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Professor Dirk De Ridder

Dirk de RidderProfessor Dirk De Ridder is the Neurological Foundation Chair of Neurosurgery. In his clinical capacity, Professor Dirk De Ridder is responsible for skull base surgery (vestibular schwannomas, pituitary surgery), and microvascular decompression surgery.

His research interests are centered on a Darwinian predictive brain model with Bayesian updating to adapt to an ever changing environment. This model is the basis to understand common pathophysiological mechanisms clustering groups of pathologies, such as thalamocortical dysrhythmias (pain, tinnitus, epilepsy, depression, Parkinson's disease, schizophrenia) or obsessive compulsive spectrum disorder (such as addiction, OCD, or eating disorders).

This pathophysiological clustering permits to translate knowledge obtained from one disease to other diseases with similar underlying mechanisms, and to develop novel neuromodulation treatments based on it.

Our clinical neuromodulation research is based on the following concept:

1. All aspects of human normal and pathological behaviour are based on brain activity and connectivity
2. This activity and connectivity can be visualised by functional imaging techniques (PET, fMRI, EEG, MEG)
3. Non-invasive neuromodulation techniques (TMS, tDCS, tRNS, tACS, EEGfeedback) can be used to modulate the abnormal activity and   connectivity
4. If this exerts a clinical benefit a permanent electrode can be implanted on the areas that yield clinical benefit with non-invasive techniques.

A third line of scientific interests focuses on the neural correlates of the "self", how the self is generated in the brain (out of body experiences), its relation to the environment (perception and phantom perception), to others (morality and its pathologies) and god (religion).

Find out more about Professor Dirk De Ridder's research

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Publications

He, J., Aa, J.-Y., Sun, J.-G., Smith, P. F., De Ridder, D., Wang, G.-J., & Zheng, Y. (2021). Metabolic changes in the brain and blood of rats following acoustic trauma, tinnitus and hyperacusis. Progress in Brain Research. Advance online publication. doi: 10.1016/bs.pbr.2020.09.002

Sui, Y., Tian, Y., Ko, W. K. D., Wang, Z., Jiang, F., Horn, A., De Ridder, D., … Li, L. (2021). Deep brain stimulation initiative: Toward innovative technology, new disease indications, and approaches to current and future clinical challenges in neuromodulation therapy. Frontiers in Neurology, 11, 597451. doi: 10.3389/fneur.2020.597451

Vanneste, S., Mohan, A., De Ridder, D., & To, W. T. (2021). The BDNF Val66Met polymorphism regulates vulnerability to chronic stress and phantom perception. Progress in Brain Research. Advance online publication. doi: 10.1016/bs.pbr.2020.08.005

De Ridder, D., Schlee, W., Vanneste, S., Londero, A., Weisz, N., Kleinjung, T., … Kleinstaeuber, M., … Zheng, Y., … Adhia, D. (2021). Tinnitus and tinnitus disorder: Theoretical and operational definitions (an international multidisciplinary proposal). Progress in Brain Research. Advance online publication. doi: 10.1016/bs.pbr.2020.12.002

Han, J. J., De Ridder, D., Vanneste, S., Chen, Y.-C., Koo, J.-W., & Song, J.-J. (2020). Pre-treatment ongoing cortical oscillatory activity predicts improvement of tinnitus after partial peripheral reafferentation with hearing aids. Frontiers in Neuroscience, 14, 410. doi: 10.3389/fnins.2020.00410

Chapter in Book - Research

De Ridder, D., Vancamp, T., & Vanneste, S. (2018). Fundamentals of burst stimulation of the spinal cord and brain. In E. S. Krames, P. H. Peckham & A. R. Rezai (Eds.), Neuromodulation (Vol. 1: Comprehensive textbook of principles, technologies, and therapies). (2nd ed.) (pp. 147-160). London, UK: Academic Press. doi: 10.1016/B978-0-12-805353-9.00014-0

