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Associate Professor Steve Kerr

Steve KerrAssociate Professor Steve Kerr’s research in neurotoxicology uses electrophysiological, anatomical, behavioural and molecular approaches to uncover the mechanisms of neuroprotection for the central nervous system and the supersensitivity of the aged brain to excitotoxic insult. In addition, his lab has undertaken studies of cardiac damage following exposure to domoic acid, the neurotoxin that causes amnesic shellfish poisoning. Results to date indicate that a novel central nervous system neuroprotective mechanism involves G protein-linked receptors which impart "tolerance" to domoic acid and related excitotoxins. Age-related changes in hippocampal AMPA and KA receptors contribute to excitotoxic damage in the central nervous system.

Find out more about Associate Professor Kerr’s research.

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Publications

Nayak, P. K., & Kerr, D. S. (2015). Functional preservation of hippocampal CA1 by low-dose GYKI-52466 preconditioning in a rat model of hypoxic-ischemic brain injury. Brain Research, 1613, 100-109. doi: 10.1016/j.brainres.2015.04.004

Read, M. I., Harrison, J. C., Kerr, D. S., & Sammut, I. A. (2015). Atenolol offers better protection than clonidine against cardiac injury in kainic acid-induced status epilepticus. British Journal of Pharmacology, 172, 4626-4638. doi: 10.1111/bph.13132

Hellyer, S. D., Selwood, A. I., van Ginkel, R., Munday, R., Sheard, P., Miles, C. O., … Kerr, D. S. (2014). In vitro labelling of muscle type nicotinic receptors using a fluorophore-conjugated pinnatoxin F derivative. Toxicon, 87, 17-25. doi: 10.1016/j.toxicon.2014.05.013

Read, M. I., Andreianova, A. A., Harrison, J. C., Goulton, C. S., Sammut, I. A., & Kerr, D. S. (2014). Cardiac electrographic and morphological changes following status epilepticus: Effect of clonidine. Seizure, 23(1), 55-61. doi: 10.1016/j.seizure.2013.09.012

Nayak, P. K., & Kerr, D. S. (2013). Low-dose GYKI-52466: Prophylactic preconditioning confers long-term neuroprotection and functional recovery following hypoxic-ischaemic brain injury. Neuroscience, 232, 128-138. doi: 10.1016/j.neuroscience.2012.11.063

Journal - Research Article

Nayak, P. K., & Kerr, D. S. (2015). Functional preservation of hippocampal CA1 by low-dose GYKI-52466 preconditioning in a rat model of hypoxic-ischemic brain injury. Brain Research, 1613, 100-109. doi: 10.1016/j.brainres.2015.04.004

Read, M. I., Harrison, J. C., Kerr, D. S., & Sammut, I. A. (2015). Atenolol offers better protection than clonidine against cardiac injury in kainic acid-induced status epilepticus. British Journal of Pharmacology, 172, 4626-4638. doi: 10.1111/bph.13132

Read, M. I., Andreianova, A. A., Harrison, J. C., Goulton, C. S., Sammut, I. A., & Kerr, D. S. (2014). Cardiac electrographic and morphological changes following status epilepticus: Effect of clonidine. Seizure, 23(1), 55-61. doi: 10.1016/j.seizure.2013.09.012

Hellyer, S. D., Selwood, A. I., van Ginkel, R., Munday, R., Sheard, P., Miles, C. O., … Kerr, D. S. (2014). In vitro labelling of muscle type nicotinic receptors using a fluorophore-conjugated pinnatoxin F derivative. Toxicon, 87, 17-25. doi: 10.1016/j.toxicon.2014.05.013

Hellyer, S. D., Selwood, A. I., Rhodes, L., & Kerr, D. S. (2013). Neuromuscular blocking activity of pinnatoxins E, F and G. Toxicon, 76, 214-220. doi: 10.1016/j.toxicon.2013.10.009

Nayak, P. K., Zhang, H., & Kerr, D. S. (2013). Determination of 1-(4’-aminophenyl)-4-methyl-7,8-methylene-dioxy-2,3-benzodiazepine by high-performance liquid chromatography—diode array detection in plasma and brain in healthy and hypoxic–ischaemic rats. Neuroscience, 232, 139-150. doi: 10.1016/j.neuroscience.2012.12.001

