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Pharmacy staff profile

Professor Thomas Rades

PositionResearch Chair in Pharmaceutical Design and Drug Delivery, Department of Pharmacy, University of Copenhagen
QualificationsPGCert (Pharmacy), Dipl.Pharm. (MPharm, Germany/Austria), MPharm/MSc, PhD
Research summaryFormulation and drug delivery and physical characterisation of the solid and liquid crystalline state of matter.

Research

The research in both areas aims to improve drug therapy through appropriate formulation of medicines and to increase our understanding of the physico-chemical properties of drugs and medicines. It combines physical, chemical, and biological sciences and technology to optimally formulate drugs for human and veterinary uses. Specific research interests are:

  1. Colloidal delivery systems for bioactives
  2. The solid state of drugs and dosage forms

Additional details

Professor Rades’ profile on the University of Copenhagen website

Publications

Walker, G., Römann, P., Poller, B., Löbmann, K., Grohganz, H., Rooney, J. S., Huff, G. S., Smith, G. P. S., Rades, T., Gordon, K. C., Strachan, C. J., & Fraser-Miller, S. J. (2017). Probing pharmaceutical mixtures during milling: The potency of low frequency Raman spectroscopy in identifying disorder. Molecular Pharmaceutics. Advance online publication. doi: 10.1021/acs.molpharmaceut.7b00803

Foged, C., Rades, T., Perrie, Y., & Hook, S. (Eds.). (2015). Subunit vaccine delivery. New York: Springer. doi: 10.1007/978-1-4939-1417-3

Kojarunchitt, T., Baldursdottir, S., Dong, Y.-D., Boyd, B. J., Rades, T., & Hook, S. (2015). Modified thermoresponsive Poloxamer 407 and chitosan sol-gels as potential sustained-release vaccine delivery systems. European Journal of Pharmaceutics & Biopharmaceutics, 89, 74-81. doi: 10.1016/j.ejpb.2014.11.026

Mah, P. T., Fraser, S. J., Reish, M. E., Rades, T., Gordon, K. C., & Strachan, C. J. (2015). Use of low-frequency Raman spectroscopy and chemometrics for the quantification of crystallinity in amorphous griseofulvin tablets. Vibrational Spectroscopy, 77, 10-16. doi: 10.1016/j.vibspec.2015.02.002

Madsen, C. G., Skov, A., Baldursdottir, S., Rades, T., Jorgensen, L., & Medlicott, N. J. (2015). Simple measurements for prediction of drug release from polymer matrices: Solubility parameters and intrinsic viscosity. European Journal of Pharmaceutics & Biopharmaceutics, 92, 1-7. doi: 10.1016/j.ejpb.2015.02.001

Authored Book - Research

Perrie, Y., & Rades, T. (2010). Pharmaceutics: Drug delivery and targeting. London: Pharmaceutical Press, 240p.

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Edited Book - Research

Foged, C., Rades, T., Perrie, Y., & Hook, S. (Eds.). (2015). Subunit vaccine delivery. New York: Springer. doi: 10.1007/978-1-4939-1417-3

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Chapter in Book - Research

Saupe, A., & Rades, T. (2006). Solid lipid nanoparticles. In M. R. Mozafari (Ed.), Nanocarrier technologies: Frontiers of nanotherapy. (pp. 41-50). Dordrecht, The Netherlands: Springer.

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Journal - Research Article

Walker, G., Römann, P., Poller, B., Löbmann, K., Grohganz, H., Rooney, J. S., Huff, G. S., Smith, G. P. S., Rades, T., Gordon, K. C., Strachan, C. J., & Fraser-Miller, S. J. (2017). Probing pharmaceutical mixtures during milling: The potency of low frequency Raman spectroscopy in identifying disorder. Molecular Pharmaceutics. Advance online publication. doi: 10.1021/acs.molpharmaceut.7b00803

Kojarunchitt, T., Baldursdottir, S., Dong, Y.-D., Boyd, B. J., Rades, T., & Hook, S. (2015). Modified thermoresponsive Poloxamer 407 and chitosan sol-gels as potential sustained-release vaccine delivery systems. European Journal of Pharmaceutics & Biopharmaceutics, 89, 74-81. doi: 10.1016/j.ejpb.2014.11.026

Madsen, C. G., Skov, A., Baldursdottir, S., Rades, T., Jorgensen, L., & Medlicott, N. J. (2015). Simple measurements for prediction of drug release from polymer matrices: Solubility parameters and intrinsic viscosity. European Journal of Pharmaceutics & Biopharmaceutics, 92, 1-7. doi: 10.1016/j.ejpb.2015.02.001

