Dr Margaret Ryan
Position | Senior Research Fellow |
---|---|
Department | Department of Anatomy |
Qualifications | BSc (Hons) PhD |
Research summary | Memory and Alzheimer's disease |
Research
Memory loss arising from neurodegenerative diseases such as Alzheimer's disease is devastating both to the individual and to their loved ones, robbing the individual of many of his/her uniquely identifiable characteristics. Dr Ryan's interest is in how memories are formed and stored in the brain at the molecular level and how this may be altered in Alzheimer's disease.
Publications
Mockett, B. G., & Ryan, M. M. (2023). The therapeutic potential of the neuroactive peptides of soluble amyloid precursor protein-alpha in Alzheimer’s disease and related neurological disorders. Seminars in Cell & Developmental Biology, 139, 93-101. doi: 10.1016/j.semcdb.2022.05.014
Ryan, M., Tan, V. T. Y., Thompson, N., Guévremont, D., Mockett, B. G., Tate, W. P., Abraham, W. C., Hughes, S. M., & Williams, J. (2021). Lentivirus-mediated expression of human secreted amyloid precursor protein-alpha promotes long-term induction of neuroprotective genes and pathways in a mouse model of Alzheimer’s disease. Journal of Alzheimer's Disease, 79, 1075-1090. doi: 10.3233/JAD-200757
Sweetman, E., Noble, A., Edgar, C., Mackay, A., Helliwell, A., Vallings, R., Ryan, M., & Tate, W. (2019). Current research provides insight into the biological basis and diagnostic potential for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Diagnostics, 9(3), 73. doi: 10.3390/diagnostics9030073
Sweetman, E., Ryan, M., Edgar, C., MacKay, A., Vallings, R., & Tate, W. (2019). Changes in the transcriptome of circulating immune cells of a New Zealand cohort with myalgic encephalomyelitis/chronic fatigue syndrome. International Journal of Immunopathology & Pharmacology, 33, 1-8. doi: 10.1177/2058738418820402
Ryan, M. M., Guévremont, D., Mockett, B. G., Abraham, W. C., & Williams, J. M. (2018). Circulating plasma microRNAs are altered with amyloidosis in a mouse model of Alzheimer's disease. Journal of Alzheimer's Disease, 66(2), 835-852. doi: 10.3233/jad-180385
Ryan, M., Tan, V. T. Y., Thompson, N., Guévremont, D., Mockett, B. G., Tate, W. P., Abraham, W. C., Hughes, S. M., & Williams, J. (2021). Lentivirus-mediated expression of human secreted amyloid precursor protein-alpha promotes long-term induction of neuroprotective genes and pathways in a mouse model of Alzheimer’s disease. Journal of Alzheimer's Disease, 79, 1075-1090. doi: 10.3233/JAD-200757
Journal - Research Article
Sweetman, E., Ryan, M., Edgar, C., MacKay, A., Vallings, R., & Tate, W. (2019). Changes in the transcriptome of circulating immune cells of a New Zealand cohort with myalgic encephalomyelitis/chronic fatigue syndrome. International Journal of Immunopathology & Pharmacology, 33, 1-8. doi: 10.1177/2058738418820402
Journal - Research Article
Ryan, M. M., Guévremont, D., Mockett, B. G., Abraham, W. C., & Williams, J. M. (2018). Circulating plasma microRNAs are altered with amyloidosis in a mouse model of Alzheimer's disease. Journal of Alzheimer's Disease, 66(2), 835-852. doi: 10.3233/jad-180385
Journal - Research Article
Nido, G. S., Ryan, M. M., Benuskova, L., & Williams, J. M. (2015). Dynamical properties of gene regulatory networks involved in long-term potentiation. Frontiers in Molecular Neuroscience, 8, 42. doi: 10.3389/fnmol.2015.00042
Journal - Research Article
Ryan, M. M., Guévremont, D., Luxmanan, C., Abraham, W. C., & Williams, J. M. (2015). Aging alters long-term potentiation—related gene networks and impairs synaptic protein synthesis in the rat hippocampus. Neurobiology of Aging, 36(5), 1868-1880. doi: 10.1016/j.neurobiolaging.2015.01.012
Journal - Research Article
Ryan, M. M., Morris, G. P., Mockett, B. G., Bourne, K., Abraham, W. C., Tate, W. P., & Williams, J. M. (2013). Time-dependent changes in gene expression induced by secreted amyloid precursor protein-alpha in the rat hippocampus. BMC Genomics, 14, 376. doi: 10.1186/1471-2164-14-376
Journal - Research Article
Ryan, M. M., Ryan, B., Kyrke-Smith, M., Logan, B., Tate, W. P., Abraham, W. C., & Williams, J. M. (2012). Temporal profiling of gene networks associated with the late phase of long-term potentiation in vivo. PLoS ONE, 7(7), e40538. doi: 10.1371/journal.pone.0040538
Journal - Research Article
Ryan, M. M., Mason-Parker, S. E., Tate, W. P., Abraham, W. C., & Williams, J. M. (2011). Rapidly induced gene networks following induction of long-term potentiation at perforant path synapses in vivo. Hippocampus, 21(5), 541-553. doi: 10.1002/hipo.20770
