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PRODID:-//University of Otago//Events Calendar//EN
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UID:https://www.otago.ac.nz/news/events/microbiology-seminar-professor-sheemei-lok-dukenus-medical-school-singapore
URL:https://www.otago.ac.nz/news/events/microbiology-seminar-professor-sheemei-lok-dukenus-medical-school-singapore
DTSTART;TZID=Pacific/Auckland:20260907T130000
DTEND;TZID=Pacific/Auckland:20260907T140000
SUMMARY:Microbiology seminar: Professor Sheemei Lok, Duke-NUS Medical School, Singapore
DESCRIPTION:Dengue virus antigenicity, pathogenesis and cell entry mechanismProfessor Sheemei LokDuke-NUS Medical School, Singapore My laboratory integrates cryo-electron microscopy with biochemistry and immunology to elucidate the structural basis of flavivirus infection, with a particular focus on dengue virus, and to translate these insights toward improved vaccines and therapeutics. In this talk, I will present our work on: (1) the mechanisms by which highly potent neutralizing antibodies engage dengue virus and the implications for vaccine and antibody-based therapeutic design; (2) the structural basis by which dengue non-structural protein 1 (NS1) induces endothelial hyperpermeability, a key pathogenic feature of dengue haemorrhagic fever; and (3) the early membrane fusion events during flavivirus entry. 
LOCATION:Biochemistry Seminar Room G.13 (BIG13), 710 Cumberland Street, Dunedin
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