Dr Clarkson's work focuses on promoting neuroprotection, regeneration and repair mechanisms to improve recovery of function following a stroke.
Even though acute stroke deaths have declined in recent years, as the population ages, the incidence of stroke is increasing resulting in a larger population of disabled stroke patients. The ability of the adult brain to regenerate or recover from acute injury is limited and stroke is now one of the leading causes of long-term disability.
The mechanisms of recovery after stroke have not been well defined. Recent studies show a limited capacity for neural repair after stroke, including re-mapping of cognitive functions and sprouting new connections in tissue adjacent to the stroke. Neurorehabilitation from using repetitive and patterned use of affected limbs linked to the affected brain regions has been shown to promote partial recovery via activity-based re-programming. An understanding of these neural repair mechanisms within the peri-infarct cortex may lead to therapies that promote recovery. Neurorehabiliation uses similar cognitive rules to learning and memory and Dr Clarkson postulates that cellular mechanisms of learning and memory are involved in the underlying processes of recovery following a focal brain injury.
The overall goal of his research program is to identify mechanisms of neural repair after stroke by modulating cortical excitability. Dr Clarkson's recent studies indicate that just like learning and memory processes, cortical excitability can influence neural repair after stroke. Using novel functional and cortical motor mapping techniques, he will systematically assess the molecular mechanisms associated with learning and memory and how they may support or regulate neural repair and plasticity following focal brain injury. Intensive rehabilitation, drug therapy and, more recently, stem cells are combined to enhance brain repair processes. Post-stroke recovery is assessed through optical imaging and behavioural, electrophysiological, and anatomical measures. His research may produce novel pharmacological tools to help improve neurorehabilitation and recovery.
Read more about Dr Clarkson's research
Publications
McCallum-Loudeac, J., Moody, E., Williams, J., Johnstone, G., Sircombe, K. J., Clarkson, A. N., & Wilson, M. J. (2024). Deletion of a conserved genomic region associated with adolescent idiopathic scoliosis leads to vertebral rotation in mice. Human Molecular Genetics. Advance online publication. doi: 10.1093/hmg/ddae011 Journal - Research Article
Hayward, K. S., Dalton, E. J., Barth, J., Brady, M., Cherney, L. R., Churilov, L., Clarkson, A. N., … Lang, C. E. (2023). Control intervention design for preclinical and clinical trials: Consensus-based core recommendations from the third Stroke Recovery and Rehabilitation Roundtable. Neurorehabilitation & Neural Repair. Advance online publication. doi: 10.1177/15459683231209162 Journal - Professional & Other Non-Research Articles
Liu, J., van Beusekom, H., Bu, X.-L., Chen, G., Rosado de Castro, P. H., Chen, X., … Clarkson, A. N., … Wang, Y.-J. (2023). Preserving cognitive function in patients with Alzheimer's disease: The Alzheimer's disease neuroprotection research initiative (ADNRI). Neuroprotection. Advance online publication. doi: 10.1002/nep3.23 Journal - Research Other
Hoque, A., Clarkson, A. N., Sobey, C. G., Williamson, N. A., Ang, C.-S., Cheng, H.-C., & Oakhill, J. S. (2023). Testing a new strategy to treat acute ischaemic stroke. Journal of Neurochemistry, 166(Suppl. 1), (pp. 106-107). doi: 10.1111/jnc.15897 Conference Contribution - Published proceedings: Abstract
Griem-Krey, N., Klein, A. B., Clausen, B. H., Namini, M. R. J., Nielsen, P. V., Bhuiyan, M., … Clarkson, A. N., & Wellendorph, P. (2023). The GHB analogue HOCPCA improves deficits in cognition and sensorimotor function after MCAO via CaMKIIα. Journal of Cerebral Blood Flow & Metabolism. Advance online publication. doi: 10.1177/0271678x231167920 Journal - Research Article
Ameen, S. S., Griem-Krey, N., Dufour, A., Hossain, M. I., Hoque, A., Sturgeon, S., … Clarkson, A. N. (2023). N-Terminomic changes of neurons during excitotoxicity reveal proteolytic events associated with synaptic dysfunctions and potential targets for neuroprotection. Molecular & Cellular Proteomics. Advance online publication. doi: 10.1016/j.mcpro.2023.100543 Journal - Research Article
Bhuiyan, M. H., Houlton, J., & Clarkson, A. N. (2023). Hydrogels and nanoscaffolds for long-term intraparenchymal therapeutic delivery after stroke. In V. T. Karamyan & A. M. Stowe (Eds.), Neural repair: Methods and protocols: Methods in molecular biology (Vol. 2616). (pp. 379-390). New York, NY: Springer Nature. doi: 10.1007/978-1-0716-2926-0_26 Chapter in Book - Research
Bhuiyan, M. H., Clarkson, A. N., & Ali, M. A. (2023). Optimization of thermoresponsive chitosan/β-glycerophosphate hydrogels for injectable neural tissue engineering application. Colloids & Surfaces B. Advance online publication. doi: 10.1016/j.colsurfb.2023.113193 Journal - Research Article
Cotter, K. M., Bancroft, G. L., Haas, H. A., Shi, R., Clarkson, A. N., Croxall, M. E., … Eisch, A. J. (2023). Use of an automated mouse touchscreen platform for quantification of cognitive deficits after central nervous system injury. In V. T. Karamyan & A. M. Stowe (Eds.), Neural repair: Methods and protocols: Methods in molecular biology (Vol. 2616). (pp. 279-326). New York, NY: Springer Nature. doi: 10.1007/978-1-0716-2926-0_21 Chapter in Book - Research
Potemkin, N., & Clarkson, A. N. (2023). Non-coding RNAs in stroke pathology, diagnostics, and therapeutics. Neurochemistry International, 162, 105467. doi: 10.1016/j.neuint.2022.105467 Journal - Research Other
Qasim, M., Clarkson, A. N., & Hinkley, S. F. R. (2023). Green synthesis of carbon nanoparticles (CNPs) from biomass for biomedical applications. International Journal of Molecular Sciences, 24, 1023. doi: 10.3390/ijms24021023 Journal - Research Other
Morris, G. P., Gowing, E. K., Courtney, J.-M., Coombe, H. E., King, N. E., Rewell, S. S. J., … Clarkson, A. N., & Sutherland, B. A. (2023). Vascular perfusion differs in two distinct PDGFRβ-positive zones within the ischemic core of male mice 2 weeks following photothrombotic stroke. Journal of Neuroscience Research, 101, 278-292. doi: 10.1002/jnr.25146 Journal - Research Article
Clarkson, A. (2022, August-September). Impact of comorbidities, prediabetes and hyperuricemia, on recovery following stroke. Verbal presentation at the Stroke Society of Australasia (SSA) 31st Annual Scientific Meeting, Christchurch, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Griem-Krey, N., Clarkson, A. N., & Wellendorph, P. (2022). CaMKIIα as a promising drug target for ischemic grey matter [Review]. Brain Sciences, 12(12), 1639. doi: 10.3390/brainsci12121639 Journal - Research Article
Griem-Krey, N., Gauger, S. J., Gowing, E. K., Thiesen, L., Frølund, B., Clarkson, A. N., & Wellendorph, P. (2022). The CaMKIIα hub ligand Ph-HTBA promotes neuroprotection after focal ischemic stroke by a distinct molecular interaction. Biomedicine & Pharmacotherapy, 156, 113895. doi: 10.1016/j.biopha.2022.113895 Journal - Research Article
Bhuiyan, M. H., Ali, A., & Clarkson, A. (2022, August-September). Novel thermoresponsive hydrogels (NTH) to prevent reactive gliosis after stroke. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) NZ Annual Scientific Meeting, Queenstown, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Houlton, J., Zubkova, O., & Clarkson, A. N. (2022). Recovery of post-stroke spatial memory and thalamocortical connectivity following novel glycomimetic and rhBDNF treatment. International Journal of Molecular Sciences, 23, 4817. doi: 10.3390/ijms23094817 Journal - Research Article
Smyth, L. C. D., Murray, H. C., Hill, M., van Leeuwen, E., Highet, B., Magon, N. J., … Mathiesen, S. N., Mockett, B., … Clarkson, A. N., … Abraham, W. C., Hughes, S. M., … Kettle, A. J., … Hampton, M. B. (2022). Neutrophil-vascular interactions drive myeloperoxidase accumulation in the brain in Alzheimer's disease. Acta Neuropathologicca Communications, 10, 38. doi: 10.1186/s40478-022-01347-2 Journal - Research Article
O'Sullivan, M. J., Oestreich, L. K. L., Wright, P., & Clarkson, A. N. (2022). Cholinergic and hippocampal systems facilitate cross-domain cognitive recovery after stroke. Brain, 145, 1698-1710. doi: 10.1093/brain/awac070 Journal - Research Article
Shirazi, R. S., Vyssotski, M., Lagutin, K., Thompson, D., MacDonald, C., Luscombe, V., Glass, M., … Gowing, E. K., … Clarkson, A. N. (2022). Neuroprotective activity of new Δ3-N-acylethanolamines in a focal ischemia stroke model. Lipids, 57, 17-31. doi: 10.1002/lipd.12326 Journal - Research Article
McLaughlin, A. W., McDowell, A., Clarkson, A. N., & Walker, G. F. (2022). Characterization of poly(lactic-co-glycolic acid) nanofibers electrospun using a sustainable green chemistry with a low toxicity solvent system. International Journal of Polymeric Materials & Polymeric Biomaterials, 71(13), 983-992. doi: 10.1080/00914037.2021.1933976 Journal - Research Article
Lamtahri, R., Hazime, M., Gowing, E. K., Nagaraja, R. Y., Maucotel, J., Alasoadura, M., … Clarkson, A. N., … Chuquet, J. (2021). The gliopeptide ODN, a ligand for the benzodiazepine site of GABAA receptors, boosts functional recovery after stroke. Journal of Neuroscience, 41(33), 7148-7159. doi: 10.1523/jneurosci.2255-20.2021 Journal - Research Article
