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Professor Dirk De Ridder

Dirk de RidderProfessor Dirk De Ridder is the Neurological Foundation Chair of Neurosurgery. In his clinical capacity, Professor Dirk De Ridder is responsible for skull base surgery (vestibular schwannomas, pituitary surgery), and microvascular decompression surgery.

His research interests are centered on a Darwinian predictive brain model with Bayesian updating to adapt to an ever changing environment. This model is the basis to understand common pathophysiological mechanisms clustering groups of pathologies, such as thalamocortical dysrhythmias (pain, tinnitus, epilepsy, depression, Parkinson's disease, schizophrenia) or obsessive compulsive spectrum disorder (such as addiction, OCD, or eating disorders).

This pathophysiological clustering permits to translate knowledge obtained from one disease to other diseases with similar underlying mechanisms, and to develop novel neuromodulation treatments based on it.

Our clinical neuromodulation research is based on the following concept:

1. All aspects of human normal and pathological behaviour are based on brain activity and connectivity
2. This activity and connectivity can be visualised by functional imaging techniques (PET, fMRI, EEG, MEG)
3. Non-invasive neuromodulation techniques (TMS, tDCS, tRNS, tACS, EEGfeedback) can be used to modulate the abnormal activity and   connectivity
4. If this exerts a clinical benefit a permanent electrode can be implanted on the areas that yield clinical benefit with non-invasive techniques.

A third line of scientific interests focuses on the neural correlates of the "self", how the self is generated in the brain (out of body experiences), its relation to the environment (perception and phantom perception), to others (morality and its pathologies) and god (religion).

Find out more about Professor Dirk De Ridder's research

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Publications

Lee, S.-Y., Rhee, J., Shim, Y. J., Kim, Y., Koo, J.-W., De Ridder, D., … Song, J.-J. (2019). Changes in the resting-state cortical oscillatory activity 6 months after modified tinnitus retraining therapy. Frontiers in Neuroscience, 13, 1123. doi: 10.3389/fnins.2019.01123

Hullfish, J., Abenes, I., Yoo, H. B., De Ridder, D., & Vanneste, S. (2019). Frontostriatal network dysfunction as a domain-general mechanism underlying phantom perception. Human Brain Mapping. Advance online publication. doi: 10.1002/hbm.24521

Kandeepan, S., Maudoux, A., Ribeiro de Paula, D., Zheng, J. Y., Cabay, J. E., Gómez, F., … De Ridder, D., … Soddu, A. (2019). Tinnitus distress: A paradoxical attention to the sound? Journal of Neurology. Advance online publication. doi: 10.1007/s00415-019-09390-1

Yearwood, T., De Ridder, D., Bin Yoo, H., Falowski, S., Venkatesan, L., To, W. T., & Vanneste, S. (2019). Comparison of neural activity in chronic pain patients during tonic and burst spinal cord stimulation using fluorodeoxyglucose positron emission tomography. Neuromodulation. Advance online publication. doi: 10.1111/ner.12960

Mani, R., Adhia, D. B., Leong, S. L., Vanneste, S., & De Ridder, D. (2019). Sedentary behaviour facilitates conditioned pain modulation in middle-aged and older adults with persistent musculoskeletal pain: A cross-sectional investigation. PAIN Reports, 4, e773. doi: 10.1097/PR9.0000000000000773

Chapter in Book - Research

De Ridder, D., Vancamp, T., & Vanneste, S. (2018). Fundamentals of burst stimulation of the spinal cord and brain. In E. S. Krames, P. H. Peckham & A. R. Rezai (Eds.), Neuromodulation (Vol. 1: Comprehensive textbook of principles, technologies, and therapies). (2nd ed.) (pp. 147-160). London, UK: Academic Press. doi: 10.1016/B978-0-12-805353-9.00014-0

De Ridder, D., Manning, P., Cape, G., Vanneste, S., Langguth, B., & Glue, P. (2016). Pathophysiology-based neuromodulation for addictions: An overview. In V. R. Preedy (Ed.), Neuropathology of drug addictions and substance misuse (Vol. 1: Foundations of understanding, tobacco, alcohol, cannabinoids and opioids). (pp. 14-24). London: Elsevier. doi: 10.1016/B978-0-12-800213-1.00002-X

Johnson, R. D., De Ridder, D., & Gillett, G. (2014). Neurosurgery to enhance brain functions: Ethical dilemmas for the neuroscientist and society. In S. J. Thompson (Ed.), Global issues and ethical considerations in human enhancement technologies. (pp. 96-118). Hershey, PA: IGI Global. doi: 10.4018/978-1-4666-6010-6.ch006

