Professor Joel Tyndall
Contact Details
- Phone
- 64 3 479 7293
- joel.tyndall@otago.ac.nz
University Links
- Position
- Professor and Associate Dean (Internationalisation)
- Qualifications
- BSc(Hons)(Monash) PhD(Qld)
- Research summary
- Drug design and discovery
- Teaching
- Medicinal Chemistry
Research
Drug design and discovery using computational techniques. Drug discovery in the areas of inflammatory disorders, cancer, antifungals, bacterial infections (chlamydia, tuberculosis), and viral infections targeting both enzymes and GPCRs. Techniques include virtual screening, structural biology, enzymatic, and cellular assays.
Publications
Adolph, C., Cheung, C.-Y., McNeil, M. B., Jowsey, W. J., Williams, Z. C., Hards, K., Harold, L. K., … Tyndall, J. D. A., … Cook, G. M. (2023). A dual-targeting succinate dehydrogenase and F1Fo-ATP synthase inhibitor rapidly sterilizes replicating and non-replicating Mycobacterium tuberculosis. Cell Chemical Biology. Advance online publication. doi: 10.1016/j.chembiol.2023.12.002 Journal - Research Article
Payne, C., Awalt, J. K., May, L. T., Tyndall, J. D. A., Jörg, M., & Vernall, A. J. (2023). Bifunctional tools to study adenosine receptors. In V. Colotta & C. T. Supuran (Eds.), Purinergic receptors and their modulators. (pp. 179-221). Cham, Switzerland: Springer. doi: 10.1007/7355_2022_154 Chapter in Book - Research
Tyndall, J. (2023, September). Targeting HtrA protease: Systematic modification to potential new antibacterial leads. Department of Microbiology and Immunology Seminar, University of Otago, Dunedin, New Zealand. [Department Seminar]. Other Research Output
Tyndall, J. (2023, July). Looking at molecules and what they do in disease. University of Otago, Dunedin, New Zealand. [Inaugural Professorial Lecture]. Other Research Output
Yin, J., Sharma, R., Tyndall, J. D. A., Grimsey, N. L., & Vernall, A. J. (2023). Synthesis and characterization of a cannabinoid type 2 receptor photoactivated prodrug. ChemPhotoChem, 7, e202200291. doi: 10.1002/cptc.202200291 Journal - Research Article
2023
Chapter in Book - Research
Payne, C., Awalt, J. K., May, L. T., Tyndall, J. D. A., Jörg, M., & Vernall, A. J. (2023). Bifunctional tools to study adenosine receptors. In V. Colotta & C. T. Supuran (Eds.), Purinergic receptors and their modulators. (pp. 179-221). Cham, Switzerland: Springer. doi: 10.1007/7355_2022_154
Journal - Research Article
Adolph, C., Cheung, C.-Y., McNeil, M. B., Jowsey, W. J., Williams, Z. C., Hards, K., Harold, L. K., … Tyndall, J. D. A., … Cook, G. M. (2023). A dual-targeting succinate dehydrogenase and F1Fo-ATP synthase inhibitor rapidly sterilizes replicating and non-replicating Mycobacterium tuberculosis. Cell Chemical Biology. Advance online publication. doi: 10.1016/j.chembiol.2023.12.002
Yin, J., Sharma, R., Tyndall, J. D. A., Grimsey, N. L., & Vernall, A. J. (2023). Synthesis and characterization of a cannabinoid type 2 receptor photoactivated prodrug. ChemPhotoChem, 7, e202200291. doi: 10.1002/cptc.202200291
Other Research Output
Tyndall, J. (2023, September). Targeting HtrA protease: Systematic modification to potential new antibacterial leads. Department of Microbiology and Immunology Seminar, University of Otago, Dunedin, New Zealand. [Department Seminar].
Tyndall, J. (2023, July). Looking at molecules and what they do in disease. University of Otago, Dunedin, New Zealand. [Inaugural Professorial Lecture].
2022
Journal - Research Article
Lawer, A., Tyler, C., Hards, K., Keighley, L. M., Cheung, C.-Y., Kierek, F., Su, S., … McInnes, T., Tyndall, J. D. A., Krause, K. L., Cook, G. M., & Gamble, A. B. (2022). Synthesis and biological evaluation of aurachin D analogues as inhibitors of Mycobacterium tuberculosis cytochrome bd oxidase. ACS Medicinal Chemistry Letters, 13, 1663-1669. doi: 10.1021/acsmedchemlett.2c00401
Hards, K., Cheung, C.-Y., Waller, N., Adolph, C., Keighley, L., Tee, Z. S., Harold, L. K., Menorca, A., … Tyndall, J. D. A., McNeil, M. B., … Opel-Reading, H. K., Krause, K. L., … Berney, M., … Cook, G. M. (2022). An amiloride derivative is active against the F1Fo-ATP synthase and cytochrome bd oxidase of Mycobacterium tuberculosis. Communications Biology, 5, 166. doi: 10.1038/s42003-022-03110-8
Hwang, J., Mros, S., Gamble, A. B., Tyndall, J. D. A., & McDowell, A. (2022). Improving antibacterial activity of a HtrA protease inhibitor JO146 against Helicobacter pylori: A novel approach using microfluidics-engineered PLGA nanoparticles. Pharmaceutics, 14(2), 348. doi: 10.3390/pharmaceutics14020348
McNeil, N. M. R., Gates, E. W. J., Firoozi, N., Cundy, N. J., Leccese, J., Eisinga, S., Tyndall, J. D. A., … Keillor, J. W. (2022). Structure-activity relationships of N-terminal variants of peptidomimetic tissue transglutaminase inhibitors. European Journal of Medicinal Chemistry, 232, 114172. doi: 10.1016/j.ejmech.2022.114172
Ruma, Y. N., Keniya, M. V., Tyndall, J. D. A., & Monk, B. C. (2022). Characterisation of Candida parapsilosis CYP51 as a drug target using Saccharomyces cerevisiae as host. Journal of Fungi, 8(1), 69. doi: 10.3390/jof8010069
Hwang, J., Strange, N., Mazraani, R., Phillips, M. J., Gamble, A. B., Huston, W. M., & Tyndall, J. D. A. (2022). Design, synthesis and biological evaluation of P2-modified proline analogues targeting the HtrA serine protease in Chlamydia. European Journal of Medicinal Chemistry. doi: 10.1016/j.ejmech.2021.114064
Journal - Research Other
Tyndall, J. D. A. (2022). S-217622, a 3CL protease inhibitor and clinical candidate for SARS-CoV-2. Journal of Medicinal Chemistry, 65, 6496-6498. doi: 10.1021/acs.jmedchem.2c00624
Liddle, I., Glass, M., Tyndall, J. D. A., & Vernall, A. J. (2022). Covalent cannabinoid receptor ligands: Structural insight and selectivity challenges. RSC Medicinal Chemistry, 13, 497-510. doi: 10.1039/D2MD00006G
Conference Contribution - Published proceedings: Abstract
Liddle, I., Glass, M., Tyndall, J. D. A., & Vernall, A. J. (2022). Covalent chromenopyrazole chemical tools for the cannabinoid type 2 receptor. In L. Wilson, H. Harcombe, P. Jayakaran, L. Burga, J. Antony, K. Morgaine, M. Garelja, A. Middleton, M. Anwar & T. Milne (Eds.), Proceedings of the 263rd Otago Medical School Research Society (OMSRS) Meeting: PhD Student Speaker Awards. Dunedin, New Zealand: OMSRS. Retrieved from https://ourarchive.otago.ac.nz/handle/10523/12839
Conference Contribution - Verbal presentation and other Conference outputs
Rana, Z., Tyndall, J. D. A., Diermeier, S., Hanif, M., & Rosengren, R. J. (2022, August). Cytostatic role of safe novel HDAC inhibitors in AR- prostate cancer. Verbal presentation at the Cancer Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.
