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Dr Ailsa McGregor

Ailsa McGregorDr McGregor's areas of interest are:

  • Neurodegenerative diseases
  • Neuroprotection and repair
  • The development of disease models for investigating potential therapies

Her research focuses on pharmacological enhancement of motor recovery after stroke and cholinergic dysfunction in Huntington's Disease and vascular dementia.

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Publications

Thakkar, P., McGregor, A., Barber, P. A., Paton, J. F. R., Barrett, C., & McBryde, F. (2019). Hypertensive response to ischemic stroke in the normotensive Wistar rat. Stroke. Advance online publication. doi: 10.1161/STROKEAHA.119.026459

Hubbard, K., Shome, A., Sun, B., Pontré, B., McGregor, A., & Mountjoy, K. G. (2019). Chronic high-fat diet exacerbates sexually-dimorphic Pomctm1/tm1 mouse obesity. Endocrinology. Advance online publication. doi: 10.1210/en.2018-00924

Mountjoy, K. G., Caron, A., Hubbard, K., Shome, A., Grey, A. C., Sun, B., … McGregor, A., … Elmquist, J. K. (2018). Desacetyl-α-melanocyte stimulating hormone and α-melanocyte stimulating hormone are required to regulate energy balance. Molecular Metabolism, 9, 207-216. doi: 10.1016/j.molmet.2017.11.008

Chen, S., Bennet, L., & McGregor, A. L. (2017). Delayed varenicline administration reduces inflammation and improves forelimb use following experimental stroke. Journal of Stroke & Cerebrovascular Diseases, 26(12), 2778-2787. doi: 10.1016/j.jstrokecerebrovasdis.2017.06.051

Kang, W., Svirskis, D., Sarojini, V., McGregor, A. L., Bevitt, J., & Wu, Z. (2017). Cyclic-RGDyC functionalized liposomes for dual-targeting of tumor vasculature and cancer cells in glioblastoma: An in vitro boron neutron capture therapy study. Oncotarget, 8(22), 36614-36627. doi: 10.18632/oncotarget.16625

Journal - Research Article

Thakkar, P., McGregor, A., Barber, P. A., Paton, J. F. R., Barrett, C., & McBryde, F. (2019). Hypertensive response to ischemic stroke in the normotensive Wistar rat. Stroke. Advance online publication. doi: 10.1161/STROKEAHA.119.026459

Hubbard, K., Shome, A., Sun, B., Pontré, B., McGregor, A., & Mountjoy, K. G. (2019). Chronic high-fat diet exacerbates sexually-dimorphic Pomctm1/tm1 mouse obesity. Endocrinology. Advance online publication. doi: 10.1210/en.2018-00924

Mountjoy, K. G., Caron, A., Hubbard, K., Shome, A., Grey, A. C., Sun, B., … McGregor, A., … Elmquist, J. K. (2018). Desacetyl-α-melanocyte stimulating hormone and α-melanocyte stimulating hormone are required to regulate energy balance. Molecular Metabolism, 9, 207-216. doi: 10.1016/j.molmet.2017.11.008

Chen, S., Bennet, L., & McGregor, A. L. (2017). Delayed varenicline administration reduces inflammation and improves forelimb use following experimental stroke. Journal of Stroke & Cerebrovascular Diseases, 26(12), 2778-2787. doi: 10.1016/j.jstrokecerebrovasdis.2017.06.051

Kang, W., Svirskis, D., Sarojini, V., McGregor, A. L., Bevitt, J., & Wu, Z. (2017). Cyclic-RGDyC functionalized liposomes for dual-targeting of tumor vasculature and cancer cells in glioblastoma: An in vitro boron neutron capture therapy study. Oncotarget, 8(22), 36614-36627. doi: 10.18632/oncotarget.16625

McGregor, A. L., D'Souza, G., Kim, D., & Tingle, M. D. (2017). Varenicline improves motor and cognitive deficits and decreases depressive-like behaviour in late-stage YAC128 mice. Neuropharmacology, 116, 233-246. doi: 10.1016/j.neuropharm.2016.12.021

McGregor, A. L., Dysart, J., Tingle, M. D., Russell, B. R., Kydd, R. R., & Finucane, G. (2016). Varenicline improves motor and cognitive symptoms in early Huntington’s disease. Neuropsychiatric Disease & Treatment, 12, 2381-2386. doi: 10.2147/NDT.S111083

Chen, S., Bennet, L., & McGregor, A. L. (2015). MacGreen mice: A novel tool to investigate inflammation following experimental stroke. Journal of Experimental Stroke & Translational Medicine, 8, 1-10.

