Associate Professor Graeme Hammond-Tooke is a clinical neurologist with particular interests in neuromuscular diseases and psychogenic disorders. Current studies include repetitive transcranial magnetic stimulation as a treatment for neurological disease and the combined use of transcranial magnetic stimulation, electroencephalography and functional magnetic resonance imaging to assess cortical excitability and connectivity. He is also studying inhibitory processes in functional neurological disorders and epilepsy.
Previous studies have investigated the reliability and predictive values of clinical methods used in the neurological examination and functional magnetic resonance imaging in conversion weakness.
Find out more about Associate Professor Hammond-Tooke’s research.
Publications
Theadom, A., Rodrigues, M., Poke, G., O'Grady, G., Love, D., Hammond-Tooke, G., … Ranta, A., … On Behalf of the MDPrev Research Group. (2019). A nationwide, population-based prevalence study of genetic muscle disorders. Neuroepidemiology, 52, 128-135. doi: 10.1159/000494115
Jones, G. T., Sandiford, P., Hill, G. B., Williams, M. J. A., Khashram, M., Tilyard, M. W., Hammond-Tooke, G. D., Krysa, J., & van Rij, A. M. (2019). Correcting for body surface area identifies the true prevalence of abdominal aortic aneurysm in screened women. European Journal of Vascular & Endovascular Surgery, 57(2), 221-228. doi: 10.1016/j.ejvs.2018.08.048
Hammond-Tooke, G. D., Tallabs Grajeda, F., Macrorie, H., & Franz, E. A. (2018). Response inhibition in patients with functional neurological symptom disorder. Journal of Clinical Neuroscience. Advance online publication. doi: 10.1016/j.jocn.2018.08.005
Rodrigues, M. J., O'Grady, G. L., Hammond-Tooke, G., Kidd, A., Love, D. O., Baker, R. K., & Roxburgh, R. H. (2017). The New Zealand Neuromuscular Disease Patient Registry: Five years and a thousand patients. Journal of Neuromuscular Diseases, 4(3), 183-188. doi: 10.3233/jnd-170240
Buenz, E. J., Parry, G. J., Bauer, B. A., Howe, C. L., Hammond-Tooke, G., Tsuchihara, T., … Peacey, M. (2017). A potential therapeutic for chronic pain from the new zealand native stinging nettle Urtica ferox (ongaonga). Journal of Neurology, Neurosurgery & Psychiatry, 88(5), (pp. e5). doi: 10.1136/jnnp-2017-316074.11
Other Research Output
Hammond-Tooke, G. (2011, March). Stimulating the brain with electricity: From electric rays to magnetic coils. Brain Day Dunedin, University of Otago, New Zealand. [Public Lecture].
Chapter in Book - Research
Hammond-Tooke, G. D., Sebastian, A., Oliver, J., Fulton, J., Watts, R., & Franz, E. E. (2011). Functional imaging of psychogenic and feigned weakness. In M. Hallet, A. E. Lang, J. Jankovic, S. Fahn, P. W. Halligan, V. Voon & C. R. Cloninger (Eds.), Psychogenic movement disorders and other conversion disorders. (pp. 180-183). Cambridge University Press.
Hammond-Tooke, G. D., & Pollock, M. (1999). Depression, dementia and Parkinson's disease. In A. B. Joseph & R. R. Young (Eds.), Movement disorders in Neurology and Neuropsychiatry. (pp. 195-204). Boston: Blackwell Scientific Publications.
