Associate Professor Phil Sheard is interested in sarcopenia, the age-related loss of muscle mass and strength that has profound implications for the elderly.
He is specifically interested in the role of the motor nerve terminal because progressive withdrawal of the motor nerve from the muscle fibre seems to be a conspicuous feature of elderly muscle. He is currently examining age-related changes to the neuromuscular junction with a view to using this information to establish whether motor nerve withdrawal is a cause of muscle fibre death, or a consequence of it.
Associate Professor Sheard uses electrophysiology, electron microscopy, confocal microscopy, fluorescence and transmitted light microscopy, histochemistry, immunohistochemistry, and anterograde and retrograde cell tracing techniques.
Peeters, W. M., Gram, M., Dias, G. J., Vissers, M. C. M., Hampton, M. B., Dickerhof, N., Bekhit, A. E., … Bayer, S., … Sheard, P. W., Danielson, K. M., … Cornwall, J., & Rowlands, D. S. (2023). Changes to insulin sensitivity in glucose clearance systems and redox following dietary supplementation with a novel cysteine-rich protein: A pilot randomized controlled trial in humans with type-2 diabetes. Redox Biology, 67, 102918. doi: 10.1016/j.redox.2023.102918
Journal - Research Article
Redmond, A. K., Davies, T. M., Schofield, M. R., & Sheard, P. W. (2023). New tools for the investigation of muscle fiber-type spatial distributions across histological sections. Skeletal Muscle, 13, 7. doi: 10.1186/s13395-023-00316-0
Journal - Research Article
Lal, N. N., Cornwall, J., & Sheard, P. W. (2023). Use of a novel technique to assess impact of age-related denervation on mouse soleus muscle function. Biogerontology. Advance online publication. doi: 10.1007/s10522-023-10021-6
Journal - Research Article
Sheard, P. (2022, March). Is age-related loss of skeletal muscle mass primarily a neurodegenerative disease? UOC Research Seminar Series, University of Otago, Christchurch, New Zealand. [Research Presentation].
Other Research Output
Sheard, P. (2022, February). The cellular basis for age-related loss of muscle mass. Verbal presentation at the Collaboration of Ageing Research Excellence (CARE) Research Symposium, [Online].
Conference Contribution - Verbal presentation and other Conference outputs
Lal, N. N., Cornwall, J., & Sheard, P. W. (2021). Age-related structural changes show that loss of fibers is not a significant contributor to muscle atrophy in old mice. Experimental Gerontology, 156, 111618. doi: 10.1016/j.exger.2021.111618
Journal - Research Article
Gillon, A., Steel, C., Cornwall, J., & Sheard, P. (2020). Increased nuclear permeability is a driver for age-related motoneuron loss. GeroScience, 42, 833-847. doi: 10.1007/s11357-020-00155-7
Journal - Research Article
Gillon, A. P., Cornwall, J. E., & Sheard, P. W. (2020). Age-related neurodegeneration may be caused by defects at the nuclear envelope, and attenuated by exercise. Australasian Journal on Ageing, 39(Suppl. 2), (pp. 17). doi: 10.1111/ajag.12808
Conference Contribution - Published proceedings: Abstract
Lal, N., Cornwall, J., Slatter, T., & Sheard, P. W. (2020). Age-related changes in muscle architecture differentially obscure accurate myofibre counts: Is age-related decline in myofibre number a technical artefact? Clinical Anatomy, 33(2), (pp. E37-E38). doi: 10.1002/ca.23370
Conference Contribution - Published proceedings: Abstract
Lal, N., Cornwall, J., Slatter, T., & Sheard, P. W. (2020). Age-related changes in muscle morphology elucidatea role for myofibre fibrosis as an additional mechanism underpinning sarcopenia. Clinical Anatomy, 33(2), (pp. E38). doi: 10.1002/ca.23370
Conference Contribution - Published proceedings: Abstract
Lal, N., Cornwall, J., Slatter, T., Kleffmann, T., & Sheard, P. (2020). Proteomic differences between young, elderly, and exercised-elderly murine soleus muscles and their correlations with deficits in force production. Australasian Journal on Ageing, 39(Suppl. 2), (pp. 18). doi: 10.1111/ajag.12808
Conference Contribution - Published proceedings: Abstract