Kamal, T., Green, T. N., Morel-Kopp, M.-C., Ward, C. M., McGregor, A. L., McGlashan, S. R., … Kalev-Zylinska, M. L. (2015). Inhibition of glutamate regulated calcium entry into leukemic megakaryoblasts reduces cell proliferation and supports differentiation. Cellular Signaling, 27, 1860-1872. doi: 10.1016/j.cellsig.2015.05.004

Yung, R., Seyfoddin, V., Guise, C., Tijono, S., McGregor, A., Connor, B., & Ching, L.-M. (2014). Efficacy against subcutaneous or intracranial murine GL261 gliomas in relation to the concentration of the vascular-disrupting agent, 5,6-dimethylxanthenone-4-acetic acid (DMXAA), in the brain and plasma. Cancer Chemotherapy & Pharmacology, 73(3), 639-649. doi: 10.1007/s00280-014-2395-y

Fourie, C., Kim, E., Waldvogel, H., Wong, J. M., McGregor, A., Faull, R. L. M., & Montgomery, J. M. (2014). Differential changes in postsynaptic density proteins in postmortem Huntington's disease and Parkinson's disease human brains. Journal of Neurodegenerative Diseases, 2014, 938530. doi: 10.1155/2014/938530

Maucksch, C., McGregor, A. L., Yang, M., Gordon, R. J., Yang, M., & Connor, B. (2013). IGF-I redirects doublecortin-positive cell migration in the normal adult rat brain. Neuroscience, 241, 106-115. doi: 10.1016/j.neuroscience.2013.03.021

Evans, J., Sun, Y., McGregor, A., & Connor, B. (2012). Allopregnanolone regulates neurogenesis and depressive/anxiety-like behaviour in a social isolation rodent model of chronic stress. Neuropharmacology, 63(8), 1315-1326. doi: 10.1016/j.neuropharm.2012.08.012

Gordon, R. J., McGregor, A. L., & Connor, B. (2009). Chemokines direct neural progenitor cell migration following striatal cell loss. Molecular & Cellular Neuroscience, 41(2), 219-232. doi: 10.1016/j.mcn.2009.03.001

McColl, B. W., McGregor, A. L., Wong, A., Harris, J. D., Amalfitano, A., Magnoni, S., … Horsburgh, K. (2007). APOE ε3 gene transfer attenuates brain damage after experimental stroke. Journal of Cerebral Blood Flow & Metabolism, 27(3), 477-487. doi: 10.1038/sj.jcbfm.9600361

Gordon, R. J., Tattersfield, A. S., Vazey, E. M., Kells, A. P., McGregor, A. L., Hughes, S. M., & Connor, B. (2007). Temporal profile of subventricular zone progenitor cell migration following quinolinic acid–induced striatal cell loss. Neuroscience, 146(4), 1704-1718. doi: 10.1016/j.neuroscience.2007.03.011

Milne, S. A., McGregor, A. L., McCulloch, J., & Sharkey, J. (2005). Increased expression of macrophage receptor with collagenous structure (MARCO) in mouse cortex following middle cerebral artery occlusion. Neuroscience Letters, 383, 58-62. doi: 10.1016/j.neulet.2005.03.065

Kerr, L. E., McGregor, A. L., Amet, L. E. A., Asada, T., Spratt, C., Allsopp, T. E., … Sharkey, J. (2004). Mice overexpressing human caspase 3 appear phenotypically normal but exhibit increased apoptosis and larger lesion volumes in response to transient focal cerebral ischaemia. Cell Death & Differentiation, 11, 1102-1111. doi: 10.1038/sj.cdd.4401449

Owens, J., Tebbutt, A. A., McGregor, A. L., Kodama, K., Magar, S. S., Perlman, M. E., … McCulloch, J. (2000). Synthesis and binding characteristics of N-(1-naphthyl)-N′-(3-[125I]-iodophenyl)-N′-methylguanidine ([125I]-CNS 1261): A potential SPECT agent for imaging NMDA receptor activation. Nuclear Medicine & Biology, 27(6), 557-564. doi: 10.1016/S0969-8051(00)00102-5

