

PositionAssociate Professor

Publications

Zhou, X., Meng, X., Cheng, L., Su, C., Sun, Y., Sun, L., … Fawcett, J. P., … Gu, J. (2017). Development and application of an MSALL-based approach for the quantitative analysis of linear polyethylene glycols in rat plasma by liquid chromatography triple-quadrupole/time-of-flight mass spectrometry. Analytical Chemistry, 89(10), 5193-5200. doi: 10.1021/acs.analchem.6b04058

Su, C., Yang, H., Meng, X., Fawcett, J. P., Cao, J., Yang, Y., & Gu, J. (2017). Determination of rabeprazole enantiomers in dog plasma by supercritical fluid chromatography tandem mass spectrometry and its application to a pharmacokinetic study. Journal of Separation Science, 40(4), 1010-1016. doi: 10.1002/jssc.201601232

Su, C., Sun, H., Yang, H., Yin, L., Zhang, J., Fawcett, J. P., & Gu, J. (2017). A validated UPLC-MS/MS method coupled with protein precipitation and ion exchange solid phase extraction for the quantitation of porcine relaxin B29 in dog plasma and its application to a pharmacokinetic study. Analytical & Bioanalytical Chemistry. Advance online publication. doi: 10.1007/s00216-017-0604-3

Yin, L., Su, C., Ren, T., Meng, X., Shi, M., Fawcett, J. P., … Gu, J. (2017). MSAll strategy for comprehensive quantitative analysis of PEGylated-doxorubicin, PEG and doxorubicin by LC-high resolution q-q-TOF mass spectrometry coupled with all window acquisition of all fragment ion spectra. Analyst. Advance online publication. doi: 10.1039/c7an00470b

Meng, X., Xu, H., Zhang, Z., Fawcett, J. P., Li, J., Yang, Y., & Gu, J. (2017). Differential mobility spectrometry tandem mass spectrometry with multiple ion monitoring for the bioanalysis of liraglutide. Analytical & Bioanalytical Chemistry. Advance online publication. doi: 10.1007/s00216-017-0431-6

Edited Book - Research

Mikov, M., & Fawcett, J. P. (Eds.). (2007). Bile acids: Chemistry, biosynthesis, analysis, chemical and metabolic transformations and pharmacology. Geneva, Switzerland: Mediset, 226p.

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Chapter in Book - Research

Rathbone, M. J., Shen, J., Fawcett, J. P., Ogle, C. R., Burggraaf, S., & Bunt, C. R. (2000). Stability testing of veterinary drug products. In M. J. Rathbone & R. Gurney (Eds.), Controlled Release Veterinary Drug Delivery. (pp. 333-352). Amsterdam: Elsevier.

Moffitt, T. E., Caspi, A., Fawcett, J. P., Brammer, G. L., Raleigh, M., Yuwiler, A., & Silva, P. A. (1997). Whole blood serotonin and family background relate to male violence. In A. Raine, P. A. Brennan, D. P. Farrington & S. A. Mednick (Eds.), Biosocial Bases of Violence. (pp. 231-249). New York: Plenum Press.

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Journal - Research Article

Zhou, X., Meng, X., Cheng, L., Su, C., Sun, Y., Sun, L., … Fawcett, J. P., … Gu, J. (2017). Development and application of an MSALL-based approach for the quantitative analysis of linear polyethylene glycols in rat plasma by liquid chromatography triple-quadrupole/time-of-flight mass spectrometry. Analytical Chemistry, 89(10), 5193-5200. doi: 10.1021/acs.analchem.6b04058

Meng, X., Xu, H., Zhang, Z., Fawcett, J. P., Li, J., Yang, Y., & Gu, J. (2017). Differential mobility spectrometry tandem mass spectrometry with multiple ion monitoring for the bioanalysis of liraglutide. Analytical & Bioanalytical Chemistry. Advance online publication. doi: 10.1007/s00216-017-0431-6

Yin, L., Su, C., Ren, T., Meng, X., Shi, M., Fawcett, J. P., … Gu, J. (2017). MSAll strategy for comprehensive quantitative analysis of PEGylated-doxorubicin, PEG and doxorubicin by LC-high resolution q-q-TOF mass spectrometry coupled with all window acquisition of all fragment ion spectra. Analyst. Advance online publication. doi: 10.1039/c7an00470b