Neumann, S., Campbell, K., Woodall, M. J., Evans, M., Clarkson, A. N., & Young, S. L. (2021). Obesity has a systemic effect on immune cells in naïve and cancer-bearing mice. International Journal of Molecular Sciences, 22, 8803. doi: 10.3390/ijms22168803 Journal - Research Article
Leurs, U., Klein, A. B., McSpadden, E. D., Griem-Krey, N., Solbaka, S. M. Ø., Houlton, J., … Gowing, E. K., … Clarkson, A. N., & Wellendorph, P. (2021). GHB analogs confer neuroprotection through specific interaction with the CaMKIIα hub domain. PNAS, 118(31), e2108079118. doi: 10.1073/pnas.2108079118 Journal - Research Article
Jobson, D. D., Hase, Y., Clarkson, A. N., & Kalaria, R. N. (2021). The role of the medial prefrontal cortex in cognition, ageing and dementia. Brain Communications, 3(3), fcab125. doi: 10.1093/braincomms/fcab125 Journal - Research Article
van Nieuwenhuijzen, P. S., Parker, K., Liao, V., Houlton, J., Kim, H.-Y., Johnston, G. A. R., … Clarkson, A. N. (2021). Targeting GABAC receptors improves post‐stroke motor recovery. Brain Sciences, 11(3), 315. doi: 10.3390/brainsci11030315 Journal - Research Article
Barzegar-Fallah, A., Houlton, J., Barwick, D., Shavandi, A., Ali, M. A., Clarkson, A. N., & Alimoradi, H. (2021). From barriers to bridges: Glycans in naonparenteral nanomedicines. In P. Kesharwani, S. Taurin & K. Greish (Eds.), Theory and applications of nonparenteral nanomedicines. (pp. 467-487). London, UK: Elsevier. doi: 10.1016/B978-0-12-820466-5.00019-3 Chapter in Book - Research
Houlton, J., Barwick, D., & Clarkson, A. N. (2021). Frontal cortex stroke-induced impairment in spatial working memory on the trial-unique nonmatching-to-location task in mice. Neurobiology of Learning & Memory, 177, 107355. doi: 10.1016/j.nlm.2020.107355 Journal - Research Article
Boni, R., Ali, A., Giteru, S. G., Shavandi, A., & Clarkson, A. N. (2020). Silk fibroin nanoscaffolds for neural tissue engineering. Journal of Materials Science: Materials in Medicine, 31, 81. doi: 10.1007/s10856-020-06422-5 Journal - Research Article
Atienza-Roca, P., Kieser, D., Cui, X., Bathish, B., Ramaswamy, Y., Hooper, G. J., Clarkson, A. N., … Wise, L. M., Woodfield, T. B. F., & Lim, K. S. (2020). Visible light mediated PVA-tyramine hydrogels for covalent incorporation and tailorable release of functional growth factors. Biomaterials Science, 8(18), 5005-5019. doi: 10.1039/D0BM00603C Journal - Research Article
Soo, J. Y., Wiese, M. D., Dyson, R. M., Gray, C. L., Clarkson, A. N., Morrison, J. L., & Berry, M. J. (2020). Methamphetamine administration increases hepatic CYP1A2 but not CYP3A activity in female guinea pigs. PLoS ONE, 15(5), e0233010. doi: 10.1371/journal.pone.0233010 Journal - Research Article
Boltze, J., Abe, K., Clarkson, A. N., Detante, O., Pimentel-Coelho, P. M., Rosado-de-Castro, P. H., & Janowski, M. (2020). Cell-based therapies for stroke: Promising solution or dead end? Frontiers in Neurology, 11, 171. doi: 10.3389/fneur.2020.00171 Journal - Research Other
Lumsden, S. C., Clarkson, A. N., & Cakmak, Y. O. (2020). Neuromodulation of the pineal gland via electrical stimulation of its sympathetic innervation pathway. Frontiers in Neuroscience, 14, 264. doi: 10.3389/fnins.2020.00264 Journal - Research Other
Cirillo, J., Mooney, R. A., Ackerley, S. J., Barber, P. A., Borges, V. M., Clarkson, A. N., … Byblow, W. D. (2020). Neurochemical balance and inhibition at the subacute stage after stroke. Journal of Neurophysiology, 123, 1775-1790. doi: 10.1152/jn.00561.2019 Journal - Research Article
McFall, A., Hietamies, T. M., Bernard, A., Aimable, M., Allan, S. M., Bath, P. M., … Clarkson, A. N., … Quinn, T. J. (2020). UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: Questionnaire and workshop proceedings. Journal of Cerebral Blood Flow & Metabolism, 47(7), 1402-1414. doi: 10.1177/0271678X20910552 Journal - Research Article
Ganesh, M., Clare, A. J., Dragunow, M., Hughes, S. M., Clarkson, A. N., & Empson, R. M. (2019). Deciphering the fate of integrated pericytes in mouse motor cortex. Proceedings of the 39th Australasian Neuroscience Society (ANS) Annual Scientific Meeting. 12491. Retrieved from https://www.ans.org.au Conference Contribution - Published proceedings: Abstract
Clarkson, A. N. (2019, August-September). Use of biomaterials to enhance neural tissue regeneration. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Gowing, E., Nagaraja, R., Lefranc, B., Leprince, J., Chuquet, J., & Clarkson, A. (2019). The gliopeptide ODN regulates tonic GABAA receptor currents and boosts functional recovery after stroke. In K. Hillman (Ed.), Proceedings of the 37th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 54). Retrieved from http://www.otago.ac.nz/awcbr Conference Contribution - Published proceedings: Abstract
Golden, E., Gowing, E., & Clarkson, A. (2019). Establishing an animal model of paediatric mild traumatic brain injury. In K. Hillman (Ed.), Proceedings of the 37th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 53). Retrieved from http://www.otago.ac.nz/awcbr Conference Contribution - Published proceedings: Abstract
Barnett, E., Gowing, E., & Clarkson, A. (2019). Assessing the impact of comorbidities on axonal sprouting after stroke to the motor cortex. In K. Hillman (Ed.), Proceedings of the 37th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 52). Retrieved from http://www.otago.ac.nz/awcbr Conference Contribution - Published proceedings: Abstract
Houlton, J., Barwick, D., Clarke, C., & Clarkson, A. (2019). Stroke-induced impairment in spatial working memory on the trial-unique nonmatched-to-location task. In K. Hillman (Ed.), Proceedings of the 37th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 45). Retrieved from http://www.otago.ac.nz/awcbr Conference Contribution - Published proceedings: Abstract
Lumsden, S. C., Clarkson, A. N., & Cakmak, Y. O. (2019). Neuromodulation of the pineal gland. In K. Hillman (Ed.), Proceedings of the 37th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 44). Retrieved from http://www.otago.ac.nz/awcbr Conference Contribution - Published proceedings: Abstract
Ganesh, M., Clare, A. J., Dragunow, M., Hughes, S. M., Clarkson, A. N., & Empson, R. M. (2019). Deciphering the fate of integrate pericytes in mouse motor cortex. In K. Hillman (Ed.), Proceedings of the 37th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 35). Retrieved from http://www.otago.ac.nz/awcbr Conference Contribution - Published proceedings: Abstract
Van der Giessen, H., Barwick, D., & Clarkson, A. N. (2019). Silent stroke to the medial dorsal nucleus of the thalamus impairs olfactory circuitry. Proceedings of the Society for Neuroscience Annual Meeting. 657.07/F36. SfN. Retrieved from https://www.sfn.org Conference Contribution - Published proceedings: Abstract
Houlton, J. M., Clarke, C., Barwick, D. K., & Clarkson, A. N. (2019). Stroke induced impairment in spatial working memory on the trial unique nonmatched to location task. Proceedings of the Society for Neuroscience Annual Meeting. 135.11/H39. SfN. Retrieved from https://www.sfn.org Conference Contribution - Published proceedings: Abstract
Neumann, S., Boothman-Burrell, L., Gowing, E. K., Jacobsen, T. A., Ahring, P. K., Young, S. L., … Clarkson, A. N. (2019). The delta-subunit selective GABAA receptor modulator, DS2, improves stroke recovery via an anti-inflammatory mechanism. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) and the Population Approach Group of Australia and New Zealand (PAGANZ) Joint Scientific Meeting: Shared Horizons: Optimizing Drug Response to Improve Patient Outcomes. (pp. 57). Retrieved from https://www.asceptasm.com Conference Contribution - Published proceedings: Abstract
Richter, G. A., van Nieuwenhuijzen, P. S., Rahardjo, G. L., Clarkson, A., & Chebib, M. (2019). Brain activity in response to z-drugs: Role for GABAA γ1 and γ3 subunits. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) and the Population Approach Group of Australia and New Zealand (PAGANZ) Joint Scientific Meeting: Shared Horizons: Optimizing Drug Response to Improve Patient Outcomes. (pp. 51). Retrieved from https://www.asceptasm.com Conference Contribution - Published proceedings: Abstract
Neumann, S., Boothman-Burrell, L., Gowing, E. K., Jacobsen, T. A., Ahring, P. K., Young, S. L., … Clarkson, A. N. (2019). The delta-subunit selective GABAA receptor modulator, DS2, improves stroke recovery via an anti-inflammatory mechanism. Frontiers in Neuroscience, 13, 1133. doi: 10.3389/fnins.2019.01133 Journal - Research Article
McDonald, M. W., Black, S. E., Copland, D. A., Corbett, D., Dijkhuizen, R. M., Farr, T. D., … Clarkson, A. N., & O'Sullivan, M. J. (2019). Cognition in stroke rehabilitation and recovery research: Consensus-based core recommendations from the second Stroke Recovery and Rehabilitation Roundtable. Neurorehabilitation & Neural Repair, 33(11), 943-950. doi: 10.1177/1545968319886444 Journal - Research Other
Bernhardt, J., Borschmann, K., Kwakkel, G., Burridge, J., Eng, J., Walker, M., … Clarkson, A., & Corbett, D. (2019). Consensus building at the Second International Stroke Recovery and Rehabilitation Roundtable. International Journal of Stroke, 14(2, Suppl.), (pp. 12). doi: 10.1177/1747493019862960 Conference Contribution - Published proceedings: Abstract
