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Professor Dirk De Ridder

Dirk de RidderProfessor Dirk De Ridder is responsible for skull base surgery (vestibular schwannomas, pituitary surgery), and microvascular decompression surgery.

His research interests are centered on a Darwinian predictive brain model with Bayesian updating to adapt to an ever changing environment. This model is the basis to understand common pathophysiological mechanisms clustering groups of pathologies, such as thalamocortical dysrhythmias (pain, tinnitus, epilepsy, depression, Parkinson's disease, schizophrenia) or obsessive compulsive spectrum disorder (such as addiction, OCD, or eating disorders).

This pathophysiological clustering permits to translate knowledge obtained from one disease to other diseases with similar underlying mechanisms, and to develop novel neuromodulation treatments based on it.

Our clinical neuromodulation research is based on the following concept:

1. All aspects of human normal and pathological behaviour are based on brain activity and connectivity
2. This activity and connectivity can be visualised by functional imaging techniques (PET, fMRI, EEG, MEG)
3. Non-invasive neuromodulation techniques (TMS, tDCS, tRNS, tACS, EEGfeedback) can be used to modulate the abnormal activity and   connectivity
4. If this exerts a clinical benefit a permanent electrode can be implanted on the areas that yield clinical benefit with non-invasive techniques.

A third line of scientific interests focuses on the neural correlates of the "self", how the self is generated in the brain (out of body experiences), its relation to the environment (perception and phantom perception), to others (morality and its pathologies) and god (religion).

Find out more about Professor Dirk De Ridder's research

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Publications

Adhia, D. B., Mani, R., Reynolds, J. N. J., Vanneste, S., & De Ridder, D. (2022). High-definition transcranial infraslow pink noise stimulation for chronic low back pain: protocol for a pilot, safety and feasibility randomised placebo-controlled trial. BMJ Open, 12, e056842. doi: 10.1136/bmjopen-2021-056842

Raymaekers, V., Bamps, S., Duyvendak, W., Put, E., Roosen, G., Vanvolsem, S., … De Ridder, D., & Plazier, M. (2022). Real world data collection and cluster analysis in patients with sciatica due to lumbar disc herniation. Clinical Neurology & Neurosurgery, 217, 107246. doi: 10.1016/j.clineuro.2022.107246

Perez, T. M., Mathew, J., Glue, P., Adhia, D. B., & De Ridder, D. (2022). Is there evidence for the specificity of closed-loop brain training in the treatment of internalizing disorders? A systematic review. Frontiers in Neuroscience, 16, 821136. doi: 10.3389/fnins.2022.821136

De Ridder, D., Vanneste, S., Smith, M., & Adhia, D. (2022). Pain and the triple network model. Frontiers in Neurology, 13, 757241. doi: 10.3389/fneur.2022.757241

Thissen, J., De Ridder, D., Maciaczyk, J., & Bara, G. A. (2022). Endoscopic lateral approach for dorsal root ganglion burst stimulation: Technical note and illustrative case series. Neuromodulation. Advance online publication. doi: 10.1016/j.neurom.2021.10.022

Langguth, B., Kleinjung, T., de Ridder, D., Schlee, W., & Vanneste, S. (Eds.). (2021). Tinnitus: An interdisciplinary approach towards individualized treatment: Towards understanding the complexity of tinnitus: Progress in brain research (Vol. 262). Amsterdam, The Netherlands: Elsevier, 526p.

Edited Book - Research

Schlee, W., Langguth, B., Kleinjung, T., Vanneste, S., & De Ridder, D. (Eds.). (2021). Tinnitus: An interdisciplinary approach towards individualized treatment: From heterogeneity to personalized medicine: Progress in brain research (Vol. 260). Amsterdam, The Netherlands: Elsevier, 451p.

Edited Book - Research

De Ridder, D., & Vanneste, S. (2021). The Bayesian brain in imbalance: Medial, lateral and descending pathways in tinnitus and pain: A perspective. In B. Langguth, T. Kleinjung, D. De Ridder, W. Schlee & S. Vanneste (Eds.), Tinnitus: An interdisciplinary approach towards individualized treatment: Towards understanding the complexity of tinnitus: Progress in brain research (Vol. 262). (pp. 309-334). Amsterdam, The Netherlands: Elsevier. doi: 10.1016/bs.pbr.2020.07.012

Chapter in Book - Research

De Ridder, D., Adhia, D., & Langguth, B. (2021). Tinnitus and brain stimulation. In Current topics in behavioral neurosciences. Berlin, Germany: Springer. doi: 10.1007/7854_2021_219