Su, C., Sun, H., Yang, H., Yin, L., Zhang, J., Fawcett, J. P., & Gu, J. (2017). A validated UPLC-MS/MS method coupled with protein precipitation and ion exchange solid phase extraction for the quantitation of porcine relaxin B29 in dog plasma and its application to a pharmacokinetic study. Analytical & Bioanalytical Chemistry. Advance online publication. doi: 10.1007/s00216-017-0604-3

Su, C., Yang, H., Meng, X., Fawcett, J. P., Cao, J., Yang, Y., & Gu, J. (2017). Determination of rabeprazole enantiomers in dog plasma by supercritical fluid chromatography tandem mass spectrometry and its application to a pharmacokinetic study. Journal of Separation Science, 40(4), 1010-1016. doi: 10.1002/jssc.201601232

Jacobson, G. A., & Fawcett, J. P. (2016). Beta2-agonist doping control and optical isomer challenges. Sports Medicine, 46(12), 1787-1795. doi: 10.1007/s40279-016-0547-4

Yang, Z., Xu, X., Sun, L., Zhao, X., Wang, H., Fawcett, J. P., … Gu, J. (2016). Development and validation of an enantioselective SFC-MS/MS method for simultaneous separation and quantification of oxcarbazepine and its chiral metabolites in beagle dog plasma. Journal of Chromatography B, 1020, 36-42. doi: 10.1016/j.jchromb.2016.03.013

Liang, C., Yang, Z., Meng, X., Yin, L., Fawcett, J. P., Wang, C., … Gu, J. (2016). Development of a GC-MS method for the determination and pharmacokinetics of trans-π-oxocamphor after intravenous administration of Vitacamphorae injection in rat. Analytical Methods, 8(23), 4720-4726. doi: 10.1039/c6ay00113k

Zadehvakili, B., McNeill, S. M., Fawcett, J. P., & Giles, G. I. (2016). The design of redox active thiol peroxidase mimics: Dihydrolipoic acid recognition correlates with cytotoxicity and prooxidant action. Biochemical Pharmacology, 104, 19-28. doi: 10.1016/j.bcp.2016.01.012

Xu, X., Zhao, X., Yang, Z., Wang, H., Meng, X., Su, C., … Fawcett, J. P., … Gu, J. (2016). Significant improvement of metabolic characteristics and bioactivities of clopidogrel and analogs by selective deuteration. Molecules, 21(6), 704. doi: 10.3390/molecules21060704

Zadehvakili, B., Giles, N. M., Fawcett, J. P., & Giles, G. I. (2016). Data on the catalytic mechanism of thiol peroxidase mimics. Data in Brief, 8, 207-210. doi: 10.1016/j.dib.2016.05.037

Shi, M., Yang, Y., Zhou, X., Cai, L., Fang, C., Wang, C., … Fawcett, J. P. (2015). Determination of thymopentin in beagle dog blood by liquid chromatography with tandem mass spectrometry and its application to a preclinical pharmacokinetic study. Journal of Separation Science, 38(8), 1351-1357. doi: 10.1002/jssc.201401198

Yang, L., Feng, F., Fawcett, J. P., & Tucker, I. G. (2015). Kinetic and equilibrium studies of bile salt-liposome interactions. Journal of Liposome Research, 25(1), 58-66. doi: 10.3109/08982104.2014.928888

Wang, H., Sun, Y., Yang, Y., Guo, W., Zheng, M., Zhang, W., Fawcett, J. P., & Gu, J. (2015). Application of a high-throughput, parallel HPLC system for quantitative chiral analysis of pantoprazole. Bioanalysis, 7(23), 2981-2990. doi: 10.4155/bio.15.215

Yin, L., Meng, X., Zhou, X., Zhang, T., Sun, H., Yang, Z., … Fawcett, J. P., … Gu, J. (2015). Simultaneous determination of carboprost methylate and its active metabolite carboprost in dog plasma by liquid chromatography–tandem mass spectrometry with positive/negative ion-switching electrospray ionization and its application to a pharmacokinetic study. Journal of Chromatography B, 998-999, 8-14. doi: 10.1016/j.jchromb.2015.05.039

Zhang, Y., Sun, Y., He, Q., Han, J., Shi, M., Fang, C., Fawcett, J. P., … Gu, J. (2014). Simultaneous determination of temozolomide acid and its hexyl ester in plasma by LC-MS/MS: Application to the first pharmacokinetic study of temozolomide hexyl ester in rats. Analytical Methods, 6(22), 8973-8978. doi: 10.1039/c4ay01641f

