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Professor Cliff Abraham

Cliff Abraham

Co-Director, Brain Research NZ - Ranghau Roro Aotearoa

Email cabraham@psy.otago.ac.nz
Tel 64 3 479 7648

Professor Cliff Abraham has research interests in the neural mechanisms of memory. He has played a leading role in promoting neuroscience research and teaching at the University of Otago, and has promoted neuroscience at a national level by serving as chair of the Australasian Winter Conference on Brain Research, New Zealand’s annual neuroscience meeting in Queenstown, for 12 years.

In 1997 he was elected as a Fellow of the Royal Society of New Zealand, and in 2007 was awarded a James Cook Fellowship. Currently he is Co-Director of Brain Research NZ - Ranghau Roro Aotearoa, and is Director of a major HRC-funded research programme investigating biomarkers and therapeutic agents for Alzheimer’s Disease.

Cliff received a BA with Distinction in Psychology from the University of Virginia, and a PhD in Neuroscience from the University of Florida. He then undertook five years of postdoctoral research at the University of Otago and the University of Gothenburg, Sweden, before taking up a Lectureship in Psychology at Otago. He chaired the Department in 2003-2005, and was awarded the University of Otago Distinguished Research Medal in 2009.

Teaching

PSYC 474 Nervous System Plasticity

Research Interests

  • Mechanisms of synaptic plasticity and metaplasticity
  • Alzheimer’s disease
  • Limbic system function and dysfunction

Find out more about Professor Abraham's research

Downloadable list of publications

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Publications

Abraham, W. C. (2008). Metaplasticity: Tuning synapses and networks for plasticity. Nature Reviews Neuroscience, 9(5), 387-399.

Hulme, S. R., Jones, O. D., & Abraham, W. C. (2013). Emerging roles of metaplasticity in behaviour and disease. Trends in Neurosciences, 36(6), 353-362. doi: 10.1016/j.tins.2013.03.007

Mockett, B. G., Guévremont, D., Wutte, M., Hulme, S. R., Williams, J. M., & Abraham, W. C. (2011). Calcium/calmodulin-dependent protein kinase II mediates Group I metabotropic glutamate receptor-dependent protein synthesis and long-term depression in rat hippocampus. Journal of Neuroscience, 31(20), 7380-7391. doi: 10.1523/JNEUROSCI.6656-10.2011

Mockett, B. G., Guévremont, D., Williams, J. M., & Abraham, W. C. (2007). Dopamine D1/D5 receptor activation reverses NMDA receptor-dependent long-term depression in rat hippocampus. Journal of Neuroscience, 27(11), 2918-2926. doi: 10.1523/JNEUROSCI.0838-06.2007

Williams, J. M., Guévremont, D., Mason-Parker, S. E., Luxmanan, C., Tate, W. P., & Abraham, W. C. (2007). Differential trafficking of AMPA and NMDA receptors during long-term potentiation in awake adult animals. Journal of Neuroscience, 27(51), 14171-14178.

Journal - Research Article

Eckert, M. J., Guévremont, D., Williams, J. M., & Abraham, W. C. (2013). Rapid visual stimulation increases extrasynaptic glutamate receptor expression but not visual-evoked potentials in the adult rat primary visual cortex. European Journal of Neuroscience, 37(3), 400-406. doi: 10.1111/ejn.12053

Hulme, S. R., Jones, O. D., & Abraham, W. C. (2013). Emerging roles of metaplasticity in behaviour and disease. Trends in Neurosciences, 36(6), 353-362. doi: 10.1016/j.tins.2013.03.007

Bowden, J. B., Abraham, W. C., & Harris, K. M. (2012). Differential effects of strain, circadian cycle, and stimulation pattern on LTP and concurrent LTD in the dentate gyrus of freely moving rats. Hippocampus, 22(6), 1363-1370. doi: 10.1002/hipo.20972

Baratchi, S., Evans, J., Tate, W. P., Abraham, W. C., & Connor, B. (2012). Secreted amyloid precursor proteins promote proliferation and glial differentiation of adult hippocampal neural progenitor cells. Hippocampus, 22(7), 1517-1527. doi: 10.1002/hipo.20988

Ryan, M. M., Ryan, B., Kyrke-Smith, M., Logan, B., Tate, W. P., Abraham, W. C., & Williams, J. M. (2012). Temporal profiling of gene networks associated with the late phase of long-term potentiation in vivo. PLoS ONE, 7(7), e40538. doi: 10.1371/journal.pone.0040538

Kameda, M., Taylor, C. J., Walker, T. L., Black, D. M., Abraham, W. C., & Bartlett, P. F. (2012). Activation of latent precursors in the hippocampus is dependent on long-term potentiation. Translational Psychiatry, 2, e72. doi: 10.1038/tp.2011.70

Ryan, M. M., Mason-Parker, S. E., Tate, W. P., Abraham, W. C., & Williams, J. M. (2011). Rapidly induced gene networks following induction of long-term potentiation at perforant path synapses in vivo. Hippocampus, 21(5), 541-553. doi: 10.1002/hipo.20770

