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Our publications

Dr Andrea Vernall

  • Vernall A. J, Hill S. J, Kellam B.; 2013; The Evolving Small-Molecule Fluorescent-Conjugate Toolbox for Class A GPCRs; Br. J. Pharmacol., June, DOI: 10.1111/bph.12265.
  • Vernall A. J, Stoddart L. A, Briddon S. J, Ng H. W, Laughton C. A, Doughty S. W, Hill S. J, Kellam B; 2013; Conversion of a non-selective adenosine receptor antagonist into A3-selective high affinity fluorescent probes using peptide-based linkers; Org. Biomol. Chem., 11, 5673-5682.
  • Stoddart, L.A.; Vernall, A.J; Denman, J; Briddon, S. J.; Kellam, B.; Hill, S. J.; 2012; Fragment screening at adenosine-A3 receptors in living cells using a fluorescence-based binding assay; Chem. Biol., 19, 1105-1115.
  • Vernall, A.J; Stoddart, L.A.; Briddon, S. J.; Hill, S. J.; Kellam, B.; 2012; Highly potent and selective fluorescent antagonists of the human adenosine A3 receptor based on the 1,2,4-triazolo[4,3-a]quinoxalin-1-one scaffold; J. Med. Chem., 55, 1771-1782.
  • Vernall, A. J; Cassidy, P; Alewood, P. F; 2009; A single alpha-helical turn stabilized by replacement of an internal hydrogen bond with a covalent ethylene bridge; Angew. Chem. Int. Edit., 48, 5675-5678.
  • Vernall, A. J; Ballet, S; Abell, A. D; 2008; Cross-metathesis and ring-closing metathesis reactions of amino acid-based substrates; Tetrahedron, 64, 3980-3997.
  • Vernall, A. J; Abell, A. D; 2004; Cross-metathesis coupling of sugars and fatty acids to lysine and cysteine; Org. Biomol. Chem., 2, 2555-2557.
  • Vernall, A. J; Abell, A. D; 2003; Cross-metathesis of Nitrogen-containing Compounds; Aldrichimica Acta, 36, 93-105.
  • Martyn, D. C; Vernall, A. J; Clark, B. M; Abell, A. D; 2003; Ring-deactivated hydroxyalkylpyrrole-based inhibitors of alpha-chymotrypsin: synthesis and mechanism of action; Org. Biomol. Chem.,1, 2103-2110.

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Dr Allan Gamble

  • Matikonda, S. S.; Orsi, D. L.; Staudacher, V.; Jenkins, I. A.; Fiedler, F.; Chen, J.; Gamble, A. B. Bioorthogonal prodrug activation driven by a 1,3-dipolar cycloaddition. Chem. Sci. 2015, 6, 1212-1218. 
  • Spencer, E. S.; Dale, E. J.; Gommans, A. L.; Rutledge, M. T.; Vo, C. T.; Nakatani, Y.; Gamble, A. B.; Smith, R. A. J; Wilbanks, S. M.; Hampton, M. B. Tyndall, J. D. A. Multiple binding modes of isothiocyanates that inhibit macrophage migration inhibitory factor. Eur. J. Med. Chem. 2015, 93, 501-510
  • Morris, K. M.; Cao, F.; Onagi, H.; Altamore, T. M.; Gamble, A. B.; Easton, C. J. Prohormone-substrate peptide sequence recognition by peptidylglycine alpa-amidating monooxygenase and its reflection in increased glycolate inhibitor potency. Bioorg. Med. Chem. Lett. 2012, 22, 7015-7018.
  • Cao, F.; Gamble, A. B.; Kim, H-K; Onagi, H.; Gresser, M. J.; Kerr, J.; Easton, C. J. Potent and Selective Inhibitors of Human Peptidylglycine -Amidating Monooxygenase. Med. Chem. Commun. 2011, 2, 760-763.
  • Gamble. A. B.; Keller, P. A. Synthesis of Reaction Ready 6,6’-Biindole and 6,6’-Biisatin via Palladium(II)-Catalysed Intramolecular C-H Functionalisation. Chem. Commun. 2010, 46, 4076-4078.