Journal - Research Article
Giger, T., Khaitovich, P., Somel, M., Lorenc, A., Lizano, E., Harris, L. W., Ryan, M. M., … Pääbo, S. (2010). Evolution of neuronal and endothelial transcriptomes in primates. Genome Biology & Evolution, 2, 284-292. doi: 10.1093/gbe/evq018
Journal - Research Article
Harris, L. W., Wayland, M., Lan, M., Ryan, M., Giger, T., Lockstone, H., … Bahn, S. (2008). The cerebral microvasculature in schizophrenia: A laser capture microdissection study. PLoS ONE, 3(12), e3964. doi: 10.1371/journal.pone.0003964
Journal - Research Article
Tkachev, D., Mimmack, M. L., Huffaker, S. J., Ryan, M., & Bahn, S. (2007). Further evidence for altered myelin biosynthesis and glutamatergic dysfunction in schizophrenia. International Journal of Neuropsychopharmacology, 10, 557-563. doi: 10.1017/S1461145706007334
Journal - Research Article
Ryan, M. M., Lockstone, H. E., Huffaker, S. J., Wayland, M. T., Webster, M. J., & Bahn, S. (2006). Gene expression analysis of bipolar disorder reveals downregulation of the ubiquitin cycle and alterations in synaptic genes. Molecular Psychiatry, 11, 965-978. doi: 10.1038/sj.mp.4001875
Journal - Research Article
Franz, H., Ullmann, C., Becker, A., Ryan, M., Bahn, S., Arendt, T., & … (2005). Systematic analysis of gene expression in human brains before and after death. Genome Biology, 6(13).
Journal - Research Article
Prabakaran, S., Swatton, J. E., Ryan, M. M., Huffaker, S. J., Huang, J. T.-J., Griffin, J. L., & et al (2004). Mitochondrial dysfunction in schizophrenia: Evidence for compromised brain metabolism and oxidative stress. Molecular Psychiatry, 9, 684-697.
Journal - Research Article
Ryan, M. M., Huffaker, S. J., Webster, M. J., Wayland, M., Freeman, T., & Bahn, S. (2004). Application and optimization of microarray technologies for human postmortem brain studies. Biological Psychiatry, 55, 329-336.
Journal - Research Article
Wilson, K. E., Ryan, M. M., Prime, J. E., Pashby, D. P., Orange, P. R., O'Beirne, G., … Morris, C. M. (2004). Functional genomics and proteomics: Application in neurosciences. Journal of Neurology, Neurosurgery & Psychiatry, 75, 529-538. doi: 10.1136/jnnp.2003.026260
Journal - Research Article
Marchbanks, R. M., Ryan, M., Day, I. N. M., Owen, M., McGuffin, P., & Whatley, S. A. (2003). A mitochondrial DNA sequence variant associated with schizophrenia and oxidative stress. Schizophrenia Research, 65, 33-38.
Journal - Research Article
Tkachev, D., Mimmack, M. L., Ryan, M. M., Wayland, M., Freeman, T., Jones, P. B., & … (2003). Oligodendrocyte dysfunction in schizoprenia and bipolar disorder. Lancet, 362, 798-805.
Journal - Research Article
Bahn, S., Mimmack, M., Ryan, M., Caldwell, M. A., Jauniaux, E., Starkey, M., & Svendsen, C. N. (2002). Neuronal target genes of the neuron-restrictive silencer factor in neurospheres derived from fetuses with Down's syndrome: A gene expression study. Lancet, 359, 310-315.
Journal - Research Article
Mimmack, M. L., Ryan, M., Baba, H., Navarro-Ruiz, J., Iritani, S., Faull, R. M. L., & ... (2002). Gene expression analysis in schizophrenia: Reproducible up-regulation of several members of the apolipoprotein L family located in a high-susceptibility locus for schizophrenia on chromosome 22. PNAS, 99(7), 4680-4685.
Journal - Research Article
Bahn, S., Augood, S. J., Ryan, M., Standaert, D. G., Starkey, M., & Emson, P. C. (2001). Gene expression profiling in the post-mortem human brain: No cause for dismay. Journal of Chemical Neuroanatomy, 22, 79-94.
Journal - Research Article
Ryan, M., Starkey, M., Faull, R., Emson, P., & Bahn, S. (2001). Indexing-based differential display: Studies on post-mortem Alzheimer's brain. Molecular Brain Research, 88, 199-202.
Journal - Research Article
Mockett, B. G., & Ryan, M. M. (2023). The therapeutic potential of the neuroactive peptides of soluble amyloid precursor protein-alpha in Alzheimer’s disease and related neurological disorders. Seminars in Cell & Developmental Biology, 139, 93-101. doi: 10.1016/j.semcdb.2022.05.014
Journal - Research Other
Sweetman, E., Noble, A., Edgar, C., Mackay, A., Helliwell, A., Vallings, R., Ryan, M., & Tate, W. (2019). Current research provides insight into the biological basis and diagnostic potential for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Diagnostics, 9(3), 73. doi: 10.3390/diagnostics9030073
Journal - Research Other