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Pharmacy staff profile

Dr Hu Zhang

PositionSenior Research Fellow
QualificationsMD(Anhui), PhD(Otago)
Research summaryPharmaceutical sciences

Research

My research areas have been the following inter-related areas: biopharmaceutical analysis, pharmacokinetics, drug metabolism, toxicity, drug discovery and development. My research interests are preclinical study of bioactives, especially anti-aging agents in various animal models and the extrapolation of these results to humans, uptake of drugs into the brain, and the transport and metabolism of xenobiotics.

I have an interest in disease biomarker identification and their potential use in drug discovery and development. Since 2005, I have been collaborating with Dr. Ping Liu (Department of Anatomy & Structural Biology) on the contribution of the arginine metabolic pathway to age-associated cognitive decline. We are currently funded by the New Zealand Neurological Foundation and Health Research Council of New Zealand. Knowledge gained from these work will contribute significantly to our basic understanding of the neurobiology of brain ageing and may lead to discovery of a LC/MS based metabolomic biomarker and the development of agmatine-based therapeutics for cognitive decline during ageing and in Alzheimer's disease.

Publications

Liu, P., Gupta, N., Jing, Y., Collie, N. D., Zhang, H., & Smith, P. F. (2017). Further studies of the effects of aging on arginine metabolites in the rat vestibular nucleus and cerebellum. Neuroscience. Advance online publication. doi: 10.1016/j.neuroscience.2017.02.033

Zhang, J., Jing, Y., Zhang, H., Bilkey, D. K., & Liu, P. (2017). Maternal immune activation leads to increased nNOS immunoreactivity in the brain of postnatal day 2 rat offspring. Synapse. Advance online publication. doi: 10.1002/syn.22011

Knox, L. T., Jing, Y., Bawazier-Edgecombe, J., Collie, N. D., Zhang, H., & Liu, P. (2017). Effects of withdrawal from repeated phencyclidine administration on behavioural function and brain arginine metabolism in rats. Pharmacology Biochemistry & Behavior, 153, 45-59. doi: 10.1016/j.pbb.2016.12.006

Zhang, J., Jing, Y., Zhang, H., Bilkey, D. K., & Liu, P. (2017). Effects of maternal immune activation on brain arginine metabolism of postnatal day 2 rat offspring. Schizophrenia Research. Advance online publication. doi: 10.1016/j.schres.2017.05.016

Liu, P., Jing, Y., Collie, N. D., Dean, B., Bilkey, D. K., & Zhang, H. (2016). Altered brain arginine metabolism in schizophrenia. Translational Psychiatry, 6, e871. doi: 10.1038/tp.2016.144

Journal - Research Article

Liu, P., Gupta, N., Jing, Y., Collie, N. D., Zhang, H., & Smith, P. F. (2017). Further studies of the effects of aging on arginine metabolites in the rat vestibular nucleus and cerebellum. Neuroscience. Advance online publication. doi: 10.1016/j.neuroscience.2017.02.033

Zhang, J., Jing, Y., Zhang, H., Bilkey, D. K., & Liu, P. (2017). Effects of maternal immune activation on brain arginine metabolism of postnatal day 2 rat offspring. Schizophrenia Research. Advance online publication. doi: 10.1016/j.schres.2017.05.016

Knox, L. T., Jing, Y., Bawazier-Edgecombe, J., Collie, N. D., Zhang, H., & Liu, P. (2017). Effects of withdrawal from repeated phencyclidine administration on behavioural function and brain arginine metabolism in rats. Pharmacology Biochemistry & Behavior, 153, 45-59. doi: 10.1016/j.pbb.2016.12.006

Zhang, J., Jing, Y., Zhang, H., Bilkey, D. K., & Liu, P. (2017). Maternal immune activation leads to increased nNOS immunoreactivity in the brain of postnatal day 2 rat offspring. Synapse. Advance online publication. doi: 10.1002/syn.22011

Liu, P., Jing, Y., Collie, N. D., Dean, B., Bilkey, D. K., & Zhang, H. (2016). Altered brain arginine metabolism in schizophrenia. Translational Psychiatry, 6, e871. doi: 10.1038/tp.2016.144