McDonald, M. W., Black, S. E., Copland, D. A., Corbett, D., Dijkhuizen, R. M., Farr, T. D., … Clarkson, A. N., & O'Sullivan, M. J. (2019). Cognition in stroke rehabilitation and recovery research: Consensus-based core recommendations from the second Stroke Recovery and Rehabilitation Roundtable. International Journal of Stroke, 14(8), 774-782. doi: 10.1177/1747493019873600 Journal - Research Other
Cirillo, J., Mooney, R., Ackerley, S. J., Borges, V., Smith, M.-C., Mangold, C., … Clarkson, A., … Byblow, W. D. (2019). The influence of motor cortex inhibition on upper limb recovery: A multimodal study. Stroke, 50(Suppl. 1), 69. doi: 10.1161/str.50.suppl_1.69 Conference Contribution - Published proceedings: Abstract
Houlton, J., Abumaria, N., Hinkley, S. F. R., & Clarkson, A. N. (2019). Therapeutic potential of neurotrophins for repair after brain injury: A helping hand from biomaterials. Frontiers in Neuroscience, 13, 790. doi: 10.3389/fnins.2019.00790 Journal - Research Article
Hillman, K. L., Wall, H. J., Matthews, L. O., Gowing, E. K., & Clarkson, A. N. (2019). Altered hippocampal-prefrontal dynamics following medial prefrontal stroke in mouse. NeuroMolecular Medicine, 21, 401-413. doi: 10.1007/s12017-019-08557-3 Journal - Research Article
Kim, H., Evans, M. A., Zhang, S. R., Drummond, G. R., Arumugam, T. V., Clarkson, A. N., … Sobey, C. G. (2019). Functional impairment after stroke is exacerbated by vitamin D deficiency but is mitigated by supplementation. Journal of Cerebral Blood Flow & Metabolism, 39(1, Suppl.), (pp. 348). doi: 10.1177/0271678X19851020 Conference Contribution - Published proceedings: Abstract
Clarkson, A. N., & Houlton, J. (2019). BDNF improves cognitive function after stroke in aged mice. Journal of Cerebral Blood Flow & Metabolism, 39(1, Suppl.), (pp. 344). doi: 10.1177/0271678X19851020 Conference Contribution - Published proceedings: Abstract
Clarkson, A. N., Barwick, D. K., Zubkova, O., & Carmichael, S. T. (2019). Combined treatment of rehabilitation and novel glycosominoglycan treatment abolishes forelimb impiarments following motor cortex stroke in mice. Journal of Cerebral Blood Flow & Metabolism, 39(1, Suppl.), (pp. 458-459). doi: 10.1177/0271678X19851020 Conference Contribution - Published proceedings: Abstract
Bernhardt, J., Borschmann, K. N., Kwakkel, G., Burridge, J. H., Walker, M. F., Bird, M.-L., … Clarkson, A. N., … for the SRRR2 Collaboration. (2019). Setting the scene for the Second Stroke Recovery and Rehabilitation Roundtable. International Journal of Stroke, 14(5), 450-456. doi: 10.1177/1747493019851287 Journal - Research Other
Abumaria, N., Li, W., & Clarkson, A. N. (2019). Role of the chanzyme TRPM7 in the nervous system in health and disease. Cellular & Molecular Life Sciences, 76, 3301-3310. doi: 10.1007/s00018-019-03124-2 Journal - Research Other
Houlton, J., Zhou, L. Y. Y., Barwick, D., Gowing, E. K., & Clarkson, A. N. (2019). Stroke induces a BDNF-dependent improvement in cognitive flexibility in aged mice. Neural Plasticity, 2019, 1460890. doi: 10.1155/2019/1460890 Journal - Research Article
Clarkson, A. N., Boothman-Burrell, L., Dósa, Z., Nagaraja, R. Y., Jin, L., Parker, K., … Neumann, S., Gowing, E. K., … Chebib, M. (2019). The flavonoid, 2'-methoxy-6-methylflavone, affords neuroprotection following focal cerebral ischaemia. Journal of Cerebral Blood Flow & Metabolism, 39(7), 1266-1282. doi: 10.1177/0271678x18755628 Journal - Research Article
Lie, M. E. K., Gowing, E. K., Johansen, N. B., Dalby, N. O., Thiesen, L., Wellendorph, P., & Clarkson, A. N. (2019). GAT3 selective substrate L-isoserine upregulates GAT3 expression and increases functional recovery after a focal ischemic stroke in mice. Journal of Cerebral Blood Flow & Metabolism, 39(1), 74-88. doi: 10.1177/0271678x17744123 Journal - Research Article
Zhou, L., Barwick, D., Gowing, E., & Clarkson, A. (2018). Stroke to the prefrontal cortex disrupts cholinergic signalling and impairs attention. International Journal of Stroke, 13(2, Suppl.), (pp. 148). doi: 10.1177/1747493018789543 Conference Contribution - Published proceedings: Abstract
Houlton, J., Zhou, L., & Clarkson, A. (2018). Age-related differences in recovery of cognitive function following stroke to the prefrontal cortex is dependent on brain-derived neurotrophic factor signaling. International Journal of Stroke, 13(2, Suppl.), (pp. 82). doi: 10.1177/1747493018789543 Conference Contribution - Published proceedings: Abstract
De Silva, M., Evans, M., Pokhriyal, P., Drummond, G., Arumugam, T., Ah Kim, H., … Clarkson, A. (2018). Vitamin D therapy for ischemic stroke. Proceedings of the 38th Australasian Neuroscience Society (ANS) Annual Scientific Meeting. 9479. Retrieved from https://www.ans.org.au Conference Contribution - Published proceedings: Abstract
Clarkson, A. (2018, April). Using polymer gels for targeted brain delivery of bioactives for the treatment of stroke. Verbal presentation at the University of Otago Centre for Bioengineering & Nanomedicine Symposium: Biomaterials and Regenerative Medicine, Dunedin, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Boni, R., Ali, A., Shavandi, A., & Clarkson, A. N. (2018). Current and novel polymeric biomaterials for neural tissue engineering. Journal of Biomedical Science, 25, 90. doi: 10.1186/s12929-018-0491-8 Journal - Research Other
Neumann, S., Gowing, E., Young, S., & Clarkson, A. (2018, August). Investigating post-stroke immune responses in lean and obese mice. Verbal presentation at the Queenstown Molecular Biology (QMB) and Australasian Society for Immunology New Zealand Branch (ASI-NZ) Joint Meeting, Queenstown, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Clarkson, A., Zhou, L., & Houlton, J. (2018). Age-related differences in recovery of cognitive function following stroke to the prefrontal cortex. International Journal of Stroke, 13(Suppl. 1), (pp. 47). doi: 10.1177/1747493018778666 Conference Contribution - Published proceedings: Abstract
Kluge, M. G., Jones, K., Ong, L. K., Gowing, E. K., Nilsson, M., Clarkson, A. N., & Walker, F. R. (2018). Age-dependent disturbances of neuronal and glial protein expression profiles in areas of secondary neurodegeneration post-stroke. Neuroscience, 393, 185-195. doi: 10.1016/j.neuroscience.2018.07.034 Journal - Research Article
Johnston, M., Clarkson, A. N., Gowing, E. K., Scarf, D., & Colombo, M. (2018). The effects of nidopallium caudolaterale inactivation on serial-order behaviour in pigeons (Columba livia). Journal of Neurophysiology, 120(3), 1143-1152. doi: 10.1152/jn.00167.2018 Journal - Research Article
Allan, P. D., Tzeng, Y.-C., Gowing, E. K., Clarkson, A. N., & Fan, J.-L. (2018). Dietary nitrate supplementation reduces low frequency blood pressure fluctuations in rats following distal middle cerebral artery occlusion. Journal of Applied Physiology, 125(3), 862-869. doi: 10.1152/japplphysiol.01081.2017 Journal - Research Article
Evans, M. A., Ah Kim, H., Hann Ling, Y., Uong, S., Vinh, A., De Silva, T. M., … Clarkson, A. N., … Sobey, C. G. (2018). Vitamin D3 supplementation reduces subsequent brain injury and inflammation associated with ischemic stroke. NeuroMolecular Medicine, 20(1), 147-159. doi: 10.1007/s12017-018-8484-z Journal - Research Article
Evans, M. A., Lim, R., Kim, H. A., Chu, H. X., Gardiner-Mann, C. V., Taylor, K. W. E., … Neumann, S., … Gowing, E. K., … Clarkson, A. N., … Broughton, B. R. S. (2018). Acute or delayed systemic administration of human amnion epithelial cells improves outcomes in experimental stroke. Stroke, 49(3), 700-709. doi: 10.1161/strokeaha.117.019136 Journal - Research Article
Lie, M. E. K., Gowing, E. K., Clausen, R. P., Wellendorph, P., & Clarkson, A. N. (2018). Inhibition of GABA transporters fails to afford significant protection following focal cerebral ischemia. Journal of Cerebral Blood Flow & Metabolism, 38(1), 166-173. doi: 10.1177/0271678x17743669 Journal - Research Article
Evans, M. A., Kim, H. A., De Silva, T. M., Arumugam, T. V., Clarkson, A. N., Drummond, G. R., … Sobey, C. G. (2018). Diet-induced vitamin D deficiency has no effect on acute post-stroke outcomes in young male mice. Journal of Cerebral Blood Flow & Metabolism, 38(11), 1968-1978. doi: 10.1177/0271678x17719208 Journal - Research Article
van Nieuwenhuijzen, P. S., Chan, V., Clarkson, A., & Chebib, M. (2017). Z-drugs as novel therapeutic for stroke recovery. Proceedings of the Australasian Neuroscience Society 37th Annual Scientific Meeting. Retrieved from http://ans2017.aomevents.com.au Conference Contribution - Published proceedings: Abstract
Zhou, L. Y. Y., Barwick, D. K., Gowing, E. K., Young, S., & Clarkson, A. N. (2017). Stroke to the prefrontal cortex disrupts cholinergic signalling and impairs attention. Proceedings of the Australasian Neuroscience Society 37th Annual Scientific Meeting. Retrieved from http://ans2017.aomevents.com.au Conference Contribution - Published proceedings: Abstract
Corbett, D., Carmichael, S. T., Murphy, T. H., Jones, T. A., Schwab, M. E., Jolkkonen, J., Clarkson, A. N., … Joy, M. T. (2017). Enhancing the alignment of the preclinical and clinical stroke recovery research pipeline: Consensus-based core recommendations from the Stroke Recovery and Rehabilitation Roundtable translational working group. Neurorehabilitation & Neural Repair, 31(8), 699-707. doi: 10.1177/1545968317724285 Journal - Professional & Other Non-Research Articles