Mah, P. T., Fraser, S. J., Reish, M. E., Rades, T., Gordon, K. C., & Strachan, C. J. (2015). Use of low-frequency Raman spectroscopy and chemometrics for the quantification of crystallinity in amorphous griseofulvin tablets. Vibrational Spectroscopy, 77, 10-16. doi: 10.1016/j.vibspec.2015.02.002

Ou, Z.-Q., Rades, T., & McDowell, A. (2015). Anti-ageing effects of Sonchus oleraceus L. (pūhā) leaf extracts on H2O2-induced cell senescence. Molecules, 20(3), 4548-4564. doi: 10.3390/molecules20034548

Surwase, S. A., Itkonen, L., Aaltonen, J., Saville, D., Rades, T., Peltonen, L., & Strachan, C. J. (2015). Polymer incorporation method affects the physical stability of amorphous indomethacin in aqueous suspension. European Journal of Pharmaceutics & Biopharmaceutics, 96, 32-43. doi: 10.1016/j.ejpb.2015.06.005

Kanjanakawinkul, W., Medlicott, N. J., Rades, T., Puttipipatkhachorn, S., & Pongjanyakul, T. (2015). Lysozyme–magnesium aluminum silicate microparticles: Molecular interaction, bioactivity and release studies. International Journal of Biological Macromolecules, 80, 651-658. doi: 10.1016/j.ijbiomac.2015.07.033

Mah, P. T., Laaksonen, T., Rades, T., Peltonen, L., & Strachan, C. J. (2015). Differential scanning calorimetry predicts the critical quality attributes of amorphous glibenclamide. European Journal of Pharmaceutical Sciences, 80, 74-81. doi: 10.1016/j.ejps.2015.08.006

Greatrex, B. W., Daines, A. M., Hook, S., Lenz, D. H., McBurney, W., Rades, T., & Rendle, P. M. (2015). Synthesis, formulation, and adjuvanticity of monodesmosidic saponins with olenanolic acid, hederagenin and gypsogenin aglycones, and some C-28 ester derivatives. ChemistryOpen, 4(6), 740-755. doi: 10.1002/open.201500149

Mah, P. T., Laaksonen, T., Rades, T., Aaltonen, J., Peltonen, L., & Strachan, C. J. (2014). Unravelling the relationship between degree of disorder and the dissolution behavior of milled glibenclamide. Molecular Pharmaceutics, 11(1), 234-242. doi: 10.1021/mp4004145

Ou, Z.-Q., Schmierer, D. M., Strachan, C. J., Rades, T., & McDowell, A. (2014). Influence of postharvest processing and storage conditions on key antioxidants in pūhā (Sonchus oleraceus L.). Journal of Pharmacy & Pharmacology, 66, 998-1008. doi: 10.1111/jphp.12220

Grohganz, H., Priemel, P. A., Löbmann, K., Nielsen, L. H., Laitinen, R., Mullertz, A., … Rades, T. (2014). Refining stability and dissolution rate of amorphous drug formulations. Expert Opinion on Drug Delivery, 11(6), 977-989. doi: 10.1517/17425247.2014.911728

Feltrin, K. L., Brennan, I. M., Rades, T., Horowitz, M., & Feinle-Bisset, C. (2014). Acute oral administration of lauric acid reduces energy intake in healthy males. e-SPEN Journal, 9(2), e69-e75. doi: 10.1016/j.clnme.2014.01.004

Neumann, S., Burkert, K., Kemp, R., Rades, T., Dunbar, P. R., & Hook, S. (2014). Activation of the NLRP3 inflammasome is not a feature of all particulate vaccine adjuvants. Immunology & Cell Biology, 92, 535-542. doi: 10.1038/icb.2014.21

Hubert, M., Larsen, D. S., Hayman, C. M., Rades, T., & Hook, S. (2014). Physical characterization of synthetic phosphatidylinositol dimannosides and analogues in binary systems with phosphatidylcholine. Molecular Pharmaceutics, 11(3), 913-921. doi: 10.1021/mp400588y

Haaser, M., Karrout, Y., Velghe, C., Cuppok, Y., Gordon, K. C., Pepper, M., … Rades, T., … Strachan, C. J. (2013). Application of terahertz pulsed imaging to analyse film coating characteristics of sustained-release coated pellets. International Journal of Pharmaceutics, 457(2), 521-526. doi: 10.1016/j.ijpharm.2013.05.039