Feng, B., Zhu, H., Guan, J., Zhao, L., Gu, J., Yin, L., Fawcett, J. P., & Liu, W. (2014). A rapid and sensitive UFLC-MS/MS method for the simultaneous determination of gentiopicroside and swertiamarin in rat plasma and its application in pharmacokinetics. Journal of Pharmacy & Pharmacology, 66(10), 1369-1376. doi: 10.1111/jphp.12266

Wu, X.-J., Zhang, M.-L., Cui, X.-Y., Fawcett, J. P., & Gu, J.-K. (2014). Comparative pharmacokinetics and the bioavailability of escin Ib and isoescin Ib following the administration of escin, pure escin Ib and isoescin Ib in rats. Journal of Ethnopharmacology, 151(2), 839-845. doi: 10.1016/j.jep.2013.11.039

Wang, H., Sun, Y., Guo, W., Fang, C., Fawcett, J. P., Li, W., … Gu, J. (2014). Determination of a deuterohemin–peptide conjugate in rat plasma by liquid chromatography–tandem mass spectrometry and application to a preclinical pharmacokinetic study. Journal of Pharmaceutical & Biomedical Analysis, 98, 401-406. doi: 10.1016/j.jpba.2014.06.026

Shi, M., Yang, Y., Sun, Y., Cheng, L., Zhao, S., Xu, H., Fawcett, J. P., … Gu, J. (2014). Pharmacokinetic study of calenduloside E and its active metabolite oleanolic acid in beagle dog using liquid chromatography-tandem mass spectrometry. Journal of Chromatography B, 951-952, 129-134. doi: 10.1016/j.jchromb.2014.01.036

Shi, M., Yin, L., Cai, L., Wang, C., Liu, X., Zhao, S., … Fawcett, J. P., … Gu, J. (2014). LC-MS/MS method for the quantitation of cefotetan in human plasma and its application to pharmacokinetic study. Chemical Research in Chinese Universities, 30(6), 900-904. doi: 10.1007/s40242-014-4116-9

Wang, T., Ma, W., Sun, Y., Yang, Y., Zhang, W., Fawcett, J. P., … Gu, J. (2013). Ultra-sensitive assay for paclitaxel in intracellular compartments of A549 cells using liquid chromatography–tandem mass spectrometry. Journal of Chromatography B, 912, 93-97. doi: 10.1016/j.jchromb.2012.10.033

Yang, L., Fawcett, J. P., Zhang, H., & Tucker, I. G. (2013). Effect of 12-oxochenodeoxycholate on the pharmacokinetics and pharmacodynamics of morphine 6-glucuronide in Wistar rats. Journal of Pharmacy & Pharmacology, 65(4), 561-566. doi: 10.1111/jphp.12020

Yin, L., Zhang, Y.-H., Zhao, S., Cheng, L.-M., Shi, M.-Y., Yang, Y., … Fawcett, J. P. (2013). Rapid quantification of astilbin in rat plasma by liquid chromatography-tandem mass spectrometry and its application to pharmacokinetic study. Chemical Research in Chinese Universities, 29(6), 1078-1082. doi: 10.1007/s40242-013-3166-8

Zhang, Y., Yang, Y., Zhao, S., Yang, Z., Yang, H., Fawcett, J. P., … Sun, T. (2013). Phenolic esters of O-desmethylvenlafaxine with improved oral bioavailability and brain uptake. Molecules, 18(12), 14920-14934. doi: 10.3390/molecules181214920

Yin, L., Shi, M., Sun, Y., Sun, X., Meng, H., Fawcett, J. P., … Gu, J. (2013). A liquid chromatography—tandem mass spectrometric method for the simultaneous quantitation of five components of Ixeris sonchifoliain (Bge.) Hance in rat plasma and its application to a pharmacokinetic study. Journal of Chromatography B, 931, 12-16. doi: 10.1016/j.jchromb.2013.04.039

Li, X.-J., Sun, Y.-T., Yin, L., Zhang, X.-J., Yang, Y., Fawcett, J. P., … Gu, J.-K. (2013). Quantitation of bivalirudin, a novel anticoagulant peptide, in human plasma by LC-MS/MS: Method development, validation and application to pharmacokinetics. Journal of Pharmaceutical Analysis, 3(1), 1-8. doi: 10.1016/j.jpha.2012.10.006

Wu, X.-J., Zhang, M.-L., Cui, X.-Y., Gao, F., He, Q., Li, X.-J., … Fawcett, J. P., & Gu, J.-K. (2012). Comparative pharmacokinetics and bioavailability of escin Ia and isoescin Ia after administration of escin and of pure escin Ia and isoescin Ia in rats. Journal of Ethnopharmacology, 139(1), 201-206. doi: 10.1016/j.jep.2011.11.003

