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Associate Professor Ivan Sammut

Ivan SammutAssociate Professor Sammut’s group is interested in studying and treating the consequences of heart failure, including the cardiovascular effects following hypoxia–ischemia induced brain damage. He is also investigating the mitochondrial pathophysiology in neurodegeneration and stroke injury, and the neuroprotective effects of pharmacological agents following hypoxia–ischemia induced brain damage.


Find out more about Assoc Prof Sammut’s research.

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Publications

Kueh, J. T. B., Stanley, N. J., Hewitt, R. J., Woods, L. M., Larsen, L., Harrison, J. C., … Sammut, I. A., & Larsen, D. S. (2017). Norborn-2-en-7-ones as physiologically-triggered carbon monoxide-releasing prodrugs. Chemical Science, (8), 5454-5459. doi: 10.1039/c7sc01647f

Read, M. I., Harrison, J. C., Kerr, D. S., & Sammut, I. A. (2015). Atenolol offers better protection than clonidine against cardiac injury in kainic acid-induced status epilepticus. British Journal of Pharmacology, 172, 4626-4638. doi: 10.1111/bph.13132

Read, M. I., McCann, D. M., Millen, R. N., Harrison, J. C., Kerr, D. S., & Sammut, I. A. (2015). Progressive development of cardiomyopathy following altered autonomic activity in status epilepticus. American Journal of Physiology: Heart & Circulatory Physiology, 309(9), H1554-H1564. doi: 10.1152/ajpheart.00256.2015

Yao, Y., Fomison-Nurse, I. C., Harrison, J. C., Walker, R. J., Davis, G., & Sammut, I. A. (2014). Chronic bilateral renal denervation attenuates renal injury in a transgenic rat model of diabetic nephropathy. American Journal of Physiology: Renal Physiology, 307, F251-F262. doi: 10.1152/ajprenal.00578.2013

Yao, Y., Davis, G., Harrison, J. C., Walker, R. J., & Sammut, I. A. (2017). Renal functional responses in diabetic nephropathy following chronic bilateral renal denervation. Autonomic Neuroscience, 204, 98-104. doi: 10.1016/j.autneu.2016.09.019

Journal - Research Article

Kueh, J. T. B., Stanley, N. J., Hewitt, R. J., Woods, L. M., Larsen, L., Harrison, J. C., … Sammut, I. A., & Larsen, D. S. (2017). Norborn-2-en-7-ones as physiologically-triggered carbon monoxide-releasing prodrugs. Chemical Science, (8), 5454-5459. doi: 10.1039/c7sc01647f

Yao, Y., Davis, G., Harrison, J. C., Walker, R. J., & Sammut, I. A. (2017). Renal functional responses in diabetic nephropathy following chronic bilateral renal denervation. Autonomic Neuroscience, 204, 98-104. doi: 10.1016/j.autneu.2016.09.019

Read, M. I., McCann, D. M., Millen, R. N., Harrison, J. C., Kerr, D. S., & Sammut, I. A. (2015). Progressive development of cardiomyopathy following altered autonomic activity in status epilepticus. American Journal of Physiology: Heart & Circulatory Physiology, 309(9), H1554-H1564. doi: 10.1152/ajpheart.00256.2015

Read, M. I., Harrison, J. C., Kerr, D. S., & Sammut, I. A. (2015). Atenolol offers better protection than clonidine against cardiac injury in kainic acid-induced status epilepticus. British Journal of Pharmacology, 172, 4626-4638. doi: 10.1111/bph.13132

Thaung, H. P. A., Yao, Y., Bussey, C. T., Hughes, G., Jones, P. P., Bahn, A., Sammut, I. A., & Lamberts, R. R. (2015). Chronic bilateral renal denervation reduces cardiac hypertrophic remodelling but not β-adrenergic responsiveness in hypertensive type 1 diabetic rats. Experimental Physiology, 100(6), 628-639. doi: 10.1113/EP085021

Kumari, S., Sammut, I. A., & Giles, G. I. (2014). The design of nitric oxide donor drugs: S-nitrosothiol tDodSNO is a superior photoactivated donor in comparison to GSNO and SNAP. European Journal of Pharmacology, 737, 168-176. doi: 10.1016/j.ejphar.2014.05.012

Yao, Y., Fomison-Nurse, I. C., Harrison, J. C., Walker, R. J., Davis, G., & Sammut, I. A. (2014). Chronic bilateral renal denervation attenuates renal injury in a transgenic rat model of diabetic nephropathy. American Journal of Physiology: Renal Physiology, 307, F251-F262. doi: 10.1152/ajprenal.00578.2013