Sheard, P., Nielsen, K., Lal, N., & Cornwall, J. (2020). Structural alterations at the myotendinous junction in elderly and exercised mouse skeletal muscles. Australasian Journal on Ageing, 39(Suppl. 2), (pp. 17-18). doi: 10.1111/ajag.12808
Conference Contribution - Published proceedings: Abstract
Davies, T. M., Schofield, M. R., Cornwall, J., & Sheard, P. W. (2019). Modelling multilevel spatial behaviour in binary-mark muscle fibre configurations. Annals of Applied Statistics, 13(3), 1329-1347. doi: 10.1214/18-AOAS1214
Journal - Research Article
Sheard, P., Gillon, A., Nielsen, K., Lal, N., & Cornwall, J. (2019, September). Is sarcopenia a neurodegenerative disease? Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Gillon, A., Nielsen, K., Steel, C., Cornwall, J., & Sheard, P. (2018). Exercise attenuates age-associated changes in motoneuron number, nucleocytoplasmic transport proteins and neuromuscular health. GeroScience, 40, 177-192. doi: 10.1007/s11357-018-0020-4
Journal - Research Article
Nielsen, K. B., Lal, N. N., & Sheard, P. W. (2018). Age-related remodelling of the myotendinous junction in the mouse soleus muscle. Experimental Gerontology, 104, 52-59. doi: 10.1016/j.exger.2018.01.021
Journal - Research Article
Tan, C. L., Sheard, P. W., & Jasoni, C. L. (2018). Developing neurites from mouse basal forebrain gonadotropin-releasing hormone neurons use Sonic hedgehog to modulate their growth. International Journal of Developmental Neuroscience, 68, 89-97. doi: 10.1016/j.ijdevneu.2018.05.005
Journal - Research Article
Gillon, A., Cornwall, J., & Sheard, P. (2018). Age-related skeletal muscle atrophy may be driven by defects at the motorneuron nuclear envelope. Proceedings of the Australian & New Zealand Society for Sarcopenia & Frality Research (ANZSSFR) Annual Meeting. (pp. 22). Retrieved from https://anzssfr.org/past-meetings
Conference Contribution - Published proceedings: Abstract
Lal, N., Cornwall, J., Slatter, T., & Sheard, P. (2018). Identification of denervated fibers in elderly skeletal muscles. Proceedings of the Australian & New Zealand Society for Sarcopenia & Frality Research (ANZSSFR) Annual Meeting. (pp. 22). Retrieved from https://anzssfr.org/past-meetings
Conference Contribution - Published proceedings: Abstract
Lal, N., Cornwall, J., Slatter, T., & Sheard, P. (2018). Is myofiber death a major contributor to age-related skeletal muscle atrophy? Proceedings of the Australian & New Zealand Society for Sarcopenia & Frality Research (ANZSSFR) Annual Meeting. (pp. 22). Retrieved from https://anzssfr.org/past-meetings
Conference Contribution - Published proceedings: Abstract
Sheard, P. (2018). Dissecting the cellular changes that drive age-related loss of skeletal muscle [Invited]. Proceedings of the Australian & New Zealand Society for Sarcopenia & Frality Research (ANZSSFR) Annual Meeting. (pp. 17). Retrieved from https://anzssfr.org/past-meetings
Conference Contribution - Published proceedings: Abstract
Hennebry, A., Oldham, J., Shavlakadze, T., Grounds, M. D., Sheard, P., Fiorotto, M. L., … McMahon, C. D. (2017). IGF1 stimulates greater muscle hypertrophy in the absence of myostatin in male mice. Journal of Endocrinology, 234(2), 187-200. doi: 10.1530/joe-17-0032
Journal - Research Article
Cornwall, J., Lal, N., Slatter, T., Rowlands, D., & Sheard, P. (2017). Autophagic dysfunction has a key role in age-related myofibre death. Australasian Journal on Ageing, 36(Suppl. 1), (pp. 20). doi: 10.1111/ajag.12395
Conference Contribution - Published proceedings: Abstract
Nielsen, K., & Sheard, P. (2017). The protective role of endurance exercise in age-related loss of muscle mass. Australasian Journal on Ageing, 36(Suppl. 1), (pp. 21). doi: 10.1111/ajag.12395
Conference Contribution - Published proceedings: Abstract
Sheard, P., Brady, J., Nielsen, K., & Cornwall, J. (2017). Age and exercise-related changes in Neurotrophin-r and Neuregulin amongst mouse lumbar motoneurons. Australasian Journal on Ageing, 36(Suppl. 1), (pp. 20). doi: 10.1111/ajag.12395
Conference Contribution - Published proceedings: Abstract
Cornwall, J., Farrell, S. F., & Sheard, P. W. (2016). Fibre types of human suboccipital muscles. European Journal of Anatomy, 20(1), 31-36.