Langguth, B., & De Ridder, D. (2013). Tinnitus: Therapeutic use of superficial brain stimulation. In A. M. Lozano & M. Hallett (Eds.), Handbook of clinical neurology (Vol. 116): Brain stimulation. (pp. 441-467). Amsterdam, The Netherlands: Elsevier. doi: 10.1016/B978-0-444-53497-2.00036-X

Langguth, B., Elgoyhen, A. B., De Ridder, D., & Salvi, R. J. (2013). Positive spontaneous auditory phenomena: Tinnitus. In G. G. Celesia (Ed.), Disorders of peripheral and central auditory processing: Handbook of clinical neurophysiology (Vol. 10). (pp. 345-381). Elsevier. doi: 10.1016/B978-0-7020-5310-8.00018-1

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Journal - Research Article

Lee, S.-Y., Rhee, J., Shim, Y. J., Kim, Y., Koo, J.-W., De Ridder, D., … Song, J.-J. (2019). Changes in the resting-state cortical oscillatory activity 6 months after modified tinnitus retraining therapy. Frontiers in Neuroscience, 13, 1123. doi: 10.3389/fnins.2019.01123

Mani, R., Adhia, D. B., Leong, S. L., Vanneste, S., & De Ridder, D. (2019). Sedentary behaviour facilitates conditioned pain modulation in middle-aged and older adults with persistent musculoskeletal pain: A cross-sectional investigation. PAIN Reports, 4, e773. doi: 10.1097/PR9.0000000000000773

Yearwood, T., De Ridder, D., Bin Yoo, H., Falowski, S., Venkatesan, L., To, W. T., & Vanneste, S. (2019). Comparison of neural activity in chronic pain patients during tonic and burst spinal cord stimulation using fluorodeoxyglucose positron emission tomography. Neuromodulation. Advance online publication. doi: 10.1111/ner.12960

Kandeepan, S., Maudoux, A., Ribeiro de Paula, D., Zheng, J. Y., Cabay, J. E., Gómez, F., … De Ridder, D., … Soddu, A. (2019). Tinnitus distress: A paradoxical attention to the sound? Journal of Neurology. Advance online publication. doi: 10.1007/s00415-019-09390-1

Hullfish, J., Abenes, I., Yoo, H. B., De Ridder, D., & Vanneste, S. (2019). Frontostriatal network dysfunction as a domain-general mechanism underlying phantom perception. Human Brain Mapping. Advance online publication. doi: 10.1002/hbm.24521

Ahmed, S., Plazier, M., Ost, J., Stassijns, G., Deleye, S., Ceyssens, S., … De Ridder, D., & Vanneste, S. (2018). The effect of occipital nerve field stimulation on the descending pain pathway in patients with fibromyalgia: A water PET and EEG imaging study. BMC Neurology, 18(1), 191. doi: 10.1186/s12883-018-1190-5

Han, J. J., Jang, J. H., De Ridder, D., Vanneste, S., Koo, J.-W., & Song, J.-J. (2018). Increased parietal circuit-breaker activity in delta frequency band and abnormal delta/theta band connectivity in salience network in hyperacusis subjects. PLoS ONE, 13(1), e0191858. doi: 10.1371/journal.pone.0191858

Ting To, W., De Ridder, D., Hart, Jr, J., & Vanneste, S. (2018). Changing brain networks through non-invasive neuromodulation. Frontiers in Human Neuroscience, 12, 128. doi: 10.3389/fnhum.2018.00128

Vanneste, S., Song, J.-J., & De Ridder, D. (2018). Thalamocortical dysrhythmia detected by machine learning. Nature Communications, 9(1), 1103. doi: 10.1038/s41467-018-02820-0

Huang, Y., Mohan, A., De Ridder, D., Sunaert, S., & Vanneste, S. (2018). The neural correlates of the unified percept of alcohol-related craving: A fMRI and EEG study. Scientific Reports, 8, 923. doi: 10.1038/s41598-017-18471-y

Leong, S. L., De Ridder, D., Vanneste, S., Sutherland, W., Ross, S., & Manning, P. (2018). High definition transcranial pink noise stimulation of anterior cingulate cortex on food craving: An explorative study. Appetite, 120, 673-678. doi: 10.1016/j.appet.2017.10.034

Leong, S. L., Vanneste, S., Lim, J., Smith, M., Manning, P., & De Ridder, D. (2018). A randomised, double-blind, placebo-controlled parallel trial of closed-loop infraslow brain training in food addiction. Scientific Reports, 8, 11659. doi: 10.1038/s41598-018-30181-7

Vanneste, S., Joos, K., Ost, J., & De Ridder, D. (2018). Influencing connectivity and cross-frequency coupling by real-time source localized neurofeedback of the posterior cingulate cortex reduces tinnitus related distress. Neurobiology of Stress, 8, 211-224. doi: 10.1016/j.ynstr.2016.11.003