Journal - Research Article
Theadom, A., Rodrigues, M., Poke, G., O'Grady, G., Love, D., Hammond-Tooke, G., … Ranta, A., … On Behalf of the MDPrev Research Group. (2019). A nationwide, population-based prevalence study of genetic muscle disorders. Neuroepidemiology, 52, 128-135. doi: 10.1159/000494115
Jones, G. T., Sandiford, P., Hill, G. B., Williams, M. J. A., Khashram, M., Tilyard, M. W., Hammond-Tooke, G. D., Krysa, J., & van Rij, A. M. (2019). Correcting for body surface area identifies the true prevalence of abdominal aortic aneurysm in screened women. European Journal of Vascular & Endovascular Surgery, 57(2), 221-228. doi: 10.1016/j.ejvs.2018.08.048
Hammond-Tooke, G. D., Tallabs Grajeda, F., Macrorie, H., & Franz, E. A. (2018). Response inhibition in patients with functional neurological symptom disorder. Journal of Clinical Neuroscience. Advance online publication. doi: 10.1016/j.jocn.2018.08.005
Rodrigues, M. J., O'Grady, G. L., Hammond-Tooke, G., Kidd, A., Love, D. O., Baker, R. K., & Roxburgh, R. H. (2017). The New Zealand Neuromuscular Disease Patient Registry: Five years and a thousand patients. Journal of Neuromuscular Diseases, 4(3), 183-188. doi: 10.3233/jnd-170240
Diab, A. S., Hale, L. A., Skinner, M. A., Hammond-Tooke, G., Ward, A. L., & Waters, D. L. (2016). Body composition and postural instability in people with idiopathic Parkinson's disease. Journal of Aging Research & Clinical Practice, 5(1), 14-19. doi: 10.14283/jarcp.2016.86
Harrington, A., & Hammond-Tooke, G. D. (2015). Theta burst stimulation of the cerebellum modifies the TMS-evoked N100 potential, a marker of GABA inhibition. PLoS ONE, 10(11), e0141284. doi: 10.1371/journal.pone.0141284
Blakemore, R. L., Hyland, B. I., Hammond-Tooke, G. D., & Anson, J. G. (2015). Deficit in late-stage contingent negative variation provides evidence for disrupted movement preparation in patients conversion paresis. Biological Psychology, 109, 73-85. doi: 10.1016/j.biopsycho.2015.04.009
Tallabs, F. A., & Hammond-Tooke, G. D. (2013). Theta priming of 1-Hz rTMS in healthy volunteers: Effects on motor inhibition. Journal of Clinical Neurophysiology, 30(1), 79-85. doi: 10.1097/WNP.0b013e31827ed0e3
Blakemore, R. L., Hyland, B. I., Hammond-Tooke, G. D., & Anson, J. G. (2013). Distinct modulation of event-related potentials during motor preparation in patients with motor conversion disorder. PLoS ONE, 8(4), e62539. doi: 10.1371/journal.pone.0062539
Sullivan, S. J., Hammond-Tooke, G. D., Schneiders, A. G., Gray, A. R., & McCrory, P. (2012). The diagnostic accuracy of selected neurological tests. Journal of Clinical Neuroscience, 19(3), 423-427. doi: 10.1016/j.jocn.2011.09.011
Amer, M., Hubert, G., Sullivan, S. J., Herbison, P., Franz, E. A., & Hammond-Tooke, G. D. (2012). Reliability and diagnostic characteristics of clinical tests of upper limb motor function. Journal of Clinical Neuroscience, 19(9), 1246-1251. doi: 10.1016/j.jocn.2011.12.007
Hammond-Tooke, G. D., Goei, J., du Plessis, L. J., & Franz, E. A. (2010). Concussion causes transient dysfunction in cortical inhibitory networks but not the corpus callosum. Journal of Clinical Neuroscience, 17(3), 315-319. doi: 10.1016/j.jocn.2009.06.026
Schneiders, A. G., Sullivan, S. J., Gray, A. R., Hammond-Tooke, G. D., & McCrory, P. R. (2010). Normative values for three clinical measures of motor performance used in the neurological assessment of sports concussion. Journal of Science & Medicine in Sport, 13(2), 196-201. doi: 10.1016/j.jsams.2009.05.004
Kanzaki, M., Tsuchihara, T., McMorran, D., Taylor, P., & Hammond-Tooke, G. D. (2010). A rat model of Urtica ferox neuropathy. NeuroToxicology, 31(6), 709-714. doi: 10.1016/j.neuro.2010.07.004
Harkins, C., Hammond-Tooke, G., & Faed, J. (2009). Intravenous immunoglobulin therapy for neurological disorders. New Zealand Medical Journal, 122(1305). Retrieved from http://journal.nzma.org.nz/journal/122-1305/3850/content.pdf
Kanzaki, M., Mochizuki, H., Ogawa, G., Tanaka, K., Araki, M., Motoyoshi, K., Hammond-Tooke, G., & Kamakura, K. (2008). Clinical features of opticospinal multiple sclerosis with anti-aquaporin 4 antibody. European Neurology, 60, 37-42.
Hammond-Tooke, G. D., Taylor, P., Punchihewa, S., & Beasley, M. (2007). Urtica ferox neuropathy. Muscle & Nerve, 35, 804-807. doi: 10.1002/mus.20730
Connor, A., Stebbings, S., Hung, N. A., Hammond-Tooke, G., Meikle, G., & Highton, J. (2007). STIR MRI to direct muscle biopsy in suspected idiopathic inflammatory myopathy. Journal of Clinical Rheumatology, 13(6), 341-345.
