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Dr Thorsten Stanley, Department of Paediatrics and Child Health

photo-of-Tosh-Stanley

MB ChB DCH DObstRCOG FRCP
Senior Lecturer in the Department of Paediatrics

Email: Thorsten.Stanley@otago.ac.nz


Dr Thorsten Stanley completed his undergraduate studies at the University of Edinburgh, Scotland and his paediatric specialty training in Yorkhill and Royal Maternity hospitals, Glasgow with a special interest in immunology before coming to NZ initially as a lecturer and then Senior Lecturer in 1980.

Dr Stanley has clinical and after-hours responsibilities within both general paediatrics and neonatology and his clinics specialise in allergic disease and epilepsy/neurology.
He has been convenor of the DCH diploma CHHX702 course since 1997 and established and convenes the annual regional paediatric update meetings for GPs since 2001. He also has extensive commitments in undergraduate teaching to both 5th and 6th year medical students. He has been actively involved in introducing videoconferencing via the internet using Adobe Connect.

Research Interests

Dr Stanley's research interests have included paediatric infectious disease, neonatology, neurology and neonatal seizures but increasingly over the past decade have tended to focus on paediatric allergy and asthma.
Dr Stanley has been acting Head of the Academic Department from 1995-1997, 2007-2010, and March –July 2011.
Dr Stanley has developed expertise in medical misadventure and regularly advises both ACC and the Medical Council of New Zealand.
He has recently developed a closer clinical and research collaboration with Xiamen, China
Dr Stanley's research has focused on the areas of allergy and infectious disease and he has increasingly been involved in collaborations with the Department of Medicine and in particular WARG (Wellington Asthma Research Group) and Public Health, and valuable collaborations with the Department of Paediatrics at Auckland Medical School, Massey University, Perth, West Australia and University of Kuopio, Finland.
Recent research has looked at the role of probiotics in preventing infant eczema and atopy, Vitamin D in bronchiolitis, dampness and fungal spores in childhood wheeze, gut permeability in eczema, the use of exhaled nitric oxide in assessing asthma control and effectiveness of allergen desensitisation.
HRC grants have been approved to look at the use of probiotics in early pregnancy in preventing premature labour, maternal vaginosis, maternal Group B Streptococcal carriage and infant atopy, and the role of dampness in the home on bronchiolitis severity. Future research pending successful HRC applications include the role of dampness on the viability and infectivity of rhinoviruses in wheezy children; the effect of early food allergen exposure on the development of infant food allergy and eczema; the long term effects of probiotic supplementation on the development of asthma and rhinitis and the potential role of the infrared camera in paediatric research.

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Publications

Wickens, K., Stanley, T. V., Mitchell, E. A., Barthow, C., Fitzharris, P., Purdie, G., Siebers, R., … Crane, J. (2013). Early supplementation with Lactobacillus rhamnosus HN001 reduces eczema prevalence to 6 years: Does it also reduce atopic sensitization? Clinical & Experimental Allergy, 43(9), 1048-1057. doi: 10.1111/cea.12154

Wickens, K., Black, P. N., Stanley, T. V., Mitchell, E., Fitzharris, P., Tannock, G. W., Purdie, G., Crane, J., and the Probiotic Study Group, including Jones, B., Lampshire, P., & Munro, K. (2008). A differential effect of 2 probiotics in the prevention of eczema and atopy: A double-blind, randomized, placebo-controlled trial. Journal of Allergy & Clinical Immunology, 122(4), 788-794. doi: 10.1016/j.jaci.2008.07.011

Prescott, S. L., Wickens, K., Westcott, L., Jung, W., Currie, H., Black, P. N., Stanley, T. V., … Fitzharris, P., Siebers, R., … Crane, J., and the Probiotic Study Group, including Jones, B., Lampshire, P., Nicholson, A., & Purdie, G. (2008). Supplementation with Lactobacillus rhamnosus or Bifidobacterium lactis probiotics in pregnancy increases cord blood interferon-γ and breast milk transforming growth factor-β and immunoglobin A detection. Clinical & Experimental Allergy, 38(10), 1606-1614. doi: 10.1111/j.1365-2222.2008.03061.x

Morgan, A. R., Han, D. Y., Wickens, K., Barthow, C., Mitchell, E. A., Stanley, T. V., Dekker, J., Crane, J., & Ferguson, L. R. (2014). Differential modification of genetic susceptibility to childhood eczema by two probiotics. Clinical & Experimental Allergy, 44(10), 1255-1265. doi: 10.1111/cea.12394

