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Health Sciences staff profiles

Associate Professor Christine Jasoni

PositionAssociate Professor
DepartmentDepartment of Anatomy
QualificationsBSc PhD
Research summaryNeural development

Research

The focus of Dr Jasoni's research is on discovering how the maternal environment during pregnancy affects the formation of the fetal brain. With conditions such as obesity and diabetes on the rise in Western society and the developing world, it is critical that we fully understand the health implications of these disorders for future generations. Specifically, there is clear epidemiological data showing that maternal obesity can greatly increase the likelihood that offspring will also be obese. Dr Jasoni seeks 1) to establish specifically how maternal obesity during pregnancy alters the development of the fetal brain circuits that regulate offspring body weight; 2) to discover epigenetic changes in the brains of the offspring of obese or diabetic mothers, as a further mechanism to explain the influence of maternal health on offspring brain function.

Research interests

My team uses an array of techniques including molecular and cellular biology, mouse genetic models, live cell imaging, and bioinformatics to address their scientific questions. In addition, they have active collaborations with laboratories in the Centre for Neuroendocrinology, the National Research Centre for Growth and Development (one of the 7 national Centres of Research Excellence), as well as overseas collaborations. This collaborative research creates a vibrant, intellectually invigorating environment in which to conduct cutting-edge science that is internationally recognized and will benefit health outcomes in New Zealand and the world.

Laboratory of Developmental Neuroscience

Publications

Sanders, T. R., Glendining, K. A., & Jasoni, C. L. (2017). Obesity during pregnancy in the mouse alters the Netrin-1 responsiveness of foetal arcuate nucleus neuropeptide Y neurones. Journal of Neuroendocrinology, 29(12), e12556. doi: 10.1111/jne.12556

Glendining, K. A., Markie, D., Gardner, R. J. M., Franz, E. A., Robertson, S. P., & Jasoni, C. L. (2017). A novel role for the DNA repair gene Rad51 in Netrin-1 signalling. Scientific Reports, 7, 39823. doi: 10.1038/srep39823

Thomson-Laing, G., Jasoni, C. L., & Lokman, P. M. (2017). The effects of migratory stage and 11-ketotestosterone on the expression of rod opsin genes in the shortfinned eel (Anguilla australis). General & Comparative Endocrinology. Advance online publication. doi: 10.1016/j.ygcen.2017.06.025

Méneret, A., Franz, E. A., Trouillard, O., Oliver, T. C., Zagar, Y., Robertson, S. P., … Gardner, R. J. M., … Jasoni, C. L., … Markie, D. (2017). Mutations in the netrin-1 gene cause congenital mirror movements. Journal of Clinical Investigation, 127(11), 3923-3936. doi: 10.1172/jci95442

Kim, D. W., Glendining, K. A., Grattan, D. R., & Jasoni, C. L. (2016). Maternal obesity in the mouse compromises the blood-brain barrier in the arcuate nucleus of offspring. Endocrinology, 157(6), 2229-2242. doi: 10.1210/en.2016-1014

Journal - Research Article

Sanders, T. R., Glendining, K. A., & Jasoni, C. L. (2017). Obesity during pregnancy in the mouse alters the Netrin-1 responsiveness of foetal arcuate nucleus neuropeptide Y neurones. Journal of Neuroendocrinology, 29(12), e12556. doi: 10.1111/jne.12556

Méneret, A., Franz, E. A., Trouillard, O., Oliver, T. C., Zagar, Y., Robertson, S. P., … Gardner, R. J. M., … Jasoni, C. L., … Markie, D. (2017). Mutations in the netrin-1 gene cause congenital mirror movements. Journal of Clinical Investigation, 127(11), 3923-3936. doi: 10.1172/jci95442

Thomson-Laing, G., Jasoni, C. L., & Lokman, P. M. (2017). The effects of migratory stage and 11-ketotestosterone on the expression of rod opsin genes in the shortfinned eel (Anguilla australis). General & Comparative Endocrinology. Advance online publication. doi: 10.1016/j.ygcen.2017.06.025