Haaser, M., Naelapää, K., Gordon, K. C., Pepper, M., Rantanen, J., Strachan, C. J., … Zeitler, J. A., & Rades, T. (2013). Evaluating the effect of coating equipment on tablet film quality using terahertz pulsed imaging. European Journal of Pharmaceutics & Biopharmaceutics, 85(3), 1095-1102. doi: 10.1016/j.ejpb.2013.03.019

Munk, T., Baldursdottir, S., Hietala, S., Rades, T., Nuopponen, M., Kalliomäki, K., … Strachan, C. J. (2013). Investigation of the phase separation of PNIPAM using infrared spectroscopy together with multivariate data analysis. Polymer, 54(26), 6947-6953. doi: 10.1016/j.polymer.2013.10.033

Priemel, P. A., Laitinen, R., Grohganz, H., Rades, T., & Strachan, C. J. (2013). In situ amorphisation of indomethacin with Eudragit® E during dissolution. European Journal of Pharmaceutics & Biopharmaceutics, 85(3), 1259-1265. doi: 10.1016/j.ejpb.2013.09.010

Grohganz, H., Löbmann, K., Priemel, P., Tarp Jensen, K., Graeser, K., Strachan, C., & Rades, T. (2013). Amorphous drugs and dosage forms. Journal of Drug Delivery Science & Technology, 23(4), 403-408.

Laitinen, R., Löbmann, K., Strachan, C. J., Grohganz, H., & Rades, T. (2013). Emerging trends in the stabilization of amorphous drugs. International Journal of Pharmaceutics, 453(1), 65-79. doi: 10.1016/j.ijpharm.2012.04.066

Löbmann, K., Laitinen, R., Grohganz, H., Strachan, C., Rades, T., & Gordon, K. C. (2013). A theoretical and spectroscopic study of co-amorphous naproxen and indomethacin. International Journal of Pharmaceutics, 453(1), 80-87. doi: 10.1016/j.ijpharm.2012.05.016

Ou, Z.-Q., Schmierer, D. M., Rades, T., Larsen, L., & McDowell, A. (2013). Application of an online post-column derivatization HPLC-DPPH assay to detect compounds responsible for antioxidant activity in Sonchus oleraceus L. leaf extracts. Journal of Pharmacy & Pharmacology, 65(2), 271-279. doi: 10.1111/j.2042-7158.2012.01591.x

Rehder, S., Wu, J. X., Laackmann, J., Moritz, H.-U., Rantanen, J., Rades, T., & Leopold, C. S. (2013). A case study of real-time monitoring of solid-state phase transformations in acoustically levitated particles using near infrared and Raman spectroscopy. European Journal of Pharmaceutical Sciences, 48(1-2), 97-103. doi: 10.1016/j.ejps.2012.10.001

Rizwan, S. B., McBurney, W. T., Young, K., Hanley, T., Boyd, B. J., Rades, T., & Hook, S. (2013). Cubosomes containing the adjuvants imiquimod and monophosphoryl lipid A stimulate robust cellular and humoral immune responses. Journal of Controlled Release, 165(1), 16-21. doi: 10.1016/j.jconrel.2012.10.020

Thomas, N., Holm, R., Garmer, M., Karlsson, J. J., Müllertz, A., & Rades, T. (2013). Supersaturated self-nanoemulsifying drug delivery systems (Super-SNEDDS) enhance the bioavailability of the poorly water-soluble drug simvastatin in dogs. AAPS Journal, 15(1), 219-227. doi: 10.1208/s12248-012-9433-7

Pongjanyakul, T., Khunawattanakul, W., Strachan, C. J., Gordon, K. C., Puttipipatkhachorn, S., & Rades, T. (2013). Characterization of chitosan-magnesium aluminum silicate nanocomposite films for buccal delivery of nicotine. International Journal of Biological Macromolecules, 55, 24-31. doi: 10.1016/j.ijbiomac.2012.12.043

Kanjanakawinkul, W., Rades, T., Puttipipatkhachorn, S., & Pongjanyakul, T. (2013). Nicotine-magnesium aluminum silicate microparticle surface modified with chitosan for mucosal delivery. Materials Science & Engineering: C, 33(3), 1727-1736. doi: 10.1016/j.msec.2012.12.086