De Ridder, D., Manning, P., Cape, G., Vanneste, S., Langguth, B., & Glue, P. (2016). Pathophysiology-based neuromodulation for addictions: An overview. In V. R. Preedy (Ed.), Neuropathology of drug addictions and substance misuse (Vol. 1: Foundations of understanding, tobacco, alcohol, cannabinoids and opioids). (pp. 14-24). London: Elsevier. doi: 10.1016/B978-0-12-800213-1.00002-X

Johnson, R. D., De Ridder, D., & Gillett, G. (2014). Neurosurgery to enhance brain functions: Ethical dilemmas for the neuroscientist and society. In S. J. Thompson (Ed.), Global issues and ethical considerations in human enhancement technologies. (pp. 96-118). Hershey, PA: IGI Global. doi: 10.4018/978-1-4666-6010-6.ch006

Langguth, B., & De Ridder, D. (2013). Tinnitus: Therapeutic use of superficial brain stimulation. In A. M. Lozano & M. Hallett (Eds.), Handbook of clinical neurology (Vol. 116): Brain stimulation. (pp. 441-467). Amsterdam, The Netherlands: Elsevier. doi: 10.1016/B978-0-444-53497-2.00036-X

Langguth, B., Elgoyhen, A. B., De Ridder, D., & Salvi, R. J. (2013). Positive spontaneous auditory phenomena: Tinnitus. In G. G. Celesia (Ed.), Disorders of peripheral and central auditory processing: Handbook of clinical neurophysiology (Vol. 10). (pp. 345-381). Elsevier. doi: 10.1016/B978-0-7020-5310-8.00018-1

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Journal - Research Article

He, J., Aa, J.-Y., Sun, J.-G., Smith, P. F., De Ridder, D., Wang, G.-J., & Zheng, Y. (2021). Metabolic changes in the brain and blood of rats following acoustic trauma, tinnitus and hyperacusis. Progress in Brain Research. Advance online publication. doi: 10.1016/bs.pbr.2020.09.002

De Ridder, D., Schlee, W., Vanneste, S., Londero, A., Weisz, N., Kleinjung, T., … Kleinstaeuber, M., … Zheng, Y., … Adhia, D. (2021). Tinnitus and tinnitus disorder: Theoretical and operational definitions (an international multidisciplinary proposal). Progress in Brain Research. Advance online publication. doi: 10.1016/bs.pbr.2020.12.002

Vanneste, S., Mohan, A., De Ridder, D., & To, W. T. (2021). The BDNF Val66Met polymorphism regulates vulnerability to chronic stress and phantom perception. Progress in Brain Research. Advance online publication. doi: 10.1016/bs.pbr.2020.08.005

Sui, Y., Tian, Y., Ko, W. K. D., Wang, Z., Jiang, F., Horn, A., De Ridder, D., … Li, L. (2021). Deep brain stimulation initiative: Toward innovative technology, new disease indications, and approaches to current and future clinical challenges in neuromodulation therapy. Frontiers in Neurology, 11, 597451. doi: 10.3389/fneur.2020.597451

Han, J. J., De Ridder, D., Vanneste, S., Chen, Y.-C., Koo, J.-W., & Song, J.-J. (2020). Pre-treatment ongoing cortical oscillatory activity predicts improvement of tinnitus after partial peripheral reafferentation with hearing aids. Frontiers in Neuroscience, 14, 410. doi: 10.3389/fnins.2020.00410

de Ridder, D., Langguth, B., & Vanneste, S. (2020). Vagus nerve stimulation for tinnitus: A review and perspective. Progress in Brain Research. Advance online publication. doi: 10.1016/bs.pbr.2020.08.011

De Ridder, D., & Vanneste, S. (2020). The Bayesian brain in imbalance: Medial, lateral and descending pathways in tinnitus and pain: A perspective. Progress in Brain Research. Advance online publication. doi: 10.1016/bs.pbr.2020.07.012