Chapter in Book - Research

de Ridder, D., Langguth, B., & Vanneste, S. (2021). Vagus nerve stimulation for tinnitus: A review and perspective. In B. Langguth, T. Kleinjung, D. De Ridder, W. Schlee & S. Vanneste (Eds.), Tinnitus: An interdisciplinary approach towards individualized treatment: Towards understanding the complexity of tinnitus: Progress in brain research (Vol. 262). (pp. 451-467). Amsterdam, The Netherlands: Elsevier. doi: 10.1016/bs.pbr.2020.08.011

Chapter in Book - Research

De Ridder, D., Schlee, W., Vanneste, S., Londero, A., Weisz, N., Kleinjung, T., … Kleinstaeuber, M., … Zheng, Y., … Adhia, D. (2021). Tinnitus and tinnitus disorder: Theoretical and operational definitions (an international multidisciplinary proposal). In W. Schlee, B. Langguth, T. Kleinjung, S. Vanneste & D. De Ridder (Eds.), Tinnitus: An interdisciplinary approach towards individualized treatment: From heterogeneity to personalized medicine: Progress in brain research (Vol. 260). (pp. 1-25). Amsterdam, The Netherlands: Elsevier. doi: 10.1016/bs.pbr.2020.12.002

Chapter in Book - Research

He, J., Aa, J.-Y., Sun, J.-G., Smith, P. F., De Ridder, D., Wang, G.-J., & Zheng, Y. (2021). Metabolic changes in the brain and blood of rats following acoustic trauma, tinnitus and hyperacusis. In B. Langguth, T. Kleinjung, D. De Ridder, W. Schlee & S. Vanneste (Eds.), Tinnitus: An interdisciplinary approach towards individualized treatment: Towards understanding the complexity of tinnitus: Progress in brain research (Vol. 262). (pp. 399-430). Amsterdam, The Netherlands: Elsevier. doi: 10.1016/bs.pbr.2020.09.002

Chapter in Book - Research

Li, J., Deng, J. D., Adhia, D., & de Ridder, D. (2021). Resting-state EEG sex classification using selected brain connectivity representation. In T. D. Pham, H. Yan, M. W. Ashraf & F. Sjöberg (Eds.), Advances in artificial intelligence, computation, and data science: For medicine and life science. (pp. 319-329). Cham, Switzerland: Springer. doi: 10.1007/978-3-030-69951-2_13

Chapter in Book - Research

To, W. T., Song, J.-J., Mohan, A., De Ridder, D., & Vanneste, S. (2021). Thalamocortical dysrhythmia underpin the log-dynamics in phantom sounds. In B. Langguth, T. Kleinjung, D. De Ridder, W. Schlee & S. Vanneste (Eds.), Tinnitus: An interdisciplinary approach towards individualized treatment: Towards understanding the complexity of tinnitus: Progress in brain research (Vol. 262). (pp. 511-526). Amsterdam, The Netherlands: Elsevier. doi: 10.1016/bs.pbr.2021.04.001

Chapter in Book - Research

Vanneste, S., Mohan, A., De Ridder, D., & To, W. T. (2021). The BDNF Val66Met polymorphism regulates vulnerability to chronic stress and phantom perception. In W. Schlee, B. Langguth, T. Kleinjung, S. Vanneste & D. De Ridder (Eds.), Tinnitus: An interdisciplinary approach towards individualized treatment: From heterogeneity to personalized medicine: Progress in brain research (Vol. 260). (pp. 301-326). Amsterdam, The Netherlands: Elsevier. doi: 10.1016/bs.pbr.2020.08.005

Chapter in Book - Research

Yoo, H. B., Mohan, A., De Ridder, D., & Vanneste, S. (2021). Paradoxical relationship between distress and functional network topology in phantom sound perception. In W. Schlee, B. Langguth, T. Kleinjung, S. Vanneste & D. De Ridder (Eds.), Tinnitus: An interdisciplinary approach towards individualized treatment: From heterogeneity to personalized medicine: Progress in brain research (Vol. 260). (pp. 367-395). Amsterdam, The Netherlands: Elsevier. doi: 10.1016/bs.pbr.2020.08.007

Chapter in Book - Research

De Ridder, D., Vancamp, T., & Vanneste, S. (2018). Fundamentals of burst stimulation of the spinal cord and brain. In E. S. Krames, P. H. Peckham & A. R. Rezai (Eds.), Neuromodulation (Vol. 1: Comprehensive textbook of principles, technologies, and therapies). (2nd ed.) (pp. 147-160). London, UK: Academic Press. doi: 10.1016/B978-0-12-805353-9.00014-0

