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Health Sciences staff profiles

Dr Elodie Kip

PositionAssistant Research Fellow
DepartmentDepartment of Anatomy
Research summaryUse of optogenetics and viral vectors for the treatment of Parkinson's Disease

Research

Elodie Kip was awarded her PhD thesis at Sciensano in Brussels and the VIB Center for Inflammation research in Ghent, on neurotropic virus pathogenesis and neuroinflammation. She is experienced in Oncology, Inflammation, Immunology, Virology and Neurosciences.

At the University of Otago she is integrating her experience working with viruses and the brain and expanding her knowledge in Neurosciences. Her role is to train, advise and support members of Brain Research New Zealand in conducting optogenetic stimulation experiments and to contribute to the project entitled “Implantable light stimulator to treat Parkinson’s disease”. For this she will be using optogenetics technology and viral vectors in a rat model of Parkinson’s disease.

Additional details

Major techniques

  • Virus production
  • Functional and genomic virus titration
  • Flow cytometry for immune cells in the brain
  • Seroneutralisation test for measure of neutralizing antibodies in the blood
  • qRT-PCR
  • Immunohistochemistry
  • ELISA
  • Cell culture
  • Breeding of transgenic mice and genotyping
  • Rodent stereotaxic surgery
  • Viral vectors
  • Optogenetic experiments

Publications

Kip, E., Staal, J., Tima, H. G., Verstrepen, L., Romano, M., Lemeire, K., … Beyaert, R. (2018). Inhibition of MALT1 decreases neuroinflammation and pathogenicity of virulent rabies virus in mice. Journal of Virology, 92(22), e00720-18. doi: 10.1128/ JVI.00720-18

Kip, E., Staal, J., Verstrepen, L., Tima, H. G., Terryn, S., Romano, M., … Van Gucht, S. (2018). MALT1 controls attenuated rabies virus by inducing early inflammation and T cell activation in the brain. Journal of Virology, 92(8), e02029-17. doi: 10.1128/JVI.02029-17

Kip, E., Naze, F., Suin, V., Vanden Berghe, T., Francart, A., Lamoral, S., … Kalai, M. (2017). Impact of caspase-1/11, -3, -7, or IL-1β/IL-18 deficiency on rabies virus-induced macrophage cell death and onset of disease. Cell Death Discovery, 3, 17012. doi: 10.1038/cddiscovery.2017.12