Ganesh, M., Clare, A., Dragunow, M., Hughes, S., Clarkson, A., & Empson, R. (2017). Pericyte therapeutics to repair the stroke-lesioned brain. Proceedings of the University of Otago Student Research Symposium: Te Wānaka Rakahau: Ākoka. (pp. 28). Retrieved from http://www.otago.ac.nz/graduate-research/scholarships/otago643219.html Conference Contribution - Published proceedings: Abstract
Chebib, M., van Nieuwenhuijzen, P., Chan, V., Ahring, P., & Clarkson, A. N. (2017). The paradox of Z-drugs in motor recovery after stroke. Proceedings of the Australasian Pharmaceutical Science Association and the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (APSA-ASCEPT) Joint Scientific Meeting. (pp. 45). Retrieved from http://www.asceptasm.com/ Conference Contribution - Published proceedings: Abstract
Cirillo, J., Mooney, R. A., Borges, V. M., Barber, P. A., Clarkson, A. N., Ackerley, S. J., … Byblow, W. D. (2017). Does tonic inhibition in the sub-acute period after stroke alter the trajectory of upper limb recovery? Proceedings of the Society for Neuroscience 47th Annual Meeting. 674.03/Z24. SfN. Retrieved from https://www.sfn.org/ Conference Contribution - Published proceedings: Abstract
Hartiadi, L. Y., van Nieuwenhuijzen, P. S., Gowing, E., Boothman-Burrell, L., Clarkson, A., & Chebib, M. (2017). The role of the extrasynaptic δ-containing GABAA receptors early in stroke. Proceedings of the Society for Neuroscience 47th Annual Meeting. 200.07/B60. SfN. Retrieved from https://www.sfn.org/ Conference Contribution - Published proceedings: Abstract
Soo, J. Y., Wiese, M., Dyson, R., Gray, C., Clarkson, A., Morrison, J., & Berry, M. (2017, September). The effect of methamphetamine on drug metabolism: A pilot study. Poster session presented at the Otago Spotlight Series: Child Health Research, Wellington, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Ganesh, M., Clare, A., Dragunow, M., Hughes, S., Clarkson, A., & Empson, R. (2017). Pericyte therapeutics to repair the stroke-lesioned brain. In B. Leitch (Ed.), Proceedings of the 35th International Australasian Winter Conference on Brain Research. (pp. 51). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr/index.html Conference Contribution - Published proceedings: Abstract
Power, E. M., Potapov, D., Knopfel, T., Clarkson, A., & Empson, R. M. (2017). Mesoscopic voltage imaging of neuronal activity in mice using genetically encoded voltage indicators (GEVI). In B. Leitch (Ed.), Proceedings of the 35th International Australasian Winter Conference on Brain Research. (pp. 32). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr/index.html Conference Contribution - Published proceedings: Abstract
Cirillo, J., Mooney, R., Borges, V., Barber, P. A., Clarkson, A., Ackerley, S., … Byblow, W. (2017). Does tonic inhibition in the sub-acute period after stroke alter the trajectory of upper limb recovery? International Journal of Stroke, 12(3, Suppl.), (pp. 22). doi: 10.1177/1747493017720548 Conference Contribution - Published proceedings: Abstract
Lie, M. E. K., Al-Khawaja, A., Damgaard, M., Haugaard, A. S., Schousboe, A., Clarkson, A. N., & Wellendorph, P. (2017). Glial GABA transporters as modulators of inhibitory signalling in epilepsy and stroke. In A. Ortega & A. Schousboe (Eds.), Glial amino acid transporters. (pp. 137-167). Cham, Switzerland: Springer. doi: 10.1007/978-3-319-55769-4_7 Chapter in Book - Research
Corbett, D., Carmichael, S. T., Murphy, T. H., Jones, T. A., Schwab, M. E., Jolkkonen, J., Clarkson, A. N., … Joy, M. T. (2017). Enhancing the alignment of the preclinical and clinical stroke recovery research pipeline: Consensus-based core recommendations from the Stroke Recovery and Rehabilitation Roundtable translational working group. International Journal of Stroke, 12(5), 462-471. doi: 10.1177/1747493017711814 Journal - Professional & Other Non-Research Articles
Smith, G. P. S., McLaughlin, A., Clarkson, A. N., Gordon, K. C., & Walker, G. F. (2017). Raman microscopic imaging of electrospun fibers made from a polycaprolactone and polyethylene oxide blend. Vibrational Spectroscopy, 92, 27-34. doi: 10.1016/j.vibspec.2017.05.002 Journal - Research Article
Parker, K., Berretta, A., Saenger, S., Sivaramakrishnan, M., Shirley, S. A., Metzger, F., & Clarkson, A. N. (2017). PEGylated insulin-like growth factor-I affords protection and facilitates recovery of lost functions post-focal ischemia. Scientific Reports, 7(1), 241. doi: 10.1038/s41598-017-00336-z Journal - Research Article
Yarragudi, S. B., Richter, R., Lee, H., Walker, G. F., Clarkson, A. N., Kumar, H., & Rizwan, S. B. (2017). Formulation of olfactory-targeted microparticles with tamarind seed polysaccharide to improve nose-to-brain transport of drugs. Carbohydrate Polymers, 163, 216-226. doi: 10.1016/j.carbpol.2017.01.044 Journal - Research Article
Neumann, S., Gowing, E., Lateef, Z., Chebib, M., Young, S., & Clarkson, A. N. (2016, April). DS2 has an anti-inflammatory effect and improves stroke recovery. Poster session presented at the 9th International Symposium on Neuroprotection and Neurorepair, Leipzig, Germany. Conference Contribution - Poster Presentation (not in published proceedings)
Neumann, S., Gowing, E., Lateef, Z., Chebib, M., Young, S., & Clarkson, A. (2016). Anti-inflammatory effects of GABAA receptor modulators. European Journal of Immunology, 46(Suppl. 1), (pp. 564). doi: 10.1002/eji.201670200 Conference Contribution - Published proceedings: Abstract
Younus, M., Clarkson, A. N., Boyd, B. J., & Rizwan, S. B. (2016). Investigating the effects of Tween 80 on sterically stabilising non-lamellar liquid crystalline nanoparticles of selachyl alcohol. Proceedings of the Drug Delivery Australia Conference. (pp. 57). Retrieved from http://www.crsaustralia.org/ Conference Contribution - Published proceedings: Abstract
Johnston, M., Scarf, D., Clarkson, A., & Colombo, M. (2016). The role of avian nidopallium caudolaterale in a four-item serial order task. Proceedings of the Psycolloquy Seminar. (pp. 21). Dunedin, New Zealand: Department of Psychology, University of Otago. Retrieved from http://www.otago.ac.nz/psychology/research/otago059081.html Conference Contribution - Published proceedings: Abstract
Wise, L., Libuda, F., Real, N., Stuart, G., Wilkins, S., Wakelin, K., Mercer, A., Clarkson, A., Walker, G., … Theoret, C. (2016). Combined delivery of orf virus proteins VEGF-E and IL-10 dampens inflammation and promotes repair processes in equine skin wounds. Proceedings of the Diagnostics, Drugs, Devices, Discovery (D4) Conference. Retrieved from http://www.otago.ac.nz/d4/index.html Conference Contribution - Published proceedings: Abstract
Rizwan, S. B., Yarragudi, S. B., Richter, R., Walker, G. F., & Clarkson, A. N. (2016). Olfactory-targeted microparticles: A novel approach to bypass the blood-brain barrier. In B. Leitch (Ed.), Proceedings of the 34th International Australasian Winter Conference on Brain Research. (pp. 60). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr Conference Contribution - Published proceedings: Abstract
Power, E. M., Gowing, E. K., Knöpfel, T., Clarkson, A. N., & Empson, R. M. (2016). Regional changes in mouse motor cortex excitability after focal stroke. In B. Leitch (Ed.), Proceedings of the 34th International Australasian Winter Conference on Brain Research. (pp. 59). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr Conference Contribution - Published proceedings: Abstract
Younus, M., Prentice, R. N., Clarkson, A. N., Boyd, B. J., & Rizwan, S. B. (2016). Incorporation of an endogenous neuromodulatory lipid, oleoylethanolamide, into cubosomes: Nanostructural characterization. Langmuir, 32(35), 8942-8950. doi: 10.1021/acs.langmuir.6b02395 Journal - Research Article
Zhou, L., Barwick, D., Boltze, C., Gowing, E., & Clarkson, A. (2016). Prefrontal cortex stroke disrupts cholinergic pathways and impairs learning. Cerebrovascular Diseases, 42(Suppl. 1), (pp. 85). doi: 10.1159/000447732 Conference Contribution - Published proceedings: Abstract
Che Has, A. T., Absalom, N., van Nieuwenhuijzen, P. S., Clarkson, A. N., Ahring, P. K., & Chebib, M. (2016). Zolpidem is a potent stoichiometry-selective modulator of α1β3 GABAA receptors: Evidence of a novel benzodiazepine site in the α1-α1 interface. Scientific Reports, 6, 28674. doi: 10.1038/srep28674 Journal - Research Article
Berretta, A., Gowing, E. K., Jasoni, C. L., & Clarkson, A. N. (2016). Sonic hedgehog stimulates neurite outgrowth in a mechanical stretch model of reactive-astrogliosis. Scientific Reports, 6, 21896. doi: 10.1038/srep21896 Journal - Research Article
Zhou, L. Y. Y., Wright, T. E., & Clarkson, A. N. (2016). Prefrontal cortex stroke induces delayed impairment in spatial memory. Behavioural Brain Research, 296, 373-378. doi: 10.1016/j.bbr.2015.08.022 Journal - Research Article
Che Has, A. T., Absalom, N., Clarkson, A., Ahring, P., & Chebib, M. (2015). Zolpidem enhances GABA-induced currents at (α1)3(β3)2 GABAA receptors via a novel binding interface. Proceedings of the Society for Neuroscience 45th Annual Meeting. 477.24/A100. SfN. Retrieved from https://www.sfn.org Conference Contribution - Published proceedings: Abstract
Berretta, A., & Clarkson, A. N. (2015). Astrocytes selectively regulate the expression of different GABA-A receptor subunits in cortical neurons. Proceedings of the Society for Neuroscience 45th Annual Meeting. 477.16/A92. SfN. Retrieved from https://www.sfn.org Conference Contribution - Published proceedings: Abstract