Read, M. I., Andreianova, A. A., Harrison, J. C., Goulton, C. S., Sammut, I. A., & Kerr, D. S. (2014). Cardiac electrographic and morphological changes following status epilepticus: Effect of clonidine. Seizure, 23(1), 55-61. doi: 10.1016/j.seizure.2013.09.012

Garrett, A. T., Goosens, N. G., Rehrer, N. J., Patterson, M. J., Harrison, J., Sammut, I., & Cotter, J. D. (2014). Short-term heat acclimation is effective and may be enhanced rather than impaired by dehydration. American Journal of Human Biology, 26(3), 311-320. doi: 10.1002/ajhb.22509

Sutherland, B. A., Harrison, J. C., Nair, S. M., & Sammut, I. A. (2013). Inhalation gases or gaseous mediators as neuroprotectants for cerebral ischaemia. Current Drug Targets, 14(1), 56-73. doi: 10.2174/138945013804806433

Winburn, I. C., Gunatunga, K., McKernan, R. D., Walker, R. J., Sammut, I. A., & Harrison, J. C. (2012). Cell damage following carbon monoxide releasing molecule exposure: Implications for therapeutic applications. Basic & Clinical Pharmacology & Toxicology, 111(1), 31-41. doi: 10.1111/j.1742-7843.2012.00856.x

Vranyac-Tramoundanas, A., Harrison, J. C., Sawant, P. M., Kerr, D. S., & Sammut, I. A. (2011). Ischemic cardiomyopathy following seizure induction by domoic acid. American Journal of Pathology, 179(1), 141-154. doi: 10.1016/j.ajpath.2011.03.017

Nair, S. M., Rahman, R. M. A., Clarkson, A. N., Sutherland, B. A., Taurin, S., Sammut, I. A., & Appleton, I. (2011). Melatonin treatment following stroke induction modulates L-arginine metabolism. Journal of Pineal Research, 51(3), 313-323. doi: 10.1111/j.1600-079X.2011.00891.x

Sutherland, B. A., Shaw, O. M., Clarkson, A. N., Winburn, I. C., Errington, A. C., Dixon, C. L., Lees, G., Sammut, I. A., & Appleton, I. (2011). Tin protoporphyrin provides protection following cerebral hypoxia-ischemia: Involvement of alternative pathways. Journal of Neuroscience Research, 89(8), 1284-1294. doi: 10.1002/jnr.22661

Vranyac-Tramoundanas, A., Harrison, J. C., Clarkson, A. N., Kapoor, M., Winburn, I. C., Kerr, D. S., & Sammut, I. A. (2008). Domoic acid impairment of cardiac energetics. Toxicological Sciences, 105(2), 395-407. doi: 10.1093/toxsci/kfn132

Clarkson, A. N., Clarkson, J., Jackson, D. M., & Sammut, I. A. (2007). Mitochondrial involvement in transhemispheric diaschisis following hypoxia-ischemia: Clomethiazole-mediated amelioration. Neuroscience, 144, 547-561.

Clarkson, A. N., Liu, H., Schiborra, F., Shaw, O., Sammut, I. A., Jackson, D. M., & Appleton, I. (2007). Angiogenesis as a predictive marker of neurological outcome following hypoxia-ischemia. Brain Research, 1171, 111-121.

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Conference Contribution - Published proceedings: Full paper

Eason, C., Murphy, E., Ogilvie, S., Blackie, H., Ross, J., Kaveramann, M., … Harrison, J., Giles, G., Sammut, I., … Brimble, M. (2010). Trends in vetebrate pesticide use and new developments: New Zealand initiatives and international implications. In R. M. Timm & K. A. Fagerstone (Eds.), Proceedings of the 24th Vertebrate Pest Conference. (pp. 91-96). [Full Paper]

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Conference Contribution - Published proceedings: Abstract

Thaung, A., Sammut, I., Yao, Y., & Lamberts, R. (2011). Effect of chronic renal denervation on cardiac response to β-adrenergic stimulation in diabetic hypertensive rat model. New Zealand Medical Journal, 124(1346). Retrieved from http://journal.nzma.org.nz/journal/124-1346/4980/content.pdf

Yao, Y., Harrison, J. C., Davis, G., & Sammut, I. A. (2011). Chronic bilateral renal denervation reduces the progression of renal disease in a transgenic rat model of diabetic nephropathy. Nephrology, 16(Suppl. 1), 159, (pp. 65). doi: 10.1111/j.1440-1797.2011.01491.x

Parry, D. J., Smart, S. D., Stubbs, S., Winburn, I. C., Harrison, J. C., & Sammut, I. A. (2010). Carbon monoxide: The silent killer comes good? Heart, Lung & Circulation, 19(8), (pp. 498-499). doi: 10.1016/j.hlc.2010.04.108