Schwab, M., McGoverin, C. M., Gordon, K. C., Winter, G., Rades, T., Myschik, J., & Strachan, C. J. (2013). Studies on the lipase induced degradation of lipid based drug delivery systems: Part II: Investigations on the mechanisms leading to collapse of the lipid structure. European Journal of Pharmaceutics & Biopharmaceutics, 84(3), 456-463. doi: 10.1016/j.ejpb.2012.12.023

Hubert, M., Compton, B. J., Hayman, C. M., Larsen, D. S., Painter, G. F., Rades, T., & Hook, S. (2013). Physicochemical and biological characterization of synthetic phosphatidylinositol dimannosides and analogues. Molecular Pharmaceutics, 10(5), 1928-1939. doi: 10.1021/mp300707a

Löbmann, K., Grohganz, H., Laitinen, R., Strachan, C., & Rades, T. (2013). Amino acids as co-amorphous stabilizers for poorly water soluble drugs: Part 1: Preparation, stability and dissolution enhancement. European Journal of Pharmaceutics & Biopharmaceutics, 85(3), 873-881. doi: 10.1016/j.ejpb.2013.03.014

Haaser, M., Gordon, K. C., Strachan, C. J., & Rades, T. (2013). Terahertz pulsed imaging as an advanced characterisation tool for film coatings: A review. International Journal of Pharmaceutics, 457(2), 510-520. doi: 10.1016/j.ijpharm.2013.03.053

Löbmann, K., Laitinen, R., Strachan, C., Rades, T., & Grohganz, H. (2013). Amino acids as co-amorphous stabilizers for poorly water-soluble drugs: Part 2: Molecular interactions. European Journal of Pharmaceutics & Biopharmaceutics, 85(3), 882-888. doi: 10.1016/j.ejpb.2013.03.026

Rehder, S., Christensen, N. P. A., Rantanen, J., Rades, T., & Leopold, C. S. (2013). High-shear granulation as a manufacturing method for cocrystal granules. European Journal of Pharmaceutics & Biopharmaceutics, 85(3), 1019-1030. doi: 10.1016/j.ejpb.2013.04.022

Scherließ, R., Buske, S., Young, K., Weber, B., Rades, T., & Hook, S. (2013). In vivo evaluation of chitosan as an adjuvant in subcutaneous vaccine formulations. Vaccine, 31(42), 4812-4819. doi: 10.1016/j.vaccine.2013.07.081

Rattanapak, T., Birchall, J., Young, K., Ishii, M., Meglinski, I., Rades, T., & Hook, S. (2013). Transcutaneous immunization using microneedles and cubosomes: Mechanistic investigations using Optical Coherence Tomography and two-photon microscopy. Journal of Controlled Release, 172(3), 894-903. doi: 10.1016/j.jconrel.2013.08.018

Priemel, P. A., Laitinen, R., Barthold, S., Grohganz, H., Lehto, V.-P., Rades, T., & Strachan, C. J. (2013). Inhibition of surface crystallisation of amorphous indomethacin particles in physical drug–polymer mixtures. International Journal of Pharmaceutics, 456(2), 301-306. doi: 10.1016/j.ijpharm.2013.08.046

Pirayavaraporn, C., Rades, T., Gordon, K. C., & Tucker, I. G. (2013). Quantification of the types of water in Eudragit RLPO polymer and the kinetics of water loss using FTIR. International Journal of Pharmaceutics, 458(1), 90-98. doi: 10.1016/j.ijpharm.2013.10.012

Karmwar, P., Graeser, K., Gordon, K. C., Strachan, C. J., & Rades, T. (2012). Effect of different preparation methods on the dissolution behaviour of amorphous indomethacin. European Journal of Pharmaceutics & Biopharmaceutics, 80(2), 459-464. doi: 10.1016/j.ejpb.2011.10.006

Kao, J. Y., McGoverin, C. M., Graeser, K. A., Rades, T., & Gordon, K. C. (2012). Measurement of amorphous indomethacin stability with NIR and Raman spectroscopy. Vibrational Spectroscopy, 58, 19-26. doi: 10.1016/j.vibspec.2011.09.009

Loebmann, K., Strachan, C., Grohganz, H., Rades, T., Korhonen, O., & Laitinen, R. (2012). Co-amorphous simvastatin and glipizide combinations show improved physical stability without evidence of intermolecular interactions. European Journal of Pharmaceutics & Biopharmaceutics, 81, 159-169. doi: 10.1016/j.ejpb.2012.02.004