Nayak, P. K., & Kerr, D. S. (2013). Low-dose GYKI-52466: Prophylactic preconditioning confers long-term neuroprotection and functional recovery following hypoxic-ischaemic brain injury. Neuroscience, 232, 128-138. doi: 10.1016/j.neuroscience.2012.11.063

Vranyac-Tramoundanas, A., Harrison, J. C., Sawant, P. M., Kerr, D. S., & Sammut, I. A. (2011). Ischemic cardiomyopathy following seizure induction by domoic acid. American Journal of Pathology, 179(1), 141-154. doi: 10.1016/j.ajpath.2011.03.017

Hellyer, S. D., Selwood, A., Rhodes, L., & Kerr, D. S. (2011). Marine algal pinnatoxins E and F cause neuromuscular block in an in vitro hemidiaphragm preparation. Toxicon, 58, 693-699. doi: 10.1016/j.toxicon.2011.09.006

Sawant, P. M., Mountfort, D. O., & Kerr, D. S. (2010). Spectral analysis of electrocorticographic activity during pharmacological preconditioning and seizure induction by intrahippocampal domoic acid. Hippocampus, 20(8), 994-1002. doi: 10.1002/hipo.20698

Sawant, P. M., Tyndall, J. D. A., Holland, P. T., Peake, B. M., Mountfort, D. O., & Kerr, D. S. (2010). In vivo seizure induction and affinity studies of domoic acid and isodomoic acids-D, -E and -F. Neuropharmacology, 59, 129-138. doi: 10.1016/j.neuropharm.2010.03.019

Goulton, C. S., Patten, A. R., Kerr, J. R., & Kerr, D. S. (2010). Pharmacological preconditioning with GYKI 52466: A prophylactic approach to neuroprotection. Frontiers in Neuroscience, 4, 54. doi: 10.3389/fnins.2010.00054

Vranyac-Tramoundanas, A., Harrison, J. C., Clarkson, A. N., Kapoor, M., Winburn, I. C., Kerr, D. S., & Sammut, I. A. (2008). Domoic acid impairment of cardiac energetics. Toxicological Sciences, 105(2), 395-407. doi: 10.1093/toxsci/kfn132

Sawant, P. M., Holland, P. T., Mountfort, D. O., & Kerr, D. S. (2008). In vivo seizure induction and pharmacological preconditioning by domoic acid and isodomoic acids A, B and C. Neuropharmacology, 55, 1412-1418. doi: 10.1016/j.neuropharm.2008.09.001

Hesp, B. R., Clarkson, A. N., Sawant, P. M., & Kerr, D. S. (2007). Domoic acid preconditioning and seizure induction in young and aged rats. Epilepsy Research, 76, 103-112.

Sawant, P. M., Weare, B. A., Holland, P. T., Selwood, A. I., King, K. L., Mikulski, C. M., … Kerr, D. S. (2007). Isodomoic acids A and C exhibit low KA receptor affinity and reduced in vitro potency relative to domoic acid in region CA1 of rat hippocampus. Toxicon, 50, 627-638.

Brewer, L. D., Porter, N. M., Kerr, D. S., Landfield, P. W., & Thibault, O. (2006). Chronic 1 alpha,25-(OH)(2) vitamin D-3 treatment reduces Ca2+-mediated hippocampal biomarkers of aging. Cell Calcium, 40(3), 277-286.

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Conference Contribution - Published proceedings: Abstract

Hellyer, S., & Kerr, S. (2010). Development of an in vitro rat retinal-optic nerve preparation. New Zealand Medical Journal, 123(1314). Retrieved from http://journal.nzma.org.nz/journal/123-1314/4120/content.pdf

Kerr, D. S., Guy, K., Liu, P., & Collie, N. (2008). Acute and preconditioning effects of domoic acid on spatial memory and LTP and LTD induction in rat hippocampus. In J. G. Anson (Ed.), Proceedings of the 26th International Australasian Winter Conference on Brain Research. 26, (pp. 52). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/2008Abstracts.pdf

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