Chapter in Book - Research

De Ridder, D., Manning, P., Cape, G., Vanneste, S., Langguth, B., & Glue, P. (2016). Pathophysiology-based neuromodulation for addictions: An overview. In V. R. Preedy (Ed.), Neuropathology of drug addictions and substance misuse (Vol. 1: Foundations of understanding, tobacco, alcohol, cannabinoids and opioids). (pp. 14-24). London: Elsevier. doi: 10.1016/B978-0-12-800213-1.00002-X

Chapter in Book - Research

Johnson, R. D., De Ridder, D., & Gillett, G. (2014). Neurosurgery to enhance brain functions: Ethical dilemmas for the neuroscientist and society. In S. J. Thompson (Ed.), Global issues and ethical considerations in human enhancement technologies. (pp. 96-118). Hershey, PA: IGI Global. doi: 10.4018/978-1-4666-6010-6.ch006

Chapter in Book - Research

Langguth, B., & De Ridder, D. (2013). Tinnitus: Therapeutic use of superficial brain stimulation. In A. M. Lozano & M. Hallett (Eds.), Handbook of clinical neurology (Vol. 116): Brain stimulation. (pp. 441-467). Amsterdam, The Netherlands: Elsevier. doi: 10.1016/B978-0-444-53497-2.00036-X

Chapter in Book - Research

Langguth, B., Elgoyhen, A. B., De Ridder, D., & Salvi, R. J. (2013). Positive spontaneous auditory phenomena: Tinnitus. In G. G. Celesia (Ed.), Disorders of peripheral and central auditory processing: Handbook of clinical neurophysiology (Vol. 10). (pp. 345-381). Elsevier. doi: 10.1016/B978-0-7020-5310-8.00018-1

Chapter in Book - Research

Raymaekers, V., Bamps, S., Duyvendak, W., Put, E., Roosen, G., Vanvolsem, S., … De Ridder, D., & Plazier, M. (2022). Real world data collection and cluster analysis in patients with sciatica due to lumbar disc herniation. Clinical Neurology & Neurosurgery, 217, 107246. doi: 10.1016/j.clineuro.2022.107246

Journal - Research Article

Bretherton, B., de Ridder, D., Crowther, T., Black, S., Whelan, A., & Baranidharan, G. (2021). Men and women respond equally well to spinal cord and dorsal root ganglion stimulation. Neuromodulation. Advance online publication. doi: 10.1111/ner.13484

Journal - Research Article

Lee, S.-Y., Chang, M., Kwon, B., Choi, B. Y., Koo, J.-W., Moon, T., De Ridder, D., … Song, J.-J. (2021). Is the posterior cingulate cortex an on-off switch for tinnitus?: A comparison between hearing loss subjects with and without tinnitus. Hearing Research, 41, 108356. doi: 10.1016/j.heares.2021.108356

Journal - Research Article

Leong, S. L., De Ridder, D., Deer, T., & Vanneste, S. (2021). Potential therapeutic effect of low amplitude burst spinal cord stimulation on pain. Neuromodulation, 24(3), 574-580. doi: 10.1111/ner.13090

Journal - Research Article

Schultheis, B. C., Wille, C., Ross-Steinhagen, N. E., De Ridder, D., Vancamp, T., & Weidle, P. A. (2021). Alternative dorsal root ganglion neuromodulation electrode implantation: A report of 2 Cases with 3 different techniques. Journal of Neurological Surgery: Part A. Advance online publication. doi: 10.1055/s-0041-1739219

Journal - Research Article

Song, J.-J., Park, J., Koo, J.-W., Lee, S.-Y., Vanneste, S., De Ridder, D., … Lim, S. (2021). The balance between Bayesian inference and default mode determines the generation of tinnitus from decreased auditory input: A volume entropy-based study. Human Brain Mapping. Advance online publication. doi: 10.1002/hbm.25539

Journal - Research Article

Sui, Y., Tian, Y., Ko, W. K. D., Wang, Z., Jiang, F., Horn, A., De Ridder, D., … Li, L. (2021). Deep brain stimulation initiative: Toward innovative technology, new disease indications, and approaches to current and future clinical challenges in neuromodulation therapy. Frontiers in Neurology, 11, 597451. doi: 10.3389/fneur.2020.597451