2021
Journal - Research Article
Graham, D. O., Wilson, R. K., Ruma, Y. N., Keniya, M. V., Tyndall, J. D. A., & Monk, B. C. (2021). Structural insights into the azole resistance of the Candida albicans Darlington strain using Saccharomyces cerevisiae lanosterol 14α-demethylase as a surrogate. Journal of Fungi, 7, 897. doi: 10.3390/jof7110897
McDougall, L., Kueh, J. T. B., Ward, J., Tyndall, J. D. A., Woolley, A. G., Mehta, S., Stayner, C., Larsen, D. S., & Eccles, M. R. (2021). Chemical synthesis of the PAX protein inhibitor EG1 and its ability to slow the growth of human colorectal carcinoma cells. Frontiers in Oncology, 11, 709540. doi: 10.3389/fonc.2021.709540
Hwang, J., Strange, N., Phillips, M. J. A., Krause, A. L., Heywood, A., Gamble, A. B., … Tyndall, J. D. A. (2021). Optimization of peptide-based inhibitors targeting the HtrA serine protease in Chlamydia: Design, synthesis and biological evaluation of pyridone-based and N-Capping group-modified analogues. European Journal of Medicinal Chemistry, 224(113692). doi: 10.1016/j.ejmech.2021.113692
Trinh, P. N. H., Chong, D. J. W., Leach, K., Hill, S. J., Tyndall, J. D. A., May, L. T., Vernall, A. J., & Gregory, K. J. (2021). Development of covalent, clickable probes for adenosine A1 and A3 receptors. Journal of Medicinal Chemistry, 64, 8161-8178. doi: 10.1021/acs.jmedchem.0c02169
Murugayah, S. A., Evans, G. B., Tyndall, J. D. A., & Gerth, M. L. (2021). A single point mutation converts a glutaryl-7-aminocephalosporanic acid acylase into an N-acyl-homoserine lactone acylase. Biotechnology Letters, 43, 1467-1473. doi: 10.1007/s10529-021-03135-9
Wen, Y., Cai, W., Yang, J., Fu, X., Putha, L., Xia, Q., … Tyndall, J. D. A., … Huang, W. (2021). Targeting macrophage migration inhibitory factor in acute pancreatitis and pancreatic cancer. Frontiers in Pharmacology, 12, 638950. doi: 10.3389/fphar.2021.638950
Liang, G., Yang, J., Liu, T., Wang, S., Wen, Y., Han, C., … Tyndall, J. D. A., … Xia, Q. (2021). A multi-strategy platform for quality control and Q-markers screen of Chaiqin chengqi decoction. Phytomedicine, 85, 153525. doi: 10.1016/j.phymed.2021.153525
Rana, Z., Tyndall, J. D. A., Hanif, M., Hartinger, C. G., & Rosengren, R. J. (2021). Cytostatic action of novel histone deacetylase inhibitors in androgen receptor-null prostate cancer cells. Pharmaceuticals, 14, 103. doi: 10.3390/ph14020103
Singh, S., Liddle, I., Macdonald, C., Tyndall, J. D. A., Glass, M., & Vernall, A. (2021). Development of chromenopyrazole-based selective cannabinoid 2 receptor agonists. Australian Journal of Chemistry, 74, 433-442. doi: 10.1071/CH20263
Journal - Research Other
Edupuganti, V. V. S. R., Tyndall, J. D. A., & Gamble, A. B. (2021). Self-immolative linkers in prodrugs and antibody drug conjugates in cancer treatment. Recent Patents on Anti-Cancer Drug Discovery, 16(4), 479-497. doi: 10.2174/1574892816666210509001139
2020
Journal - Research Article
Handley, T. N. G., Tan, H.-X., Rutledge, M. T., Brewitz, H. H., Tyndall, J. D. A., Kleffmann, T., Butler, M. I., Poulter, R. T. M., & Wilbanks, S. M. (2020). Engineered biosynthesis of cyclotides. New Zealand Journal of Botany, 58(4), 358-377. doi: 10.1080/0028825X.2020.1791914
Schneider, M., Hannaway, R. F., Lamichhane, R., de la Harpe, S. M., Tyndall, J. D. A., Vernall, A. J., Kettle, A. J., & Ussher, J. E. (2020). Neutrophils suppress mucosal-associated invariant T cells in humans. European Journal of Immunology, 50, 643-655. doi: 10.1002/eji.201948394
Lamichhane, R., Galvin, H., Hannaway, R. F., de la Harpe, S. M., Munro, F., Tyndall, J. D. A., Vernall, A. J., McCall, J. L., Husain, M., & Ussher, J. E. (2020). Type I interferons are important co-stimulatory signals during T cell receptor mediated human MAIT cell activation. European Journal of Immunology, 50, 178-191. doi: 10.1002/eji.201948279
2019
Journal - Research Article
Lamichhane, R., Schneider, M., de la Harpe, S. M., Harrop, T. W. R., Hannaway, R. F., Dearden, P. K., Kirman, J. R., Tyndall, J. D. A., Vernall, A. J., & Ussher, J. E. (2019). TCR- or cytokine-activated CD8+ mucosal-associated invariant T cells are rapid polyfunctional effectors that can coordinate immune responses. Cell Reports, 28(12), 3061-3076.e5. doi: 10.1016/j.celrep.2019.08.054
Agbowuro, A. A., Hwang, J., Peel, E., Mazraani, R., Springwald, A., Marsh, J. W., … Gamble, A. B., … Tyndall, J. D. A. (2019). Structure-activity analysis of peptidic Chlamydia HtrA inhibitors. Bioorganic & Medicinal Chemistry, 27, 4185-4199. doi: 10.1016/j.bmc.2019.07.049
Monk, B. C., Keniya, M. V., Sabherwal, M., Wilson, R. K., Graham, D. O., Hassan, H. F., Chen, D., & Tyndall, J. D. A. (2019). Azole resistance reduces susceptibility to the tetrazole antifungal VT-1161. Antimicrobial Agents & Chemotherapy, 63(1), e02114-18. doi: 10.1128/AAC.02114-18
Conference Contribution - Published proceedings: Abstract
Hosseini, P., Keniya, M. V., Tyndall, J. D. A., & Monk, B. C. (2019). Functional expression of Aspergillus fumigatus CYP51 isoforms in Saccharomyces cerevisiae. Proceedings of the New Zealand Microbiological Society (NZMS) Annual Conference. 666. Retrieved from https://www.nzmscoference.org.nz
Monk, B. C., Lackner, M., Tyndall, J. D. A., & Keniya, M. V. (2019). Amino acid substitutions in lanosterol 14α-demethylase responsible for intrinsic azole resistance in mucormycetes. Proceedings of the New Zealand Microbiological Society (NZMS) Annual Conference. 571. Retrieved from https://www.nzmscoference.org.nz
Ruma, Y. N., Keniya, M. V., Tyndall, J. D. A., & Monk, B. C. (2019). Characterization of Cryptococcus neoformans lanosterol 14α-demethylase. New Zealand Dental Journal, 115, (pp. 167). [Abstract]
Conference Contribution - Verbal presentation and other Conference outputs
Monk, B. C., Sagatova, A. A., Wilson, R. K., Tyndall, J. D. A., Lackner, M., Ruma, Y. N., Hosseini, P., & Keniya, M. V. (2019, August-September). Drug discovery using the antifungal target lanosterol 14α-demethylase. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Singh, S., Oyagawa, C. R. M., Grimsey, N. L., Tyndall, J. D. A., Glass, M., & Vernall, A. J. (2019, August-September). Chromenopyrazole-based chemical tools to study cannabinoid type 2 receptor. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
2018
Journal - Research Article
Cooper, A. G., Oyagawa, C. R. M., Manning, J. J., Singh, S., Hook, S., Grimsey, N. L., Glass, M., Tyndall, J. D. A., & Vernall, A. J. (2018). Development of selective, fluorescent cannabinoid type 2 receptor ligands based on a 1,8-naphthyridin-2-(1H)-one-3-carboxamide scaffold. MedChemComm, 9(12), 2055-2067. doi: 10.1039/c8md00448j
Keniya, M. V., Ruma, Y. N., Tyndall, J. D. A., & Monk, B. C. (2018). Heterologous expression of full-length lanosterol 14α-demethylases of prominent fungal pathogens Candida albicans and Candida glabrata provides tools for antifungal discovery. Antimicrobial Agents & Chemotherapy, 62(11), e01131-18. doi: 10.1128/aac.01131-18
Keniya, M. V., Sabherwal, M., Wilson, R. K., Woods, M. A., Sagatova, A. A., Tyndall, J. D. A., & Monk, B. C. (2018). Crystal structures of full-length lanosterol 14α-demethylases of prominent fungal pathogens Candida albicans and Candida glabrata provide tools for antifungal discovery. Antimicrobial Agents & Chemotherapy, 62(11), e01134-18. doi: 10.1128/aac.01134-18
Singh, S., Cooper, S. L., Glenn, J. R., Beresford, J., Percival, L. R., Tyndall, J. D. A., … Vernall, A. J. (2018). Synthesis of novel (benzimidazolyl)isoquinolinols and evaluation as adenosine A1 receptor tools. RSC Advances, 8(29), 16362-16369. doi: 10.1039/C7RA13148H
Sagatova, A. A., Keniya, M. V., Tyndall, J. D. A., & Monk, B. C. (2018). The impact of homologous resistance mutations from pathogenic yeast on Saccharomyces cerevisiae lanosterol 14α-demethylase. Antimicrobial Agents & Chemotherapy, 62(3), e02242-17. doi: 10.1128/aac.02242-17
Cooper, A. G., MacDonald, C., Glass, M., Hook, S., Tyndall, J. D. A., & Vernall, A. J. (2018). Alkyl indole-based cannabinoid type 2 receptor tools: Exploration of linker and fluorophore attachment. European Journal of Medicinal Chemistry, 145, 770-789. doi: 10.1016/j.ejmech.2017.11.076
Agbowuro, A. A., Mazraani, R., McCaughey, L. C., Huston, W. M., Gamble, A. B., & Tyndall, J. D. A. (2018). Stereochemical basis for the anti-chlamydial activity of the phosphonate protease inhibitor JO146. Tetrahedron, 74(12), 1184-1190. doi: 10.1016/j.tet.2017.10.031
Journal - Research Other
Agbowuro, A. A., Huston, W. M., Gamble, A. B., & Tyndall, J. D. A. (2018). Proteases and protease inhibitors in infectious diseases. Medicinal Research Reviews, 38(4), 1295-1331. doi: 10.1002/med.21475
Conference Contribution - Published proceedings: Abstract
Ruma, Y. N., Keniya, M. V., Sagatova, A. A., Tyndall, J., & Monk, B. (2018). Interactions between new azole drugs and their target enzyme. Proceedings of the New Zealand Microbiological Society (NZMS) New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) Joint Annual Conference: Microbes & Molecules. (pp. 49). Retrieved from https://www.nzmsconference.org.nz
Keniya, M. V., Sagatova, A., Tyndall, J. D., & Monk, B. C. (2018). Co-expression of the cognate reductase for Candida albicans lanosterol 14α-demethylase enhances function in Saccharomyces cerevisiae. Proceedings of the 14th American Society for Microbiology Conference on Candida and Candidiasis. 52A. Retrieved from https://www.asm.org
Conference Contribution - Poster Presentation (not in published proceedings)
Agbowuro, A. A., Hwang, J., Peel, E., Mazraani, R., Springwald, A., Marsh, J. W., … Gamble, A. B., … Tyndall, J. D. A. (2018, August). Structure-activity relationships and binding optimization of Chlamydia HtrA inhibitors. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Putha, L., Kok, L. K., Chen, K., Sagatova, A. A., Wilbanks, S. M., Gamble, A. B., Vernall, A. J., & Tyndall, J. D. (2018, August). New isothiocyanates: Covalent inhibitors of macrophage migration inhibitory factor. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Ruma, Y., Keniya, M., Sagatova, A., Tyndall, J., & Monk, B. (2018, September). Interactions between new azole drugs and their target enzyme. Poster session presented at the Otago Spotlight Symposium on Infectious Disease, Wellington, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Lamichhane, R., de la Harpe, S., Harrop, T., Vernall, A., Tyndall, J., Dearden, P., Kirman, J., & Ussher, J. E. (2018, August). Differential regulation of MR1- and cytokine stimulated MAIT cells. Verbal presentation at the Queenstown Molecular Biology (QMB) and Australasian Society for Immunology New Zealand Branch (ASI-NZ) Joint Meeting, Queenstown, New Zealand.