Weckhuysen, S., Mandelstam, S., Suls, A., Audenaert, D., Deconinck, T., Claes, L. R. F., … Stanley, T., … de Jonghe, P. (2012). KCNQ2 encephalopathy: Emerging phenotype of a neonatal epileptic encephalopathy. Annals of Neurology, 71(1), 15-25. doi: 10.1002/ana.22644

Journal - Research Article

Marlow, G., Han, D. Y., Wickens, K., Stanley, T., Crane, J., Mitchell, E. A., … Barthow, C., … Morgan, A. R. (2015). Differential effects of two probiotics on the risks of eczema and atopy associated with single nucleotide polymorphisms to Toll-like receptors. Pediatric Allergy & Immunology, 26(3), 262-271. doi: 10.1111/pai.12371

Grinton, B. E., Heron, S. E., Pelekanos, J. T., Zuberi, S. M., Kivity, S., Afawi, Z., … Stanley, T., … Berkovic, S. F. (2015). Familial neonatal seizures in 36 families: Clinical and genetic features correlate with outcome. Epilepsia, 56(7), 1071-1080. doi: 10.1111/epi.13020

Morgan, A. R., Han, D. Y., Wickens, K., Barthow, C., Mitchell, E. A., Stanley, T. V., Dekker, J., Crane, J., & Ferguson, L. R. (2014). Differential modification of genetic susceptibility to childhood eczema by two probiotics. Clinical & Experimental Allergy, 44(10), 1255-1265. doi: 10.1111/cea.12394

Wickens, K., Stanley, T. V., Mitchell, E. A., Barthow, C., Fitzharris, P., Purdie, G., Siebers, R., … Crane, J. (2013). Early supplementation with Lactobacillus rhamnosus HN001 reduces eczema prevalence to 6 years: Does it also reduce atopic sensitization? Clinical & Experimental Allergy, 43(9), 1048-1057. doi: 10.1111/cea.12154

Weckhuysen, S., Mandelstam, S., Suls, A., Audenaert, D., Deconinck, T., Claes, L. R. F., … Stanley, T., … de Jonghe, P. (2012). KCNQ2 encephalopathy: Emerging phenotype of a neonatal epileptic encephalopathy. Annals of Neurology, 71(1), 15-25. doi: 10.1002/ana.22644

Wickens, K., Black, P., Stanley, T. V., Mitchell, E., Barthow, C., Fitzharris, P., Purdie, G., & Crane, J. (2012). A protective effect of Lactobacillus rhamnosus HN001 against eczema in the first 2 years of life persists to age 4 years. Clinical & Experimental Allergy, 42(7), 1071-1079. doi: 10.1111/j.1365-2222.2012.03975.x

Smith, C., Stanley, T., Crane, J., & Siebers, R. (2011). Do other components of bedding dust affect sensitisation to house dust mites? ISRN Allergy, 2011, 426941. doi: 10.5402/2011/426941

Dekker, J. W., Wickens, K., Black, P. C., Stanley, T. V., Mitchell, E. A., Fitzharris, P., Tannock, G. W., Purdie, G., & Crane, J. (2009). Safety aspects of probiotic bacterial strains Lactobacillus rhamnosus HN001 and Bifidobacterium animalis subsp. lactis HN019 in human infants aged 0-2 years. International Dairy Journal, 19(3), 149-154. doi: 10.1016/j.idairyj.2008.10.004

Wickens, K., Black, P. N., Stanley, T. V., Mitchell, E., Fitzharris, P., Tannock, G. W., Purdie, G., Crane, J., and the Probiotic Study Group, including Jones, B., Lampshire, P., & Munro, K. (2008). A differential effect of 2 probiotics in the prevention of eczema and atopy: A double-blind, randomized, placebo-controlled trial. Journal of Allergy & Clinical Immunology, 122(4), 788-794. doi: 10.1016/j.jaci.2008.07.011

Prescott, S. L., Wickens, K., Westcott, L., Jung, W., Currie, H., Black, P. N., Stanley, T. V., … Fitzharris, P., Siebers, R., … Crane, J., and the Probiotic Study Group, including Jones, B., Lampshire, P., Nicholson, A., & Purdie, G. (2008). Supplementation with Lactobacillus rhamnosus or Bifidobacterium lactis probiotics in pregnancy increases cord blood interferon-γ and breast milk transforming growth factor-β and immunoglobin A detection. Clinical & Experimental Allergy, 38(10), 1606-1614. doi: 10.1111/j.1365-2222.2008.03061.x

Harkin, L. A., McMahon, J. M., Iona, X., Dibbens, L., Pelekanos, J. T., Zuberi, S. M., Sadleir, L. G., … Stanley, T., … The Early Infantile Epileptic Encephalopathy Referral Consortium, … Scheffer, I. E. (2007). The spectrum of SCNIA-related infantile epileptic encephalopathies. Brain, 130, 843-852.