He, Q., Shi, M., Liu, X., Sun, Y., Hu, L., Yang, Y., Fawcett, J. P., … Zhao, L. (2012). Determination of landiolol, an ultra-short-acting β1-receptor antagonist, in human plasma by liquid chromatography—tandem mass spectrometry. Journal of Chromatography B, 891-892, 7-11. doi: 10.1016/j.jchromb.2011.12.024

Gai, Y.-Y., Liu, W.-H., Sha, C.-J., Wang, Y.-L., Sun, Y.-T., Li, X.-J., Fawcett, J. P., & Gu, J.-K. (2012). Pharmacokinetics and bioavailability of cimicifugosides after oral administration of Cimicifuga foetida L. extract to rats. Journal of Ethnopharmacology, 143, 249-255. doi: 10.1016/j.jep.2012.06.031

Yang, L., Fawcett, J. P., Østergaard, J., Zhang, H., & Tucker, I. G. (2012). Mechanistic studies of the effect of bile salts on rhodamine 123 uptake into RBE4 cells. Molecular Pharmaceutics, 9(1), 29-36. doi: 10.1021/mp200201y

Lee, H. J., Zhang, H., Orlovich, D. A., & Fawcett, J. P. (2012). The influence of probiotic treatment on sulfasalazine metabolism in rat. Xenobiotica, 42(8), 791-797. doi: 10.3109/00498254.2012.660508

Zadehvakili, B., Fawcett, J. P., & Giles, G. I. (2012). Synthesis, structure activity relationship studies and antioxidant activity evaluation of some organochalcogen catalysts as novel GPx mimics. Free Radical Biology & Medicine, 53(Suppl. 1), S99. doi: 10.1016/j.freeradbiomed.2012.08.206

Zhang, M., Yang, J., Tao, L., Li, L., Ma, P., & Fawcett, J. P. (2012). Acarbose bioequivalence: Exploration of new pharmacodynamic parameters. AAPS Journal, 14(2), 345-351. doi: 10.1208/s12248-012-9341-x

Hu, L., Fawcett, J. P., & Gu, J. (2012). Protein target discovery of drug and its reactive intermediate metabolite by using proteomic strategy. Acta Pharmaceutica Sinica B, 2(2), 126-136. doi: 10.1016/j.apsb.2012.02.001

Chen, G., Yang, L., Zhang, H., Tucker, I. G., & Fawcett, J. P. (2012). Effect of ketocholate derivatives on methotrexate uptake in Caco-2 cell monolayers. International Journal of Pharmaceutics, 433, 89-93. doi: 10.1016/j.ijpharm.2012.04.077

Krittaphol, W., McDowell, A., Thomson, C. D., Mikov, M., & Fawcett, J. P. (2011). Biotransformation of L-selenomethionine and selenite in rat gut contents. Biological Trace Element Research, 139(2), 188-196. doi: 10.1007/s12011-010-8653-x

Zhang, C., Cui, X., Yang, Y., Gao, F., Sun, Y., Gu, J., Fawcett, J. P., … Wang, W. (2011). Pharmacokinetics of felbinac after intravenous administration of felbinac trometamol in rats. Xenobiotica, 41(4), 340-348. doi: 10.3109/00498254.2010.544422

Yang, L., Zhang, H., Fawcett, J. P., Mikov, M., & Tucker, I. G. (2011). Effect of bile salts on the transport of morphine-6-glucuronide in rat brain endothelial cells. Journal of Pharmaceutical Sciences, 100(4), 1516-1524. doi: 10.1002/jps.22390

Krittaphol, W., Wescombe, P. A., Thomson, C. D., McDowell, A., Tagg, J. R., & Fawcett, J. P. (2011). Metabolism of L-selenomethionine and selenite by probiotic bacteria: In vitro and in vivo studies. Biological Trace Element Research, 144, 1358-1369. doi: 10.1007/s12011-011-9057-2

Cui, X., Zhang, M., Guan, X., Yin, L., Sun, Y., Fawcett, J. P., & Gu, J. (2011). LC-MS-MS determination of troxerutin in plasma and its application to a pharmacokinetic study. Chromatographia, 73(1-2), 165-169. doi: 10.1007/s10337-010-1827-z