Journal - Research Article

Han, J. J., De Ridder, D., Vanneste, S., Chen, Y.-C., Koo, J.-W., & Song, J.-J. (2020). Pre-treatment ongoing cortical oscillatory activity predicts improvement of tinnitus after partial peripheral reafferentation with hearing aids. Frontiers in Neuroscience, 14, 410. doi: 10.3389/fnins.2020.00410

Journal - Research Article

Lee, S.-Y., Choi, B. Y., Koo, J.-W., De Ridder, D., & Song, J.-J. (2020). Cortical oscillatory signatures reveal the prerequisites for tinnitus perception: A comparison of subjects with sudden sensorineural hearing loss with and without tinnitus. Frontiers in Neuroscience, 14, 596647. doi: 10.3389/fnins.2020.596647

Journal - Research Article

Leong, S. L., Glue, P., Manning, P., Vanneste, S., Lim, L. J., Mohan, A., & De Ridder, D. (2020). Anterior cingulate cortex implants for alcohol addiction: A feasibility study. Neurotherapeutics, 17, 1287-1299. doi: 10.1007/s13311-020-00851-4

Journal - Research Article

Mohan, A., Davidson, C., De Ridder, D., & Vanneste, S. (2020). Effective connectivity analysis of inter- and intramodular hubs in phantom sound perception: Identifying the core distress network. Brain Imaging & Behavior, 14, 289-307. doi: 10.1007/s11682-018-9989-7

Journal - Research Article

Ros, T., Enriquez-Geppert, S., Zotev, V., Young, K. D., Wood, G., Whitfield-Gabrieli, S., … De Ridder, D., … Thibault, R. T. (2020). Consensus on the reporting and experimental design of clinical and cognitive-behavioural neurofeedback studies (CRED-nf checklist). Brain, 143, 1674-1685. doi: 10.1093/brain/awaa009

Journal - Research Article

Yearwood, T., De Ridder, D., Bin Yoo, H., Falowski, S., Venkatesan, L., To, W. T., & Vanneste, S. (2020). Comparison of neural activity in chronic pain patients during tonic and burst spinal cord stimulation using fluorodeoxyglucose positron emission tomography. Neuromodulation, 23, 56-63. doi: 10.1111/ner.12960

Journal - Research Article

Huang, Y., Hullfish, J., De Ridder, D., & Vanneste, S. (2019). Meta-analysis of functional subdivisions within human posteromedial cortex. Brain Structure & Function, 224, 435-452. doi: 10.1007/s00429-018-1781-3

Journal - Research Article

Hullfish, J., Abenes, I., Yoo, H. B., De Ridder, D., & Vanneste, S. (2019). Frontostriatal network dysfunction as a domain-general mechanism underlying phantom perception. Human Brain Mapping, 40, 2241-2251. doi: 10.1002/hbm.24521

Journal - Research Article

Kandeepan, S., Maudoux, A., Ribeiro de Paula, D., Zheng, J. Y., Cabay, J. E., Gómez, F., … De Ridder, D., … Soddu, A. (2019). Tinnitus distress: A paradoxical attention to the sound? Journal of Neurology, 266, 2197-2207. doi: 10.1007/s00415-019-09390-1

Journal - Research Article

Lee, S.-Y., Rhee, J., Shim, Y. J., Kim, Y., Koo, J.-W., De Ridder, D., … Song, J.-J. (2019). Changes in the resting-state cortical oscillatory activity 6 months after modified tinnitus retraining therapy. Frontiers in Neuroscience, 13, 1123. doi: 10.3389/fnins.2019.01123

Journal - Research Article

Mani, R., Adhia, D. B., Leong, S. L., Vanneste, S., & De Ridder, D. (2019). Sedentary behaviour facilitates conditioned pain modulation in middle-aged and older adults with persistent musculoskeletal pain: A cross-sectional investigation. PAIN Reports, 4, e773. doi: 10.1097/PR9.0000000000000773

Journal - Research Article

Vanneste, S., Alsaman, O., & De Ridder, D. (2019). Top-down and bottom-up regulated auditory phantom perception. Journal of Neuroscience, 39(2), 364-378. doi: 10.1523/jneurosci.0966-18.2018

Journal - Research Article

Ahmed, S., Plazier, M., Ost, J., Stassijns, G., Deleye, S., Ceyssens, S., … De Ridder, D., & Vanneste, S. (2018). The effect of occipital nerve field stimulation on the descending pain pathway in patients with fibromyalgia: A water PET and EEG imaging study. BMC Neurology, 18(1), 191. doi: 10.1186/s12883-018-1190-5