Yoo, H. B., Mohan, A., De Ridder, D., & Vanneste, S. (2020). Paradoxical relationship between distress and functional network topology in phantom sound perception. Progress in Brain Research. Advance online publication. doi: 10.1016/bs.pbr.2020.08.007

Ros, T., Enriquez-Geppert, S., Zotev, V., Young, K. D., Wood, G., Whitfield-Gabrieli, S., … De Ridder, D., … Thibault, R. T. (2020). Consensus on the reporting and experimental design of clinical and cognitive-behavioural neurofeedback studies (CRED-nf checklist). Brain, 143, 1674-1685. doi: 10.1093/brain/awaa009

Yearwood, T., De Ridder, D., Bin Yoo, H., Falowski, S., Venkatesan, L., To, W. T., & Vanneste, S. (2020). Comparison of neural activity in chronic pain patients during tonic and burst spinal cord stimulation using fluorodeoxyglucose positron emission tomography. Neuromodulation, 23, 56-63. doi: 10.1111/ner.12960

Lee, S.-Y., Choi, B. Y., Koo, J.-W., De Ridder, D., & Song, J.-J. (2020). Cortical oscillatory signatures reveal the prerequisites for tinnitus perception: A comparison of subjects with sudden sensorineural hearing loss with and without tinnitus. Frontiers in Neuroscience, 14, 596647. doi: 10.3389/fnins.2020.596647

Mohan, A., Davidson, C., De Ridder, D., & Vanneste, S. (2020). Effective connectivity analysis of inter- and intramodular hubs in phantom sound perception: Identifying the core distress network. Brain Imaging & Behavior, 14, 289-307. doi: 10.1007/s11682-018-9989-7

Leong, S. L., Glue, P., Manning, P., Vanneste, S., Lim, L. J., Mohan, A., & De Ridder, D. (2020). Anterior cingulate cortex implants for alcohol addiction: A feasibility study. Neurotherapeutics, 17, 1287-1299. doi: 10.1007/s13311-020-00851-4

Lee, S.-Y., Rhee, J., Shim, Y. J., Kim, Y., Koo, J.-W., De Ridder, D., … Song, J.-J. (2019). Changes in the resting-state cortical oscillatory activity 6 months after modified tinnitus retraining therapy. Frontiers in Neuroscience, 13, 1123. doi: 10.3389/fnins.2019.01123

Leong, S. L., De Ridder, D., Deer, T., & Vanneste, S. (2019). Potential therapeutic effect of low amplitude burst spinal cord stimulation on pain. Neuromodulation. Advance online publication. doi: 10.1111/ner.13090

Mani, R., Adhia, D. B., Leong, S. L., Vanneste, S., & De Ridder, D. (2019). Sedentary behaviour facilitates conditioned pain modulation in middle-aged and older adults with persistent musculoskeletal pain: A cross-sectional investigation. PAIN Reports, 4, e773. doi: 10.1097/PR9.0000000000000773

Hullfish, J., Abenes, I., Yoo, H. B., De Ridder, D., & Vanneste, S. (2019). Frontostriatal network dysfunction as a domain-general mechanism underlying phantom perception. Human Brain Mapping, 40, 2241-2251. doi: 10.1002/hbm.24521

Huang, Y., Hullfish, J., De Ridder, D., & Vanneste, S. (2019). Meta-analysis of functional subdivisions within human posteromedial cortex. Brain Structure & Function, 224, 435-452. doi: 10.1007/s00429-018-1781-3

Kandeepan, S., Maudoux, A., Ribeiro de Paula, D., Zheng, J. Y., Cabay, J. E., Gómez, F., … De Ridder, D., … Soddu, A. (2019). Tinnitus distress: A paradoxical attention to the sound? Journal of Neurology, 266, 2197-2207. doi: 10.1007/s00415-019-09390-1