Zhang, J., Gao, F., Guan, X., Sun, Y.-T., Gu, J.-K., & Fawcett, J. P. (2011). Determination of repaglinide in human plasma by high-performance liquid chromatography-tandem mass spectrometry. Acta Pharmaceutica Sinica B, 1(1), 40-45. doi: 10.1016/j.apsb.2011.04.004

Lee, H. J., Waller, R. D., Stebbings, S., Highton, J., Orlovich, D. A., Schmierer, D., & Fawcett, J. P. (2010). The effects of an orally administered probiotic on sulfasalazine metabolism in individuals with rheumatoid arthritis: A preliminary study. International Journal of Rheumatic Diseases, 13(1), 48-54. doi: 10.1111/j.1756-185X.2009.01449.x

Li, Y., Zhang, H., Fawcett, J. P., & Tucker, I. G. (2010). Effect of cyclosporin A on the pharmacokinetics of mitoquinone (MitoQ10), a mitochondria-targeted antioxidant, in rat. Asian Journal of Pharmaceutical Sciences, 5(3), 106-113.

Zhang, C., Wang, L., Guan, X., Fawcett, J. P., Zhao, L.-M., Sun, Y.-T., & Gu, J.-K. (2010). Rapid determination of ranitidine in human plasma by liquid chromatography-tandem mass spectrometry and its application to a clinical pharmacokinetic study. Chemical Research in Chinese Universities, 26(6), 910-914.

Wu, X., Liu, L., Zhang, M., Wu, D., Wang, Y., Sun, Y., Fawcett, J. P., & et al (2010). Simultaneous analysis of isomers of escin saponins in human plasma by liquid chromatography-tandem mass spectrometry: Application to a pharmacokinetic study after oral administration. Journal of Chromatography B, 878, 861-867. doi: 10.1016/j.jchromb.2010.02.002

Li, H., Zhang, C., Wang, J., Jiang, Y., Fawcett, J. P., & Gu, J. (2010). Simultaneous quantitation of paracetamol, caffeine, pseudoephedrine, chlorpheniramine and cloperastine in human plasma by liquid chromatography-tandem mass spectrometry. Journal of Pharmaceutical & Biomedical Analysis, 51(3), 716-722. doi: 10.1016/j.jpba.2009.10.009

Han, J., Jiang, S., Cui, X., Sun, Y., Li, G., Zhang, J., Fawcett, J. P., & Gu, J. (2009). Quantitation of the tacrine analogue octahydroaminoacridine in human plasma by liquid chromatography-tandem mass spectrometry. Journal of Pharmaceutical & Biomedical Analysis, 50(2), 171-174. doi: 10.1016/j.jpba.2009.03.022

Si, D., Wang, Y., Zhou, Y.-H., Guo, Y., Wang, J., Zhou, H., … Fawcett, J. P. (2009). Mechanism of CYP2C9 inhibition by flavones and flavonols. Drug Metabolism & Disposition, 37(3), 629-634. doi: 10.1124/dmd.108.023416

Krittaphol, W., McDowell, A., Thomson, C. D., Tucker, I. G., Fawcett, J. P., & Mikov, M. (2009). An improved HPLC method for the investigation of L-selenomethionine metabolism in rat gut contents. Biomedical Chromatography, 23, 1169-1174. doi: 10.1002/bmc.1239

Lee, H. J., Orlovich, D. A., Tagg, J. R., & Fawcett, J. P. (2009). Detection and specific enumeration of multi-strain probiotics in the lumen contents and mucus layers of the rat intestine after oral administration. Probiotics & Antimicrobial Proteins, 1(2), 113-120. doi: 10.1007/s12602-009-9019-6

Sun, Y., Liu, M., Zhang, J., Jiang, Y., Yu, W., Fawcett, J. P., & Gu, J. (2009). Rapid and sensitive assay for trantinterol, a novel β2-adrenoceptor agonist, in human plasma using liquid chromatography-tandem mass spectrometry. Journal of Pharmaceutical & Biomedical Analysis, 49(4), 1056-1059. doi: 10.1016/j.jpba.2009.01.012

Chen, G., Fawcett, J. P., Mikov, M., & Tucker, I. G. (2009). Simultaneous determination of methotrexate and its polyglutamate metabolites in Caco-2 cells by liquid chromatography-tandem mass spectrometry. Journal of Pharmaceutical & Biomedical Analysis, 50(2), 262-266. doi: 10.1016/j.jpba.2009.04.025

Al-Salami, H., Butt, G., Tucker, I., Fawcett, J. P., Golocorbin-Kon, S., Mikov, I., & Mikov, M. (2009). Gliclazide reduces MKC intestinal transport in healthy but not diabetic rats. European Journal of Drug Metabolism & Pharmacokinetics, 34(1), 43-50.