Wiessner, C., Allegrini, P. R., Rupalla, K., Sauer, D., Oltersdorf, T., McGregor, A. L., … van der Putten, H. (1999). Neuron-specific transgene expression of Bcl-XL but not Bcl-2 genes reduced lesion size after permanent middle cerebral artery occlusion in mice. Neuroscience Letters, 268(3), 119-122. doi: 10.1016/S0304-3940(99)00392-4

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Journal - Research Other

MacLeod, M. R., Ramage, L., McGregor, A. L., & Seckl, J. R. (2003). Reduced NMDA-induced apoptosis in neurons lacking ataxia telangiectasia mutated protein. NeuroReport, 14(2), 215-217. doi: 10.1097/00001756-200302100-00011

McCarter, J. F., McGregor, A. L., Jones, P. A., & Sharkey, J. (2001). FK 506 protects brain tissue in animal models of stroke. Transplantation Proceedings, 33, 2390-2392.

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Conference Contribution - Published proceedings: Abstract

McGregor, A. L., Chen, S., Kurniawan, N., & Bennett, L. (2017). Delayed varenicline administration increases inflammation and white matter damage and is detrimental to functional recovery after stroke. In B. Leitch (Ed.), Proceedings of the 35th International Australasian Winter Conference on Brain Research. (pp. 28). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr/index.html

Wolfe, K. M., McGregor, A. L., & Kerr, D. S. (2017). Anti-inflammatory characteristics exhibited by heterocyclic cyclohexanone curcumin derivatives against LPS-induced inflammation. In B. Leitch (Ed.), Proceedings of the 35th International Australasian Winter Conference on Brain Research. (pp. 65). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr/index.html

McBryde, F., Thakkar, P., McGregor, A., Paton, J., & Barrett, C. (2017). The cardiovascular response to stroke in normal and hypertensive rats: Therapeutic or pathological? FASEB Journal, 31(Suppl. 1), 1011.3. [Abstract]

Chen, S., Bennet, L., & McGregor, A. L. (2016). Delayed administration of citalopram is associated with long-lasting motor improvements and promotes brain remodelling in an experimental model of stroke. Proceedings of the Society for Neuroscience 46th Annual Meeting. 425.15/II2. SfN. Retrieved from https://www.sfn.org/

McGregor, A. L., D'Souza, G., & Tingle, M. D. (2016). Varenicline produces long-lasting improvements in motor function and modulates neuroinflammation in YAC128 mice. In B. Leitch (Ed.), Proceedings of the 34th International Australasian Winter Conference on Brain Research. (pp. 30). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr

D'Souza, G., Tingle, M., & McGregor, A. (2015). Varenicline improves motor, cognitive and psychiatric symptoms in the YAC128 transgenic mouse model of Huntington's disease. Proceedings of the 48th Annual Winter Conference on Brain Research (WCBR). (pp. 140-141). Retrieved from http://www.winterbrain.org/documents/wcbr-2015.pdf

Kim, D., Mountjoy, K., & McGregor, A. (2014). Finding new therapeutic strategies for acute stroke: Asking the brain for direction. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 32nd International Australasian Winter Conference on Brain Research. 32, (pp. 64). AWCBR. Retrieved from https://web.psy.otago.ac.nz/awcbr/proceedings.html

Chen, S., Bennet, L., & McGregor, A. L. (2014). Delayed administration of citalopram is associated with long-lasting improvements in skilled motor function after stroke. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 32nd International Australasian Winter Conference on Brain Research. 32, (pp. 77). AWCBR. Retrieved from https://web.psy.otago.ac.nz/awcbr/proceedings.html

McGregor, A. L., D'Souza, G., & Tingle, M. (2014). Varenicline improves motor, cognitive and psychiatric symptoms in the YAC128 transgenic mouse model of Huntington's disease. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 32nd International Australasian Winter Conference on Brain Research. 32, (pp. 74). AWCBR. Retrieved from https://web.psy.otago.ac.nz/awcbr/proceedings.html

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Conference Contribution - Verbal presentation and other Conference outputs

McGregor, A. (2016, June). Can a drug that helps smokers quit control Huntington's disease symptoms? Verbal presentation at the 10th Annual Brain Health Research Centre Conference: The Developing Brain, Dunedin, New Zealand.

McGregor, A., & Clarkson, A. (2012, September). Animal models of stroke [Workshop]. Verbal presentation at the New Zealand Applied Neurosciences Conference (NZANC), Auckland, New Zealand.

More publications...