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Pharmacy staff profile

Dr Arlene McDowell

PositionSenior Lecturer
QualificationsMSc PhD
Research summaryVeterinary pharmaceutics and delivery of bioactives

Research

  • Drug delivery for veterinary species and the application of pharmaceutical formulation for wildlife applications
  • Assessment and formulation of antioxidant phytochemicals

Current projects:

  • Polymeric nanoparticles for delivery of peptides and proteins
  • Oral delivery of biocontrol agents to the brushtail possum
  • In vivo evaluation of formulations
  • Delivery of anesthetics to laboratory animals
  • Pre-formulation of antioxidant phytochemicals

McDowell Lab Group website

Publications

Rooney, J. S., McDowell, A., Strachan, C. J., & Gordon, K. C. (2015). Evaluation of vibrational spectroscopic methods to identify and quantify multiple adulterants in herbal medicines. Talanta, 138, 77-85. doi: 10.1016/j.talanta.2015.02.016

Chiu, J. Z. S., Tucker, I. G., McLeod, B. J., & McDowell, A. (2015). Arginine-tagging of polymeric nanoparticles via histidine to improve cellular uptake. European Journal of Pharmaceutics & Biopharmaceutics, 89, 48-55. doi: 10.1016/j.ejpb.2014.11.014

Ou, Z.-Q., Schmierer, D. M., Rades, T., Larsen, L., & McDowell, A. (2013). Application of an online post-column derivatization HPLC-DPPH assay to detect compounds responsible for antioxidant activity in Sonchus oleraceus L. leaf extracts. Journal of Pharmacy & Pharmacology, 65(2), 271-279. doi: 10.1111/j.2042-7158.2012.01591.x

Kafka, A. P., McLeod, B. J., Rades, T., & McDowell, A. (2011). Release and bioactivity of PACA nanoparticles containing D-Lys6-GnRH for brushtail possum fertility control. Journal of Controlled Release, 149(3), 307-313. doi: 10.1016/j.jconrel.2010.10.029

McDowell, A., Assink, L., Musgrave, R., Soper, H., Norris, P., & Williams, C. (2011). Comparison of prescribing and dispensing processes between veterinarians and pharmacists in New Zealand: Are there opportunities for cooperation? Pharmacy Practice, 9(1), 23-30.

Chapter in Book - Research

McDowell, A. (2013). Delivery systems for wildlife. In M. J. Rathbone & A. McDowell (Eds.), Long acting animal health drug products: Fundamentals and applications. (pp. 345-357). New York: Springer. doi: 10.1007/978-1-4614-4439-8_15

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Journal - Research Article

Chiu, J. Z. S., Tucker, I. G., McLeod, B. J., & McDowell, A. (2015). Arginine-tagging of polymeric nanoparticles via histidine to improve cellular uptake. European Journal of Pharmaceutics & Biopharmaceutics, 89, 48-55. doi: 10.1016/j.ejpb.2014.11.014

Rooney, J. S., McDowell, A., Strachan, C. J., & Gordon, K. C. (2015). Evaluation of vibrational spectroscopic methods to identify and quantify multiple adulterants in herbal medicines. Talanta, 138, 77-85. doi: 10.1016/j.talanta.2015.02.016

McDowell, A., Fothergill, J. A., Khan, A., & Medlicott, N. J. (2014). A cyclodextrin formulation to improve use of the anesthetic tribromoethanol (Avertin®). Journal of Pharmacy & BioAllied Sciences, 6(1), 16-21. doi: 10.4103/0975-7406.124303

Ou, Z.-Q., Schmierer, D. M., Strachan, C. J., Rades, T., & McDowell, A. (2014). Influence of postharvest processing and storage conditions on key antioxidants in pūhā (Sonchus oleraceus L.). Journal of Pharmacy & Pharmacology, 66, 998-1008. doi: 10.1111/jphp.12220