Journal - Research Article
White, Z., Terrill, J., White, R. B., McMahon, C., Sheard, P., Grounds, M. D., & Shavlakadze, T. (2016). Voluntary resistance wheel exercise from mid-life prevents sarcopenia and increases markers of mitochondrial function and autophagy in muscles of old male and female C57BL/6J mice. Skeletal Muscle, 6(1), 45. doi: 10.1186/s13395-016-0117-3
Journal - Research Article
Gillon, A., & Sheard, P. (2015). Elderly mouse skeletal muscle fibres have a diminished capacity to upregulate NCAM production in response to denervation. Biogerontology, 16(6), 811-823. doi: 10.1007/s10522-015-9608-6
Journal - Research Article
Lal, N., & Sheard, P. (2015). Dying myofibers in elderly mouse skeletal muscles are characterized by the appearance of dystrophin-encircled vacuoles. Biogerontology, 16, 443-459. doi: 10.1007/s10522-015-9565-0
Journal - Research Article
Thaung, H. P. A., Baldi, J. C., Wang, H.-Y., Hughes, G., Cook, R. F., Bussey, C. T., Sheard, P. W., Bahn, A., Jones, P. P., Schwenke, D. O., & Lamberts, R. R. (2015). Increased efferent cardiac sympathetic nerve activity and defective intrinsic heart rate regulation in type 2 diabetes. Diabetes, 64(8), 2944-2956. doi: 10.2337/db14-0955
Journal - Research Article
Brady, J., & Sheard, P. (2015). Implementation of internal intensity controls for semi-quantitative fluorescence immunohistochemistry. Proceedings of the 27th National Conference on Microscopy. Retrieved from http://microscopy2015.otago.ac.nz/index.html
Conference Contribution - Published proceedings: Abstract
Brady, J., Gillon, A., Lal, N., & Sheard, P. (2015). Age-related declines in synaptic proteins, agrin and rapsyn, and their relevance to sarcopenia. Clinical Anatomy, 28(7), (pp. 940). doi: 10.1002/ca.22520
Conference Contribution - Published proceedings: Abstract
Brady, J., Lal, N., & Sheard, P. (2015). Introducing an algorithm with user-defined parameters for improving consistency of immunofluorescence analysis. Proceedings of the 27th National Conference on Microscopy. Retrieved from http://microscopy2015.otago.ac.nz/index.html
Conference Contribution - Published proceedings: Abstract
Lal, N., Cornwall, J., & Sheard, P. (2015). Elderly dying myofibers are characterized by Dystrophin Encircle Vacuoles and invaginations with Intracellular Localization (DEVILs). Clinical Anatomy, 28(7), (pp. 945-946). doi: 10.1002/ca.22520
Conference Contribution - Published proceedings: Abstract
Hellyer, S. D., Selwood, A. I., van Ginkel, R., Munday, R., Sheard, P., Miles, C. O., … Kerr, D. S. (2014). In vitro labelling of muscle type nicotinic receptors using a fluorophore-conjugated pinnatoxin F derivative. Toxicon, 87, 17-25. doi: 10.1016/j.toxicon.2014.05.013
Journal - Research Article
McMahon, C. D., Chai, R., Radley-Crabb, H. G., Watson, T., Matthews, K. G., Sheard, P. W., … Shavlakadze, T. (2014). Lifelong exercise and locally produced insulin-like growth factor-1 (IGF-1) have a modest influence on reducing age-related muscle wasting in mice. Scandinavian Journal of Medicine & Science in Sports, 24(6), e423-e435. doi: 10.1111/sms.12200
Journal - Research Article
