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Physiology research seminar: Epithelial sodium channel influences on breast cancer progression

Undergraduate students, Postgraduate students, Staff
Event type
Department seminar
Department of Physiology

Presented by Professor Fiona McDonald, Department of Physiology.

The epithelial sodium channel (ENaC) has well established functions in the control of salt and water homeostasis and blood pressure through its activity in the kidney and blood vessels, and in maintaining the airway surface liquid layer in the lung. ENaC is also active in mammary epithelia, and our bioinformatic analysis suggests that high ENaC expression is correlated with a better prognosis in breast cancer. Many ion channels have been linked to changes in normal and cancer cell phenotypes that may drive or inhibit metastasis of tumours.

We are investigating a role for ENaC in the epithelial-mesenchymal transition pathway implicated in mammary cells developing a more cancerous phenotype. Our data suggest high levels of ENaC expression and activity are associated with cellular changes that inhibit breast cancer progression. Therefore our results hint at a role for ENaC in maintaining mammary epithelial phenotype.



Tanya Cully


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