Yu, W., Wang, Y., Zhang, Y., Zhang, D., Lan, J., Liu, Z., … Fawcett, J. P. (2009). Quantitation of bergenin in human plasma by liquid chromatography/tandem mass spectrometry. Journal of Chromatography B, 877(1), 33-36. doi: 10.1016/j.jchromb.2008.11.005

Zhang, D., Wang, Y., Han, J., Yu, W., Deng, L., Fawcett, J. P., … Gu, J. (2009). Rapid and sensitive LC-MS/MS assay for the quantitation of 20(S)-protopanaxadiol in human plasma. Journal of Chromatography B, 877(5-6), 581-585. doi: 10.1016/j.jchromb.2009.01.009

Chen, G., Fawcett, J. P., Mikov, M., & Tucker, I. G. (2009). Monoketocholate can decrease transcellular permeation of methotrexate across Caco-2 cell monolayers and reduce its intestinal absorption in rat. Journal of Pharmacy & Pharmacology, 61(7), 953-959. doi: 10.1211/jpp/61.07.0016

Yang, J., He, Y., Du, Y.-X., Tang, L.-L., Wang, G.-J., & Fawcett, J. P. (2009). Pharmacokinetic properties of S-adenosylmethionine after oral and intravenous administration of its tosylate disulfate salt: A multiple-dose, open-label, parallel-group study in healthy Chinese volunteers. Clinical Therapeutics, 31(2), 311-320. doi: 10.1016/j.clinthera.2009.02.010

Zhang, C., Wang, L., Yang, W., Wang, X., Fawcett, J. P., Sun, Y., & Gu, J. (2009). Validated LC-MS/MS assay for the determination of felbinac: Application to a preclinical pharmacokinetics study of felbinac trometamol injection in rat. Journal of Pharmaceutical & Biomedical Analysis, 50(1), 41-45. doi: 10.1016/j.jpba.2009.03.019

Woodland, C., Huang, T. T., Gryz, E., Bendayan, R., & Fawcett, J. P. (2008). Expression, activity and regulation of CYP3A in human and rodent brain. Drug Metabolism Reviews, 40, 149-168. doi: 10.1080/03602530701836712

Mikov, M., Al-Salami, H., Golocorbin-Kon, S., Skrbic, R., Raskovic, A., & Fawcett, J. P. (2008). The influence of 3α,7α-dihydroxy-12-keto-5β-cholanate on gliclazide pharmacokinetics and glucose levels in a rat model of diabetes. European Journal of Drug Metabolism & Pharmacokinetics, 33(3), 137-142.

Numata, M., Fawcett, J. P., Saville, D. J., & Rosengren, R. J. (2008). Hepatic cytochrome P450 activity and pollutant concentrations in paradise shelducks and southern black-backed gulls in the South Island of New Zealand. Ecotoxicology, 17, 697-708. doi: 10.1007/s10646-008-0218-9

Al-Salami, H., Butt, G., Fawcett, J. P., Tucker, I. G., Golocorbin-Kon, S., & Mikov, M. (2008). Probiotic treatment reduces blood glucose levels and increases systemic absorption of gliclazide in diabetic rats. European Journal of Drug Metabolism & Pharmacokinetics, 33(2), 101-106.

Wang, J., Jiang, Y., Wang, Y., Tang, Y., Teng, G., Fawcett, J. P., … Gu, J. (2008). A rapid and sensitive LC-MS/MS assay to quantify yonkenafil in rat plasma with application to preclinical pharmacokinetics studies. Journal of Pharmaceutical & Biomedical Analysis, 47, 985-989. doi: 10.1016/j.jpba.2008.04.004

Yang, Y., Li, H., Gao, K., Liu, M., Sun, Y., Yan, T., Fawcett, J. P., … Gu, J. (2008). Simultaneous quantitation of dexamethasone palmitate and dexamethasone in human plasma by liquid chromatography/tandem mass spectrometry. Journal of Chromatography B, 862, 119-124. doi: 10.1016/j.jchromb.2007.11.033

Yan, T., Li, H., Deng, L., Guo, Y., Yu, W., Fawcett, J. P., … Gu, J. (2008). Liquid chromatographic-tandem mass spectrometric method for the simultaneous quantitation of telmisartan and hydrochlorothiazide in human plasma. Journal of Pharmaceutical & Biomedical Analysis, 48, 1225-1229. doi: 10.1016/j.jpba.2008.08.021

Li, Y., Fawcett, J. P., Zhang, H., & Tucker, I. G. (2008). Transport and metabolism of some cationic ubiquinone antioxidants (MitoQn) in Caco-2 cell monolayers. European Journal of Drug Metabolism & Pharmacokinetics, 33(4), 199-204.