Ou, Z.-Q., Schmierer, D. M., Rades, T., Larsen, L., & McDowell, A. (2013). Application of an online post-column derivatization HPLC-DPPH assay to detect compounds responsible for antioxidant activity in Sonchus oleraceus L. leaf extracts. Journal of Pharmacy & Pharmacology, 65(2), 271-279. doi: 10.1111/j.2042-7158.2012.01591.x

Krittaphol, W., Wescombe, P. A., Thomson, C. D., McDowell, A., Tagg, J. R., & Fawcett, J. P. (2011). Metabolism of L-selenomethionine and selenite by probiotic bacteria: In vitro and in vivo studies. Biological Trace Element Research, 144, 1358-1369. doi: 10.1007/s12011-011-9057-2

Kafka, A. P., Kleffmann, T., Rades, T., & McDowell, A. (2011). The application of MALDI TOF MS in biopharmaceutical research. International Journal of Pharmaceutics, 417(1-2), 70-82. doi: 10.1016/j.ijpharm.2010.12.010

Kafka, A. P., McLeod, B. J., Rades, T., & McDowell, A. (2011). Release and bioactivity of PACA nanoparticles containing D-Lys6-GnRH for brushtail possum fertility control. Journal of Controlled Release, 149(3), 307-313. doi: 10.1016/j.jconrel.2010.10.029

McDowell, A., Assink, L., Musgrave, R., Soper, H., Norris, P., & Williams, C. (2011). Comparison of prescribing and dispensing processes between veterinarians and pharmacists in New Zealand: Are there opportunities for cooperation? Pharmacy Practice, 9(1), 23-30.

McDowell, A., Thompson, S., Stark, M., Ou, Z.-Q., & Gould, K. S. (2011). Antioxidant activity of puha (Sonchus oleraceus L.) as assessed by the cellular antioxidant activity (CAA) assay. Phytotherapy Research, 25(12), 1876-1882. doi: 10.1002/ptr.3648

Kafka, A. P., Kleffmann, T., Rades, T., & McDowell, A. (2010). Characterization of peptide polymer interactions in poly(alkylcyanoacrylate) nanoparticles: A mass spectrometric approach. Current Drug Delivery, 7(3), 208-215.

Kafka, A. P., Rades, T., & McDowell, A. (2010). Rapid and specific high-performance liquid chromatography for the in vitro quantification of D-Lys6-GnRH in a microemulsion-type formulation in the presence of peptide oxidation products. Biomedical Chromatography, 24(2), 132-139. doi: 10.1002/bmc.1261

Krittaphol, W., McDowell, A., Thomson, C. D., Tucker, I. G., Fawcett, J. P., & Mikov, M. (2009). An improved HPLC method for the investigation of L-selenomethionine metabolism in rat gut contents. Biomedical Chromatography, 23, 1169-1174. doi: 10.1002/bmc.1239

Graf, A., McDowell, A., & Rades, T. (2009). Poly(alkycyanoacrylate) nanoparticles for enhanced delivery of therapeutics: Is there real potential? Expert Opinion on Drug Delivery, 6(4), 371-387. doi: 10.1517/17425240902870413

McDowell, A., McLeod, B. J., Rades, T., & Tucker, I. G. (2009). Polymeric nanoparticles as an oral delivery system for biocontrol agents for the brushtail possum (Trichosurus vulpecula). New Zealand Veterinary Journal, 57(6), 370-377.

Kafka, A. P., Kleffmann, T., Rades, T., & McDowell, A. (2009). Histidine residues in the peptide D-Lys6-GnRH: Potential for copolymerization in polymeric nanoparticles. Molecular Pharmaceutics, 6(5), 1483-1491. doi: 10.1021/mp900043e

McDowell, A., McLeod, B. J., Rades, T., & Tucker, I. G. (2006). Application of pharmaceutical drug delivery for biological control of the common brushtail possum in New Zealand: A review. Wildlife Research, 33, 679-689.

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Journal - Research Other

McDowell, A., & McLeod, B. J. (2007). Physiology and pharmacology of the brushtail possum gastrointestinal tract: Relationship to the human gastrointestinal tract. Advanced Drug Delivery Reviews, 59, 1121-1132.

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