Thomas, N., Müllertz, A., Graf, A., & Rades, T. (2012). Influence of lipid composition and drug load on the in vitro performance of self-nanoemulsifying drug delivery systems. Journal of Pharmaceutical Sciences, 101(5), 1721-1731. doi: 10.1002/jps.23054

Thomas, N., Holm, R., Rades, T., & Müllertz, A. (2012). Characterising lipid lipolysis and its implication in lipid-based formulation development. AAPS Journal, 14(4), 860-871. doi: 10.1208/s12248-012-9398-6

Wu, J. X., Xia, D., van den Berg, F., Amigo, J. M., Rades, T., Yang, M., & Rantanen, J. (2012). A novel image analysis methodology for online monitoring of nucleation and crystal growth during solid state phase transformations. International Journal of Pharmaceutics, 433(1-2), 60-70. doi: 10.1016/j.ijpharm.2012.04.074

Rehder, S., Sakmann, A., Rades, T., & Leopold, C. S. (2012). Thermal degradation of amorphous glibenclamide. European Journal of Pharmaceutics & Biopharmaceutics, 80(1), 203-208. doi: 10.1016/j.ejpb.2011.07.009

Pirayavaraporn, C., Rades, T., & Tucker, I. G. (2012). Determination of moisture content in relation to thermal behaviour and plasticization of Eudragit RLPO. International Journal of Pharmaceutics, 422(1-2), 68-74. doi: 10.1016/j.ijpharm.2011.10.028

Gordon, S., Young, K., Wilson, R., Rizwan, S., Kemp, R., Rades, T., & Hook, S. (2012). Chitosan hydrogels containing liposomes and cubosomes as particulate sustained release vaccine delivery systems. Journal of Liposome Research, 22(3), 193-204. doi: 10.3109/08982104.2011.637502

Xia, D., Wu, J. X., Cui, F., Qu, H., Rades, T., Rantanen, J., & Yang, M. (2012). Solvent-mediated amorphous-to-crystalline transformation of nitrendipine in amorphous particle suspensions containing polymers. European Journal of Pharmaceutical Sciences, 46, 446-454. doi: 10.1016/j.ejps.2012.03.008

Nielsen, L. H., Keller, S. S., Gordon, K. C., Boisen, A., Rades, T., & Müllertz, A. (2012). Spatial confinement can lead to increased stability of amorphous indomethacin. European Journal of Pharmaceutics & Biopharmaceutics, 81(2), 418-425. doi: 10.1016/j.ejpb.2012.03.017

Priemel, P. A., Grohganz, H., Gordon, K. C., Rades, T., & Strachan, C. J. (2012). The impact of surface- and nano-crystallisation on the detected amorphous content and the dissolution behaviour of amorphous indomethacin. European Journal of Pharmaceutics & Biopharmaceutics, 82(1), 187-193. doi: 10.1016/j.ejpb.2012.05.012

Naelapää, K., Boetker, J. P., Veski, P., Rantanen, J., Rades, T., & Kogermann, K. (2012). Polymorphic form of piroxicam influences the performance of amorphous material prepared by ball-milling. International Journal of Pharmaceutics, 429(1–2), 69-77. doi: 10.1016/j.ijpharm.2012.03.008

Thomas, N., Holm, R., Müllertz, A., & Rades, T. (2012). In vitro and in vivo performance of novel supersaturated self-nanoemulsifying drug delivery systems (super-SNEDDS). Journal of Controlled Release, 160(1), 25-32. doi: 10.1016/j.jconrel.2012.02.027

Bushby, S. K., Thomas, N., Priemel, P. A., Coulter, C. V., Rades, T., & Kieser, J. A. (2012). Determination of methylphenidate in Calliphorid larvae by liquid-liquid extraction and liquid chromatography mass spectrometry: Forensic entomotoxicology using an in vivo rat brain model. Journal of Pharmaceutical & Biomedical Analysis, 70, 456-461. doi: 10.1016/j.jpba.2012.06.024

Munk, T., Baldursdottir, S., Hietala, S., Rades, T., Kapp, S., Nuopponen, M., … Rantanen, J. (2012). Crystal morphology modification by the addition of tailor-made stereocontrolled poly(N-isopropyl acrylamide). Molecular Pharmaceutics, 9(7), 1932-1941. doi: 10.1021/mp200643c