Numata, M., Fawcett, J. P., & Rosengren, R. J. (2008). Induction of in vitro EROD activity and in vivo caffeine metabolism in two species of New Zealand birds. Environmental Toxicology & Pharmacology, 25, 358-364. doi: 10.1016/j.etap.2007.11.005

Li, X., Wang, Y., Wang, J., Fawcett, J. P., Zhao, L., & Gu, J. (2007). Determination of miglitol in human plasma by liquid chromatography/tandem mass spectrometry. Rapid Communications in Mass Spectrometry, 21, 247-251.

Wang, Y., Wang, Y., Li, P., Tang, Y., Fawcett, J. P., & Gu, J. (2007). Quantitation of Armillarisin A in human plasma by liquid chromatography-electrospray tandem mass spectrometry. Journal of Pharmaceutical & Biomedical Analysis, 43, 1860-1863.

Teng, G., Wang, Y., Tang, Y., Wang, R., Fang, Y., Fawcett, J. P., & Gu, J. (2007). Quantitation of iptakalim in human plasma by high-performance liquid chromatography-tandem mass spectrometry. Journal of Chromatography B, 859, 256-260.

Jiang, Y., Wang, J., Wang, Y., Li, H., Fawcett, J. P., & Gu, J. (2007). Rapid and sensitive liquid chromatography-tandem mass spectrometry method for the quantitation of colchicine in human plasma. Journal of Chromatography B, 850, 564-568.

Li, Y., Zhang, H., Fawcett, J. P., & Tucker, I. G. (2007). Quantitation and metabolism of mitoquinone, a mitochondria-targeted antioxidant, in rat by liquid chromatography/tandem mass spectrometry. Rapid Communications in Mass Spectrometry, 21, 1958-1964.

Li, Y., Fawcett, J. P., Zhang, H., & Tucker, I. G. (2007). Transport and metabolism of MitoQ10, a mitochondria-targeted antioxidant, in Caco-2 cell monolayers. Journal of Pharmacy & Pharmacology, 59, 503-511.

Mikov, M., Boni, N. S., Al-Salami, H., Kuhajda, K., Kevresan, S., Golocorbin-Kon, S., & Fawcett, J. P. (2007). Bioavailability and hypoglycemic activity of the semisynthetic bile acid salt, sodium 3α,7α-dihydroxy-12-oxo-5β-cholanate, in healthy and diabetic rats. European Journal of Drug Metabolism & Pharmacokinetics, 32(1), 7-12.

Wang, J., Jiang, Y., Wang, Y., Li, H., Fawcett, J. P., & Gu, J. (2007). Highly sensitive assay for tiotropium, a quaternary ammonium, in human plasma by high-performance liquid chromatography/tandem mass spectrometry. Rapid Communications in Mass Spectrometry, 21, 1755-1758.

Jiang, Y., Wang, J., Wang, Y., Du, X., Zhang, Y., Fawcett, J. P., & Gu, J. (2007). Determination of long-acting release octreotide, an octapeptide analogue of somatostation, in human plasma by liquid chromatography/tandem mass spectrometry. Rapid Communications in Mass Spectrometry, 21, 3982-3986.

Mikov, M., Fawcett, J. P., Kuhajda, K., & Kevresan, S. (2006). Pharmacology of bile acids and their derivatives: Absorption promoters and therapeutic agents. European Journal of Drug Metabolism & Pharmacokinetics, 31(3), 237-251.

Mikov, M., Lee, H. J., & Fawcett, J. P. (2006). The influence of probiotic treatment on sulfasalazine metabolism in rat gut contents. Asian Journal of Pharmacodynamics & Pharmacokinetics, 6(4), 337-342.

Kandrac, J., Kevresan, S., Gu, J. K., Mikov, M., Fawcett, J. P., & Kuhajda, K. (2006). Isolation and determination of bile acids. European Journal of Drug Metabolism & Pharmacokinetics, 31(3), 157-177.

Kuhajda, K., Kevresan, S., Kandrac, J., Fawcett, J. P., & Mikov, M. (2006). Chemical and metabolic transformations of selected bile acids. European Journal of Drug Metabolism & Pharmacokinetics, 31(3), 179-235.