2017
Journal - Research Article
Caramalho, R., Tyndall, J. D. A., Monk, B. C., Larentis, T., Lass-Flörl, C., & Lackner, M. (2017). Intrinsic short-tailed azole resistance in mucormycetes is due to an evolutionary conserved aminoacid substitution of the lanosterol 14α-demethylase. Scientific Reports, 7(1), 15898. doi: 10.1038/s41598-017-16123-9
Cooper, A., Singh, S., Hook, S., Tyndall, J. D. A., & Vernall, A. J. (2017). Chemical tools for studying lipid-binding class A G protein-coupled receptors. Pharmacological Reviews, 69(3), 316-353. doi: 10.1124/pr.116.013243
Matikonda, S. S., Fairhall, J. M., Tyndall, J. D. A., Hook, S., & Gamble, A. B. (2017). Stability, kinetic, and mechanistic investigation of 1,8-self-immolative cinnamyl ether spacers for controlled release of phenols and generation of resonance and inductively stabilized methides. Organic Letters, 19(3), 528-531. doi: 10.1021/acs.orglett.6b03695
Journal - Research Other
Marsh, J. W., Ong, V. A., Lott, W. B., Timms, P., Tyndall, J. D. A., & Huston, W. M. (2017). CtHtrA: The lynchpin of the chlamydial surface and a promising therapeutic target. Future Microbiology, 12(9), 817-829. doi: 10.2217/fmb-2017-0017
Conference Contribution - Published proceedings: Abstract
Agbowuro, A. A., Springwald, A., Hwang, J., Marsh, J. W., Mazraani, R., McCaugney, L. C., … Gamble, A. B., & Tyndall, J. D. A. (2017). Developing chlamydia-targeted protease inhibitors as a potential treatment for chlamydiosis. New Zealand Medical Journal, 130(1467), (pp. 105). Retrieved from http://www.nzma.org.nz/journal
Conference Contribution - Poster Presentation (not in published proceedings)
Cooper, A., Macdonald, C., Manning, J., Glass, M., Hook, S., Tyndall, J., & Vernall, A. (2017, September). Design, synthesis and pharmacological evaluation of fluorescent ligands as tools for studying cannabinoid type 2 receptor. Poster session presented at the 19th RSC/SCI Medicinal Chemistry Symposium, Cambridge, UK.
Lamichhane, R., de la Harpe, S., Harrop, T., Vernall, A., Tyndall, J., Dearden, P., Kirman, J., & Ussher, J. (2017, November). Differences in the effector function of MR1- and cytokine stimulated MAIT cells. Poster session presented at the 10th International CD1-MR1 Workshop, Napa, USA.
Conference Contribution - Verbal presentation and other Conference outputs
Ussher, J., Williams, T., Lamichhane, R., de la Harpe, S., Tyndall, J., & Vernall, A. (2017, November). Bacteria license antigen presenting cells for MR1-mediated MAIT cell activation. Verbal presentation at the 10th International CD1-MR1 Workshop, Napa, USA.
Monk, B. C., Tomasiak, T. M., Sagatova, A., Keniya, M. V., Wilson, R. K., Sabherwal, M., Tyndall, J. D. A., & Stroud, R. M. (2017, September). Structure-function analysis of the antifungal target sterol 14α-demethylase. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
2016
Journal - Research Article
Lawrence, A., Fraser, T., Gillett, A., Tyndall, J. D. A., Timms, P., Polkinghorne, A., & Huston, W. M. (2016). Chlamydia serine protease inhibitor, targeting HtrA, as a new treatment for Koala Chlamydia infection. Scientific Reports, 6, 31466 . doi: 10.1038/srep31466
Tyndall, J. D. A., Sabherwal, M., Sagatova, A. A., Keniya, M. V., Negroni, J., Wilson, R. K., Woods, M. A., … Monk, B. C. (2016). Structural and functional elucidation of yeast lanosterol 14α-demethylase in complex with agrochemical antifungals. PLoS ONE, 11(12), e0167485. doi: 10.1371/journal.pone.0167485
Sagatova, A. A., Keniya, M. V., Wilson, R. K., Sabherwal, M., Tyndall, J. D. A., & Monk, B. C. (2016). Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14α-demethylase. Scientific Reports, 6, 26213. doi: 10.1038/srep26213
Conference Contribution - Published proceedings: Abstract
Agbowuro, A. A., Springwald, A., Hwang, J., Marsh, J. W., Bogyo, M., Huston, W. M., Gamble, A. B., & Tyndall, J. D. A. (2016). Targeting a chlamydial proteolytic enzyme as a therapeutic approach to overcoming current treatment drawbacks. Proceedings of the Diagnostics, Drugs, Devices, Discovery (D4) Conference. Retrieved from http://www.otago.ac.nz/d4/index.html
Singh, S., Glenn, J. R., Hill, S. J., Tyndall, J. D. A., & Vernall, A. J. (2016). Illuminating the life of A1 adenosine receptor. Proceedings of the Diagnostics, Drugs, Devices, Discovery (D4) Conference. Retrieved from http://www.otago.ac.nz/d4/index.html
Cooper, A. G., Macdonald, C., Glass, M., Hook, S., Tyndall, J. D. A., & Vernall, A. J. (2016). Development of tools for studying cannabinoid type 2 receptor: Design, synthesis and pharmacological evaluation of fluorescent ligands and intermediates. Proceedings of the Diagnostics, Drugs, Devices, Discovery (D4) Conference. Retrieved from http://www.otago.ac.nz/d4/index.html
Cooper, A. G., Macdonald, C., Glass, M., Hook, S., Tyndall, J. D. A., & Vernall, A. J. (2016). Development of fluorescent ligands as tools for studying cannabinoid type 2 receptor. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists and the Molecular Pharmacology of G Protein-Coupled Receptors (ASCEPT-MPGPCR) Joint Scientific Meeting. 709. Retrieved from http://www.asceptasm.com/
Graham, D., Wilson, R., Keniya, M., Sagatova, A., Woods, M., Sabherwal, M., Tyndall, J., & Monk, B. (2016). The molecular basis of triazole inhibition of an antifungal target. Journal of Dental Research, 95(Spec Iss B), 1262. Retrieved from http://www.iadr.org/
Keniya, M. V., Wilson, R. K., Woods, M. A., Sabherwal, M., Sagatova, A. A., Tyndall, J. D. A., & Monk, B. C. (2016). Structure of the azole drug target from pathogenic fungi. Proceedings of the Sir John Walsh Research Institute Research Symposium. (pp. 13). Retrieved from http://www.otago.ac.nz/sjwri/news/otago621026
Sagatova, A., Wilson, R. K., Sabherwal, M., Keniya, M. V., Tyndall, J. D. A., & Monk, B. C. (2016). Investigating triazole mediated resistance in yeast. Proceedings of the Sir John Walsh Research Institute Research Symposium. (pp. 13). Retrieved from http://www.otago.ac.nz/sjwri/news/otago621026
Graham, D. O., Wilson, R. K., Keniya, M. V., Sagatova, A., Woods, M. A., Sabherwal, M., Tyndall, J. D. A., & Monk, B. C. (2016). The molecular basis of triazole inhibition of an antifungal target. Proceedings of the Sir John Walsh Research Institute Research Symposium. (pp. 12-13). Retrieved from http://www.otago.ac.nz/sjwri/news/otago621026
Conference Contribution - Poster Presentation (not in published proceedings)
Cooper, A. G., Macdonald, C., Glass, M., Hook, S., Tyndall, J. D. A., & Vernall, A. J. (2016, August-September). Development of fluorescent ligands as tools for studying cannabinoid type 2 receptor. Poster session presented at the European Federation for Medicinal Chemistry (EFMC) International Symposium on Medicinal Chemistry, Manchester, UK.