  • Locke, J. M.; Stutchbury, T. K.; Vine, K. L.; Spalding, B.; Gamble, A. B.; Clingan, P. R.; Bremner, J. B.; Ranson, M. Development and assessment of novel all-in-one parenteral formulations with integrated anticoagulant properties for the concomitant delivery of 5-fluorouracil and calcium folinate, Anti-Cancer Drugs 2009, 20, 822-831.
  • Gamble, A. B.; Garner, J.; Gordon, C. P.; O’Conner, S. M. J.; Keller, P. A. Aryl nitro reduction with iron powder or stannous chloride under ultrasonic irradiation. Synth. Comm. 2007, 37, 2777-2786.

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Dr Joel Tyndall

  • Marsh, J. W., Wee, B. Tyndall J.D.A., Lott, W.B., Bastidas, R.J., Caldwell, H.D., Valdivia, R.H., Kari, L., Huston, W.M. Chlamydia trachomatis strain with a chemically generated amino acid substitution (P370L) in the cthtrA gene shows reduced elementary body production BMC Microbiology 2015 Sep 30;15(1):194
  • Kim J.S., Brownjohn P.W., Dyer B.S., Beltramo, M., Walker, C. S., Hay, D. L., Painter G.F., Tyndall J.D.A., Anderson G.M., Anxiogenic and Stressor Effects of the Hypothalamic Neuropeptide RFRP-3 are Overcome by Novel Antagonist Endocrinology, 2015, Nov;156(11):4152-62
  • Hellyer, S.D., Selwood, A.I., Tyndall, J.D.A., Rhodes, L., Kerr, D.S. Pinnatoxins E, F and G bind to multiple nicotinic receptor subtypes in mammalian tissue homogenates J Neurochem 2015 Jul 14. doi: 10.1111/jnc.13245
  • Sagatova, A., Keniya, M.V. Wilson, R., Monk, B.C., Tyndall, J.D.A., Structure of the Saccharomyces cerevisiae lanosterol 14α-demethylase complexed with fluconazole Antimicrob Agents Chemother, 2015, Aug;59(8):4982-9.
  • Spencer, E., Dale, E.J. Gommans, A.L., Rutledge, M., Vo, C.T., Nakatani, Y., Gamble, A.G., Smith, R.A.J., Hampton M.B. Wilbanks, S.M., Tyndall, J.D.A., Multiple binding modes of isothiocyanates that inhibit macrophage migration inhibitory factor, Eur J Med Chem 2015, Mar 15: 93 501-510
  • Dickerhof, N., Magon, N.J., Tyndall, J.D.A., Kettle, A.J., Hampton, M.B. Covalent modification of macrophage migration inhibitory factor (MIF) by oxidized (-)-epicatechins. Biochem J, 2014, Sep 1;462(2):303-14. doi: 10.1042/BJ20140612.
  • Monk,B.C., Tomasiak, T.M., Keniya, M.V., Huschmann, F., Tyndall, J.D.A., O'Connell III, J.D., Cannon, R.D., Finer-more, J., Stroud, R.M. Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer. PNAS, 2014 Mar 11;111(10):3865-70. doi: 10.1073/pnas.1324245111. Epub 2014 Feb 3.
  • Awasthi, A., Woolley, A., Lecomte, F., Hung, N., Baguley, B., Wilbanks, S.M., Jeffs, A., Tyndall, J.D.A., Variable expression of GLIPR1 correlates with invasive potential in melanoma cells Front. Oncol. 2013 3:225. doi: 10.3389/fonc.2013.00225
  • Marsh, J., Lott, W. B., Tyndall, J.D.A., Huston, W.M. Activation of Chlamydia trachomatis HtrA involves residue interactions  between PDZ1 domain and protease domain loops L3, LC, and beta strand β5 Cell Mol Biol Lett, 2013, 18, (DOI) 10.2478/s11658-013-0103-2
  • Rawal, M.K., Khan, M.F., Kapoor, K., Goyal, N., Sen, S., Saxena, A., Lynn, A.M., Tyndall, J.D.A., Monk, B.C., Cannon, R.D. Komath, S.S., Prasad, R. Insight into PDR ABC pump drug transport through mutagenesis of Cdr1p transmembrane domains, J Biol Chem2013Aug 23; 288(34)24480-93, doi: 10.1074/jbc.M113.488353
  • Gloeckl, S., Ong, V., Patel, P., Tyndall, J.D.A., Timms, P., Turnbull, L., Whitchurch, C., Merdanovic, M., Ehrmann, M., Verdoes, M., Bogyo, M., Huston, W.M, Identification of a serine protease inhibitor which causes inclusion vacuole reduction and is lethal to Chlamydia trachomatis Mol Microbiol. 2013 Aug;89(4):676-89. doi: 10.1111/mmi.12306.