Mockett, B. G., Guévremont, D., Wutte, M., Hulme, S. R., Williams, J. M., & Abraham, W. C. (2011). Calcium/calmodulin-dependent protein kinase II mediates Group I metabotropic glutamate receptor-dependent protein synthesis and long-term depression in rat hippocampus. Journal of Neuroscience, 31(20), 7380-7391. doi: 10.1523/JNEUROSCI.6656-10.2011

Eckert, M. J., Bilkey, D. K., & Abraham, W. C. (2010). Altered plasticity in hippocampal CA1, but not dentate gyrus, following long-term environmental enrichment. Journal of Neurophysiology, 103(6), 3320-3329. doi: 10.1152/jn.01037.2009

Eckert, M. J., & Abraham, W. C. (2010). Physiological effects of enriched environment exposure and LTP induction in the hippocampus in vivo do not transfer faithfully to in vitro slices. Learning & Memory, 17(10), 480-484. doi: 10.1101/lm.1822610

Tenorio, G., Connor, S. A., Guévremont, D., Abraham, W. C., Williams, J., O'Dell, T. J., & Nguyen, P. V. (2010). 'Silent' priming of translation-dependent LTP by β-adrenergic receptors involves phosphorylation and recruitment of AMPA receptors. Learning & Memory, 17(12), 627-638. doi: 10.1101/lm.1974510

Kennard, J. T. T., Guévremont, D., Mason-Parker, S. E., Abraham, W. C., & Williams, J. M. (2009). Increased expression, but not postsynaptic localisation, of ionotropic glutamate receptors during the late-phase of long-term potentiation in the dentate gyrus in vivo. Neuropharmacology, 56(1), 66-72. doi: 10.1016/j.neuropharm.2008.07.044

Ireland, D. R., & Abraham, W. C. (2009). Mechanisms of group I mGluR-dependent long-term depression of NMDA receptor-mediated transmission at Schaffer collateral-CA1 synapses. Journal of Neurophysiology, 101(3), 1375-1385. doi: 10.1152/jn.90643.2008

Sajikumar, S., Li, Q., Abraham, W. C., & Xiao, Z. C. (2009). Priming of short-term potentiation and synaptic tagging/capture mechanisms by ryanodine receptor activation in rat hippocampal CA1. Learning & Memory, 16(3), 178-186. doi: 10.1101/lm.1255909

Abraham, W. C., & Williams, J. M. (2008). LTP maintenance and its protein synthesis-dependence. Neurobiology of Learning & Memory, 89(3), 260-268. doi: 10.1016/j.nlm.2007.10.001

Abraham, W. C. (2008). Metaplasticity: Tuning synapses and networks for plasticity. Nature Reviews Neuroscience, 9(5), 387-399.

Taylor, C. J., Ireland, D. R., Ballagh, I., Bourne, K., Marechal, N. M., Turner, P. R., Bilkey, D. K., Tate, W. P., & Abraham, W. C. (2008). Endogenous secreted amyloid precursor protein-α regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory. Neurobiology of Disease, 31(2), 250-260. doi: 10.1016/j.nbd.2008.04.011

Mockett, B. G., Guévremont, D., Williams, J. M., & Abraham, W. C. (2007). Dopamine D1/D5 receptor activation reverses NMDA receptor-dependent long-term depression in rat hippocampus. Journal of Neuroscience, 27(11), 2918-2926. doi: 10.1523/JNEUROSCI.0838-06.2007

Williams, J. M., Guévremont, D., Mason-Parker, S. E., Luxmanan, C., Tate, W. P., & Abraham, W. C. (2007). Differential trafficking of AMPA and NMDA receptors during long-term potentiation in awake adult animals. Journal of Neuroscience, 27(51), 14171-14178.

Mellentin, C., Jahnsen, H., & Abraham, W. C. (2007). Priming of long-term potentiation mediated by ryanodine receptor activation in rat hippocampal slices. Neuropharmacology, 52, 118-125.

Benuskova, L., & Abraham, W. C. (2007). STDP rule endowed with the BCM sliding threshold accounts for hippocampal heterosynaptic plasticity. Journal of Computational Neuroscience, 22(2), 129-133. doi: 10.1007/s10827-006-0002-x

Abraham, W. C., Logan, B., Wolff, A., & Benuskova, L. (2007). ″Heterosynaptic″ LTD in the dentate gyrus of anesthetized rat requires homosynaptic activity. Journal of Neurophysiology, 98(2), 1048-1051. doi: 10.1152/jn.00250.2007

Irvine, G. I., Logan, B., Eckert, M., & Abraham, W. C. (2006). Enriched environment exposure regulates excitability, synaptic transmission, and LTP in the dentate gyrus of freely moving rats. Hippocampus, 16(2), 149-160. doi: 10.1002/hipo.20142

Abraham, W. C. (2006). Memory Maintenance: The changing nature of neural mechanisms. Current Directions in Psychological Science, 15(1), 5-8.

Abraham, W. C., Mason-Parker, S. E., Irvine, G. I., Logan, B., & Gill, A. I. (2006). Induction and activity-dependent reversal of persistent LTP and LTD in lateral perforant path synapses in vivo. Neurobiology of Learning & Memory, 86, 82-90.

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