Glendining, K. A., Markie, D., Gardner, R. J. M., Franz, E. A., Robertson, S. P., & Jasoni, C. L. (2017). A novel role for the DNA repair gene Rad51 in Netrin-1 signalling. Scientific Reports, 7, 39823. doi: 10.1038/srep39823

Kim, D. W., Glendining, K. A., Grattan, D. R., & Jasoni, C. L. (2016). Maternal obesity in the mouse compromises the blood-brain barrier in the arcuate nucleus of offspring. Endocrinology, 157(6), 2229-2242. doi: 10.1210/en.2016-1014

Kim, D. W., Glendining, K. A., Grattan, D. R., & Jasoni, C. L. (2016). Maternal obesity leads to increased proliferation and numbers of astrocytes in the developing fetal and neonatal mouse hypothalamus. International Journal of Developmental Neuroscience, 53, 18-25. doi: 10.1016/j.ijdevneu.2016.06.005

Berretta, A., Gowing, E. K., Jasoni, C. L., & Clarkson, A. N. (2016). Sonic hedgehog stimulates neurite outgrowth in a mechanical stretch model of reactive-astrogliosis. Scientific Reports, 6, 21896. doi: 10.1038/srep21896

Doynova, M. D., Berretta, A., Jones, M. B., Jasoni, C. L., Vickers, M. H., & O'Sullivan, J. M. (2016). Interactions between mitochondrial and nuclear DNA in mammalian cells are non-random. Mitochondrion, 30, 187-196. doi: 10.1016/j.mito.2016.08.003

Jasoni, C. L., Sanders, T. R., & Kim, D. W. (2015). Do all roads lead to Rome? The role of neuro-immune interactions before birth in the programming of offspring obesity. Frontiers in Neuroscience, 8, 455. doi: 10.3389/fnins.2014.00455

Franz, E. A., Chiaroni-Clarke, R., Woodrow, S., Glendining, K. A., Jasoni, C. L., Robertson, S. P., Gardner, R. J. M., & Markie, D. (2015). Congenital mirror movements: Phenotypes associated with DCC and RAD51 mutations. Journal of the Neurological Sciences, 351(1-2), 140-145. doi: 10.1016/j.jns.2015.03.006

Hale, M. W., Spencer, S. J., Conti, B., Jasoni, C. L., Kent, S., Radler, M. E., … Sominsky, L. (2015). Diet, behavior and immunity across the lifespan. Neuroscience & Biobehavioral Reviews, 58, 46-62. doi: 10.1016/j.neubiorev.2014.12.009

Sanders, T. R., Kim, D. W., Glendining, K. A., & Jasoni, C. L. (2014). Maternal obesity and IL-6 lead to aberrant developmental gene expression and deregulated neurite growth in the fetal arcuate nucleus. Endocrinology, 155(7), 2566-2577. doi: 10.1210/en.2013-1968

Kim, D. W., Young, S. L., Grattan, D. R., & Jasoni, C. L. (2014). Obesity during pregnancy disrupts placental morphology, cell proliferation, and inflammation in a sex-specific manner across gestation in the mouse. Biology of Reproduction, 90(6), 130. doi: 10.1095/biolreprod.113.117259

Wyatt, A. K., Zavodna, M., Viljoen, J. L., Stanton, J.-A. L., Gemmell, N. J., & Jasoni, C. L. (2013). Changes in methylation patterns of Kiss1 and Kiss1r gene promoters across puberty. Genetics & Epigenetics, 5, 51-62.

Low, V. F., Fiorini, Z., Fisher, L., & Jasoni, C. L. (2012). Netrin-1 stimulates developing GnRH neurons to extend neurites to the median eminence in a calcium-dependent manner. PLoS ONE, 7(10), e46999. doi: 10.1371/journal.pone.0046999

Constantin, S., Jasoni, C., Romanò, N., Lee, K., & Herbison, A. E. (2012). Understanding calcium homeostasis in postnatal gonadotropin-releasing hormone neurons using cell-specific Pericam transgenics. Cell Calcium, 51(3-4), 267-276. doi: 10.1016/j.ceca.2011.11.005