  • Vellas, S. K., Lewis, J.E.M., Shankar, M., Sagatova, A., Tyndall, J.D.A., Monk, B.C., Fitchett, C. M., Hanton, L.R., Crowley, J.D., Fe2L3 Cylinders Derived from Bis(bidentate) 2-Pyridyl-1,2,3-triazole "Click" Ligands: Synthesis, Structures and Exploration of Biological Activity Molecules 2013 18(6), 6383-6407; doi:10.3390/molecules18066383
  • Shankar, M., Wilbanks, S.M., Nakatani, Y., Monk,B.C., Tyndall, J.D.A. Catalysis product captured in lumazine synthase from the fungal pathogen Candida glabrata, Acta Crystallogr D69,2013, 1580–1586pdb 4KQ6
  • Keniya, M.V., Cannon, R.D., Nguyễn, A., Tyndall, J.D.A., Monk,B.C. Heterologous expression of Candida albicans Pma1p in Saccharomyces cerevisiae, FEMS Yeast Res 2013 May;13(3):302-11, doi: 10.1111/1567-1364.12035.
  • Tyndall, J.D.A., Lue, H., Rutledge, M., Bernhagen, J., Hampton M. B. Wilbanks, S.M., Macrophage Migration Inhibitory Factor covalently complexed with phenethyl isothiocyanate, Acta Crystallogr F. 2012 68: 999-1002; pdb4F2K
  • Niimi, K., Harding, D.R.K., Holmes, A.R., Lamping, E., Niimi, M., Tyndall, J.D.A., Cannon, R.D., Monk,B.C., Candida albicans ABC transporter Cdr1p ectodomain and a D-octapeptide derivative inhibitor Mol Microbiol Aug;85(4):747-67. doi: 10.1111/j.1365-2958.2012.08140.x.
  • Gloeckl, S., Tyndall, J.D.A., Timms, P., Huston, W.M., The active site residue V266 of chlamydial HtrA is critical for substrate binding during both in vitro and in vivo conditions. J Mol Microbiol Biotechnol 2012;22:10-16 (DOI: 10.1159/000336312)
  • Beggs, K.T., Tyndall, J.D.A, Mercer, A.R., Honey Bee Dopamine and Octopamine Receptors linked to Intracellular Calcium Signaling have a Close Phylogenetic and Pharmacological Relationship PLoS ONE 2011 6(11): e26809. doi:10.1371/journal.pone.0026809
  • Matthews, H., Ranson, M., Tyndall, J.D.A., Kelso, M.J., Synthesis and Preliminary Evaluation of Amiloride Analogs as Inhibitors of the Urokinase-Type Plasminogen Activator (uPA) Bioorg Med Chem Lett 2011, 6760–6766.
  • Huston, W.M., Tyndall, J.D.A., Stansfield, S., Timms, P., Unique residues involved in activation of the multitasking protease/chaperone HtrA from Chlamydia trachomatis PLoS ONE 2011, 6(9), e24547.
  • Suetani, R.J., Sorrenson, B., Tyndall, J.D.A., Williams, M.J.A., McCormick, S.P.A, Homology modeling and functional testing of an ABCA1 mutation causing Tangier Disease. Atherosclerosis 2011, Oct;218(2):404-10.
  • Nisa, S., Blokpoel, M.C.J., Robertson, B.D., Tyndall, J.D.A., Lun, S. Bishai, W.R., O'Toole, R. Targeting the cell division protein ParA in tuberculosis drug discovery J Antimicrob Chemother 2010 Nov;65(11):2347-58.
  • Sawant, P.M., Tyndall, J.D.A., Holland, P.T., Peake, B.M., Mountfort, D.O., Kerr, D.S. In vivo seizure induction and affinity studies of domoic acid and isodomoic acids D, E and F. Neuropharmacol, 2010 59, 129-138.