Boetker, J. P., Koradia, V., Rades, T., Rantanen, J., & Savolainen, M. (2012). Atomic pairwise distribution function analysis of the amorphous phase prepared by different manufacturing routes. Pharmaceutics, 4, 93-103. doi: 10.3390/pharmaceutics4010093

Parmentier, J., Thomas, N., Müllertz, A., Fricker, G., & Rades, T. (2012). Exploring the fate of liposomes in the intestine by dynamic in vitro lipolysis. International Journal of Pharmaceutics, 437(1-2), 253-263. doi: 10.1016/j.ijpharm.2012.08.018

Rattanapak, T., Young, K., Rades, T., & Hook, S. (2012). Comparative study of liposomes, transfersomes, ethosomes and cubosomes for transcutaneous immunisation: Characterisation and in vitro skin penetration. Journal of Pharmacy & Pharmacology, 64(11), 1560-1569. doi: 10.1111/j.2042-7158.2012.01535.x

Patel, A., Gauld, R., Norris, P., & Rades, T. (2012). Quality of generic medicines in South Africa: Perceptions versus Reality: A qualitative study. BMC Health Services Research, 12, 297. doi: 10.1186/1472-6963-12-297

Kafka, A. P., Kleffmann, T., Rades, T., & McDowell, A. (2011). The application of MALDI TOF MS in biopharmaceutical research. International Journal of Pharmaceutics, 417(1-2), 70-82. doi: 10.1016/j.ijpharm.2010.12.010

Karmwar, P., Graeser, K., Gordon, K. C., Strachan, C. J., & Rades, T. (2011). Investigation of properties and recrystallisation behaviour of amorphous indomethacin samples prepared by different methods. International Journal of Pharmaceutics, 417(1-2), 94-100. doi: 10.1016/j.ijpharm.2010.12.019

Chieng, N., Rades, T., & Aaltonen, J. (2011). An overview of recent studies on the analysis of pharmaceutical polymorphs. Journal of Pharmaceutical & Biomedical Analysis, 55(4), 618-644. doi: 10.1016/j.jpba.2010.12.020

Kojarunchitt, T., Hook, S., Rizwan, S., Rades, T., & Baldursdottir, S. (2011). Development and characterisation of modified poloxamer 407 thermoresponsive depot systems containing cubosomes. International Journal of Pharmaceutics, 408(1-2), 20-26. doi: 10.1016/j.ijpharm.2011.01.037

Rizwan, S. B., Assmus, D., Boehnke, A., Hanley, T., Boyd, B. J., Rades, T., & Hook, S. (2011). Preparation of phytantriol cubosomes by solvent precursor dilution for the delivery of protein vaccines. European Journal of Pharmaceutics & Biopharmaceutics, 79(1), 15-22. doi: 10.1016/j.ejpb.2010.12.034

Zhong, S., Shen, Y.-C., Ho, L., May, R. K., Zeitler, J. A., Evans, M., … Rades, T., Gordon, K. C., … Kleinebudde, P. (2011). Non-destructive quantification of pharmaceutical tablet coatings using terahertz pulsed imaging and optical coherence tomography. Optics & Lasers in Engineering, 49(3), 361-365. doi: 10.1016/j.optlaseng.2010.11.003

Khunawattanakul, W., Puttipipatkhachorn, S., Rades, T., & Pongjanyakul, T. (2011). Novel chitosan-magnesium aluminum silicate nanocomposite film coatings for modified-release tablets. International Journal of Pharmaceutics, 407(1-2), 132-141. doi: 10.1016/j.ijpharm.2011.01.049

Kafka, A. P., McLeod, B. J., Rades, T., & McDowell, A. (2011). Release and bioactivity of PACA nanoparticles containing D-Lys6-GnRH for brushtail possum fertility control. Journal of Controlled Release, 149(3), 307-313. doi: 10.1016/j.jconrel.2010.10.029

Haaser, M., Windbergs, M., McGoverin, C. M., Kleinebudde, P., Rades, T., Gordon, K. C., & Strachan, C. J. (2011). Analysis of matrix dosage forms during dissolution testing using Raman microscopy. Journal of Pharmaceutical Sciences, 100(10), 4452-4459. doi: 10.1002/jps.22609

Boetker, J. P., Savolainen, M., Koradia, V., Tian, F., Rades, T., Müllertz, A., … Østergaard, J. (2011). Insights into the early dissolution events of amlodipine using UV imaging and Raman spectroscopy. Molecular Pharmaceutics, 8(4), 1372-1380. doi: 10.1021/mp200205z