Sistek, D., Kelly, R., Wickens, K., Stanley, T., Fitzharris, P., & Crane, J. (2006). Is the effect of probiotics on atopic dermatitis confined to food sensitized children? Clinical & Experimental Allergy, 36, 629-633.

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Conference Contribution - Published proceedings: Abstract

Weckhuysen, S., Mandelstam, S., Suls, A., Audenaert, D., Deconinck, T., Claes, L., … Stanley, T., … de Jonghe, P. (2011). KCNQ2 mutations are a cause of neonatal epileptic encephalopathies with a recognizable clinical and radiological phenotype. Epilepsia, 52(Suppl. 6), (pp. 17).

Ong, S. H., & Stanley, T. V. (2011). Predicting successful subcutaneous immunotherapy in children: Serial exhaled nitric oxide or combined serial aeroallergen skin prick test responses? Internal Medicine Journal, 41(Suppl. 4), P64, (pp. 19). doi: 10.1111/j.1445-5994.2011.02570.x

Stanley, T., Rickard, D., Dellabarca, K., & Causer, S. (2011). Can preschool children with atopic eczema tolerate superfine merino wool cloth next to their skin? A pilot study. Allergy, 66(Suppl. 94), (pp. 105-106). doi: 10.1111/j.1398-9995.2011.02605.x

Ong, S., & Stanley, T. (2011). Predicting successful subcutaneous immunotherapy in children: Do serial exhaled nitric oxide measurements assist? Allergy, 66(Suppl. 94), (pp. 211). doi: 10.1111/j.1398-9995.2011.02606.x

Barber, R., & Stanley, T. (2011). Management of acute and chronic food allergies in childhood: How do pediatricians, emergency physicians, general practitioners and junior hospital doctors differ in their approach and what is their level of understanding? A New Zealand nationwide email survey. Allergy, 66(Suppl. 94), (pp. 216). doi: 10.1111/j.1398-9995.2011.02606.x

Wickens, K., Fitzharris, P., Stanley, T., Mitchell, E., & Crane, J. (2011). Does delaying the introduction of food in infancy increase the risk of atopic sensitisation? Allergy, 66(Suppl. 94), (pp. 47-48). doi: 10.1111/j.1398-9995.2011.02604.x

Crane, J., Wickens, K., Stanley, T., Mitchell, E., Barthow, C., Fitzharris, P., & Black, P. (2010). Staphylococcal colonisation and atopy. Internal Medicine Journal. 40(Suppl. 4), (pp. 6). doi: 10.1111/j.1445-5994.2010.02322.x

Stanley, T., Rickard, D., Wickens, K., & Villas-Boas, S. (2008). Gut permeability in infantile eczema: Relationship to severity, patch test responses and clinical history. Allergy. 63(Suppl. 88), (pp. 321-322). doi: 10.1111/j.1398-9995.2008.01760.x

Grinton, B., Heron, S., Pelekanos, J., Zuberi, S., Stanley, T., Kivity, S., … Berkovic, S. (2007). Benign familial neonatal seizures: Molecular basis and evidence for a third locus. Epilepsia, 48(Suppl. 7), (pp. 55-56). doi: 10.1111/j.1528-1167.2006.01370_7.x

Jones, B., Wickens, K., Nicholson, A., Malloy, S., Lampshire, P., Stanley, T., … Fitzharris, P., & Crane, J. (2006). Probiotics and the prevention of allergic disease: Treatment compliance at three months. Internal Medicine Journal. 36(Suppl. 6), (pp. A204).

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Conference Contribution - Verbal presentation and other Conference outputs

Jones, B., Wickens, K., Nicholson, A. L., Malloy, S., Lampshire, P., Stanley, T., Ingham, T. R., … Crane, J. (2006, September). Probiotics and the prevention of allergic disease: Treatment compliance at twelve months. Verbal presentation at the 17th Annual Scientific Meeting of the Australasian Society of Clinical Immunology & Allergy (ASCIA), Sydney, Australia.

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