Singh, S., Tyndall, J. D. A., & Vernall, A. J. (2016, August-September). Development of selective fluorescent ligands for A1 adenosine receptor as pharmacological tools. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.
Agbowuro, A. A., Sagatova, A. A., Wilbanks, S. M., Huston, W. M., Gamble, A. B., & Tyndall, J. D. A. (2016, August-September). Stereochemical basis of the anti-Chlamydial activity of JO146. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Tyndall, J. D. A., Agbowuro, A., Hwang, J., Springwald, A. H., Marsh, J., Gamble, A. B., & Huston, W. M. (2016, August-September). Targeting a multimeric protease for new Chlamydia therapeutics. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.
2015
Journal - Research Article
Kim, J. S., Brownjohn, P. W., Dyer, B. S., Beltramo, M., Walker, C. S., Hay, D. L., … Tyndall, J. D. A., & Anderson, G. M. (2015). Anxiogenic and stressor effects of the hypothalamic neuropeptide RFRP-3 are overcome by the NPFFR antagonist GJ14. Endocrinology, 156(11), 4152-4162. doi: 10.1210/en.2015-1532
Marsh, J. W., Wee, B. A., Tyndall, J. D. A., Lott, W. B., Bastidas, R. J., Caldwell, H. D., … Huston, W. M. (2015). A Chlamydia trachomatis strain with a chemically generated amino acid substitution (P370L) in the cthtrA gene shows reduced elementary body production. BMC Microbiology, 15, 194. doi: 10.1186/s12866-015-0533-2
Hellyer, S. D., Indurthi, D., Balle, T., Runder-Varga, V., Selwood, A. I., Tyndall, J. D. A., … Kerr, D. S. (2015). Pinnatoxins E, F and G target multiple nicotinic receptor subtypes. Journal of Neurochemistry, 135(3), 479-491. doi: 10.1111/jnc.13245
Sagatova, A. A., Keniya, M. V., Wilson, R. K., Monk, B. C., & Tyndall, J. D. A. (2015). Structural insights into binding of the antifungal drug fluconazole to Saccharomyces cerevisiae lanosterol 14α-demethylase. Antimicrobial Agents & Chemotherapy, 59(8), 4982-4989. doi: 10.1128/aac.00925-15
Spencer, E. S., Dale, E. J., Gommans, A. L., Rutledge, M. T., Vo, C. T., Nakatani, Y., Gamble, A. B., Smith, R. A. J., Wilbanks, S. M., Hampton, M. B., & Tyndall, J. D. A. (2015). Multiple binding modes of isothiocyanates that inhibit macrophage migration inhibitory factor. European Journal of Medicinal Chemistry, 93, 501-510. doi: 10.1016/j.ejmech.2015.02.012
Conference Contribution - Published proceedings: Abstract
Singh, S., Tyndall, J. D. A., & Vernall, A. (2015). Development of selective fluorescent ligands for A1AR as pharmacological tools. Proceedings of the Diagnostic Drug Device Discovery (D4) Conference. Retrieved from https://www.regonline.com.au/builder/site/Default.aspx?EventID=1758070
Cooper, A., Hook, S., Tyndall, J. D. A., & Vernall, A. (2015). Development of fluorescent ligands as tools for studying the cannabinoid type 2 receptor. Proceedings of the Diagnostic Drug Device Discovery (D4) Conference. Retrieved from https://www.regonline.com.au/builder/site/Default.aspx?EventID=1758070
Spencer, E., Dickerhof, N., Tyndall, J., Bernhagen, J., Kettle, A., & Hampton, M. (2015). Assessing inhibition of macrophage migration inhibitory factor by isothiocyanates. Free Radical Biology & Medicine, 86(Suppl. 1), (pp. S42-S43). doi: 10.1016/j.freeradbiomed.2015.07.145
Conference Contribution - Verbal presentation and other Conference outputs
Tyndall, J. D. A., Sagatova, A., Keniya, M. V., Sabherwal, M., Wilson, R., Negroni, J., … Monk, B. C. (2015, August-September). Structural studies of the membrane protein CYP51 reveals resistance mechanism against short-chain azole antifungals. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
2014
Journal - Research Article
Dickerhof, N., Magon, N. J., Tyndall, J. D. A., Kettle, A. J., & Hampton, M. B. (2014). Potent inhibition of macrophage migration inhibitory factor (MIF) by myeloperoxidase-dependant oxidation of epicatechins. Biochemical Journal, 462(2), 303-314. doi: 10.1042/BJ20140612
Monk, B. C., Tomasiak, T. M., Keniya, M. V., Huschmann, F. U., Tyndall, J. D. A., O'Connell, III, J. D., Cannon, R. D., … Stroud, R. M. (2014). Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer. PNAS, 111(10), 3865-3870. doi: 10.1073/pnas.1324245111
Conference Contribution - Published proceedings: Abstract
Sagatova, A., Keniya, M., Huschmann, F., Wilbanks, S., Cannon, R., Tyndall, J., & Monk, B. (2014). Triazole drug target structures in a resistant yeast strain. New Zealand Medical Journal, 127(1404). Retrieved from http://www.nzma.org.nz/journal
Tyndall, J. D. A., Spencer, E. S., Dale, E. J., Gommans, A. L., Rutledge, M. T., Vo, C. T., Nakatani, Y., Gamble, A. B., Smith, R. A. J., Wilbanks, S. M., & Hampton, M. B. (2014). Multiple binding modes of isothiocyanate inhibitors of macrophage migration inhibitory factor define structure activity relationships. Proceedings of the CRYSTAL29: 29th Biennial Conference of the Society of Crystallographers in Australia and New Zealand (SCANZ). (pp. 88). Retrieved from http://www.crystal29.com/
Tyndall, J. D. A., Sagatova, A., Tomasiak, T. M., Keniya, M. V., Huschmann, F. U., O'Connell, III, J. D., … Cannon, R. D., … Monk, B. C. (2014). Structures of full-length bitopic membrane protein CYP51 from Saccharomyces cerevisiae provide insight into substrate and drug binding and mutations affecting antifungal susceptibility. Proceedings of the CRYSTAL29: 29th Biennial Conference of the Society of Crystallographers in Australia and New Zealand (SCANZ). (pp. 50). Retrieved from http://www.crystal29.com/
Conference Contribution - Poster Presentation (not in published proceedings)
Kim, J. S., Brownjohn, P. W., Dyer, B. S., Compton, B. J., Beltramo, M., Painter, G. F., Tyndall, J. D., & Anderson, G. M. (2014, August). In vitro and in vivo analyses of novel neuropeptide FF receptor antagonists. Poster session presented at the International Congress of Neuroendocrinology (ICN), Sydney, Australia.
Kim, J. S., Brownjohn, P. W., Dyer, B. S., Compton, B. J., Painter, G. F., Tyndall, J. D., & Anderson, G. M. (2014, August). Neuropeptide FF receptors as therapeutic targets. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Sagatova, A., Keniya, M. V., Huschmann, F. U., Wilbanks, S. M., Cannon, R. D., Tyndall, J. D. A., & Monk, B. C. (2014, May). Egr11p structure in triazole resistant and susceptible strains of yeast. Poster session presented at the International Association for Dental Research (IADR) New Zealand Section Student Poster Competition, Dunedin, New Zealand.
Tyndall, J. D. A., Spencer, E. S., Dale, E. J., Gommans, A. L., Rutledge, M. T., Vo, C. T., Nakatani, Y., Gamble, A. B., Smith, R. A. J., Wilbanks, S. M., & Hampton, M. B. (2014, August). Multiple binding modes of isothiocyanate inhibitors of macrophage migration inhibitory factor define design strategies. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Sagatova, A., Keniya, M., Huschmann, F., Wilbanks, S., Cannon, R., Tyndall, J., & Monk, B. (2014, September). Erg11p structure in a triazole resistant yeast strain. Poster session presented at the Division of Health Sciences Research Forum: Learning Different Research Languages, Dunedin, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Monk, B. C., Tomasiak, T. M., Cannon, R. D., Sagatova, A., Keniya, M. V., Huschmann, F. U., Tyndall, J. D. A., … Stroud, R. M. (2014, November). A target structure to invigorate antifungal discovery. Verbal presentation at the Frontiers of Biology Satellite Meeting: From Protein Structure and Function to Drugs, Wellington, New Zealand.
Tyndall, J. D. A., Sagatova, A., Tomasiak, T. M., Keniya, M. V., Huschmann, F. U., O'Connell, III, J. D., … Cannon, R. D., … Monk, B. C. (2014, April). Structures of full-length bitopic membrane protein CYP51 from Saccharomyces cerevisiae provide insight into substrate and drug binding and mutations affecting antifungal susceptibility. Verbal presentation at the 29th Biennial Conference of the Society of Crystallographers in Australia and New Zealand (SCANZ), O'Reilly's Rainforest Retreat, Australia.
Tyndall, J. (2014, July). Structural resolution of the full-length bitopic membrane protein CYPS1 mono-oxygenase from Saccharomyces cerevisiae: Substrate, drug binding and mutations affecting antifungal susceptibility. Verbal presentation at the Oxygen Theme Meeting, Christchurch, New Zealand.
Tyndall, J. (2014, June-July). Multiple binding modes of isothiocyanate inhibitors of macrophage migration inhibitory factor define structure activity relationships. Verbal presentation at the New Zealand Structural Biology Meeting, Hanmer Springs, New Zealand.