  • Loughlin, W., Tyndall, J.D.A., Glenn, M.P., Hill, T.A., Fairlie, D.P., Update 1 of: Beta strand mimetics, Chem Rev.; 2010, 110(6),PR32-PR69
  • Madala, P. Tyndall, J.D.A., Nall, T., Fairlie, D.P Update 1 of: Proteases Universally Recognize Beta Strands in their active sites Chem Rev 2010, 110(6), PR1-PR31
  • Ruiz-Gómez, G., Tyndall, J.D.A., Pfeiffer, B., Abbenante, G., Fairlie, D.P., Update 1 of: Over 100 Peptide-Activated G Protein-Coupled Receptors Recognize Ligands With Turn Structure, Chem Rev 2010, 110(4): PR1-PR41
  • Brown, K.K., Blaikie, F.H., Smith, R.A.J., Tyndall, J.D.A., Lue, H., Bernhagen, J., Winterbourn, C.C., Hampton, M.B. Direct Modification of the Pro-Inflammatory Cytokine MIF by Dietary Isothiocyanates J Biol Chem  2009 284(47), 32425-32433
  • Westphal, D., Ledgerwood, E.C., Tyndall, J.D.A., Ueda, N., Fleming, S.B., Mercer, A.A., Orf virus protein ORFV125 inhibits a subset of BH3-only proteins, and also binds and neutralizes active Bax. Apoptosis, 2009 14(11); 1317–1330
  • Fry, B.G., Roelants, K., Champagne, D.E., Scheib, H., Tyndall, J.D.A., King, G.F., Nevalainen, T.J., Norman, J.A., Lewis, R.J., Norton, R.S., Renjifo, C., Rodríguez de la Vega, R.C., The toxicogenomic multiverse: convergent recruitment of proteins into animal venoms Annu. Rev. Genomics Hum. Genet, 2009, 10: 483-511
  • Lamping, E., Ranchod, A., Nakamura, K., Tyndall, J.D., Niimi, K., Holmes, A.R., Niimi, M., Cannon, R.D., ABC1p is a multidrug efflux transporter that tips the balance in favour of innate azole resistance in Candida krusei. Antimicrob Agents Chemother 2009 Feb;53(2):354-69
  • Ashton, J.C., Wright, J.L., McPartland, J.M., Tyndall, J.D.A. Cannabinoid CB1 and CB2 receptor ligand specificity and the development of CB2-selective agonists Curr Med Chem, 2008, 15(14):1428-43.
  • Tyndall, J.D.A., Pattenden, L.K., Reid, R.C., Hu, S-H., Alewood, D., Alewood, P.F., Walsh, T., Fairlie, D.P., Martin, J.L. Crystal Structures Of Highly Constrained Substrate And Hydrolysis Products Bound To HIV-1 Protease. Implications For Catalytic Mechanism Biochemistry, 2008, 47, 3736-3744.
  • Tyndall, J.D.A., Kelso, M.J., Clingan, P., Ranson, M. Peptides and Small Molecules Targeting the Plasminogen Activation System: Towards Prophylactic Anti-Metastasis Drugs for Breast Cancer, Recent Patents Anticancer Drug Discov. 2008 Jan;3(1):1-13.
  • Gee, C.L., Drinkwater, N., Tyndall, J.D.A., Grunewald, G.L., Wu, Q., Mcleish, M.J., Martin, J.L., Enzyme adaptation to inhibitor binding: a cryptic binding site in phenylethanolamine N-methyltransferase, J Med Chem, 2007¸ 50, 4845-483
  • Pearl, E.J., Tyndall, J.D.A., Poulter, R.T., Wilbanks, S.M., Sequence requirements for splicing by the Cne PRP8 intein, FEBS lett, 2007, 581 (16), 3000-3004
  • Kahnberg, P., Lucke, A.J. Glenn, M.P., Boyle, G.M., Tyndall, J.D.A., Parsons, P.G., Fairlie, D.P., Design, Synthesis, Potency and Cytoselectivity Of Anticancer Agents Derived By Parallel Synthesis From a-Aminosuberic Acid, J Med Chem, 2006,49, 7611-7622.
  • Tyndall, J.D.A., Sandilya, R. GPCR Agonists and Antagonists in the Clinic, Med Chem 2005, 1(4), 405-421
  • Sobhani, A.M., Amini, S.R., Tyndall, J.D.A., Azizi, E., Daneshtalb, M., Khalaj, A., A Theory of Mode of Action of Azolylalkylquinolines as DNA Binding Agents Using Automated Flexible Ligand Docking, J Mol Graph Model, 2006, 25(4), 459-69.