Bergin, D. H., Jing, Y., Zhang, H., & Liu, P. (2015). A single intracerebroventricular Aβ25-35 infusion leads to prolonged alterations in arginine metabolism in the rat hippocampus and prefrontal cortex. Neuroscience, 298, 367-379. doi: 10.1016/j.neuroscience.2015.04.034

Knox, L. T., Jing, Y., Collie, N. D., Zhang, H., & Liu, P. (2014). Effects of acute phencyclidine administration on arginine metabolism in the hippocampus and prefrontal cortex in rats. Neuropharmacology, 81, 195-205. doi: 10.1016/j.neuropharm.2014.02.004

Liu, P., Fleete, M. S., Jing, Y., Collie, N. D., Curtis, M. A., Waldvogel, H. J., … Abraham, W. C., & Zhang, H. (2014). Altered arginine metabolism in Alzheimer’s disease brains. Neurobiology of Aging, 35(9), 1992-2003. doi: 10.1016/j.neurobiolaging.2014.03.013

Rushaidhi, M., Zhang, H., & Liu, P. (2013). Effects of prolonged agmatine treatment in aged male Sprague-Dawley rats. Neuroscience, 234, 116-124. doi: 10.1016/j.neuroscience.2013.01.004

Yang, L., Fawcett, J. P., Zhang, H., & Tucker, I. G. (2013). Effect of 12-oxochenodeoxycholate on the pharmacokinetics and pharmacodynamics of morphine 6-glucuronide in Wistar rats. Journal of Pharmacy & Pharmacology, 65(4), 561-566. doi: 10.1111/jphp.12020

Jing, Y., Fleete, M. S., Collie, N. D., Zhang, H., & Liu, P. (2013). Regional variations and age-related changes in arginine metabolism in the rat brain stem and spinal cord. Neuroscience, 252, 98-108. doi: 10.1016/j.neuroscience.2013.08.002

Rushaidhi, M., Jing, Y., Zhang, H., & Liu, P. (2013). Participation of hippocampal agmatine in spatial learning: An in vivo microdialysis study. Neuropharmacology, 65, 200-205. doi: 10.1016/j.neuropharm.2012.10.007

Jing, Y., Zhang, H., Wolff, A. R., Bilkey, D. K., & Liu, P. (2013). Altered arginine metabolism in the hippocampus and prefrontal cortex of maternal immune activation rat offspring. Schizophrenia Research, 148(1-3), 151-156. doi: 10.1016/j.schres.2013.06.001

Nayak, P. K., Zhang, H., & Kerr, D. S. (2013). Determination of 1-(4’-aminophenyl)-4-methyl-7,8-methylene-dioxy-2,3-benzodiazepine by high-performance liquid chromatography—diode array detection in plasma and brain in healthy and hypoxic–ischaemic rats. Neuroscience, 232, 139-150. doi: 10.1016/j.neuroscience.2012.12.001

Yang, L., Fawcett, J. P., Østergaard, J., Zhang, H., & Tucker, I. G. (2012). Mechanistic studies of the effect of bile salts on rhodamine 123 uptake into RBE4 cells. Molecular Pharmaceutics, 9(1), 29-36. doi: 10.1021/mp200201y

Gupta, N., Jing, Y., Collie, N. D., Zhang, H., & Liu, P. (2012). Ageing alters behavioural function and brain arginine metabolism in male Sprague-Dawley rats. Neuroscience, 226, 178-196. doi: 10.1016/j.neuroscience.2012.09.013

Rushaidhi, M., Jing, Y., Kennard, J. T., Collie, N. D., Williams, J. M., Zhang, H., & Liu, P. (2012). Aging affects L-arginine and its metabolites in memory-associated brain structures at the tissue and synaptoneurosome levels. Neuroscience, 209, 21-31. doi: 10.1016/j.neuroscience.2012.02.021