Hullfish, J., Abenes, I., Kovacs, S., Sunaert, S., De Ridder, D., & Vanneste, S. (2018). Functional connectivity analysis of fMRI data collected from human subjects with chronic tinnitus and varying levels of tinnitus-related distress. Data in Brief. Advance online publication. doi: 10.1016/j.dib.2018.10.044

Mohan, A., De Ridder, D., Idiculla, R., DSouza, C., & Vanneste, S. (2018). Distress-dependent temporal variability of regions encoding domain-specific and domain-general behavioral manifestations of phantom percepts. European Journal of Neuroscience. Advance online publication. doi: 10.1111/ejn.13988

Mohan, A., Alexandra, S. J., Johnson, C. V., De Ridder, D., & Vanneste, S. (2018). Effect of distress on transient network dynamics and topological equilibrium in phantom sound perception. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 84, 79-92. doi: 10.1016/j.pnpbp.2018.01.025

Vanneste, S., Alsalman, O., & De Ridder, D. (2018). COMT and the neurogenetic architecture of hearing loss induced tinnitus. Hearing Research, 365, 1-15. doi: 10.1016/j.heares.2018.05.020

Vanneste, S., Ting To, W., & De Ridder, D. (2018). Tinnitus and neuropathic pain share a common neural substrate in the form of specific brain connectivity and microstate profiles. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 88, 388-400. doi: 10.1016/j.pnpbp.2018.08.015

Yoo, H. B., Ost, J., Joos, W., Van Havenbergh, T., De Ridder, D., & Vanneste, S. (2018). Adding prefrontal transcranial direct current stimulation before occipital nerve stimulation in fibromyalgia. Clinical Journal of Pain, 35(5), 421-427. doi: 10.1097/AJP.0000000000000552

Bin Yoo, H., de la Concha, E. O., De Ridder, D., Pickut, B. A., & Vanneste, S. (2018). The functional alterations in top-down attention streams of Parkinson's disease measured by EEG. Scientific Reports, 8, 10609. doi: 10.1038/s41598-018-29036-y

Vanneste, S., Alsaman, O., & De Ridder, D. (2018). Top-down and bottom-up regulated auditory phantom perception. Journal of Neuroscience. Advance online publication. doi: 10.1523/jneurosci.0966-18.2018

Hullfish, J., Abenes, I., Kovacs, S., Sunaert, S., De Ridder, D., & Vanneste, S. (2018). Functional brain changes in auditory phantom perception evoked by different stimulus frequencies. Neuroscience Letters, 683, 160-167. doi: 10.1016/j.neulet.2018.07.043

Huang, Y., Hullfish, J., De Ridder, D., & Vanneste, S. (2018). Meta-analysis of functional subdivisions within human posteromedial cortex. Brain Structure & Function. Advance online publication. doi: 10.1007/s00429-018-1781-3

Mohan, A., Davidson, C., De Ridder, D., & Vanneste, S. (2018). Effective connectivity analysis of inter- and intramodular hubs in phantom sound perception - identifying the core distress network. Brain Imaging & Behavior. Advance online publication. doi: 10.1007/s11682-018-9989-7

Pattyn, T., Vanneste, S., De Ridder, D., Van Rompaey, V., Veltman, D. J., Van de Heyning, P., … Van Den Eede, F. (2018). Differential electrophysiological correlates of panic disorder in non-pulsatile tinnitus. Journal of Psychosomatic Research, 109, 57-62. doi: 10.1016/j.jpsychores.2018.03.168

To, W. T., De Ridder, D., Menovsky, T., & Vanneste, S. (2017). The role of the dorsal Anterior Cingulate Cortex (dACC) in a cognitive and emotional counting Stroop task: Two cases. Restorative Neurology & Neuroscience, 35(3), 333-345. doi: 10.3233/rnn-170730

To, W. T., Ost, J., Hart, Jr, J., De Ridder, D., & Vanneste, S. (2017). The added value of auditory cortex transcranial random noise stimulation (tRNS) after bifrontal transcranial direct current stimulation (tDCS) for tinnitus. Journal of Neural Transmission, 124(1), 79-88. doi: 10.1007/s00702-016-1634-2

Lefaucheur, J.-P., Antal, A., Ayache, S. S., Benninger, D. H., Brunelin, J., Cogiamanian, F., … De Ridder, D., … Paulus, W. (2017). Evidence-based guidelines on the therapeutic use of transcranial direct current stimulation (tDCS). Clinical Neurophysiology, 128(1), 56-92. doi: 10.1016/j.clinph.2016.10.087

Lee, S.-Y., Nam, D. W., De Ridder, D., Vanneste, S., & Song, J.-J. (2017). No auditory experience, no tinnitus: Lessons from subjects with congenital- and acquired single-sided deafness. Hearing Research, 354, 9-15. doi: 10.1016/j.heares.2017.08.002