Karmwar, P., Boetker, J. P., Graeser, K. A., Strachan, C. J., Rantanen, J., & Rades, T. (2011). Investigations on the effect of different cooling rates on the stability of amorphous indomethacin. European Journal of Pharmaceutical Sciences, 44, 341-350. doi: 10.1016/j.ejps.2011.08.010

Bøtker, J. P., Karmwar, P., Strachan, C. J., Cornett, C., Tian, F., Zujovic, Z., … Rades, T. (2011). Assessment of crystalline disorder in cryo-milled samples of indomethacin using atomic pair-wise distribution functions. International Journal of Pharmaceutics, 417(1-2), 112-119. doi: 10.1016/j.ijpharm.2010.12.018

Löbmann, K., Laitinen, R., Grohganz, H., Gordon, K. C., Strachan, C., & Rades, T. (2011). Coamorphous drug systems: Enhanced physical stability and dissolution rate of indomethacin and naproxen. Molecular Pharmaceutics, 8(5), 1919-1928. doi: 10.1021/mp2002973

Wu, J. X., Yang, M., van den Berg, F., Pajander, J., Rades, T., & Rantanen, J. (2011). Influence of solvent evaporation rate and formulation factors on solid dispersion physical stability. European Journal of Pharmaceutical Sciences, 44(5), 610-620. doi: 10.1016/j.ejps.2011.10.008

Rehder, S., Klukkert, M., Löbmann, K. A. M., Strachan, C. J., Sakmann, A., Gordon, K., Rades, T., & Leopold, C. S. (2011). Investigation of the formation process of two piracetam cocrystals during grinding. Pharmaceutics, 3(4), 706-722. doi: 10.3390/pharmaceutics3040706

Zimper, U., Aaltonen, J., McGoverin, C. M., Gordon, K. C., Krauel-Goellner, K., & Rades, T. (2010). Quantification of process induced disorder in milled samples using different analytical techniques. Pharmaceutics, 2(1), 30-49. doi: 10.3390/pharmaceutics2010030

Graeser, K. A., Patterson, J. E., Zeitler, J. A., & Rades, T. (2010). The role of configurational entropy in amorphous systems. Pharmaceutics, 2(2), 224-244. doi: 10.3390/pharmaceutics2020224

Gordon, S., Teichmann, E., Young, K., Finnie, K., Rades, T., & Hook, S. (2010). In vitro and in vivo investigation of thermosensitive chitosan hydrogels containing silica nanoparticles for vaccine delivery. European Journal of Pharmaceutical Sciences, 41(2), 360-368. doi: 10.1016/j.ejps.2010.07.004

Glaessl, B., Siepmann, F., Tucker, I., Rades, T., & Siepmann, J. (2010). Deeper insight into the drug release mechanisms in Eudragit RL-based delivery systems. International Journal of Pharmaceutics, 389, 139-146. doi: 10.1016/j.ijpharm.2010.01.031

Simovic, S., Hui, H., Song, Y., Davey, A. K., Rades, T., & Prestidge, C. A. (2010). An oral delivery system for indomethicin engineered from cationic lipid emulsions and silica nanoparticles. Journal of Controlled Release, 143, 367-373. doi: 10.1016/j.jconrel.2010.01.008

Ho, L., Müller, R., Krüger, C., Gordon, K. C., Kleinebudde, P., Pepper, M., Rades, T., … Zeitler, J. A. (2010). Investigating dissolution performance critical areas on coated tablets: A case study using terahertz pulsed imaging. Journal of Pharmaceutical Sciences, 99(1), 392-402. doi: 10.1002/jps.21845

Patel, A., Gauld, R., Norris, P., & Rades, T. (2010). ″This body does not want free medicines″: South African consumer perceptions of drug quality. Health Policy & Planning, 25(1), 61-69. doi: 10.1093/heapol/czp039

Kafka, A. P., Kleffmann, T., Rades, T., & McDowell, A. (2010). Characterization of peptide polymer interactions in poly(alkylcyanoacrylate) nanoparticles: A mass spectrometric approach. Current Drug Delivery, 7(3), 208-215.