Younus, M., Clarkson, A. N., Boyd, B. J., & Rizwan, S. B. (2015). Structural stability of oleoylethanolamide, an endogenous neuromodulatory lipid is conserved when incorporated into cubosomes. Proceedings of the Diagnostic Drug Device Discovery (D4) Conference. Retrieved from https://www.regonline.com.au/builder/site/Default.aspx?EventID=1758070 Conference Contribution - Published proceedings: Abstract
Yarragudi, S. B., Ritcher, R., Walker, G. F., Clarkson, A. N., & Rizwan, S. B. (2015). Formulation of monodispursed mucoadhesive microparticles for nose-to-brain delivery. Proceedings of the Diagnostic Drug Device Discovery (D4) Conference. Retrieved from https://www.regonline.com.au/builder/site/Default.aspx?EventID=1758070 Conference Contribution - Published proceedings: Abstract
Zhou, L. Y. Y., Wright, T. E., & Clarkson, A. N. (2015). Prefontal cortex stroke induces delayed impairment in spatial memory. In B. Leitch (Ed.), Proceedings of the 33rd International Australasian Winter Conference on Brain Research. (pp. 57). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr Conference Contribution - Published proceedings: Abstract
Barwick, D. K., Boltze, C. M., Gowing, E. K., Zhou, L. Y. Y., & Clarkson, A. N. (2015). Prefontal cortex stroke disrupts cholinergic pathways and impairs learning. In B. Leitch (Ed.), Proceedings of the 33rd International Australasian Winter Conference on Brain Research. (pp. 55). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr Conference Contribution - Published proceedings: Abstract
Berretta, A., & Clarkson, A. N. (2015). Astrocytes selectively regulate the expression of neuronal GABA-A receptor subunits. In B. Leitch (Ed.), Proceedings of the 33rd International Australasian Winter Conference on Brain Research. (pp. 27). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr Conference Contribution - Published proceedings: Abstract
Neumann, S., Shields, N. J., Balle, T., Chebib, M., & Clarkson, A. N. (2015). Innate immunity and inflammation post-stroke: An α7-nicotinic agonist perspective. International Journal of Molecular Sciences, 16(12), 29029-29046. doi: 10.3390/ijms161226141 Journal - Research Article
Walker, F., Jones, K., Zouikr, I., Patience, M., Clarkson, A., Spratt, N., … Nilsson, M. (2015). Understanding ‘stress x microglial interactions’ in stroke-induced secondary neurodegeneration: A major opportunity for the preservation of viable brain tissue. Brain, Behavior & Immunity, 49(Suppl.), (pp. e19-e20). doi: 10.1016/j.bbi.2015.06.085 Conference Contribution - Published proceedings: Abstract
Walker, F. R., Jones, K., Zouikr, I., Patience, M., Clarkson, A., Isgaard, J., … Nilsson, M. (2015). Understanding 'stress x microglial interactions' in stroke-induced secondary neurodegeneration: A major opportunity for the preservation of viable brain tissue. Journal of Neurochemistry, 134(Suppl. 1), (pp. 250). doi: 10.1111/jnc.13189 Conference Contribution - Published proceedings: Abstract
Mohammad, Y., Clarkson, A. N., Boyd, B. J., & Rizwan, S. B. (2015). Aqueous mixtures of phytantriol-oleoylethanolamide and pluronic F127 result in an intriguing variety of self-assembled lipid nanoparticles as revealed by Cryogenic Transmission Electron Microscopy (cryo-TEM). Proceedings of the 27th National Conference on Microscopy. Retrieved from http://microscopy2015.otago.ac.nz/index.html Conference Contribution - Published proceedings: Abstract
Yarragudi, S. B., Walker, G. F., Clarkson, A. N., & Rizwan, S. B. (2015). Scanning electron microscopy as a tool to understand the effects of process variables on microparticle formation. Proceedings of the 27th National Conference on Microscopy. Retrieved from http://microscopy2015.otago.ac.nz/index.html Conference Contribution - Published proceedings: Abstract
Clarkson, A. N., Parker, K., Nilsson, M., Walker, F. R., & Gowing, E. K. (2015). Combined ampakine and BDNF treatments enhance poststroke functional recovery in aged mice via AKT-CREB signaling. Journal of Cerebral Blood Flow & Metabolism, 35, 1272-1279. doi: 10.1038/jcbfm.2015.33 Journal - Research Article
Van Slooten, A. R., Sun, Y., Clarkson, A. N., & Connor, B. J. (2015). L-NIO as a novel mechanism for inducing focal cerebral ischemia in the adult rat brain. Journal of Neuroscience Methods, 245, 44-57. doi: 10.1016/j.jneumeth.2015.02.022 Journal - Research Article
Jones, K. A., Zouikr, I., Patience, M., Clarkson, A. N., Isgaard, J., Johnson, S. J., … Walker, F. R. (2015). Chronic stress exacerbates neuronal loss associated with secondary neurodegeneration and suppresses microglial-like cells following focal motor cortex ischemia in the mouse. Brain, Behavior & Immunity, 48, 57-67. doi: 10.1016/j.bbi.2015.02.014 Journal - Research Article
Patience, M. J., Zouikr, I., Jones, K., Clarkson, A. N., Isgaard, J., Johnson, S. J., … Nilsson, M. (2015). Photothrombotic stroke induces persistent ipsilateral and contralateral astrogliosis in key cognitive control nuclei. Neurochemical Research, 40(2), 362-371. doi: 10.1007/s11064-014-1487-8 Journal - Research Article
Clarkson, A. (2014, June). Increasing tonic currents via delta subunit-containing GABAA receptors mediates neuroprotection following focal cerebral ischemia. Verbal presentation at the 8th Annual Brain Health Research Centre Conference, Dunedin, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Yarragudi, S., Walker, G., Clarkson, A., & Rizwan, S. (2014, November). Formulation and characterisation of a novel microparticle system for nose-to-brain drug delivery. Poster session presented at the Devices for Diagnostics and Drug Delivery (D4) Conference, Dunedin, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Mohammad, Y., Clarkson, A., Boyd, B., & Rizwan, S. (2014, November). Formulation and characterisation of phytantriol-oleoylethanolamide cubosomes. Poster session presented at the Devices for Diagnostics and Drug Delivery (D4) Conference, Dunedin, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
McLaughlin, A., Berretta, A., Clarkson, A., & Walker, G. (2014, November). An alternative solvent system for electrospinning polycaprolactone. Poster session presented at the Devices for Diagnostics and Drug Delivery (D4) Conference, Dunedin, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Wright, T., & Clarkson, A. N. (2014). Environmental enrichment and stroke: Good or bad? In B. Leitch & J. Shemmell (Eds.), Proceedings of the 32nd International Australasian Winter Conference on Brain Research. 32, (pp. 63). AWCBR. Retrieved from https://web.psy.otago.ac.nz/awcbr/proceedings.html Conference Contribution - Published proceedings: Abstract
Zhou, L. Y. Y., & Clarkson, A. N. (2014). Prefrontal cortex stroke results in delayed onset impairment. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 32nd International Australasian Winter Conference on Brain Research. 32, (pp. 40). AWCBR. Retrieved from https://web.psy.otago.ac.nz/awcbr/proceedings.html Conference Contribution - Published proceedings: Abstract
Clarkson, A. N., & Chebib, M. (2014). The role of peri-synaptic GABA receptors after stroke. In A. C. Errington, V. Crunelli & G. Di Giovanni (Eds.), Extrasynaptic GABAA receptors: The receptors (Vol. 27). (pp. 179-205). New York: Springer. doi: 10.1007/978-1-4939-1426-5_9 Chapter in Book - Research
Berretta, A., Tzeng, Y.-C., & Clarkson, A. N. (2014). Post-stroke recovery: The role of activity-dependent release of brain-derived neurotrophic factor. Expert Review of Neurotherapeutics, 14(11), 1335-1344. doi: 10.1586/14737175.2014.969242 Journal - Research Other
López-Valdés, H. E., Clarkson, A. N., Ao, Y., Charles, A. C., Carmichael, S. T., Sofroniew, M. V., & Brennan, K. C. (2014). Memantine enhances recovery from stroke. Stroke, 45, 2093-2100. doi: 10.1161/strokeaha.113.004476 Journal - Research Article
Van Slooten, A., Clarkson, A., & Connor, B. (2013). A novel method for inducing focal ischemia in the rat using L-N5-(1-Iminoethyl)ornithine. Proceedings of the Society for Neuroscience 43rd Annual Meeting. SfN. Retrieved from http://www.sfn.org/annual-meeting/neuroscience-2013/abstracts-and-sessions Conference Contribution - Published proceedings: Abstract
Yelahanka Nagaraja, R., Boothman-Burrell, L., Parker, K., & Clarkson, A. N. (2013). The role of zolpidem in post-stroke recovery. Proceedings of the Society for Neuroscience 43rd Annual Meeting. SfN. Retrieved from http://www.sfn.org/annual-meeting/neuroscience-2013/abstracts-and-sessions Conference Contribution - Published proceedings: Abstract
Clarkson, A. N., Karim, N., Boothman-Burrell, L., Dosa, Z., Nagaraja, R. Y., Jin, L., … Parker, K., … Chebib, M. (2013). 2'-methoxy-6-methylflavone modulates tonic inhibitory currents mediated by δ-containing GABAA receptors, and is neuroprotective following focal cerebral ischemia in mice. Proceedings of the Society for Neuroscience 43rd Annual Meeting. SfN. Retrieved from http://www.sfn.org/annual-meeting/neuroscience-2013/abstracts-and-sessions Conference Contribution - Published proceedings: Abstract