2013
Journal - Research Article
Marsh, J. W., Lott, W. B., Tyndall, J. D. A., & Huston, W. M. (2013). Proteolytic activation of Chlamydia trachomatis HTRA is mediated by PDZ1 domain interactions with protease domain loops L3 and LC and beta strand β5. Cellular & Molecular Biology Letters, 18(4), 522-537. doi: 10.2478/s11658-013-0103-2
Rawal, M. K., Khan, M. F., Kapoor, K., Goyal, N., Sen, S., Saxena, A. K., … Tyndall, J. D. A., Monk, B. C., Cannon, R. D., … Prasad, R. (2013). Insight into pleiotropic drug resistance ATP-binding cassette pump drug transport through mutagenesis of Cdr1p transmembrane domains. Journal of Biological Chemistry, 288(34), 24480-24493. doi: 10.1074/jbc.M113.488353
Awasthi, A., Woolley, A. G., Lecomte, F. J., Hung, N., Baguley, B. C., Wilbanks, S. M., Jeffs, A. R., & Tyndall, J. D. A. (2013). Variable expression of GLIPR1 correlates with invasive potential in melanoma cells. Frontiers in Oncology, 3, 225. doi: 10.3389/fonc.2013.00225
Shankar, M., Wilbanks, S. M., Nakatani, Y., Monk, B. C., & Tyndall, J. D. A. (2013). Catalysis product captured in lumazine synthase from the fungal pathogen Candida glabrata. Acta Crystallographica Section D, 69(8), 1580-1586. doi: 10.1107/S0907444913010949
Gloeckl, S., Ong, V. A., Patel, P., Tyndall, J. D. A., Timms, P., Beagley, K. W., … Huston, W. M. (2013). Identification of a serine protease inhibitor which causes inclusion vacuole reduction and is lethal to Chlamydia trachomatis. Molecular Microbiology, 89(4), 676-689. doi: 10.1111/mmi.12306
Vellas, S. K., Lewis, J. E. M., Shankar, M., Sagatova, A., Tyndall, J. D. A., Monk, B. C., Fitchett, C. M., Hanton, L. R., & Crowley, J. D. (2013). [Fe2L3]4+ cylinders derived from bis(bidentate) 2-pyridyl-1,2,3-triazole "click" ligands: Synthesis, structures and exploration of biological activity. Molecules, 18(6), 6383-6407. doi: 10.3390/molecules18066383
Keniya, M. V., Cannon, R. D., Nguyễn, Ấ., Tyndall, J. D. A., & Monk, B. C. (2013). Heterologous expression of Candida albicans Pma1p in Saccharomyces cerevisiae. FEMS Yeast Research, 13(3), 302-311. doi: 10.1111/1567-1364.12035
Conference Contribution - Published proceedings: Abstract
Huschmann, F. U., Tomasiak, T. M., Keniya, M. V., O'Connell, III, J. D., Luckner, S. R., Krause, K., Cannon, R. D., … Tyndall, J. D. A., & Monk, B. C. (2013). Antifungal drug discovery: Crystallization of the cytochrome P450 triazole target. Proceedings of the Australasian Pharmaceutical Science Association (APSA) Conference. Retrieved from http://apsa-online.org/home.html
Huschmann, F. U., Tomasiak, T. M., Keniya, M. V., O'Connell, III, J. D., Luckner, S. R., Krause, K., Cannon, R. D., … Tyndall, J. D. A., & Monk, B. C. (2013). Crystallization of Erg11p: The cytochrome P450 target of triazole antifungals. Acta Crystallographica Section A, A69, (pp. s64). [Abstract]
Cannon, R., Niimi, K., Lamping, E., Huschmann, F. U., Niimi, M., Keniya, M. V., Tyndall, J. D. A., Holmes, A. R., & Monk, B. C. (2013). Overcoming antifungal drug resistance. Proceedings of the Sir John Walsh Research Institute Research Day. (pp. 6). Retrieved from http://sjwri.otago.ac.nz/research/sjwri/
Conference Contribution - Poster Presentation (not in published proceedings)
Spencer, E. S., Dale, E., Smith, R. A. J., Gamble, A. B., Tyndall, J. D. A., Rutledge, M. T., Wilbanks, S. M., Dickerhof, N., Kettle, A. J., & Hampton, M. B. (2013, August). Assessing inhibition of macrophage migration inhibitory factor by novel isothiocyanates. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Monk, B. C., Tomasiak, T. M., Keniya, M. V., Cannon, R. D., Huschmann, F. U., Tyndall, J. D. A., … Stroud, R. M. (2013, August). Crystal structures of full-length Saccharomyces cerevisiae Erg11p give insight into triazole and substrate binding. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Gommans, A., Hampton, M. B., Tyndall, J. D. A., & Wilbanks, S. M. (2013, August). Improved-resolution structure of macrophage migration inhibitory factor complexed with phenethyl isothiocyanate. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Mansfield, R. E., Lo, A. T. Y., Li, N., Tyndall, J. D. A., & Dixon, N. E. (2013, February). Targeting a bacterial protein interaction 'hub' in the search for a new class of antibiotics. Verbal presentation at the 38th Lorne Conference on Protein Structure and Function, Lorne, Australia.
Gommans, A. L., Tyndall, J. D. A., Hampton, M. B., & Wilbanks, S. M. (2013, February). Improved resolution of macrophage migration inhibitory factor complexed with phenethyl isothiocyanate. Verbal presentation at the 38th Lorne Conference on Protein Structure and Function, Lorne, Australia.
2012
Journal - Research Article
Tyndall, J. D. A., Lue, H., Rutledge, M. T., Bernhagen, J., Hampton, M. B., & Wilbanks, S. M. (2012). Macrophage migration inhibitory factor covalently complexed with phenethyl isothiocyanate. Acta Crystallographica Section F, 68(9), 999-1002. doi: 10.1107/s1744309112030552
Niimi, K., Harding, D. R. K., Holmes, A. R., Lamping, E., Niimi, M., Tyndall, J. D. A., Cannon, R. D., & Monk, B. C. (2012). Specific interactions between the Candida albicans ABC transporter Cdr1p ectodomain and a D-octapeptide derivative inhibitor. Molecular Microbiology, 85(4), 747-767. doi: 10.1111/j.1365-2958.2012.08140.x
Conference Contribution - Published proceedings: Abstract
Spencer, E., Tyndall, J., Smith, R. A. J., & Hampton, M. (2012). Biological properties of isothiocyanates. Proceedings of the Oxygen Theme Meeting. (pp. 21). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf
Conference Contribution - Poster Presentation (not in published proceedings)
Tomasiak, T. M., Monk, B. C., Keniya, M. V., Huschmann, F. U., Tyndall, J. D. A., O'Connell, III, J. D., Cannon, R. D., … Stroud, R. M. (2012, November). Structure of a full-length bitopic single membrane spanning cytochrome p450: The antifungal target lanosterol 14-alpha demethylase. Poster session presented at the 4th Membrane Protein Technologies Meeting: NIH Roadmap to Membrane Protein Structures and Complexes, San Francisco, CA.
Huschmann, F., Monk, B. C., Cannon, R. D., & Tyndall, J. D. A. (2012, August). Overcoming resistance in fungal pathogens: Towards crystallization of the azole target from Candida albicans. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Monk, B. C., Tomasiak, T. M., Keniya, M. V., Huschmann, F. U., Tyndall, J. D. A., O'Connell, III, J. D., Cannon, R. D., … Stroud, R. M. (2012, November). A cytochrome P450 monospanner in the works: Structure of full-length yeast lanosterol 14α-demethylase. Verbal presentation at the 4th Membrane Protein Technologies Meeting: NIH Roadmap to Membrane Protein Structures and Complexes, San Francisco, CA.
2011
Chapter in Book - Research
Marsh, J., Gloeckl, S., Tyndall, J., & Huston, W. M. (2011). The role of HtrA as a chaperone and protease in bacterial pathogenesis. In L. V. Berhardt (Ed.), Advances in Medicine and Biology (Vol. 27). (pp. 87-121). New York: Nova Science.
Journal - Research Article
Beggs, K. T., Tyndall, J. D. A., & Mercer, A. R. (2011). Honey bee dopamine and octopamine receptors linked to intracellular calcium signaling have a close phylogenetic and pharmacological relationship. PLoS ONE, 6(11), e26809. doi: 10.1371/journal.pone.0026809
Huston, W. M., Tyndall, J. D. A., Lott, W. B., Stansfield, S. H., & Timms, P. (2011). Unique residues involved in activation of the multitasking protease/chaperone HtrA from Chlamydia trachomatis. PLoS ONE, 6(9), e24547. doi: 10.1371/journal.pone.0024547
Matthews, H., Ranson, M., Tyndall, J. D. A., & Kelso, M. J. (2011). Synthesis and preliminary evaluation of amiloride analogs as inhibitors of the urokinase-type plasminogen activator (uPA). Bioorganic & Medicinal Chemistry Letters, 21(22), 6760-6766. doi: 10.1016/j.bmcl.2011.09.044
Suetani, R. J., Sorrenson, B., Tyndall, J. D. A., Williams, M. J. A., & McCormick, S. P. A. (2011). Homology modeling and functional testing of an ABCA1 mutation causing Tangier disease. Atherosclerosis, 218(2), 404-410. doi: 10.1016/j.atherosclerosis.2011.06.019
Conference Contribution - Poster Presentation (not in published proceedings)
Suetani, R., Sorrenson, B., Tyndall, J., Williams, M., & McCormick, S. (2011, September). Homology modelling and functional testing of ABCA1 mutations. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Tyndall, J. (2011, March). Differential expression of GLIPR1 correlates with invasive potential in melanoma cells. Verbal presentation at the New Zealand/Singapore Cancer Symposium, Dunedin, New Zealand.