  • Gee, C.L., Tyndall, J.D.A., Grunewald, G.L., Wu, Q., Mcleish, M.J., Martin, J.L., Binding mode of methyl acceptor substrates to the adrenaline-synthesising enzyme PNMT: implications for catalysis, Biochemistry, 2005 44(51), 16875-16885.
  • Wu, Q., Gee, C.L., Lin, F, Tyndall, J.D.A., Martin, J.L., Grunewald, G.L., Mcleish, M.J., Structural, Mutagenic and Kinetioc Analysis of the Binding of Substrates and Inhibitors of Human Phenylethanloamine N-Methyltransferase, J Med Chem, 2005 48, 7242-7252.
  • Gee, C.L., Nourse, A., Hsin, A-Y., Wu, Q., Tyndall, J.D.A., Grunewald, G.L., Mcleish, M.J., Martin, J.L., Disulphide-linkedDimers of Human Adrenaline Synthesizing Enzyme PNMT are Catalytically Active Biochimica et Biophysica Acta Proteins and Proteomics 2005, 1750, 82-92.
  • Tyndall, J.D.A., Nall, T., Fairlie, D.P Proteases Universally Recognize Beta Strands in their active sites  Chem Rev 2005,105(3), 973-1000.
  • Tyndall, J.D.A., Pfeiffer, B., Abbenante, G., Fairlie, D.P., Over 100 Peptide-Activated G Protein-Coupled Receptors Recognize Ligands With Turn Structure, Chem Rev 2005,105(3), 793-826.
  • Loughlin, W., Tyndall, J.D.A., Glenn, M.P., Fairlie, D.P., Beta strand mimetics, Chem Rev.; 2004; Dec;104(12):6085-117
  • Higginbottom A., Cain S.A., Woodruff T.M., Proctor L.M., Madala P.K., Tyndall J.D.A., Taylor S.M., Fairlie D.P., Monk P.N., Comparative agonist/antagonist responses in mutant human C5a receptors define the ligand binding site J Biol Chem, 2005 May 6;280(18):17831-40. Jan 20;
  • Chappell, K. J., Nall, T. A., Stoermer, M.J., Fang, N-X., Tyndall, J.D.A., Fairlie D.P., Young, P.R., West Nile Virus NS3 Protease : Site-Directed Mutagenesis and Kinetic Studies That Identify Key Enzyme-Substrate Interactions. J Biol Chem, 2005 Jan 28;280(4):2896-903. Epub 2004 Oct 19.
  • van den Brenk, A. L., Tyndall, J.D.A., Cusack, R.M., Jones, J., Fairlie, D.P., Gahan, L.R., Hanson, G.R., Formation of Mononuclear and Chlorobridged Binuclear Copper(II) Complexes of Patellamide D, a Naturally Occurring Cyclic Peptide: Influence of Anion and Solvent J Inorg Biochem, 2004, 98,1857-1866.
  • Nall, T., Chappell, K.J., Stoermer, M.J.,  Ning-Xia Fang, Tyndall, J.D.A.,  Young, P.R., Fairlie, D.P., Enzymatic Characterisation and Homology Model Of A Catalytically Active Recombinant West Nile Virus NS3 Protease. J Biol Chem, 2004 Nov 19;279(47):48535-42.
  • Dutertre, S., Tyndall, J.D.A., Nicke, A., Lewis, R.J., Determination of a-conotoxin binding modes on neuronal nicotinic acetylcholine receptors. J Mol Recognit2004, 17, 339-347
  • Reid, R., Pattenden, L.K., Tyndall, J.D.A., Martin, J.L., Walsh, T., Fairlie, D.P., Countering Cooperative Effects in Protease Inhibitors using Constrained beta Strand-Mimicking templates in Focused Combinatorial Libraries. J Med Chem 2004, 47(7): 1641-51.
  • March, D.R., Proctor, L.M., Stoermer, M.J., Sbaglia, R., Abbenante, G., Reid, R.C., Wadi, K., Tyndall, J.D.A., Taylor, S.M., Fairlie, D.P., Potent Cyclic Antagonists Of The Complement C5a Receptor On Human Polymorphonuclear Leukocytes. Structure-Activity Relationships. Mol Pham 2004, 65, (4) 868-879.