Read, K. M., Hutchinson, D., Veale, A., Anderson, N., Hammond-Tooke, G. D., & Macfie, A. E. (2001). Acid maltase deficiency: Clinical and laboratory features of adult-onset cases. New Zealand Medical Journal, 114, 406-409.
Murakami, N., McLennan, I. S., Nonaka, I., Koishi, K., Baker, C. S., & Hammond-Tooke, G. D. (1999). Transforming growth factor-beta 2 is elevated in skeletal muscle disorders. Muscle & Nerve, 22, 889-898.
Journal - Research Other
Hammond-Tooke, G. D. (2014). Management of transient ischaemic attack: The importance of time and specialised clinics. New Zealand Medical Journal, 127(1390). Retrieved from http://www.nzma.org.nz/journal
Rodrigues, M., Hammond-Tooke, G., Kidd, A., Love, D., Patel, R., Dawkins, H., … Roxburgh, R. (2012). The New Zealand Neuromuscular Disease Registry. Journal of Clinical Neuroscience, 19(12), 1749-1750. doi: 10.1016/j.jocn.2012.04.008
Jones, G. T., Deng, M., Hammond-Tooke, G. D., McCormick, S. P. A., & van Rij, A. M. (2009). Increased plasma lipoprotein(a) found in large-artery atherosclerotic, but not small-artery occlusive, stroke [Letter to the editor]. Clinical Chemistry, 55(10), 1888-1890. doi: 10.1373/clinchem.2009.126771
De Silva, M. L., McLaughlin, M. T., Rodrigues, E. J., Broadbent, J. C., Gray, A. R., & Hammond-Tooke, G. D. (2008). A Mini-Mental Status Examination for the hearing impaired [Research letter]. Age & Ageing, 37(5), 593-595. doi: 10.1093/ageing/afn146
Conference Contribution - Published proceedings: Abstract
Buenz, E. J., Parry, G. J., Bauer, B. A., Howe, C. L., Hammond-Tooke, G., Tsuchihara, T., … Peacey, M. (2017). A potential therapeutic for chronic pain from the new zealand native stinging nettle Urtica ferox (ongaonga). Journal of Neurology, Neurosurgery & Psychiatry, 88(5), (pp. e5). doi: 10.1136/jnnp-2017-316074.11
Hammond-Tooke, G. D., & Harrington, A. (2015). Modulation of transcranial magnetic stimulation evoked potentials by 30 Hz theta burst stimulation of the cerebellum. Brain Stimulation, 8(2), (pp. 378). doi: 10.1016/j.brs.2015.01.210
Diab, A. K. S., Hale, L. A., Skinner, M. A., Waters, D. L., & Hammond-Tooke, G. (2014). Strength, balance, and self-reported falls in adults with idiopathic Parkinson's disease: A controlled observational study. Physiotherapy New Zealand Conference: Linking the Chain. (pp. 78). Wellington, New Zealand: Physiotherapy New Zealand. [Abstract]
Hammond-Tooke, G., & Harrington, A. (2014). Modification of transcranial magnetic stimulation-evoked potentials by cerebellar theta burst stimulation. Journal of Clinical Neuroscience, 21(11), (pp. 2055). doi: 10.1016/j.jocn.2014.06.085
Scott, R., Hyland, B., Hammond-Tooke, G., Franz, L., Shemmell, J., & Anson, G. (2011). Distinct neural mechanisms underlie movement deficits in conversion and feigned paresis. Proceedings of the Australasian Neuroscience Society (ANS) Sensorimotor Satellite Meeting. Retrieved from http://www.sensorimotorcontrolmeeting.org
Goei, J., Franz, E. A., & Hammond-Tooke, G. (2011). A blue G and a G in blue: The involvement of associative memory in synaesthesia. In B. Leitch (Ed.), Proceedings of the 29th International Australasian Winter Conference on Brain Research. 29, 6.6. AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/abstracts/abstracts2011.html
Scott, R. L., Hyland, B. I., Hammond-Tooke, G. D., Franz, E. A., & Anson, J. G. (2010). Feigned paresis affects behaviour but not neuromotor preparatory activity. In B. Leitch (Ed.), Proceedings of the 28th International Australasian Winter Conference on Brain Research. 28, (pp. 54). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2010.htm
Scott, R. L., Hyland, B. I., Hammond-Tooke, G. D., Franz, E. A., & Anson, J. G. (2010). Neural mechanisms of impaired volitional movement in conversion disorder. Proceedings of the Society for Neuroscience 40th Annual Meeting. SfN. Retrieved from http://www.abstractsonline.com/Plan/SSResults.aspx