Huston, W. M., Tyndall, J. D. A., Lott, W. B., Stansfield, S., & Timms, P. (2011, October). A novel activation mechanism for the multitasking protease/chaperone HTRA from chlamydia trachomatis. Verbal presentation at the Seventh International Proteolysis Society General Meeting, San Diego, CA.
Tyndall, J. (2011, December). Drug leads, drug targets and drug design. Verbal presentation at the Maurice Wilkins Centre for Molecular Biodiscovery Workshop: Celebrating Collaboration in Biomedical Research, Dunedin, New Zealand.
Tyndall, J. D. A., Dale, E. J., Spencer, E. S., Falvey, J. D., Smith, R. A. J., & Hampton, M. B. (2011, November-December). Isothiocyanate inhibitors of the proinflammatory cytokine macrophage migration inhibitory factor. Verbal presentation at the New Zealand Institute of Chemistry (NZIC) Conference, Hamilton, New Zealand.
2010
Chapter in Book - Research
Tyndall, J. D. A., Kelso, M. J., & Ranson, M. (2010). Inhibitors of the plasminogen activation system: Promising new agents for suppressing breast cancer metastasis. In Atta-ur-Rahman & M. I. Choudhary (Eds.), Frontiers in anti-cancer drug discovery (Vol. 1). (pp. 55-78). Bentham Science.
Journal - Research Article
Loughlin, W. A., Tyndall, J. D. A., Glenn, M. P., Hill, T. A., & Fairlie, D. P. (2010). Update 1 of: Beta-strand mimetics. Chemical Reviews, 110(6), PR32-PR69. doi: 10.1021/cr900395y
Madala, P. K., Tyndall, J. D. A., Nall, T., & Fairlie, D. P. (2010). Update 1 of: Proteases universally recognize beta strands in their active sites. Chemical Reviews, 110(6), PR1-PR31. doi: 10.1021/cr900368a
Nisa, S., Blokpoel, M. C. J., Robertson, B. D., Tyndall, J. D. A., Lun, S., Bishai, W. R., & O'Toole, R. (2010). Targeting the chromosome partitioning protein ParA in tuberculosis drug discovery. Journal of Antimicrobial Chemotherapy, 65(11), 2347-2358. doi: 10.1093/jac/dkq311
Ruiz-Gómez, G., Tyndall, J. D. A., Pfeiffer, B., Abbenante, G., & Fairlie, D. P. (2010). Update 1 of: Over one hundred peptide-activated G protein-coupled receptors recognize ligands with turn structure. Chemical Reviews, 110, PR1-PR41. doi: 10.1021/cr900344w
Sawant, P. M., Tyndall, J. D. A., Holland, P. T., Peake, B. M., Mountfort, D. O., & Kerr, D. S. (2010). In vivo seizure induction and affinity studies of domoic acid and isodomoic acids-D, -E and -F. Neuropharmacology, 59, 129-138. doi: 10.1016/j.neuropharm.2010.03.019
Conference Contribution - Published proceedings: Abstract
Nguyen, A., Milne, T., Monk, B., & Tyndall, J. (2010). A model system for heterologous expression of cysteine-rich secretory proteins, antigen 5 and pathogenesis-related group 1 proteins in E. coli. New Zealand Medical Journal, 123(1321). Retrieved from http://journal.nzma.org.nz/journal/123-1321/4329/content.pdf
Conference Contribution - Verbal presentation and other Conference outputs
Brown, K. K., Blaikie, F. H., Smith, R. A. J., Tyndall, J. D. A., Lue, H., Bernhagen, J., Winterbourn, C. C., & Hampton, M. B. (2010, November-December). N-terminal proline of macrophage migration inhibitory factor as a biological target of isothiocyanates. Verbal presentation at the Society for Free Radical Research (SFRR) Australasia 19th Annual Conference, Akaroa, New Zealand.
Other Research Output
Tyndall, J. (2010, February). HtrA: A new potential drug target in Chlamydia trachomatis. University of Otago School of Pharmacy Seminar. Dunedin, New Zealand. [Department Seminar].
2009
Journal - Research Article
Brown, K. K., Blaikie, F. H., Smith, R. A. J., Tyndall, J. D. A., Lue, H., Bernhagen, J., Winterbourn, C. C., & Hampton, M. B. (2009). Direct modification of the proinflammatory cytokine macrophage migration inhibitory factor by dietary isothiocyanates. Journal of Biological Chemistry, 284(47), 32425-32433. doi: 10.1074/jbc.M109.047092
Westphal, D., Ledgerwood, E. C., Tyndall, J. D. A., Hibma, M. H., Ueda, N., Fleming, S. B., & Mercer, A. A. (2009). The orf virus inhibitor of apoptosis functions in a Bcl-2-like manner, binding and neutralizing a set of BH3-only proteins and active Bax. Apoptosis, 14(11), 1317-1330. doi: 10.1007/s10495-009-0403-1
Fry, B. G., Roelants, K., Champagne, D. E., Scheib, H., Tyndall, J. D. A., …, & Rodríguez de la Vega, R. C. (2009). The toxicogenomic multiverse: Convergent recruitment of proteins into animal venoms. Annual Review of Genomics & Human Genetics, 10, 483-511. doi: 10.1146/annurev.genom.9.081307.164356
Lamping, E., Ranchod, A., Nakamura, K., Tyndall, J. D. A., Niimi, K., Holmes, A. R., Niimi, M., & Cannon, R. D. (2009). Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. Antimicrobial Agents & Chemotherapy, 53(2), 354-369. doi: 10.1128/AAC.01095-08
Conference Contribution - Published proceedings: Abstract
Nguyen, A. B., Milne, T. J., Monk, B. C., & Tyndall, J. D. A. (2009). Re-engineering Tex31 for expression and purification. Proceedings of the ComBio2009 Conference. [CD-ROM] [Abstract]
Brace, R. J., Williams, M. J., Tyndall, J. D. A., Sviridov, D., Mukhamedova, N., Albrecht, C., & McCormick, S. P. A. (2009). Characterisation of a novel Tangier disease ABCA1 protein. Proceedings of the ComBio2009 Conference. [CD-ROM] [Abstract]
Tyndall, J. D. A., Awasthi, A., Jeffs, A., & Wilbanks, S. M. (2009). GLIPR1 is differentially expressed in melanoma cells and correlates with invasive potential. Proceedings of the ComBio2009 Conference. [CD-ROM] [Abstract]
Kerr, D., Sawant, P. M., Tyndall, J., Mountfort, D. O., & Holland, P. (2009). Quantitative structure-activity relationships for domoic acid and its isomers. Proceedings of the Society for Neuroscience 39th Annual Meeting. SfN. Retrieved from http://www.abstractsonline.com/plan/AdvancedSearch.aspx
Lees, G., Dixon, C., & Tyndall, J. (2009). Exploring the mechanisms for the neurotoxicity of Efavirenz (EFV). Proceedings of the Webster Centre for Infectious Diseases Symposium. WCID. Retrieved from http://www.webstercentre.otago.ac.nz/WCIDSymposiumProgramme.pdf
Conference Contribution - Verbal presentation and other Conference outputs
Tyndall, J. D. A., Timms, P., & Huston, W. M. (2009, October). Development of an assay for testing substrate specificity determinants for Chlamydia trachomatis heat activated serine protease HtrA. Verbal presentation at the Sixth General Meeting of the International Proteolysis Society, Surfers Paradise, Australia.
Gloeckl, S., Tyndall, J. D. A., Timms, P., & Huston, W. M. (2009, September). Characterisation of the role of the chlamydial serine protease, HtrA, in growth and virulence by identifying and examining its native substrates. Verbal presentation at the Australian Society for Microbiology Conference: The Molecular Biology of Bacterial Pathogens (BacPath 10), Barossa Valley, Australia.
Lees, G., Dixon, C., Maggo, S., Clark, D., Tyndall, J., & Strandell, J. (2009, September). Modulation of ion channels by the antiviral drug efavirenz. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting, Dunedin, New Zealand.
Sawant, P. M., Tyndall, J., Mountfort, D. O., Holland, P. T., & Kerr, D. S. (2009, September). In vivo potency, receptor binding and molecular modeling identify structure-activity relationships for domoic acid and its isomers. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting, Dunedin, New Zealand.
Awasthi, A., Tyndall, J. D. A., Jeffs, A., & Wilbanks, S. M. (2009, February). Glioma pathogenesis related protein: A survival factor for gliomas and melanomas. Verbal presentation at the New Zealand Chapter of the Controlled Release Society 11th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand.
2008
Journal - Research Article
Tyndall, J. D. A., Kelso, M. J., Clingan, P., & Ranson, M. (2008). Peptides and small molecules targeting the plasminogen activation system: Towards prophylactic anti-metastasis drugs for breast cancer. Recent Patents on Anti-Cancer Drug Discovery, 3(1), 1-13.