Jasoni, C. L., & Campbell, S. R. S. (2011). Defining the cellular targets of IL6 in the fetal mouse brain. Journal of Developmental Origins of Health & Disease, 2(Suppl. 1), S77. doi: 10.1017/S2040174411000481

Fiorini, Z., & Jasoni, C. L. (2010). A novel developmental role for Kisspeptin in the growth of GnRH neurites to the median eminence in the mouse. Journal of Neuroendocrinology, 22(10), 1113-1125. doi: 10.1111/j.1365-2826.2010.02059.x

Constantin, S., Jasoni, C. L., Wadas, B., & Herbison, A. E. (2010). γ-aminobutyric acid and glutamate differentially regulate intracellular calcium concentrations in mouse gonadotropin-releasing hormone neurons. Endocrinology, 151(1), 262-270. doi: 10.1210/en.2009-0817

Jasoni, C. L., Romanò, N., Constantin, S., Lee, K., & Herbison, A. E. (2010). Calcium dynamics in gonadotropin-releasing hormone neurons. Frontiers in Neuroendocrinology, 31, 259-269. doi: 10.1016/j.yfrne.2010.05.005

Jasoni, C. L., Porteous, R. W., & Herbison, A. E. (2009). Anatomical location of mature GnRH neurons corresponds with their birthdate in the developing mouse. Developmental Dynamics, 238(3), 524-531.

Romanò, N., Lee, K., Ábrahám, I. M., Jasoni, C. L., & Herbison, A. E. (2008). Nonclassical estrogen modulation of presynaptic GABA terminals modulates calcium dynamics in gonadotropin-releasing hormone neurons. Endocrinology, 149(11), 5335-5344. doi: 10.1210/en.2008-0424

Grattan, D. R., Jasoni, C. L., Liu, X., Anderson, G. M., & Herbison, A. E. (2007). Prolactin regulation of gonadotropin-releasing hormone neurons to suppress luteinizing hormone secretion in mice. Endocrinology, 148(9), 4344-4351.

Jasoni, C. L., Todman, M. G., Strumia, M. M., & Herbison, A. E. (2007). Cell type-specific expression of a genetically encoded calcium indicator reveals intrinsic calcium oscillations in adult gonadotropin-releasing hormone neurons. Journal of Neuroscience, 27(4), 860-867.

Jasoni, C. L., Todman, M. G., Han, S.-K., & Herbison, A. E. (2005). Expression of mRNAs encoding receptors that mediate stress signals in gonadotropin-releasing hormone neurons of the mouse. Neuroendocrinology, 82, 320-328.

Namciu, S. J., Friedman, R. D., Marsden, M. D., Sarausad, L. M., Jasoni, C. L., & Fournier, R. E. K. (2004). Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1. Mammalian Genome, 15, 162-178.

Neiman, P. E., Ruddell, A., Jasoni, C., Loring, G., Thomas, S. J., Brandvold, K. A., … Delrow, J. (2001). Analysis of gene expression during myc oncogene-induced lymphomagenesis in the bursa of Fabricius. PNAS, 98(11), 6378-6383. doi: 10.1073/pnas.111144898

The MHC Sequencing Consortium, including Jasoni, C. (1999). Mapping HLA for single nucleotide polymorphisms. Reviews in Immunogenetics, 1(2), 231-238.

Jasoni, C., Hendrickson, A., & Roelink, H. (1999). Analysis of chicken Wnt-13 expression demonstrates coincidence with cell division in the developing eye and is consistent with a role in induction. Developmental Dynamics, 215(3), 215-224.

The MHC Sequencing Consortium, including Jasoni, C. (1999). Complete sequence and gene map of a humanmajor histocompatability complex. Nature, 401(6756), 921-923.

Johnston, L. A., Ostrow, B. D., Jasoni, C. L., & Blochlinger, K. (1998). The homeobox gene cut interacts genetically with the homeotic genes proboscipedia and antennapedia. Genetics, 149(1), 131-142.

Bumsted, K., Jasoni, C. L., Szel, A., & Hendrickson, A. (1997). Spatial and temporal expression of cone opsins during monkey retinal development. Journal of Comparative Neurology, 378(1), 117-134.

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