Journal - Research Article

Bin Yoo, H., de la Concha, E. O., De Ridder, D., Pickut, B. A., & Vanneste, S. (2018). The functional alterations in top-down attention streams of Parkinson's disease measured by EEG. Scientific Reports, 8, 10609. doi: 10.1038/s41598-018-29036-y

Journal - Research Article

Han, J. J., Jang, J. H., De Ridder, D., Vanneste, S., Koo, J.-W., & Song, J.-J. (2018). Increased parietal circuit-breaker activity in delta frequency band and abnormal delta/theta band connectivity in salience network in hyperacusis subjects. PLoS ONE, 13(1), e0191858. doi: 10.1371/journal.pone.0191858

Journal - Research Article

Huang, Y., Mohan, A., De Ridder, D., Sunaert, S., & Vanneste, S. (2018). The neural correlates of the unified percept of alcohol-related craving: A fMRI and EEG study. Scientific Reports, 8, 923. doi: 10.1038/s41598-017-18471-y

Journal - Research Article

Hullfish, J., Abenes, I., Kovacs, S., Sunaert, S., De Ridder, D., & Vanneste, S. (2018). Functional brain changes in auditory phantom perception evoked by different stimulus frequencies. Neuroscience Letters, 683, 160-167. doi: 10.1016/j.neulet.2018.07.043

Journal - Research Article

Leong, S. L., De Ridder, D., Vanneste, S., Sutherland, W., Ross, S., & Manning, P. (2018). High definition transcranial pink noise stimulation of anterior cingulate cortex on food craving: An explorative study. Appetite, 120, 673-678. doi: 10.1016/j.appet.2017.10.034

Journal - Research Article

Leong, S. L., Vanneste, S., Lim, J., Smith, M., Manning, P., & De Ridder, D. (2018). A randomised, double-blind, placebo-controlled parallel trial of closed-loop infraslow brain training in food addiction. Scientific Reports, 8, 11659. doi: 10.1038/s41598-018-30181-7

Journal - Research Article

Mohan, A., Alexandra, S. J., Johnson, C. V., De Ridder, D., & Vanneste, S. (2018). Effect of distress on transient network dynamics and topological equilibrium in phantom sound perception. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 84, 79-92. doi: 10.1016/j.pnpbp.2018.01.025

Journal - Research Article

Mohan, A., De Ridder, D., Idiculla, R., DSouza, C., & Vanneste, S. (2018). Distress-dependent temporal variability of regions encoding domain-specific and domain-general behavioral manifestations of phantom percepts. European Journal of Neuroscience, 48(2), 1743-1764. doi: 10.1111/ejn.13988

Journal - Research Article

Pattyn, T., Vanneste, S., De Ridder, D., Van Rompaey, V., Veltman, D. J., Van de Heyning, P., … Van Den Eede, F. (2018). Differential electrophysiological correlates of panic disorder in non-pulsatile tinnitus. Journal of Psychosomatic Research, 109, 57-62. doi: 10.1016/j.jpsychores.2018.03.168

Journal - Research Article

Ting To, W., De Ridder, D., Hart, Jr, J., & Vanneste, S. (2018). Changing brain networks through non-invasive neuromodulation. Frontiers in Human Neuroscience, 12, 128. doi: 10.3389/fnhum.2018.00128

Journal - Research Article

Vanneste, S., Alsalman, O., & De Ridder, D. (2018). COMT and the neurogenetic architecture of hearing loss induced tinnitus. Hearing Research, 365, 1-15. doi: 10.1016/j.heares.2018.05.020

Journal - Research Article

Vanneste, S., Joos, K., Ost, J., & De Ridder, D. (2018). Influencing connectivity and cross-frequency coupling by real-time source localized neurofeedback of the posterior cingulate cortex reduces tinnitus related distress. Neurobiology of Stress, 8, 211-224. doi: 10.1016/j.ynstr.2016.11.003

Journal - Research Article

Vanneste, S., Song, J.-J., & De Ridder, D. (2018). Thalamocortical dysrhythmia detected by machine learning. Nature Communications, 9(1), 1103. doi: 10.1038/s41467-018-02820-0

Journal - Research Article

Vanneste, S., Ting To, W., & De Ridder, D. (2018). Tinnitus and neuropathic pain share a common neural substrate in the form of specific brain connectivity and microstate profiles. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 88, 388-400. doi: 10.1016/j.pnpbp.2018.08.015

Journal - Research Article

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