Tyndall, J. D. A., Pattenden, L. K., Reid, R. C., Hu, S.-H., Alewood, D., Alewood, P. F., … Martin, J. L. (2008). Crystal structures of highly constrained substrate and hydrolysis products bound to HIV-1 protease: Implications for the catalytic mechanism. Biochemistry, 47, 3736-3744.
Ashton, J. C., Wright, J. L., McPartland, J. M., & Tyndall, J. D. A. (2008). Cannabinoid CB1 and CB2 receptor ligand specificity and the development of CB2-selective agonists. Current Medicinal Chemistry, 15, 1428-1443.
Conference Contribution - Published proceedings: Abstract
Tyndall, J. D. A., Reid, R. C., Monk, P. N., & Fairlie, D. P. (2008). Targeting inflammation via the complement system: Designing antagonists against C5A. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting. ASCEPT. Retrieved from http://phal.otago.ac.nz/ascept_docos/programme%202008.pdf
Ashton, J. C., Wright, J. L., McPartland, J. M., Gertsch, J., & Tyndall, J. D. A. (2008). Development of drugs targeting the cannabinoid CB2 receptor for therapeutic use. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting. ASCEPT. Retrieved from http://phal.otago.ac.nz/ascept_docos/programme%202008.pdf
Conference Contribution - Poster Presentation (not in published proceedings)
Nguyen, A. B., Milne, T. J., Tyndall, J. D. A., & Monk, B. C. (2008, November-December). Expression of recombinant Tex31. Poster session presented at the New Zealand Institute of Chemistry, New Zealand Society for Biochemistry and Molecular Biology and the New Zealand Society of Plant Biologists Combined Conference, Dunedin, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Awasthi, A., Wilbanks, S. M., Jeffs, A., & Tyndall, J. D. A. (2008, November-December). Is glioma pathogenesis related protein a survival factor for gliomas? Verbal presentation at the New Zealand Institute of Chemistry, New Zealand Society for Biochemistry and Molecular Biology and the New Zealand Society of Plant Biologists Combined Conference, Dunedin, New Zealand.
2007
Journal - Research Article
Gee, C. L., Drinkwater, N., Tyndall, J. D. A., Grunewald, G. L., Wu, Q., McLeish, M. J., & Martin, J. L. (2007). Enzyme adaptation to inhibitor binding: A cryptic binding site in phenylethanolamine N-methyltransferase. Journal of Medicinal Chemistry, 50(20), 4845-4853.
Pearl, E. J., Tyndall, J. D. A., Poulter, R. T. M., & Wilbanks, S. M. (2007). Sequence requirements for splicing by the Cne PRP8 intein. FEBS Letters, 581, 3000-3004.
Journal - Professional & Other Non-Research Articles
Tyndall, J. D. A., & Duffull, S. B. (2007). New drugs targeting GPCRs: Recent agonists and antagonists in the clinic. Screening, 1, 22-25.
Conference Contribution - Published proceedings: Abstract
Clarkson, A. N., Koishi, K., Tyndall, J. D. A., & McLennan, I. S. (2007). The MIS type-II receptor, MISRII, has splice variants in the CNS. In J. G. Anson (Ed.), Proceedings of the 25th International Australasian Winter Conference on Brain Research. 25, (pp. 62). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/2007Abstracts.pdf
Conference Contribution - Poster Presentation (not in published proceedings)
Wilbanks, S. M., Pearl, E., Tyndall, J. D. A., & Poulter, R. T. M. (2007, August). Conformational shifts contribute to protein splicing by Cne PRP8, an intein of the human pathogen Cryptococcus neoformans. Poster session presented at the 17th Queenstown Molecular Biology Meeting, Queenstown, New Zealand.
Awasthi, A., Slobbe, L., Tyndall, J. D. A., & Wilbanks, S. M. (2007, August). Modelling and expression of Glioma pathogenesis related protein: A potential drug target for Gliomas. Poster session presented at the 17th Queenstown Molecular Biology Meeting, Queenstown, New Zealand.
Tyndall, J. D. A., McCormick, S., & Monk, B. C. (2007, February). The ABC of mapping sequence to structure via homology modelling: A tale of two transporters. Poster session presented at the Proteins: Structure, Function and Assembly in Health and Disease, Rotorua, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Tyndall, J. (2007, December). Crystal structures of highly constrained substrate and hydrolysis products bound to HIV-1 protease: Implications for catalytic mechanism and drug design. Verbal presentation at the Webster Centre for Molecular Research in Infectious Diseases Mini-Symposium, Dunedin, New Zealand.
2006
Journal - Research Article
Kahnberg, P., Lucke, A. J., Glenn, M. P., Boyle, G. M., Tyndall, J. D. A., Parsons, P. G., & Fairlie, D. P. (2006). Design, synthesis, potency, and cytoselectivity of anticancer agents derived by parallel synthesis from α-aminosuberic acid. Journal of Medicinal Chemistry, 49, 7611-7622.
Sobhani, A. M., Amini, S. R., Tyndall, J. D. A., Azizi, E., Daneshtalab, M., & Khalaj, A. (2006). A theory of mode of action of azolylalkylquinolines as DNA binding agents using automated flexible ligand docking. Journal of Molecular Graphics & Modelling, 25, 459-469.
Conference Contribution - Published proceedings: Abstract
Monk, P. N., Higginbottom, A., Madala, P. K., Tyndall, J. D. A., Stoermer, M., & Fairlie, D. P. (2006). Defining the ligand binding site on the human C5a receptor. Proceedings of the American Chemical Society Meeting. 231, (pp. U408). Washington, DC: ACS. [Abstract]
Drinkwater, N., Gee, C. L., Tyndall, J. D., Grunewald, G. L., Wu, Q., McLeish, M. J., & Martin, J. L. (2006). Encountering conformational changes in structure-based inhibitor design. Proceedings of the Australian Society for Biochemistry and Molecular Biology (ComBio). 38. Retrieved from http://www.asbmb.org.au/cgi-bin/combio/combio2006-abstract-search.cgi
Conference Contribution - Poster Presentation (not in published proceedings)
Drinkwater, N., Gee, C. L., Tyndall, J. D., Grunewald, G. L., Qian, W., McLeish, M. J., & Martin, J. L. (2006, November). Coupling crystallography with kinetic studies leads to identification of a previously unknown binding pocket. Poster session presented at the Joint Conference of the Asian Crystallographic Association and the Crystallographic Society of Japan, Epochal Tsukuba, Japan.
Conference Contribution - Verbal presentation and other Conference outputs
Tyndall, J. (2006, October). Investigating CAP proteins. Verbal presentation at the Pharmacy School Seminar Series, Dunedin, New Zealand.
2005
Journal - Research Article
Wu, Q., Gee, C. L., Lin, F., Tyndall, J. D., Martin, J. L., Grunewald, G. L., & McLeish, M. J. (2005). Structural, mutagenic, and kinetic analysis of the binding of substrates and inhibitors of human phenylethanolamine N-methyltransferase. Journal of Medicinal Chemistry, 48(23), 7243-7252.
Gee, C. L., Tyndall, J. D. A., Grunewald, G. L., Wu, Q., McLeish, M. J., & Martin, J. L. (2005). Mode of binding of methyl acceptor substrates to the adrenaline-synthesizing enzyme phenylethanolamine N-methyltransferase: Implications for catalysis. Biochemistry, 44, 16875-16885.
Gee, C. L., Nourse, A., Hsin, A.-Y., Wu, Q., Tyndall, J. D., Grunewald, G. L., … Martin, J. L. (2005). Disulfide-linked dimers of human adrenaline synthesizing enzyme PNMT are catalytically active. Biochimica et Biophysica Acta: Proteins & Proteomics, 1750, 82-92.
Chappell, K. J., Nall, T. A., Stoermer, M. J., Fang, N.-X., Tyndall, J. D. A., Fairlie, D. P., & Young, P. R. (2005). Site-directed mutagenesis and kinetic studies of the West Nile virus NS3 protease identify key enzyme-substrate interactions. Journal of Biological Chemistry, 280(4), 2896-2903.
Tyndall, J. D. A., & Sandilya, R. (2005). GPCR agonists and antagonists in the clinic. Medicinal Chemistry, 1, 405-421.
Tyndall, J. D. A., Nall, T., & Fairlie, D. P. (2005). Proteases universally recognize beta strands in their active sites. Chemistry Review, 105, 973-999.
Tyndall, J. D. A., Pfeiffer, B., Abbenante, G., & Fairlie, D. P. (2005). Over one hundred peptide-activated G protein-coupled receptors recognize ligands with turn structure. Chemistry Review, 105, 793-826.
Higginbottom, A., Cain, S. A., Woodruff, T. M., Proctor, L. M., Madala, P. K., Tyndall, J. D. A., … Monk, P. N. (2005). Comparative agonist/antagonist responses in mutant human C5a receptors define the ligand binding site. Journal of Biological Chemistry, 280(18), 17831-17840.
Conference Contribution - Published proceedings: Abstract
Tyndall, J., Malack, S., Holland, P., Mountfort, D., & Kerr, S. (2005). 3D-QSAR of AMPA and kainate ionotropic glutamate receptor agonists. Proceedings of the International Chemical Congress of Pacific Basin Societies. (pp. 104). [Abstract]
Fairlie, D. P., Tyndall, J., Abbenante, G., & Pfeiffer, B. (2005). Over 100 peptide-activated GPCRS recognize turn motifs in ligands. Proceedings of the 229th American Chemical Society Division of Medicinal Chemistry National Meeting. [Abstract]
Conference Contribution - Poster Presentation (not in published proceedings)
Amini, S. R., Tyndall, J., & Daneshtalab, M. (2005, May). Primary DNA modeling study on the novel designed cytotoxic quinolines. Poster session presented at the First Seminar of Medicinal & Natural Products Chemistry, Shiraz, Iran.