Mohan, A., De Ridder, D., & Vanneste, S. (2017). Robustness and dynamicity of functional networks in phantom sound. NeuroImage, 146, 171-187. doi: 10.1016/j.neuroimage.2016.04.033

Mohan, A., Moreno, N., Song, J.-J., De Ridder, D., & Vanneste, S. (2017). Evidence for behaviorally segregated, spatiotemporally overlapping subnetworks in phantom sound perception. Brain Connectivity, 7(3), 197-210. doi: 10.1089/brain.2016.0459

He, J., Zhu, Y., Aa, J., Smith, P. F., De Ridder, D., Wang, G., & Zheng, Y. (2017). Brain metabolic changes in rats following acoustic trauma. Frontiers in Neuroscience, 11, 148. doi: 10.3389/fnins.2017.00148

De Ridder, D., Perera, S., & Vanneste, S. (2017). State of the art: Novel applications for cortical stimulation. Neuromodulation, 20(3), 206-214. doi: 10.1111/ner.12593

Song, J.-J., Kim, K., Sunwoo, W., Lee, S.-Y., Mertens, G., Van de Heyning, P., De Ridder, D., … Choi, J.-W. (2017). A quantitative electroencephalography study on cochlear implant-induced cortical changes in single-sided deafness with tinnitus. Frontiers in Human Neuroscience, 11, 210. doi: 10.3389/fnhum.2017.00210

Vanneste, S., Ost, J., van Havenbergh, T., & De Ridder, D. (2017). Resting state electrical brain activity and connectivity in fibromyalgia. PLoS ONE, 12(6), e0178516. doi: 10.1371/journal.pone.0178516

To, W. T., James, E., Ost, J., Hart, Jr, J., De Ridder, D., & Vanneste, S. (2017). Differential effects of bifrontal and occipital nerve stimulation on pain and fatigue using transcranial direct current stimulation in fibromyalgia patients. Journal of Neural Transmission, 124(7), 799-808. doi: 10.1007/s00702-017-1714-y

De Ridder, D., & Vanneste, S. (2017). Occipital nerve field transcranial direct current stimulation normalizes imbalance between pain detecting and pain inhibitory pathways in fibromyalgia. Neurotherapeutics, 14(2), 484-501. doi: 10.1007/s13311-016-0493-8

Kriek, N., Groeneweg, J. G., Stronks, D. L., de Ridder, D., & Huygen, F. J. P. M. (2017). Preferred frequencies and waveforms for spinal cord stimulation in patients with complex regional pain syndrome: A multicentre, double-blind, randomized and placebo-controlled crossover trial. European Journal of Pain, 21(3), 507-519. doi: 10.1002/ejp.944

Acquadro, M. A. S., Congedo, M., & De Ridder, D. (2016). Music performance as an experimental approach to hyperscanning studies. Frontiers in Human Neuroscience, 10, 242. doi: 10.3389/fnhum.2016.00242

Alsaman, O., Ost, J., Vanspauwen, R., Blaivie, C., De Ridder, D., & Vanneste, S. (2016). The neural correlates of chronic symptoms of vertigo proneness in humans. PLoS ONE, 11(4), e0152309. doi: 10.1371/journal.pone.0152309

Yoo, H. B., De Ridder, D., & Vanneste, S. (2016). The importance of aging in gray matter changes within tinnitus patients shown in cortical thickness, surface area and volume. Brain Topography, 29(6), 885-896. doi: 10.1007/s10548-016-0511-5

Song, J.-J., An, G. S., Choi, I., De Ridder, D., Kim, S. Y., Choi, H. S., … Lee, K. (2016). Objectification and differential diagnosis of vascular pulsatile tinnitus by transcanal sound recording and spectrotemporal analysis: A preliminary study. Otology & Neurotology, 37(6), 613-620. doi: 10.1097/mao.0000000000001005

Shekhawat, G. S., Sundram, F., Bikson, M., Truong, D., De Ridder, D., Stinear, C. M., Welch, D., & Searchfield, G. D. (2016). Intensity, duration, and location of high-definition transcranial direct current stimulation for tinnitus relief. Neurorehabilitation & Neural Repair, 30(4), 349-359. doi: 10.1177/1545968315595286

Mohan, A., De Ridder, D., & Vanneste, S. (2016). Graph theoretical analysis of brain connectivity in phantom sound perception. Scientific Reports, 6, 19683. doi: 10.1038/srep19683

Yoo, H. B., De Ridder, D., & Vanneste, S. (2016). White matter changes in tinnitus: Is it all age and hearing loss? Brain Connectivity, 6(1), 84-93. doi: 10.1089/brain.2015.0380

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