Rowlands, D. S., Page, R. A., Sukala, W. R., Giri, M., Ghimbovschi, S. D., Hayat, I., … Leikis, M., Sheard, P. W., Wakefield, St. J., … Krebs, J., … Hoffman, E. P. (2014). Multi-omic integrated networks connect DNA methylation and miRNA with skeletal muscle plasticity to chronic exercise in Type 2 diabetic obesity. Physiological Genomics, 46(20), 747-765. doi: 10.1152/physiolgenomics.00024.2014
Journal - Research Article
Cornwall, J., & Sheard, P. (2014). Fibre types in human suboccipital muscles. Annals of Anatomy, 196(Suppl.), (pp. 88). doi: 10.1016/j.aanat.2014.05.035
Conference Contribution - Published proceedings: Abstract
Lal, N., Sheard, P., & Cornwall, J. (2014). Age-related myofibre death in human skeletal muscle may be evident by the appearance of vacuolated myofibres. Annals of Anatomy, 196(Suppl.), (pp. 106). doi: 10.1016/j.aanat.2014.05.035
Conference Contribution - Published proceedings: Abstract
Brady, J., Gillon, A. P., & Sheard, P. W. (2014, September). Altered expression of the synaptic proteins agrin and rapsyn with age: Implications for sarcopenia. Verbal presentation at the New Zealand Association of Gerontology Conference: The Age of Ageing, Dunedin, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Gillon, A. P., & Sheard, P. W. (2014, September). A role for terminal Schwann cells in age related degeneration of the motor nerve terminal? Verbal presentation at the New Zealand Association of Gerontology Conference: The Age of Ageing, Dunedin, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Lal, N., & Sheard, P. (2014, September). Autophagic dysfunction accompanies myofibre death with age and predominantly affects the innervated myofibres in elderly mouse skeletal muscles. Verbal presentation at the New Zealand Association of Gerontology Conference: The Age of Ageing, Dunedin, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Davies, T. M., Cornwall, J., & Sheard, P. W. (2013). Modelling dichotomously marked muscle fibre configurations. Statistics in Medicine, 32(24), 4240-4258. doi: 10.1002/sim.5806
Journal - Research Article
Davies, T. M., Sheard, P. W., & Cornwall, J. (2013). Development of a novel statistical method to test spatial distribution of skeletal muscle fiber types. Clinical Anatomy, 26, (pp. 643). doi: 10.1002/ca.22235
Conference Contribution - Published proceedings: Abstract
Sheard, P. W., & Anderson, R. D. (2012). Age-related loss of muscle fibres is highly variable amongst mouse skeletal muscles. Biogerontology, 13(2), 157-167. doi: 10.1007/s10522-011-9365-0
Journal - Research Article
Cornwall, J., & Sheard, P. (2012). Spatial aggregation of Type II fibres in human cervical muslces. Clinical Anatomy, 25(4), (pp. 533). doi: 10.1002/ca.22049
Conference Contribution - Published proceedings: Abstract
Hennebry, A., Watson, T., Shavlakadze, T., Grounds, M. D., Sheard, P., Fiorotto, M., & McMahon, C. D. (2012). Overexpression of IGF-1 stimulates greater muscle development in the absence of myostatin, but reduces lifespan. Proceedings of the Medical Sciences Congress (MedSci). (pp. 39). Retrieved from http://www.medscinz.co.nz/QRW2012%20MedSci%20Abstracts.pdf
Conference Contribution - Published proceedings: Abstract
Tan, C., Sheard, P. W., & Jasoni, C. L. (2012). Sonic hedgehog stimulates gonadotropin releasing-hormone neuron axon growth. Proceedings of the Society for Neuroscience 42nd Annual Meeting. SfN. Retrieved from http://www.sfn.org/index.aspx?pagename=abstracts_am2012