Krishnamurthy, V., Hammond-Tooke, G., Fulton, J., Oliver, J., du Plessis, L. J., & Wright, R. A. (2009). Diffusion weighted imaging in transient global amnesia. Journal of the Neurological Sciences, 285(Suppl. 1), (pp. S184). doi: 10.1016/S0022-510X(09)70016-4
Scott, R. L., Hyland, B. I., Hammond-Tooke, G. D., Franz, E. A., & Anson, J. G. (2009). Conversion disorder and motor preparation: Preliminary findings. In R. Napper (Ed.), Proceedings of the 27th International Australasian Winter Conference on Brain Research. 27, (pp. 30). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2009.htm
Hammond-Tooke, G. D., Franz, E. A., Sebastian, A., Oliver, J., Fulton, J., & Watts, R. (2008). The neurobiology of hysteria and malingering: An fMRI study. In J. G. Anson (Ed.), Proceedings of the 26th International Australasian Winter Conference on Brain Research. 26, (pp. 49). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/2008Abstracts.pdf
Schneiders, A. G., Sullivan, S. J., Gray, A. R., Hammond-Tooke, G. D., & McCrory, P. R. (2008). The development of normative data for three measures of motor performance used in the identification of sport related concussion. Proceedings of the New Zealand Society of Physiotherapists Conference. (pp. 64). Wellington, New Zealand: NZSP. [Abstract]
Franz, E. A., Hammond-Tooke, G., Oliver, J., Fulton, J., & Watts, R. (2008). A functional MRI study of recovery and reorganization following unilateral cerebellar stroke. In J. G. Anson (Ed.), Proceedings of the 26th International Australasian Winter Conference on Brain Research. 26, (pp. 48). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/2008Abstracts.pdf
Baek, J.-h., Jones, G., Deng, M., van Rij, A., Hammond-Tooke, G., Cole, J., Cleveland, S., & McCormick, S. (2005). Lipoprotein (a): A risk factor for stroke? New Zealand Medical Journal, 118(1215). Retrieved from http://journal.nzma.org.nz/journal/118-1215/1486/content.pdf
Baek, J.-h., Jones, G., Deng, M., van Rij, A., Hammond-Tooke, G., Cole, J., Cleveland, S., & McCormick, S. (2005). Lipoprotein (a): A risk factor for stroke? In S. Bunn, P. Cragg, B. Galland, M. Hibma, T. Merriman, D. Oorschot, … M. Williams (Eds.), Proceedings of the 177th Scientific Meeting of the Otago Medical School Research Society. Dunedin, New Zealand: OMSRS. [Abstract]
Williams, M. J. A., Hammond-Tooke, G. D., & Restieaux, N. J. (1995). Hypokalaemic periodic paralysis with cardiac arrhythmia and prolonged QT interval. Australian and New Zealand Journal of Medicine. 25(5), (pp. 549). [Abstract]
Conference Contribution - Poster Presentation (not in published proceedings)
Hammond-Tooke, G., Heaton, J., Tallabs Grajeda, F., Endo, K., Herbison, P., & Franz, E. (2010, October-November). Modification of ipsilateral reaction times by 1 Hz repetitive transcranial magnetic stimulation of the motor cortex. Poster session presented at the 29th International Congress of Clinical Neurophysiology, Kobe, Japan.
Conference Contribution - Verbal presentation and other Conference outputs
Hammond-Tooke, G. (2017, September). Response inhibition and conflict in functional weakness. Verbal presentation at the 3rd International Conference on Functional (Psychogenic) Neurological Disorders, Edinburgh, UK.
Hammond-Tooke, G. (2015, June). How to increase GABA inhibition with transcranial magnetic stimulation. Verbal presentation at the 9th Annual Brain Health Research Centre Conference: Science for a Healthy Brain, Dunedin, New Zealand.
Goei, J., Franz, E. A., & Hammond-Tooke, G. (2009, November). Bidirectional synaesthesia: Does it really exist? Verbal presentation at the Psycolloquy Seminar, Dunedin, New Zealand.