Clarkson, A. (2013, September). Similarities between strokes and earthquakes. Verbal presentation at the Division of Health Sciences Research Forum: Foundations for Health: Otago Health Research, Christchurch, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Zhou, L., & Clarkson, A. (2013). Prefrontal cortex stroke affects learning and memory. New Zealand Medical Journal, 126(1386). Retrieved from http://www.nzma.org.nz/journal Conference Contribution - Published proceedings: Abstract
Clarkson, A. N. (2013). The changing face of GABA and targeting stroke recovery [Workshop]. International Journal of Stroke, 8(Suppl. 1), (pp. 7-8). doi: 10.1111/ijs.12141 Conference Contribution - Published proceedings: Abstract
Berretta, A., Bix, G. J., & Clarkson, A. N. (2013). Perclecan domain V reduces the levels of tissue plasminogen activator in astrocyte-neuron co-culture. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 31st International Australasian Winter Conference on Brain Research. 31, (pp. 64). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2013copy.html Conference Contribution - Published proceedings: Abstract
Zhou, L. Y. Y., Gowing, E. K., & Clarkson, A. N. (2013). Effects of prefrontal cortex stroke on learning and memory. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 31st International Australasian Winter Conference on Brain Research. 31, (pp. 59). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2013copy.html Conference Contribution - Published proceedings: Abstract
Parker, K., Berretta, A., Saenger, S., Metzger, F., & Clarkson, A. N. (2013). PEGylated insulin-like growth factor I treatment efficacy in young and aged stroked mice. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 31st International Australasian Winter Conference on Brain Research. 31, (pp. 57). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2013copy.html Conference Contribution - Published proceedings: Abstract
Gowing, E. K., Berretta, A., Jasoni, C. L., & Clarkson, A. N. (2013). The effect of Shh on sprouting after stroke: A neuronal tracer study in young and aged mice. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 31st International Australasian Winter Conference on Brain Research. 31, (pp. 54). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2013copy.html Conference Contribution - Published proceedings: Abstract
Clarkson, A. N. (2013). Modulating post-stroke tonic inhibition offers an extended therapeutic window for facilitating functional improvements. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 31st International Australasian Winter Conference on Brain Research. 31, (pp. 28). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2013copy.html Conference Contribution - Published proceedings: Abstract
Nagaraja, R. Y., Parker, K., & Clarkson, A. N. (2013). Enhancing tonic inhibition promotes post-stroke recovery. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 31st International Australasian Winter Conference on Brain Research. 31, (pp. 27). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2013copy.html Conference Contribution - Published proceedings: Abstract
Bix, G. J., Gowing, E. K., & Clarkson, A. N. (2013). Perlecan domain V is neuroprotective and affords functional improvement in a photothrombotic stroke model in young and aged mice. Translational Stroke Research, 4, 515-523. doi: 10.1007/s12975-013-0266-1 Journal - Research Article
Imhoff, F. M., Yang, D., Mathew, S. F., Clarkson, A. N., Kawagishi, Y., Tate, W. P., Koishi, K., & McLennan, I. S. (2013). The type 2 anti-Müllerian hormone receptor has splice variants that are dominant-negative inhibitors. FEBS Letters, 587(12), 1749-1753. doi: 10.1016/j.febslet.2013.04.014 Journal - Research Article
McLaughlin, A., Walker, G., & Clarkson, A. (2013). Controlled release of the nootropic drug L-655,708 from hydrogels. Proceedings of 15th Conference on Formulation and Delivery of Bioactives: Found in Translation. Retrieved from http://bioactives.otago.ac.nz/ Conference Contribution - Published proceedings: Abstract
Clarkson, A. N., López-Valdés, H. E., Overman, J. J., Charles, A. C., Brennan, K. C., & Carmichael, S. T. (2013). Multimodal examination of structural and functional remapping in the mouse photothrombotic stroke model. Journal of Cerebral Blood Flow & Metabolism, 33, 716-723. doi: 10.1038/jcbfm.2013.7 Journal - Research Article
Kahle, M., Roberts, J., Gowing, E., Clarkson, A. N., & Bix, G. J. (2012). Perlecan domain V promotes neuroprotection and neurorepair in multiple animal models of ischemic stroke. Proceedings of the Society for Neuroscience 42nd Annual Meeting. SfN. Retrieved from http://www.sfn.org/index.aspx?pagename=abstracts_am2012 Conference Contribution - Published proceedings: Abstract
Berretta, A., Gowing, E., Jasoni, C., & Clarkson, A. N. (2012). Sonic hedgehog signaling and post-stroke recovery. Proceedings of the Society for Neuroscience 42nd Annual Meeting. SfN. Retrieved from http://www.sfn.org/index.aspx?pagename=abstracts_am2012 Conference Contribution - Published proceedings: Abstract
Boothman-Burrell, L., & Clarkson, A. N. (2012). Screening novel compounds as potential protectants after stroke. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 30th International Australasian Winter Conference on Brain Research. 30, (pp. 61). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2012.html Conference Contribution - Published proceedings: Abstract
Gowing, E. K., Berretta, A., Jasoni, C., & Clarkson, A. N. (2012). Sonic hedgehog administration stimulates oligodendrogenesis and functional recovery in young and aged mice after stroke. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 30th International Australasian Winter Conference on Brain Research. 30, (pp. 40). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2012.html Conference Contribution - Published proceedings: Abstract
Clarkson, A., Antonic, A., Berretta, A., & Ackerley, S. (2012, September). Post-stroke protection and repair: Moving forward in the 21st century [Workshop]. Verbal presentation at the New Zealand Applied Neurosciences Conference (NZANC), Auckland, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
McGregor, A., & Clarkson, A. (2012, September). Animal models of stroke [Workshop]. Verbal presentation at the New Zealand Applied Neurosciences Conference (NZANC), Auckland, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Overman, J. J., Clarkson, A. N., Wanner, I. B., Overman, W. T., Eckstein, I., Maguire, J. L., … Carmichael, S. T. (2012). A role for ephrin-A5 in axonal sprouting, recovery, and activity-dependent plasticity after stroke. PNAS, 109(33), E2230-E2239. doi: 10.1073/pnas.1204386109 Journal - Research Article
Clarkson, A. N. (2012). Perisynaptic GABA receptors: The overzealous protector. Advances in Pharmacological Sciences, 2012, 708428. doi: 10.1155/2012/708428 Journal - Research Article
Clarkson, A. (2011). What role does modulating NMDA receptor signaling pathways have in post-stroke recovery? Proceedings of the Australasian Neuroscience Society (ANS) Sensorimotor Satellite Meeting. Retrieved from http://www.sensorimotorcontrolmeeting.org Conference Contribution - Published proceedings: Abstract
Clarkson, A. N. (2011). Modulating post-stroke tonic inhibition facilitates functional improvements. Proceedings of the Society for Neuroscience 41st Annual Meeting. SfN. Retrieved from http://www.sfn.org/am2011/index.aspx?pagename=abstracts_main Conference Contribution - Published proceedings: Abstract
Berretta, A., Jasoni, C., & Clarkson, A. N. (2011). Sonic hedgehog signaling and post-stroke recovery. In B. Leitch (Ed.), Proceedings of the 29th International Australasian Winter Conference on Brain Research. 29, 7.4. AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/abstracts/abstracts2011.html Conference Contribution - Published proceedings: Abstract
Nair, S. M., Rahman, R. M. A., Clarkson, A. N., Sutherland, B. A., Taurin, S., Sammut, I. A., & Appleton, I. (2011). Melatonin treatment following stroke induction modulates L-arginine metabolism. Journal of Pineal Research, 51(3), 313-323. doi: 10.1111/j.1600-079X.2011.00891.x Journal - Research Article
Sutherland, B. A., Shaw, O. M., Clarkson, A. N., Winburn, I. C., Errington, A. C., Dixon, C. L., Lees, G., Sammut, I. A., & Appleton, I. (2011). Tin protoporphyrin provides protection following cerebral hypoxia-ischemia: Involvement of alternative pathways. Journal of Neuroscience Research, 89(8), 1284-1294. doi: 10.1002/jnr.22661 Journal - Research Article
Clarkson, A. (2011, March). Understanding how the brain can be repaired after a stroke. Brain Day Dunedin, University of Otago, New Zealand. [Public Seminar]. Other Research Output
Clarkson, A. N., Overman, J. J., Zhong, S., Mueller, R., Lynch, G., & Carmichael, S. T. (2011). AMPA receptor-induced local brain-derived neurotrophic factor signaling mediates motor recovery after stroke. Journal of Neuroscience, 31(10), 3766-3775. doi: 10.1523/JNEUROSCI.5780-10.2011 Journal - Research Article
Clarkson, A. (2011, March). Understanding how the brain can be repaired after a stroke. Neurological Foundation of New Zealand Brainweek Lecture, Queenstown, New Zealand. [Public Seminar]. Other Research Output
Clarkson, A. N., Talbot, C. L., Wang, P.-Y., MacLaughlin, D. T., Donahoe, P. K., & McLennan, I. S. (2011). Müllerian inhibiting substance is anterogradely transported and does not attenuate avulsion-induced death of hypoglossal motor neurons. Experimental Neurology, 231(2), 304-308. doi: 10.1016/j.expneurol.2010.12.019 Journal - Research Article