Conference Contribution - Published proceedings: Abstract
Cornwall, J., & Sheard, P. (2011). Spatial aggregation of type II fibres in human cervical muscles. Proceedings of the 8th Annual Conference of the Australian and New Zealand Association of Clinical Anatomists (ANZACA): New Insights: Implications for Clinical Practice. (pp. 22). Retrieved from http://anzaca.otago.ac.nz/images/anzaca2011/anzaca2011_abstracts.pdf
Conference Contribution - Published proceedings: Abstract
Sheard, P. W., Bewick, G. S., Woolley, A. G., Shaw, J., Fisher, L., Fong, S. W., & Duxson, M. J. (2010). Investigation of neuromuscular abnormalities in neurotrophin-3-deficient mice. European Journal of Neuroscience, 31(1), 29-41. doi: 10.1111/j.1460-9568.2009.07032.x
Journal - Research Article
Woolley, A. G., Tait, K. J., Hurren, B. J., Fisher, L., Sheard, P. W., & Duxson, M. J. (2008). Developmental loss of NT-3 in vivo results in reduced levels of myelin-specific proteins, a reduced extent of myelination and increased apoptosis of Schwann cells. GLIA, 56(3), 306-317. doi: 10.1002/glia.20614
Journal - Research Article
Li, C., Stanton, J.-A. L., Robertson, T. M., Suttie, J. M., Sheard, P. W., Harris, A. J., & Clark, D. E. (2007). Nerve growth factor mRNA expression in the regenerating antler tip of red deer (Cervus elaphus). PLoS ONE, 2(1), e148. Retrieved from http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0000148
Journal - Research Article
Bewick, G. S., & Sheard, P. W. (2006, August). Abnormal synaptic vesicle dynamics at the motor nerve terminals of neurotrophin-3 deficient mice. Poster session presented at the Scottish Neuroscience Group Meeting, Dundee, Scotland.
Conference Contribution - Poster Presentation (not in published proceedings)
Homer, C., Knight, D. A., Hananeia, L., Sheard, P., Risk, J., Lasham, A., Royds, J. A., & Braithwaite, A. W. (2005). Y-box factor YB1 controls p53 apoptotic function. Oncogene, 24, 8314-8325. Retrieved from http://www.nature.com/onc/journal/v24/n56/abs/1208998a.html
Journal - Research Article
Sun, C.-K., Zhang, X.-Y., Sheard, P. W., Mabuchi, A., & Wheatley, A. M. (2005). Change in mitochondrial membrane potential is the key mechanism in early warm hepatic ischemia-reperfusion injury. Microvascular Research, 70, 102-110.
Journal - Research Article
Woolley, A. G., Sheard, P. W., & Duxson, M. J. (2005). Neurotrophin-3 null mutant mice display a postnatal motor neuropathy. European Journal of Neuroscience, 21, 2100-2110.
Journal - Research Article
Sheard, P. W., & Bewick, G. S. (2005, December). Abnormal synaptic vesicle dynamics at the motor nerve terminals of neurotrophin-3 deficient mice. Poster session presented at the Medical Sciences Congress, Queenstown, New Zealand.
Conference Contribution - Poster Presentation (not in published proceedings)
Mabuchi, A., Mullaney, I., Sheard, P. W., Hessian, P. A., Mallard, B. L., Tawadrous, M. N., … Wheatley, A. M. (2004). Role of hepatic stellate cell/hepatocyte interaction and activation of hepatic stellate cells in the early phase of liver regeneration in the rat. Journal of Hepatology, 40, 910-916.