Kafka, A. P., Rades, T., & McDowell, A. (2010). Rapid and specific high-performance liquid chromatography for the in vitro quantification of D-Lys6-GnRH in a microemulsion-type formulation in the presence of peptide oxidation products. Biomedical Chromatography, 24(2), 132-139. doi: 10.1002/bmc.1261

Chatterjee, L., Rades, T., & Tucker, I. G. (2010). Mechanical properties of excipients do not affect polymer matrix formation. International Journal of Pharmaceutics, 384(1/2), 87-92. doi: 10.1016/j.ijpharm.2009.09.047

Glaessl, B., Siepmann, F., Tucker, I., Rades, T., & Siepmann, J. (2010). Mathematical modeling of drug release from Eudragit RS-based delivery systems. Journal of Drug Delivery Science & Technology, 20(2), 127-133.

Khunawattanakul, W., Puttipipatkhachorn, S., Rades, T., & Pongjanyakul, T. (2010). Chitosan-magnesium aluminum silicate nanocomposite films: Physicochemical characterization and drug permeability. International Journal of Pharmaceutics, 393, 219-229. doi: 10.1016/j.ijpharm.2010.04.007

Rizwan, S. B., Boyd, B. J., Rades, T., & Hook, S. (2010). Bicontinuous cubic liquid crystals as sustained delivery systems for peptides and proteins. Expert Opinion on Drug Delivery, 7(10), 1133-1144. doi: 10.1517/17425247.2010.515584

Tan, A., Simovic, S., Davey, A. K., Rades, T., Boyd, B. J., & Prestidge, C. A. (2010). Silica nanoparticles to control the lipase-mediated digestion of lipid-based oral delivery systems. Molecular Pharmaceutics, 7(2), 522-532. doi: 10.1021/mp9002442

Zimper, U., Aaltonen, J., Krauel-Goellner, K., Gordon, K. C., Strachan, C. J., & Rades, T. (2010). The influence of milling on the dissolution performance of simvastatin. Pharmaceutics, 2(4), 419-431. doi: 10.3390/pharmaceutics2040419

Müllertz, A., Ogbonna, A., Ren, S., & Rades, T. (2010). New perspectives on lipid and surfactant based drug delivery systems for oral delivery of poorly soluble drugs. Journal of Pharmacy & Pharmacology, 62(11), 1622-1636. doi: 10.1111/j.2042-7158.2010.01107.x

Sassene, P. J., Knopp, M. M., Hesselkilde, J. Z., Koradia, V., Rades, T., & Müllertz, A. (2010). Precipitation of a poorly soluble model drug during in vitro lipolysis: Characterization and dissolution of the precipitate. Journal of Pharmaceutical Sciences, 99(12), 4982-4991. doi: 10.1002/jps.22226

McDowell, A., McLeod, B. J., Rades, T., & Tucker, I. G. (2009). Polymeric nanoparticles as an oral delivery system for biocontrol agents for the brushtail possum (Trichosurus vulpecula). New Zealand Veterinary Journal, 57(6), 370-377.

Graeser, K. A., Patterson, J. E., & Rades, T. (2009). Applying thermodynamic and kinetic parameters to predict the physical stability of two differently prepared amorphous forms of simvastatin. Current Drug Delivery, 6(4), 374-382. doi: 10.2174/156720109789000492

Ho, L., Müller, R., Gordon, K. C., Kleinebudde, P., Pepper, M., Rades, T., … Zeitler, J. A. (2009). Terahertz pulsed imaging as an analytical tool for sustained-release tablet film coating. European Journal of Pharmaceutics & Biopharmaceutics, 71(1), 117-123. doi: 10.1016/j.ejpb.2008.06.023

Graf, A., Rades, T., & Hook, S. M. (2009). Oral insulin delivery using nanoparticles based on microemulsions with different structure-types: Optimisation and in vivo evaluation. European Journal of Pharmaceutical Sciences, 37(1), 53-61. doi: 10.1016/j.ejps.2008.12.017

Tantipolphan, R., Rades, T., & Medlicott, N. J. (2009). Swelling lecithin: Cholesterol implants for the controlled release of proteins. Journal of Liposome Research, 19(1), 37-48. doi: 10.1080/08982100802636434

Tan, A., Simovic, S., Davey, A. K., Rades, T., & Prestidge, C. A. (2009). Silica-lipid hybrid (SLH) microcapsules: A novel oral delivery system for poorly soluble drugs. Journal of Controlled Release, 134(1), 62-70. doi: 10.1016/j.jconrel.2008.10.014

Songkro, S., Rades, T., & Becket, G. (2009). Effects of some terpenes on the in vitro permeation of LHRH through newborn pig skin. Pharmazie, 64(2), 110-115. doi: 10.1691/ph.2009.8243

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