Clarkson, A. N., Overman, J. J., Huang, B., Mody, I., & Carmichael, S. T. (2010). Suppressing tonic inhibition in vivo mediates post-stroke functional improvements. Proceedings of the 30th Annual Meeting of the Australian Neuroscience Society, in conjunction with the 50th Anniversary Meeting of the Australian Physiological Society (ANS/AuPS). (pp. 42). Retrieved from http://www.sallyjayconferences.com.au/sydney2010/abstracts.html Conference Contribution - Published proceedings: Abstract
Clarkson, A. N., Huang, B., Mody, I., & Carmichael, S. T. (2010). Dampening tonic inhibition promotes post-stroke functional recovery in young and aged. In B. Leitch (Ed.), Proceedings of the 28th International Australasian Winter Conference on Brain Research. 28, (pp. 50). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2010.htm Conference Contribution - Published proceedings: Abstract
Clarkson, A. N., Huang, B., MacIsaac, S. E., Mody, I., & Carmichael, S. T. (2010). Dampening tonic inhibition promotes post-stroke functional recovery in young and aged. Journal of Neurochemistry. 115(Suppl. 1), (pp. 21). doi: 10.1111/j.1471-4159.2010.06942.x Conference Contribution - Published proceedings: Abstract
Clarkson, A. N., Huang, B. S., MacIsaac, S. E., Mody, I., & Carmichael, S. T. (2010). Reducing excessive GABA-mediated tonic inhibition promotes functional recovery after stroke. Nature, 468(7321), 305-309. doi: 10.1038/nature09511 Journal - Research Article
Clarkson, A. N. (2009). Secondary cardiovascular abnormalities subsequent to cerebral hypoxia-ischaemia. In E. H. Bennington (Ed.), Horizons in world cardiovascular research (Vol. 1). New York: Nova Science. Chapter in Book - Research
Clarkson, A. N., & Carmichael, S. T. (2009). Cortical excitability and post-stroke recovery. Biochemical Society Transactions, 37(6), 1412-1414. doi: 10.1042/BST0371412 Journal - Research Other
Sutherland, B. A., Rahman, R. M. A., Clarkson, A. N., Shaw, O. M., Nair, S. M., & Appleton, I. (2009). Cerebral heme oxygenase 1 and 2 spatial distribution is modulated following injury from hypoxia-ischemia and middle cerebral artery occlusion in rats. Neuroscience Research, 65(4), 326-334. doi: 10.1016/j.neures.2009.08.007 Journal - Research Article
Wang, P.-Y., Protheroe, A., Clarkson, A. N., Imhoff, F., Koishi, K., & McLennan, I. S. (2009). Müllerian inhibiting substance contributes to sex-linked biases in the brain and behavior. PNAS, 106(17), 7203-7208. doi: 10.1073/pnas.0902253106 Journal - Research Article
Clarkson, A. N. (2008). Secondary cardiovascular abnormalities subsequent to cerebral hypoxia-ischaemia. In O. M. Roux (Ed.), Brain hypoxia-ischemia research progress. (pp. 19-56). New York: Nova Science. Chapter in Book - Research
Sutherland, B., Shaw, O. M., Clarkson, A., Winburn, I., Sammut, I., & Appleton, I. (2008). Tin protoporphyrin provides neuroprotection following hypoxia-ischaemia by modification of nitric oxide synthase, cyclooxygenase and mitochondrial complex 1. New Zealand Medical Journal, 121(1278). Retrieved from http://journal.nzma.org.nz/journal/121-1278/3179/content.pdf Conference Contribution - Published proceedings: Abstract
Sutherland, B. A., Shaw, O. M., Clarkson, A., Winburn, I. C., Sammut, I. A., & Appleton, I. (2008, May). Tin protoporphyrin provides neuroprotection following hypoxia-ischemia by modification of nitric oxide synthase, cyclooxygenase and mitochondrial complex 1. Verbal presentation at the 5th International Symposium on Neuroprotection and Neurorepair, Magdeburg, Germany. Conference Contribution - Verbal presentation and other Conference outputs
Pugazhenthi, K., Kapoor, M., Clarkson, A. N., Hall, I., & Appleton, I. (2008). Melatonin accelerates the process of wound repair in full-thickness incisional wounds. Journal of Pineal Research, 44(4), 387-396. doi: 10.1111/j.1600-079X.2007.00541.x Journal - Research Article
Vranyac-Tramoundanas, A., Harrison, J. C., Clarkson, A. N., Kapoor, M., Winburn, I. C., Kerr, D. S., & Sammut, I. A. (2008). Domoic acid impairment of cardiac energetics. Toxicological Sciences, 105(2), 395-407. doi: 10.1093/toxsci/kfn132 Journal - Research Article
Clarkson, A. N., Koishi, K., Tyndall, J. D. A., & McLennan, I. S. (2007). The MIS type-II receptor, MISRII, has splice variants in the CNS. In J. G. Anson (Ed.), Proceedings of the 25th International Australasian Winter Conference on Brain Research. 25, (pp. 62). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/2007Abstracts.pdf Conference Contribution - Published proceedings: Abstract
Clarkson, A. N., Talbot, C. L., MacLaughlin, D. T., Donahoe, P. K., & McLennan, I. S. (2007). Assessment of Müllerian Inhibiting Substance on avulsed hypoglossal motor neurons. Proceedings of the Society for Neuroscience 37th Annual Meeting. SfN. Retrieved from http://www.abstractsonline.com/viewer/SearchResults.asp Conference Contribution - Published proceedings: Abstract
Clarkson, A. N., Liu, H., Schiborra, F., Shaw, O., Sammut, I. A., Jackson, D. M., & Appleton, I. (2007). Angiogenesis as a predictive marker of neurological outcome following hypoxia-ischemia. Brain Research, 1171, 111-121. Journal - Research Article
Clarkson, A. N. (2007). Anesthetic-mediated protection/preconditioning during cerebral ischemia. Life Sciences, 80, 1157-1175. Journal - Research Other
Clarkson, A. N., Clarkson, J., Jackson, D. M., & Sammut, I. A. (2007). Mitochondrial involvement in transhemispheric diaschisis following hypoxia-ischemia: Clomethiazole-mediated amelioration. Neuroscience, 144, 547-561. Journal - Research Article
Hesp, B. R., Clarkson, A. N., Sawant, P. M., & Kerr, D. S. (2007). Domoic acid preconditioning and seizure induction in young and aged rats. Epilepsy Research, 76, 103-112. Journal - Research Article
Clarkson, A. N., & Appleton, I. (2007). Cerebral hypoxia-ischemia-induced neuronal and cardiac impairment. In C. Kaur (Ed.), Hypoxia and the central nervous system. (pp. 109-144). Trivandrum, India: Transworld Research Network. Chapter in Book - Research
Nair, S., Rahman, R., Clarkson, A., Tramaoundamas, A., Sammut, I., & Appleton, I. (2006). The protective effects of melatonin on mitochondria function in a stroke-induced model of brain damage. In C. Matthewson & M. Taumoepeau (Eds.), Proceedings of the Pacific Postgraduate Symposium: Pacific Voices III. (pp. 31). Dunedin, New Zealand: Pacific Islands Centre, University of Otago. [Abstract] Conference Contribution - Published proceedings: Abstract
Tramoundanas, A. V., Clarkson, A. N., Harrison, J. C., Sawant, P., Jones, G. T., Kerr, D. S., & Sammut, I. A. (2006). Seizure-induced cardiac damage. Hypertension. 48(4), (pp. 777-778). [Abstract] Conference Contribution - Published proceedings: Abstract
Nair, S. M., Rahman, R. M. A., Clarkson, A. N., Tramaoundamas, A. V., Sammut, I. A., & Appleton, I. (2006). The protective effects of melatonin on mitochondria function in a stroke-induced model of brain damage. Journal of Neurochemistry. 98(Suppl. 1), (pp. 65). [Abstract] Conference Contribution - Published proceedings: Abstract
Sutherland, B. A., Rahman, R. M. A., Clarkson, A. N., Shaw, O. M., Nair, S. M., & Appleton, I. (2006). Heme oxygenase isoform distribution models of ischaemia-induced neurodegeneration. Journal of Neurochemistry. 98(Suppl. 1), (pp. 66). [Abstract] Conference Contribution - Published proceedings: Abstract
Shaw, O. M., Sutherland, B. A., Clarkson, A. N., McKelvey, K., & Appleton, I. (2006). Neuroprotective effects of low dose aspirin and hypoxia-ischaemia: The role of nitric oxide. Journal of Neurochemistry. 98(Suppl. 1), (pp. 65). [Abstract] Conference Contribution - Published proceedings: Abstract
Clarkson, A. N., Wang, P., Koishi, K., & McLennan, I. S. (2006). The type-II receptor for the novel neuronal survival factor, MIS, has splice variants in the CNS. Proceedings of the Society for Neuroscience Annual Meeting. SfN. Retrieved from http://www.abstractsonline.com/plan/AdvancedSearch.aspx Conference Contribution - Published proceedings: Abstract
Koishi, K., Clarkson, A., Wang, P.-Y., & McLennan, I. S. (2006, August-September). Expansion of the biological functions of Müllerian inhibiting substance (MIS) supported by the wide range of expression of its specific receptor, MISRII. Poster session presented at the 16th Annual Queenstown Molecular Biology Meeting, Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Kapoor, M. B., Sammut, I. A., Clarkson, A., Hall, I., & Appleton, I. (2005). The role of mitochondria in wound healing. An in vivo and in vitro study on the mechanisms of action of the anti-scarring effects of epicatechin gallate. Proceedings of the 7th World Congress on Inflammation. [Abstract] Conference Contribution - Published proceedings: Abstract
Shaw, O. M., Clarkson, A. N., Sutherland, B. A., & Appleton, I. (2005). Spatial distribution of COX-1, COX-2 and iNOS enzymes in the rat brain following hypoxia-ischaemia. New Zealand Medical Journal, 118(1218). Retrieved from http://journal.nzma.org.nz/journal/118-1215/1486/content.pdf Conference Contribution - Published proceedings: Abstract
Clarkson, A. N. (2005). Lasting neuroprotection with clomethiazole following hypoxia-ischaemia-induced neurodegeneration: A mechanistic study (PhD). University of Otago, Dunedin, New Zealand. 151p. Awarded Doctoral Degree