Lee, H. J., Zhang, H., Orlovich, D. A., & Fawcett, J. P. (2012). The influence of probiotic treatment on sulfasalazine metabolism in rat. Xenobiotica, 42(8), 791-797. doi: 10.3109/00498254.2012.660508

Rushaidhi, M., Collie, N. D., Zhang, H., & Liu, P. (2012). Agmatine selectively improves behavioural function in aged male Sprague-Dawley rats. Neuroscience, 218(30), 206-215. doi: 10.1016/j.neuroscience.2012.05.015

Chen, G., Yang, L., Zhang, H., Tucker, I. G., & Fawcett, J. P. (2012). Effect of ketocholate derivatives on methotrexate uptake in Caco-2 cell monolayers. International Journal of Pharmaceutics, 433, 89-93. doi: 10.1016/j.ijpharm.2012.04.077

Gupta, N., Zhang, H., & Liu, P. (2012). Chronic difluoromethylornithine treatment impairs spatial learning and memory in rats. Pharmacology Biochemistry & Behavior, 100(3), 464-473. doi: 10.1016/j.pbb.2011.10.011

Knox, L. T., Jing, Y., Fleete, M. S., Collie, N. D., Zhang, H., & Liu, P. (2011). Scopolamine impairs behavioural function and arginine metabolism in the rat dentate gyrus. Neuropharmacology, 61(8), 1452-1462. doi: 10.1016/j.neuropharm.2011.08.042

Yang, L., Zhang, H., Fawcett, J. P., Mikov, M., & Tucker, I. G. (2011). Effect of bile salts on the transport of morphine-6-glucuronide in rat brain endothelial cells. Journal of Pharmaceutical Sciences, 100(4), 1516-1524. doi: 10.1002/jps.22390

Liu, P., Jing, Y., Collie, N. D., Campbell, S. A., & Zhang, H. (2011). Pre-aggregated Aβ25-35 alters arginine metabolism in the rat hippocampus and prefrontal cortex. Neuroscience, 193, 269-282. doi: 10.1016/j.neuroscience.2011.07.054

Li, Y., Zhang, H., Fawcett, J. P., & Tucker, I. G. (2010). Effect of cyclosporin A on the pharmacokinetics of mitoquinone (MitoQ10), a mitochondria-targeted antioxidant, in rat. Asian Journal of Pharmaceutical Sciences, 5(3), 106-113.

Liu, P., Zhang, H., Devaraj, R., Ganesalingam, G., & Smith, P. F. (2010). A multivariate analysis of the effects of aging on glutamate, GABA and arginine metabolites in the rat vestibular nucleus. Hearing Research, 269(1-2), 122-133. doi: 10.1016/j.heares.2010.06.019

Liu, P., Jing, Y., Collie, N. D., Chary, S., & Zhang, H. (2009). Memory-related changes in L-citrulline and agmatine in the rat brain. Hippocampus, 19(7), 597-602. doi: 10.1002/hipo.20561

Yang, L., Zhang, H., Mikov, M., & Tucker, I. G. (2009). Physicochemical and biological characterization of monoketocholic acid, a novel permeability enhancer. Molecular Pharmaceutics, 6(2), 448-456. doi: 10.1021/mp800143w

Gupta, N., Zhang, H., & Liu, P. (2009). Behavioral and neurochemical effects of acute putrescine depletion by difluoromethylornithine in rats. Neuroscience, 161(3), 691-706. doi: 10.1016/j.nueroscience.2009.03.075

Liu, P., Jing, Y., & Zhang, H. (2009). Age-related changes in arginine and its metabolites in memory-associated brain structures. Neuroscience, 164(2), 611-628. doi: 10.1016/j.neuroscience.2009.08.029

Liu, P., Gupta, N., Jing, Y., & Zhang, H. (2008). Age-related changes in polyamines in memory-associated brain structures in rats. Neuroscience, 155, 789-796. doi: 10.1016/j.neuroscience.2008.06.033

Liu, P., Chary, S., Devaraj, R., Jing, Y., Darlington, C. L., Smith, P. F., Tucker, I. G., & Zhang, H. (2008). Effects of aging on agmatine levels in memory-associated brain structures. Hippocampus, 18, 853-856. doi: 10.1002/hipo.20448

