Dr Kanchana Subasinghe
|Position||Professional Practice Fellow|
|Department||Department of Anatomy|
|Qualifications||MD (Russia) MSc (Otago) PhD candidate|
|Research summary||Characterisation of collagen fibre alterations in cornea following cross-linking (CXL) treatment|
|Clinical||Clinical Education Research and Clinical Anatomy Research|
Keratoconus (KC) is a disease included in a wider range of diseases called corneal ectasia which leads to spontaneous, non-inflammatory, self-limiting ectasia of the cornea that results in localised corneal thinning with protrusion of the thinned cornea. Incidence of KC varies greatly within different ethnic groups with most estimates between 50 and 230 per 100,000 of population (approximately 1 per 2000) with a prevalence of 54.5 per 100.000 in early studies. In New Zealand, the prevalence of high incidence of keratoconus has been known for more than 30 years with a considerably high percentage in Maori and Pacific Islanders in contrast to European and Asian populations.
In recent years, corneal crosslinking (CXL) treatment with ultraviolet light (UVA) and riboflavin has been introduced as a minimally invasive treatment option to arrest the progression of keratectasia and it has revolutionised the treatment of KC.
Presently I am looking into long term effects and morphological changes of corneal stromal collagen fibres following crosslinking treatment.
Subasinghe, S. K., Ogbuehi, K. C., Mitchell, L., & Dias, G. J. (2021). Morphological alterations of the cornea following Crosslinking Treatment (CXL). Clinical Anatomy. Advance online publication. doi: 10.1002/ca.23728
Subasinghe, S. K., Ogbuehi, K. C., Mitchell, L., & Dias, G. J. (2021). Animal model with structural similarity to human corneal collagen fibrillar arrangement. Anatomical Science International. Advance online publication. doi: 10.1007/s12565-020-00590-8
Subasinghe, S. K., Ogbuehi, K. C., & Dias, G. J. (2018). Current perspectives on corneal collagen crosslinking (CXL). Graefe's Archive for Clinical & Experimental Ophthalmology, 256(8), 1363-1384. doi: 10.1007/s00417-018-3966-0
Subasinghe, S. K., & Jones, D. G. (2015). Human body donation programs in Sri Lanka: Buddhist perspectives. Anatomical Sciences Education, 8(5), 484-489. doi: 10.1002/ase.1525