Groenewegen, L. G., Cotter, J. D., Rehrer, N. J., Clarkson, A. N., Harrison, J. C., Sammut, I. A., & Leader, J. P. (2005, December). Intermittent high intensity exercise and the expression of water channels in rat skeletal muscle. Poster session presented at the Medical Sciences Congress: The joint meeting of New Zealand Biomedical and Medical Societies, Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Kerr, D. S., Hesp, B. R., & Clarkson, A. N. (2005). Age-related potentiation of domoic acid induced seizures in rats: Evidence of impared renal clearance. Proceedings of the Marine Biotoxin Science Worshop No. 22. (pp. 74-89). [Full Paper] Conference Contribution - Published proceedings: Full paper
Clarkson, A. N., Jackson, D. M., Kerr, D. S., & Sammut, I. A. (2005). Clomethiazole spares mitochondrial dysfunction during hypoxia-ischaemia-induced hippocampal diaschisis. New Zealand Medical Journal, 118(1218). Retrieved from http://journal.nzma.org.nz/journal/118-1218/1568/content.pdf Conference Contribution - Published proceedings: Abstract
Kerr, D. S., Hesp, B. R., & Clarkson, A. N. (2005). Age-related potentiation of domoic acid-induced seizures. Proceedings of the Australian Neuroscience Society 25th Annual Meeting. 16, (pp. 74). [Abstract] Conference Contribution - Published proceedings: Abstract
Sammut, I. A., Zhu, P., Clarkson, A. N., Winburn, I. C., & Harrison, J. C. (2005). Cardio energetic / haemodynamic protection by carbon monoxide in an in vivo model of ischaemia reperfusion. Proceedings of the Medical Sciences Congress: The joint meeting of New Zealand biomedical and medical societies. (pp. 36). [Abstract] Conference Contribution - Published proceedings: Abstract
Kapoor, M., Clarkson, A., Sutherland, B. A., & Appleton, I. (2005). The role of antioxidants in models of inflammation: Emphasis on L-arginine and arachidonic acid metabolism. Inflammopharmacology, 12(5-6), 505-520. Journal - Research Other
Pugazhenthi, K., Kapoor, M., Young, P., Clarkson, A., Hall, I., & Appleton, I. (2005). The role of melatonin on scarring in an incisional model of dermal wound healing in rats. New Zealand Medical Journal, 118(1218). Retrieved from http://journal.nzma.org.nz/journal/118-1218/1568/content.pdf Conference Contribution - Published proceedings: Abstract
Clarkson, A. N., Sutherland, B. A., & Appleton, I. (2005). The biology and pathology of hypoxia-ischemia: An update. Archivum Immunologiae et Therapiae Experimentalis, 53, 213-225. Journal - Research Article
Kerr, D. S., Hesp, B. R., & Clarkson, A. N. (2005, January). Age-related potentiation of domoic acid-induced seizures. Poster session presented at the 25th Annual Meeting of the Australian Neuroscience Society, Perth, Australia. Conference Contribution - Poster Presentation (not in published proceedings)
Ashton, J. C., Khalessi, A., Kapoor, M., Clarkson, A., Sammut, I. A., Darlington, C. L., & Smith, P. F. (2005). Characterization of mitochondrial respiratory chain energetics in the vestibular nucleus complex [Short Communication]. Acta Oto-Laryngologica, 125, 422-425. Journal - Research Article
Clarkson, A. N., Liu, H., Rahman, R., Jackson, D. M., Appleton, I., & Kerr, D. S. (2005). Clomethiazole: Mechanisms underlying lasting neuroprotection after hypoxia-ischemia. FASEB Journal, 19(8), 1036-1038. Journal - Research Article
Sutherland, B. A., Shaw, O. M., Clarkson, A. N., Jackson, D. M., Sammut, I. A., & Appleton, I. (2005). Neuroprotective effects of (-)-epigallocatechin gallate following hypoxia-ischemia-induced brain damage: Novel mechanisms of action. FASEB Journal, 19(2), 258-260. doi: 10.1096/fj.04-2806fje Journal - Research Article
Sutherland, B. A., Shaw, O., Clarkson, A. N., & Appleton, I. (2004). Neuroprotective effect of (-)-epigallocatechin gallate in a rat model of hypoxia-ischemia-induced brain damage. New Zealand Medical Journal, 117(1202). Retrieved from http://journal.nzma.org.nz/journal/117-1202/1091/content.pdf Conference Contribution - Published proceedings: Abstract
Baek, H.-J., Clarkson, A., Tramoundanas, A., Hesp, B., Sammut, I. A., & Kerr, D. S. (2004). Domoic acid-induced cardiotoxicity: A mitochondrial approach. New Zealand Medical Journal, 117(1202). Retrieved from http://journal.nzma.org.nz/journal/117-1202/1091/content.pdf Conference Contribution - Published proceedings: Abstract
Clarkson, J., Daniel, K., Clarkson, A. N., & Donohoe, P. H. (2004, August). Postnatal changes in mitochondrial energetics. Verbal presentation at the Australasian Winter Conference on Brain Research, Queenstown, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Clarkson, A. N., Liu, H., Pearson, L., Kapoor, M., Harrison, J. C., Sammut, I. A., Jackson, D. M., & Appleton, I. (2004). Neuroprotective effects of spermine following hypoxia-ischemia-induced brain damage: A mechanistic study. FASEB Journal, 18(10), 1114-1116. Journal - Research Article
Hesp, B. R., Clarkson, A. N., & Kerr, D. S. (2004, August). Age-related increases in severity of domoic acid-induced seizures. Verbal presentation at the 22nd International Australasian Winter Conference on Brain Research, Queenstown, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Clarkson, A. N., Jackson, D. M., & Sammut, I. A. (2004, August). Chlormethiazole: Mitochondrial energetic preservation following hypoxia-ischaemia. Verbal presentation at the Australasian Winter Conference on Brain Research, Queenstown, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Clarkson, A. N., Sammut, I. A., & Jackson, D. M. (2004). Chlormethiazole preserves hippocampal mitochondrial function damaged by hypoxia-ischaemia in situ. Proceedings of the Australian Neuroscience Society Twenty-Fourth Annual Meeting. 15, (pp. 50). Melbourne, Australia: ANS. [Abstract] Conference Contribution - Published proceedings: Abstract
Clarkson, A. N., Rahman, R. M. A., & Appleton, I. (2004). Inflammation and autoimmunity as a central theme in neurodegenerative disorders: Fact or fiction? Current Opinion in Investigational Drugs, 5(7), 706-713. Journal - Research Article
Clarkson, A., Kerr, D. S., Appleton, I., & Jackson, D. M. (2003, January). Chlormethiazole provides long-term functional neuroprotection following hypoxia-ischaemia. Poster session presented at the Twenty-third Annual Meeting of the Australian Neuroscience Society, Adelaide, Australia. Conference Contribution - Poster Presentation (not in published proceedings)
Clarkson, A., Kapoor, M., Pearson, L., Liu, H., Harrison, J. C., Sammut, I. A., Jackson, D. M., & Appleton, I. (2003, November-December). Assessment of mitochondrial complex and LDH activity following hypoxia-ischaemia, and treatment with spermine. Poster session presented at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists Annual Scientific Meeting 2003, Victoria, Australia. Conference Contribution - Poster Presentation (not in published proceedings)
Sutherland, B., Shaw, O., Clarkson, A., Srinivas, R., & Appleton, I. (2003, November-December). Neuroprotective effect of (-)-epigallocatechin gallate in a rat model of hypoxia-ischaemia-induced brain damage. Poster session presented at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists Annual Scientific Meeting 2003, Sydney, Australia. Conference Contribution - Poster Presentation (not in published proceedings)
Shaw, O., Sutherland, B., Clarkson, A., Srinivas, R., & Appleton, I. (2003, November-December). Effects of the neuronal nitric oxide synthase inhibitor, ARL 17477, in the hypoxia-ischaemia model of neurodegeneration. Poster session presented at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists Annual Scientific Meeting 2003, Sydney, Australia. Conference Contribution - Poster Presentation (not in published proceedings)
Ashton, J. C., Khalessi, A., Kapoor, M., Clarkson, A., Darlington, C. L., Smith, P. F., & Sammut, I. A. (2003). Mitochondria respiratory chain activity in the vestibular nucleus and cerebellum. Proceedings of the 21st International Australasian Winter Conference on Brain Research. 21, (pp. 45). University of Otago, Dunedin: AWCBR. [Abstract] Conference Contribution - Published proceedings: Abstract
Tramoundanas, A. V., Clarkson, A., Kapoor, M., Kerr, D. S., & Sammut, I. A. (2003). Domoic acid induced cardiac mitochondrial damage. In E. A. Davis & C. G. Sobey (Eds.), Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists Annual Scientific Meeting. 10. [Abstract] Conference Contribution - Published proceedings: Abstract
Kapoor, M., Clarkson, A., Harrison, J. C., Adlam, V. J., Jackson, D. M., & Sammut, I. A. (2003). Cardiac mitochondrial protective effects of chlomethiazole in hypoxia-ischaemia. In E. A. Davis & C. G. Sobey (Eds.), Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists Annual Scientific Meeting 2003. 10. Lilydale, VIC: ASCEPT. [Abstract] Conference Contribution - Published proceedings: Abstract
Clarkson, A. N., Kerr, D. S., & Jackson, D. M. (2002). Chlormethiazole: Neuroprotection following hypoxia-ischaemia. 20th International Australian Winter Conference on Brain Research. 20, (pp. 39). [Abstract] Conference Contribution - Published proceedings: Abstract
Clarkson, A., Kerr, D. S., Liu, H., & Jackson, D. M. (2001). Clomethiazole protects hippocampal CA1 function following Hypoxic-ischaemic insult. Proceedings of the Australian Society of Clinical and Experimental Pharmacology and Toxicology. 9, (pp. 90). Victoria, Australia: ASCEPT. [Abstract] Conference Contribution - Published proceedings: Abstract