Liu, P., Collie, N. D., Chary, S., Jing, Y., & Zhang, H. (2008). Spatial learning results in elevated agmatine levels in the rat brain. Hippocampus, 18, 1094-1098. doi: 10.1002/hipo.20482

Li, Y., Fawcett, J. P., Zhang, H., & Tucker, I. G. (2008). Transport and metabolism of some cationic ubiquinone antioxidants (MitoQn) in Caco-2 cell monolayers. European Journal of Drug Metabolism & Pharmacokinetics, 33(4), 199-204.

Liu, P., Rushaidhi, M., Collie, N. D., Leong, M.-T. T., & Zhang, H. (2008). Behavioral effects of intracerebroventricular microinfusion of agmatine in adult rats. Behavioral Neuroscience, 122(3), 557-569. doi: 10.1037/0735-7044.122.3.557

Li, Y., Fawcett, J. P., Zhang, H., & Tucker, I. G. (2007). Transport and metabolism of MitoQ10, a mitochondria-targeted antioxidant, in Caco-2 cell monolayers. Journal of Pharmacy & Pharmacology, 59, 503-511.

Li, Y., Zhang, H., Fawcett, J. P., & Tucker, I. G. (2007). Quantitation and metabolism of mitoquinone, a mitochondria-targeted antioxidant, in rat by liquid chromatography/tandem mass spectrometry. Rapid Communications in Mass Spectrometry, 21, 1958-1964.

McLeod, B. J., Zhang, H., Huang, L., Thompson, E. G., Butt, A. G., & Tucker, I. G. (2005). An in situ single-pass perfusion model for assessing absorption across the intestinal mucosa of the brushtail possum. New Zealand Veterinary Journal, 53(4), 234-241.

Pukrittayakamee, S., Pitisuttithum, P., Zhang, H., Jantra, A., Wanwimolruk, S., & White, N. J. (2002). Effects of cigarette smoking on quinine pharmacokinetics in malaria. European Journal of Clinical Pharmacology, 58, 315-319.

Zhang, H., Wanwimolruk, S., Coville, P., Schofield, J. C., Williams, G., Haines, S. R., & Suttie, J. M. (2000). Toxicological evaluation of New Zealand deer velvet powder. Part 1: Acute and subchronic oral toxicity studies in rats. Food & Chemical Toxicology, 38, 985-990.

Zhang, H., Wong, P., Coville, P., & Wanwimolruk, S. (2000). Effect of the grapefruit flavonoid naringin on pharmacokinetics of quinine in rats. Drug Metabolism & Drug Interactions, 17(1-4), 351-363.

Wanwimolruk, S., Zhang, H., Coville, P., Saville, D. J., & Davis, L. S. (1999). In vitro hepatic metabolism of a CYP3A-mediated drug, quinine, in Adélie penguins. Comparative Biochemistry & Physiology Part C, 124(3), 301-307.

Zhang, H., Ramsay, N., Coville, P., & Wanwimolruk, S. (1999). Effects of erythromycin, rifampicin and isoniazid on the pharmacokinetics of quinine in rats. Pharmacy & Pharmacology Communications, 5, 467-472.

Zhang, H., Coville, P., Walker, R. J., Miners, J. O., Birkett, D. J., & Wanwimolruk, S. (1997). Evidence for involvement of human CYP3A in the 3-hydroxylation of quinine. British Journal of Clinical Pharmacology, 43(3), 245-252.

Wanwimolruk, S., Wong, S. M., Zhang, H., & Coville, P. (1996). Simultaneous determination of quinine and a major metabolite 3-hydroxyquinine in biological fluids by HPLC without extraction. Journal of Liquid Chromatography & Related Technologies, 19, 293-305.

Wanwimolruk, S., Wong, S. M., Zhang, H., Coville, P., & Walker, R. J. (1995). Metabolism of quinine in man: identification fo a major metabolite, and effects of smoking and rifampicin pretreatment. Journal of Pharmacy & Pharmacology, 47, 957-963.

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