Journal - Research Article
Mabuchi, A., Mullaney, I., Sheard, P., Hessian, P., Zimmermann, A., Senoo, H., & Wheatley, A. M. (2004). Role of hepatic stellate cells in the early phase of liver regeneration in rat: Formation of tight adhesion to parenchymal cells. Comparative Hepatology, 3(Suppl. 1), S29.
Journal - Research Article
Paul, A. C., Sheard, P. W., & Duxson, M. J. (2004). Development of a mammalian series-fibered muscle. Anatomical Record Part A, 278A, 571-578. doi: 10.1002/ar.a.20020
Journal - Research Article
Maclennan, K. M., Zheng, Y., Sheard, P. W., Williams, S. M., Darlington, C. L., & Smith, P. F. (2003). Adrenalectomy-induced cell death in the dentate gyrus: Further characterisation using TUNEL and effects of the Ginkgo biloba extract, EGb 761 and ginkgolide B. Hippocampus, 13, 212-225.
Journal - Research Article
Zhang, Y.-F., Homer, C., Edwards, S. J., Hananeia, L., Lasham, A., Royds, J., Sheard, P., & Braithwaite, A. W. (2003). Nuclear localization of Y-box factor YB1 requires wild-type p53. Oncogene, 22, 2782-2794. doi: 10.1038/sj.onc.1206357
Journal - Research Article
Paul, A. C., Sheard, P. W., Kaufman, S. J., & Duxson, M. J. (2002). Localization of α7 integrins and dystrophin suggests potential for both lateral and longitudinal transmission of tension in large mammalian muscles. Cell & Tissue Research, 308, 255-265.
Journal - Research Article
Sheard, P. W., Musaad, K., & Duxson, M. J. (2002). Distribution of neurotrophin receptors in the mouse neuromuscular system. International Journal of Developmental Biology, 46, 569-575.
Journal - Research Article
Sheard, P. W., Paul, A., & Duxson, M. J. (2002). Intramuscular force transmission. Advances in Experimental Medicine & Biology, 508, 495-499.
Journal - Research Article
Mabuchi, A., Mullaney, I., Sheard, P. W., Hessian, P. A., Zimmermann, A., Senoo, H., & Wheatley, A. M. (2002). Role of hepatic stellate cells in the early phase of liver regeneration in rat: formation of tight adhesions to parenchymal cells. 11th International Symposium on the Cells of the Hepatic Sinusoid. Retrieved from http://www.comparative-hepatology.com/
Conference Contribution - Published proceedings: Abstract
Mabuchi, A., Mullaney, I., Sheard, P. W., Hessian, P. A., Zimmermann, A., Senoo, H., & Wheatley, A. M. (2002). Role of hepatic stellate cells in the early phase of liver regeneration in rat: formation of tight adhesions to parenchymal cells. 11th International Symposium on the Cells of the Hepatic Sinusoid. Retrieved from http://www.comparative-hepatology.com/
Conference Contribution - Published proceedings: Abstract
Woolley, A., Sheard, P. W., & Duxson, M. J. (2002). Effects of NT-3 deficit on mouse neuromuscular development. Proceedings of the Third (2002) Asia Pacific Symposium on Neural Regeneration. (pp. 64). [Abstract]
Conference Contribution - Published proceedings: Abstract
Sheard, P. W., Paul, A., McHannigan, P., Young, M. A., & Duxson, M. J. (2001). Intramuscular force transmission. In S. Gandevia, U. Proske & D. Stuart (Eds.), International Union of Physiological Sciences Satellite Meeting on Movement and Sensation. (pp. S57). [Abstract]
Conference Contribution - Published proceedings: Abstract
Scarlett, J. L., Sheard, P. W., Hughes, G., Ledgerwood, E. C., Ku, H.-H., & Murphy, M. P. (2000). Changes in mitochondrial membrane potential during staurosporine-induced apoptosis in Jurkat cells. FEBS Letters, 475, 267-272.