Gee, C. L., Tyndall, J., Grunewald, G. L., McLeish, M. J., & Martin, J. L. (2005, August). A dramatic side chain movement in adrenaline-synthesising PNMT: Implications for drug design. Poster session presented at the XX Congress of the International Union of Crystallography: Congress and General Assembly, Florence.
2004
Journal - Research Article
Nall, T. A., Chappell, K. J., Stoermer, M. J., Fang, N.-X., Tyndall, J. D. A., Young, P. R., & Fairlie, D. P. (2004). Enzymatic characterization and homology model of a catalytically active recombinant West Nile Virus NS3 protease. Journal of Biological Chemistry, 279(47), 48535-48542.
Loughlin, W. A., Tyndall, J. D. A., Glenn, M. P., & Fairlie, D. P. (2004). Beta-strand mimetics. Chemical Reviews, 104, 6085-6117.
van den Brenk, A. L., Tyndall, J. D. A., Cusack, R. M., Jones, A., Fairlie, D. P., Gahan, L. R., & Hanson, G. R. (2004). Formation of mononuclear and chloro-bridged binuclear copper(II) complexes of patellamide D, a naturally occurring cyclic peptide: Influence of anion and solvent. Journal of Inorganic Biochemistry, 98, 1857-1866.
March, D. R., Proctor, L. M., Stoermer, M. J., Sbaglia, R., Abbenante, G., Reid, R. C., … Tyndall, J. D. A., … Fairlie, D. P. (2004). Potent cyclic antagonists of the complement C5a receptor on human polymorphonuclear leukocytes: Relationships between structures and activity. Molecular Pharmacology, 65(4), 868-879.
Dutertre, S., Nicke, A., Tyndall, J. D. A., & Lewis, R. J. (2004). Determination of α-conotoxin binding modes on neuronal nicotinic acetylcholine receptors. Journal of Molecular Recognition, 17, 339-347.
Reid, R. C., Pattenden, L. K., Tyndall, J. D. A., Martin, J. L., Walsh, T., & Fairlie, D. P. (2004). Countering cooperative effects in protease inhibitors using constrained β-strand-mimicking templates in focused combinatorial libraries. Journal of Medicinal Chemistry, 47, 1641-1651.
Conference Contribution - Published proceedings: Abstract
Fairlie, D. P., Tyndall, J. D. A., Nall, T., Abbenante, G., & Reid, R. C. (2004). Protease ligand conformation and inhibitor design. Proceedings of the 29th Annual Lorne Conference on Protein Structure and Function. (February). [Abstract]
Tyndall, J. D. A., Nall, T., Pfeiffer, B., & Fairlie, D. P. (2004). Distinctive recognition of structural motifs by proteases and GPCRS: An important principle for drug design. Proceedings of the 29th Annual Lorne Conference on Protein Structure and Function. (February). [Abstract]
2003
Journal - Research Article
Glenn, M. P., Kelso, M. J., Tyndall, J. D. A., & Fairlie, D. P. (2003). Conformationally homogeneous cyclic tetrapeptides: Useful new three-dimensional scaffolds. Journal of the American Chemical Society, 125(3), 640-641.
Milne, T. J., Abbenante, G., Tyndall, J. D. A., Halliday, J., & Lewis, R. J. (2003). Isolation and characterization of a cone snail protease with homology to CRISP proteins of the pathogenesis-related protein superfamily. Journal of Biological Chemistry, 278(33), 31105-31110.
Hansford, K. A., Reid, R. C., Clark, C. I., Tyndall, J. D. A., Whitehouse, M. W., Guthrie, T., … Fairlie, D. P. (2003). D-tyrosine as a chiral precusor to potent inhibitors of human nonpancreatic secretory phospholipase A2 (IIa) with antiinflammatory activity. ChemBioChem, 4(2-3), 181-185.
Lucke, A. J., Tyndall, J. D. A., Singh, Y., & Fairlie, D. P. (2003). Designing supramolecular structures from models of cyclic peptide scaffolds with heterocyclic constraints. Journal of Molecular Graphics & Modelling, 21, 341-355.
Conference Contribution - Published proceedings: Abstract
Milne, T. J., Abbenante, G., Tyndall, J. D. A., Halliday, J., & Lewis, R. J. (2003). Isolation and characterisation of a cone snail protease with homology to CRISP proteins of the pathogenesis-related protein superfamily. Proceedings of the 5th Australian Peptide Conference. Queensland, Australia. [Abstract]
Guthrie, T., Hansford, K. A., Reid, R. C., Stoermer, M. J., Tyndall, J. D. A., & Fairlie, D. P. (2003). Isoform-selective inhibitors of human non-pancreatic secretory phospholipase A2 (group IIA): Potent new antiinfalmatory drugs derived from tyrosine. Proceedings of the Brisbane Biological and Organic Chemistry Symposium (BBOCS). (November), (pp. 39). [Abstract]
Stoermer, M. J., March, D. R., Proctor, L. M., Sbaglia, R., Abbenante, G., Reid, R. C., … Tyndall, J. D. A., … Fairlie, D. P. (2003). Macrocyclic peptides as ligands for cellular receptors: When a little rigidity is just right... Proceedings of the Brisbane Biological and Organic Chemistry Symposium (BBOCS). (November), (pp. 17). [Abstract]
2002
Journal - Research Article
Sinchaikul, S., Tyndall, J. D. A., Fothergill-Gilmore, L. A., Taylor, P., Phutrakul, S., Chen, S.-T., & Walkinshaw, M. D. (2002). Expression, purification, crystallization and preliminary crystallographic analysis of a thermostable lipase from Bacillus stearothermophilus P1. Acta Crystallographica Section D, D58, 182-185.
Glenn, M. P., Pattenden, L. K., Reid, R. C., Tyssen, D. P., Tyndall, J. D. A., Birch, C. J., & Fairlie, D. P. (2002). β-strand mimicking macrocyclic amino acids: Templates for protease inhibitors with antiviral activity. Journal of Medicinal Chemistry, 45, 371-381.
Tyndall, J. D. A., Sinchaikul, S., Fothergill-Gilmore, L. A., Taylor, P., & Walkinshaw, M. D. (2002). Crystal structure of a thermostable lipase from Bacillus stearothermophilus P1. Journal of Molecular Biology, 323, 859-869.
Conference Contribution - Published proceedings: Abstract
Bond, T., Tyndall, J., Abbenante, G., Walsh, T., Halliday, J., & Lewis, R. J. (2002). Ctex31, a dibasic specific post-translational processing endoprotease isolated from Conus textile, with structural homology to the pathogenesis-related superfamily. Proceedings of the 27th Annual Lorne Conference on Protein Structure and Function. (February), (pp. B43). [Abstract]
Tyndall, J. D. A., Reid, R. C., Hansford, K., Clark, C., Martin, J. L., & Fairlie, D. P. (2002). Rational design and crystallographic studies of potent inhibitors of hnps-phospholipase A2. Proceedings of the 27th Annual Lorne Conference on Protein Structure and Function. (February), (pp. B77). [Abstract]
2001
Journal - Research Article
Tyndall, J. D. A., & Fairlie, D. P. (2001). Macrocycles mimic the extended peptide conformation recognized by aspartic, serine, cysteine and metallo proteases. Current Medicinal Chemistry, 8(8), 893-907.
Conference Contribution - Poster Presentation (not in published proceedings)
Lucke, A. J., Tyndall, J. D. A., & Fairlie, D. P. (2001, November). Molecular modelling of cyclic peptide scaffolds: Designing supramolecular structures from models. Poster session presented at the Brisbane Biological and Organic Chemistry Symposium 2001, University of Queensland, Australia.
2000
Journal - Research Article
Fairlie, D. P., Tyndall, J. D. A., Reid, R. C., Wong, A. K., Abbenante, G., Scanlon, M. J., … Burkett, B. A. (2000). Conformational selection of inhibitors and substrates by proteolytic enzymes: Implications for drug design and polypeptide processing. Journal of Medicinal Chemistry, 43, 1271-1281.
Tyndall, J. D. A., Reid, R. C., Tyssen, D. P., Jardine, D. K., Todd, B., Passmore, M., … Fairlie, D. P. (2000). Synthesis, stability, antiviral activity, and protease-bound structures of substrate-mimicking constrained macrocyclic inhibitors of HIV-1 protease. Journal of Medicinal Chemistry, 43, 3495-3504.
1999
Journal - Research Article
Tyndall, J. D. A., & Fairlie, D. P. (1999). Conformational homogeneity in molecular recognition by proteolytic enzymes. Journal of Molecular Recognition, 12, 363-370.
Huang, X., Cuajungco, M. P., Atwood, C. S., Hartshorn, M. A., Tyndall, J. D. A., Hanson, G. R., … Bush, A. I. (1999). Cu(II) potentiation of Alzheimer Aβ neurotoxicity: Correlation with cell-free hydrogen peroxide production and metal reduction. Journal of Biological Chemistry, 274(52), 37111-37116.