Harrison, J. C., Parry, D. J., Smart, S. D., Stubbs, S., Winburn, I. C., & Sammut, I. A. (2008). Low dose carbon monoxide protects cardiac haemodynamics and promotes anti-inflammatory signalling in an in vivo model of ischaemia reperfusion injury. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting. ASCEPT. Retrieved from http://phal.otago.ac.nz/ascept_docos/programme%202008.pdf

Sutherland, B., Shaw, O. M., Clarkson, A., Winburn, I., Sammut, I., & Appleton, I. (2008). Tin protoporphyrin provides neuroprotection following hypoxia-ischaemia by modification of nitric oxide synthase, cyclooxygenase and mitochondrial complex 1. New Zealand Medical Journal, 121(1278). Retrieved from http://journal.nzma.org.nz/journal/121-1278/3179/content.pdf

Winburn, I., Yao, Y., Hill, J., Endre, Z., Walker, R., & Sammut, I. (2008). Assessment of auto-regulation and endothelial function in kidneys undergoing hypothermic pulsatile perfusion. Transplantation. 86(Suppl. 2), (pp. 83-84). [Abstract]

Winburn, I., Yao, Y., Hill, J., Walker, R., Endre, Z., & Sammut, I. (2008). Renal auto-regulation and endothelial function during hypothermic pulsatile perfusion. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting. ASCEPT. Retrieved from http://phal.otago.ac.nz/ascept_docos/programme%202008.pdf

Nair, S. M., Rahman, R. M. A., Clarkson, A. N., Tramaoundamas, A. V., Sammut, I. A., & Appleton, I. (2006). The protective effects of melatonin on mitochondria function in a stroke-induced model of brain damage. Journal of Neurochemistry. 98(Suppl. 1), (pp. 65). [Abstract]

Nair, S., Rahman, R., Clarkson, A., Tramaoundamas, A., Sammut, I., & Appleton, I. (2006). The protective effects of melatonin on mitochondria function in a stroke-induced model of brain damage. In C. Matthewson & M. Taumoepeau (Eds.), Proceedings of the Pacific Postgraduate Symposium: Pacific Voices III. (pp. 31). Dunedin, New Zealand: Pacific Islands Centre, University of Otago. [Abstract]

Tramoundanas, A. V., Clarkson, A. N., Harrison, J. C., Sawant, P., Jones, G. T., Kerr, D. S., & Sammut, I. A. (2006). Seizure-induced cardiac damage. Hypertension. 48(4), (pp. 777-778). [Abstract]

Winburn, I. C., Harrison, J. C., MacGinley, R. J., Walker, R. J., & Sammut, I. A. (2006). Renal tubular damage following carbon monoxide releasing molecule exposure: Implications for future treatment of transplant ischaemia reperfusion injury. Transplantation. 82(Suppl. 3), (pp. 1043). [Abstract]

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Conference Contribution - Poster Presentation (not in published proceedings)

Besley, E. M. H., Smart, S. D., Kelly, J. R., Harrison, J. C., & Sammut, I. A. (2009, September). Renal function and fibrosis in a rat model of ischaemic heart failure. Poster session presented at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting, Dunedin, New Zealand.

Winburn, I., Yao, Y., Hill, J., Walker, R., Endre, Z., & Sammut, I. (2008, August-September). Modulation of renal vascular function following administration of carbon monoxide during hypothermic pulsatile perfusion in a model of transplant ischaemia reperfusion injury. Poster session presented at the Queenstown Molecular Biology Meetings, Queenstown, New Zealand.

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Conference Contribution - Verbal presentation and other Conference outputs

Winburn, I., Hill, J., Walker, R., Endre, Z., & Sammut, I. (2008, April). Renal vascular function during hypothermic pulsatile perfusion. Verbal presentation at the British Transplantation Society 11th Annual Congress, Glasgow, Scotland.

Sutherland, B. A., Shaw, O. M., Clarkson, A., Winburn, I. C., Sammut, I. A., & Appleton, I. (2008, May). Tin protoporphyrin provides neuroprotection following hypoxia-ischemia by modification of nitric oxide synthase, cyclooxygenase and mitochondrial complex 1. Verbal presentation at the 5th International Symposium on Neuroprotection and Neurorepair, Magdeburg, Germany.

Parry, D. J., Smart, S. D., Stubbs, S., Winburn, I. C., Harrison, J. C., & Sammut, I. A. (2008, October). Carbon monoxide: The silent killer comes good? Verbal presentation at the Australasian Society of Cardiac and Thoracic Surgeons Annual Scientific Meeting, Noosa, Australia.

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