Vanneste, S., Alsaman, O., & De Ridder, D. (2019). Top-down and bottom-up regulated auditory phantom perception. Journal of Neuroscience, 39(2), 364-378. doi: 10.1523/jneurosci.0966-18.2018

Ahmed, S., Plazier, M., Ost, J., Stassijns, G., Deleye, S., Ceyssens, S., … De Ridder, D., & Vanneste, S. (2018). The effect of occipital nerve field stimulation on the descending pain pathway in patients with fibromyalgia: A water PET and EEG imaging study. BMC Neurology, 18(1), 191. doi: 10.1186/s12883-018-1190-5

Han, J. J., Jang, J. H., De Ridder, D., Vanneste, S., Koo, J.-W., & Song, J.-J. (2018). Increased parietal circuit-breaker activity in delta frequency band and abnormal delta/theta band connectivity in salience network in hyperacusis subjects. PLoS ONE, 13(1), e0191858. doi: 10.1371/journal.pone.0191858

Ting To, W., De Ridder, D., Hart, Jr, J., & Vanneste, S. (2018). Changing brain networks through non-invasive neuromodulation. Frontiers in Human Neuroscience, 12, 128. doi: 10.3389/fnhum.2018.00128

Vanneste, S., Song, J.-J., & De Ridder, D. (2018). Thalamocortical dysrhythmia detected by machine learning. Nature Communications, 9(1), 1103. doi: 10.1038/s41467-018-02820-0

Huang, Y., Mohan, A., De Ridder, D., Sunaert, S., & Vanneste, S. (2018). The neural correlates of the unified percept of alcohol-related craving: A fMRI and EEG study. Scientific Reports, 8, 923. doi: 10.1038/s41598-017-18471-y

Leong, S. L., De Ridder, D., Vanneste, S., Sutherland, W., Ross, S., & Manning, P. (2018). High definition transcranial pink noise stimulation of anterior cingulate cortex on food craving: An explorative study. Appetite, 120, 673-678. doi: 10.1016/j.appet.2017.10.034

Leong, S. L., Vanneste, S., Lim, J., Smith, M., Manning, P., & De Ridder, D. (2018). A randomised, double-blind, placebo-controlled parallel trial of closed-loop infraslow brain training in food addiction. Scientific Reports, 8, 11659. doi: 10.1038/s41598-018-30181-7

Vanneste, S., Joos, K., Ost, J., & De Ridder, D. (2018). Influencing connectivity and cross-frequency coupling by real-time source localized neurofeedback of the posterior cingulate cortex reduces tinnitus related distress. Neurobiology of Stress, 8, 211-224. doi: 10.1016/j.ynstr.2016.11.003

Mohan, A., De Ridder, D., Idiculla, R., DSouza, C., & Vanneste, S. (2018). Distress-dependent temporal variability of regions encoding domain-specific and domain-general behavioral manifestations of phantom percepts. European Journal of Neuroscience, 48(2), 1743-1764. doi: 10.1111/ejn.13988

Mohan, A., Alexandra, S. J., Johnson, C. V., De Ridder, D., & Vanneste, S. (2018). Effect of distress on transient network dynamics and topological equilibrium in phantom sound perception. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 84, 79-92. doi: 10.1016/j.pnpbp.2018.01.025

Vanneste, S., Alsalman, O., & De Ridder, D. (2018). COMT and the neurogenetic architecture of hearing loss induced tinnitus. Hearing Research, 365, 1-15. doi: 10.1016/j.heares.2018.05.020

Vanneste, S., Ting To, W., & De Ridder, D. (2018). Tinnitus and neuropathic pain share a common neural substrate in the form of specific brain connectivity and microstate profiles. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 88, 388-400. doi: 10.1016/j.pnpbp.2018.08.015

Yoo, H. B., Ost, J., Joos, W., Van Havenbergh, T., De Ridder, D., & Vanneste, S. (2018). Adding prefrontal transcranial direct current stimulation before occipital nerve stimulation in fibromyalgia. Clinical Journal of Pain, 35(5), 421-427. doi: 10.1097/AJP.0000000000000552