Journal - Research Article
Sheard, P. W. (2000). Tension delivery from short fibers in long muscles. Exercise & Sport Sciences Reviews, 28(2), 51-56.
Journal - Research Article
Young, M., Paul, A., Rodda, J., Duxson, M. J., & Sheard, P. W. (2000). Examination of intrafascicular muscle fiber terminations: Implications for tension delivery in series-fibered muscles. Journal of Morphology, 245, 130-145.
Journal - Research Article
Shaw, J., Duxson, M. J., & Sheard, P. W. (2000). Improved neuromuscular performance following nerve crush in neurotrophin-3 deficient mice. Proceedings of the University of Otago Medical School.78(1), (pp. 16). Dunedin, New Zealand: University Print. [Abstract]
Conference Contribution - Published proceedings: Abstract
Sheard, P. W., Shaw, J., & Duxson, M. J. (2000). Impaired neuromuscular performance among neurotropin-3 deficient mice. Proceedings of the Physiological Society of New Zealand.19, (pp. 19). [Abstract]
Conference Contribution - Published proceedings: Abstract
James, A. M., Sheard, P. W., Wei, Y.-H., & Murphy, M. P. (1999). Decreased ATP synthesis is phenotypically expressed during increased energy demand in fibroblasts containing mitochondrial tRNA mutations: Implications for neurodegenerative and mitochondrial DNA diseases. European Journal of Biochemistry, 259, 462-469.
Journal - Research Article
Sheard, P. W., McHannigan, P., & Duxson, M. J. (1999). Single and paired motor unit performance in skeletal muscles: Comparison between simple and series-fibred muscles from the rat and the guinea pig. Basic & Applied Myology, 9(2), 79-87.
Journal - Research Article
Woolley, A., Sheard, P. W., Dodds, K. G., & Duxson, M. J. (1999). Alpha motoneurons are present in normal numbers but with reduced soma size in neurotrophin-3 knockout mice. Neuroscience Letters, 272, 107-110.
Journal - Research Article
Porteous, W. K., James, A. M., Sheard, P. W., Porteous, C., Packer, M., Hyslop, S. J., Melton, J. V., … Murphy, M. P. (1998). Bioenergetic consequences of accumulating the common 4977-bp mitochondrial DNA deletion. European Journal of Biochemistry, 257, 192-201.
Journal - Research Article
Paul, A. C., Sheard, P. W., & Duxson, M. J. (1998). Mechanisms of tension transmission in mammalian muscles with series-fibred architecture. Proceedings of the University of Otago Medical School.76, (pp. 10). [Abstract]
Conference Contribution - Published proceedings: Abstract
Beazley, L. D., Sheard, P. W., Tennant, M., Starac, D., & Dunlop, S. A. (1997). Optic nerve regenerates but does not restore topographic projections in the lizard Ctenophorus ornatus. Journal of Comparative Neurology, 377(1), 105-120.
Journal - Research Article
Sheard, P. W., & Duxson, M. J. (1997). The transient existence of "en passant" nerve terminals in normal embryonic rat skeletal muscle. Developmental Brain Research, 98(2), 259-264. doi: 10.1016/S0165-3806(96)00184-8
Journal - Research Article
Sheard, P. W., Oettli, H. E., Johnson, A. J., & Duxson, M. J. (1997). Variations in oxidative enzyme type profiles among prenatal rat lumbar motoneurons. Developmental Brain Research, 103(1), 67-75. doi: 10.1016/S0165-3806(97)00118-1
Journal - Research Article
Sheard, P. W., & Duxson, M. J. (1996). Composition of newly forming motor units in prenatal rat intercostal muscle. Developmental Dynamics, 205, 196-212.
Journal - Research Article
Duxson, M. J., & Sheard, P. W. (1995). Formation of new myotubes occurs exclusively at the multiple innervation zones of an embryonic large muscle. Developmental Dynamics, 204, 391-405.
Journal - Research Article
Associate Professor Phil Sheard is interested in sarcopenia, the age-related loss of muscle mass and strength that has profound implications for the elderly.