Kuhajda, K., Kandrac, J., Kevresan, S., Mikov, M., & Fawcett, J. P. (2006). Structure and origin of bile acids: An overview. European Journal of Drug Metabolism & Pharmacokinetics, 31(3), 135-143.

Kevresan, S., Kuhajda, K., Kandrac, J., Fawcett, J. P., & Mikov, M. (2006). Biosynthesis of bile acids in mammalian liver. European Journal of Drug Metabolism & Pharmacokinetics, 31(3), 145-156.

Lan, J., Wang, J., Wu, D., Wang, Y., Fawcett, J. P., & Gu, J. (2006). Liquid chromatographic/tandem mass spectrometric method for the quantitation of tranilast in human plasma. Rapid Communications in Mass Spectrometry, 20(22), 3309-3312.

Gu, Y., & Fawcett, J. P. (2005). Improved HPLC method for the simultaneous determination of tramadol and Ο-desmethyltramadol in human plasma. Journal of Chromatography B, 821, 240-243.

Tang, Y., Zhao, L., Wang, Y., Fawcett, J. P., & Gu, J. (2005). Rapid and sensitive liquid chromatography-tandem mass spectrometry method for the quantitation of levodropropizine in human plasma. Journal of Chromatography B, 819, 185-189.

Mikov, M., Raskovic, A., Jakovljevic, E., Dudvarski, D., & Fawcett, J. P. (2005). Influence of the bile salt sodium 3α,7α dihydrooxy-12-oxo-5β-cholanate on ampicillin pharmacokinetics in rats. Asian Journal of Drug Metabolism & Pharmacokinetics, 5(3), 197-200.

Shi, X. G., Fawcett, J. P., Chen, X. Y., & Zhong, D. F. (2005). Structural identification of bitespiramycin metabolites in rat: A single oral dose study. Xenobiotica, 35(4), 343-358.

Wang, J., Wang, Y., Fawcett, J. P., Wang, Y., & Gu, J. (2005). Determination of omeprazole in human plasma by liquid chromatography-electrospray quadrupole linear ion trap mass spectrometry. Journal of Pharmaceutical & Biomedical Analysis, 39(3-4), 631-635. doi: 10.1016/j.jpba.2005.04.011

Li, P., Wang, Y., Wang, Y., Tang, Y., Fawcett, J. P., Cui, Y., & Gu, J. (2005). Determination of telmisartan in human plasma by liquid chromatography-tandem mass spectrometry. Journal of Chromatography B, 828(1-2), 126-129. doi: 10.1016/j.jchromb.2005.09.021

Guo, Y., Zhang, Y., Wang, Y., Chen, X., Si, D., Zhong, D., Fawcett, J. P., & Zhou, H. (2005). Role of CYP2C9 and its variants (CYP2C9*3 and CYP2C9*13) in the metabolism of lornoxicam in humans. Drug Metabolism & Disposition, 33, 749-753.

Li, K., Tang, Y., Fawcett, J. P., Gu, J., & Zhong, D. (2005). Characterization of the pharmacokinetics of dioscin in rat. Steroids, 70, 525-530.

Wang, Y., Wang, J., Cui, Y., Fawcett, J. P., & Gu, J. (2005). Liquid chromatographic-tandem mass spectrometric method for the quantitation of sildenafil in human plasma. Journal of Chromatography B, 828, 118-121.

Wang, Y., Zhong, D., Fawcett, J. P., & Gu, J. (2005). Autosampler programming for improved sample throughput in liquid chromatography/mass spectrometry [Letter to the editor]. Clinical Chemistry, 51(11), 2216-2218.

Fawcett, J. P., Barbezat, G. O., Poulton, R., Milne, B. J., Xia, H. H. X., & Talley, N. J. (2005). Helicobacter pylori serology in a birth cohort of New Zealanders from age 11 to 26. World Journal of Gastroenterology, 11(21), 3273-3276.

Gu, Y., Wang, G., Pan, G., Fawcett, J. P., A, J., & Sun, J. (2004). Transport and bioavailability studies of Astragaloside IV, an active ingredient in Radix Astragali. Basic & Clinical Pharmacology & Toxicology, 95(6), 295-298. doi: 10.1111/j.1742-7843.2004.t01-1-pto950508.x

Shi, X., Zhang, S., Fawcett, J. P., & Zhong, D. (2004). Acid catalysed degradation of some spiramycin derivatives found in the antibiotic bitespiramycin. Journal of Pharmaceutical & Biomedical Analysis, 36, 593-600.

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