  • Milne, T.J., Abbenante, G., Tyndall, J.D.A., Halliday, J., Lewis, R.J., Isolation and characterization of a cone snail protease with homology to CRISP proteins of the pathogenesis-related protein superfamily. J Biol Chem, 2003, 278(33), p31105-10.
  • Hansford, H.A., Reid, R.C., Clark, C.I., Tyndall, J.D.A., Whitehouse, M.W., Guthrie, T., McGeary, R.P., Schafer, K., Martin, J.L., Fairlie, D.P., D-Tyrosine as a Chiral Precursor to Potent Inhibitors of Human Nonpancreatic Secretory Phospholipase A2 (IIa) with Antiinflammatory Activity. ChemBioChem, 2003, 4(2-3): p. 181-185.
  • Lucke, A.J., Tyndall, J.D.A., Singh, Y., Fairlie, D.P., Designing supramolecular structures from models of cyclic peptide scaffolds with heterocyclic constraints. J Mol Graph Model, 2003. 21(5): p. 341-55
  • Glenn, M.P., Kelso, M.J., Tyndall, J.D.A., and Fairlie, D.P., Conformationally Homogeneous Cyclic Tetrapeptides: Useful Three Dimensional Scaffolds. J Am Chem Soc, 2003. 125: p. 640-41.
  • Tyndall, J.D.A., Sinchaikul, S., Fothergill-Gilmore, L.A., Taylor, P., and Walkinshaw, M.D., Crystal structure of a thermostable lipase from Bacillus stearothermophilus P1. J Mol Biol, 2002. 323(5): p. 859-69.
  • Sinchaikul, S., Tyndall, J.D.A., Fothergill-Gilmore, L.A., Taylor, P., Phutrakul, S., Chen, S.T., and Walkinshaw, M.D., Expression, purification, crystallization and preliminary crystallographic analysis of a thermostable lipase from  Bacillus stearothermophilus P1. Acta Crystallogr D Biol Crystallogr, 2002. 58: p. 182-85.
  • Glenn, M.P., Pattenden, L.K., Reid, R.C., Tyssen, D.P., Tyndall, J.D.A., Birch, C.J., and Fairlie, D.P., Beta-strand mimicking macrocyclic amino acids: templates for protease inhibitors with antiviral activity. J Med Chem, 2002. 45(2): p. 371-81.
  • Tyndall, J.D.A. and Fairlie, D.P., Macrocycles mimic the extended peptide conformation recognized by aspartic, serine, cysteine and metallo proteases. Curr Med Chem, 2001. 8(8): p. 893-907.
  • Tyndall, J.D.A., Reid, R.C., Tyssen, D.P., Jardine, D.K., Todd, B., Passmore, M., March, D.R., Pattenden, L.K., Bergman, D.A., Alewood, D., Hu, S.H., Alewood, P.F., Birch, C.J., Martin, J.L., and Fairlie, D.P., Synthesis, stability, antiviral activity, and protease-bound structures of substrate-mimicking constrained macrocyclic inhibitors of HIV-1 protease. J Med Chem, 2000. 43(19): p. 3495-504.
  • Fairlie, D.P., Tyndall, J.D.A., Reid, R.C., Wong, A.K., Abbenante, G., Scanlon, M.J., March, D.R., Bergman, D.A., Chai, C.L., and Burkett, B.A., Conformational selection of inhibitors and substrates by proteolytic enzymes: implications for drug design and polypeptide processing. J Med Chem, 2000. 43(7): p. 1271-81.
  • Tyndall, J.D.A. and Fairlie, D.P., Conformational homogeneity in molecular recognition by proteolytic enzymes. J Mol Recognit, 1999. 12(6): p. 363-70
  • Huang, X., Cuajungco, M.P., Atwood, C.S., Hartshorn, M.A., Tyndall, J.D.A., Hanson, G.R., Stokes, K.C., Leopold, M., Multhaup, G., Goldstein, L.E., Scarpa, R.C., Saunders, A.J., Lim, J., Moir, R.D., Glabe, C., Bowden, E.F., Masters, C.L., Fairlie, D.P., Tanzi, R.E., and Bush, A.I., Cu(II) potentiation of alzheimer Abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction. J Biol Chem, 1999. 274(52): p. 37111-6.

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