Bin Yoo, H., de la Concha, E. O., De Ridder, D., Pickut, B. A., & Vanneste, S. (2018). The functional alterations in top-down attention streams of Parkinson's disease measured by EEG. Scientific Reports, 8, 10609. doi: 10.1038/s41598-018-29036-y

Hullfish, J., Abenes, I., Kovacs, S., Sunaert, S., De Ridder, D., & Vanneste, S. (2018). Functional brain changes in auditory phantom perception evoked by different stimulus frequencies. Neuroscience Letters, 683, 160-167. doi: 10.1016/j.neulet.2018.07.043

Pattyn, T., Vanneste, S., De Ridder, D., Van Rompaey, V., Veltman, D. J., Van de Heyning, P., … Van Den Eede, F. (2018). Differential electrophysiological correlates of panic disorder in non-pulsatile tinnitus. Journal of Psychosomatic Research, 109, 57-62. doi: 10.1016/j.jpsychores.2018.03.168

To, W. T., De Ridder, D., Menovsky, T., & Vanneste, S. (2017). The role of the dorsal Anterior Cingulate Cortex (dACC) in a cognitive and emotional counting Stroop task: Two cases. Restorative Neurology & Neuroscience, 35(3), 333-345. doi: 10.3233/rnn-170730

To, W. T., Ost, J., Hart, Jr, J., De Ridder, D., & Vanneste, S. (2017). The added value of auditory cortex transcranial random noise stimulation (tRNS) after bifrontal transcranial direct current stimulation (tDCS) for tinnitus. Journal of Neural Transmission, 124(1), 79-88. doi: 10.1007/s00702-016-1634-2

Lefaucheur, J.-P., Antal, A., Ayache, S. S., Benninger, D. H., Brunelin, J., Cogiamanian, F., … De Ridder, D., … Paulus, W. (2017). Evidence-based guidelines on the therapeutic use of transcranial direct current stimulation (tDCS). Clinical Neurophysiology, 128(1), 56-92. doi: 10.1016/j.clinph.2016.10.087

Lee, S.-Y., Nam, D. W., De Ridder, D., Vanneste, S., & Song, J.-J. (2017). No auditory experience, no tinnitus: Lessons from subjects with congenital- and acquired single-sided deafness. Hearing Research, 354, 9-15. doi: 10.1016/j.heares.2017.08.002

Mohan, A., De Ridder, D., & Vanneste, S. (2017). Robustness and dynamicity of functional networks in phantom sound. NeuroImage, 146, 171-187. doi: 10.1016/j.neuroimage.2016.04.033

Mohan, A., Moreno, N., Song, J.-J., De Ridder, D., & Vanneste, S. (2017). Evidence for behaviorally segregated, spatiotemporally overlapping subnetworks in phantom sound perception. Brain Connectivity, 7(3), 197-210. doi: 10.1089/brain.2016.0459

He, J., Zhu, Y., Aa, J., Smith, P. F., De Ridder, D., Wang, G., & Zheng, Y. (2017). Brain metabolic changes in rats following acoustic trauma. Frontiers in Neuroscience, 11, 148. doi: 10.3389/fnins.2017.00148

De Ridder, D., Perera, S., & Vanneste, S. (2017). State of the art: Novel applications for cortical stimulation. Neuromodulation, 20(3), 206-214. doi: 10.1111/ner.12593

Song, J.-J., Kim, K., Sunwoo, W., Lee, S.-Y., Mertens, G., Van de Heyning, P., De Ridder, D., … Choi, J.-W. (2017). A quantitative electroencephalography study on cochlear implant-induced cortical changes in single-sided deafness with tinnitus. Frontiers in Human Neuroscience, 11, 210. doi: 10.3389/fnhum.2017.00210

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