Dr Gumy is a senior research fellow in the department of anatomy. Her work focuses on the microtubule cytoskeleton and microtubule-based vesicle transport in healthy and diseased/injured neurons. Her research relies on combining high-resolution live cell imaging and quantitative analysis of cytoskeletal and transport dynamics, using advance microscopic assays and tools to visualise and manipulate proteins within cells. She also uses different biochemical methods to characterise protein-protein interactions us, this is achieved using pull-down assays and mass spectrometry-based protein identification. Dr Gumy primarily employs neuronal cultures or non-neuronal cells to image live-tissue.
Find out more about Dr Gumy’s research
Publications
Malone, L. M., Warring, S. L., Jackson, S. A., Warnecke, C., Gardner, P. P., Gumy, L. F., & Fineran, P. C. (2020). A jumbo phage that forms a nucleus-like structure evades CRISPR-Cas DNA targeting but is vulnerable to type III RNA-based immunity. Nature Microbiology, 5, 48-55. doi: 10.1038/s41564-019-0612-5
Gumy, L. (2018). Visualising intracellular transport in neurons. Proceedings of the 38th Australasian Neuroscience Society (ANS) Annual Scientific Meeting. Retrieved from https://www.ans.org.au
Mockett, B. G., Meunier, F. A., Gumy, L. F., Empson, R. M., & Micallef, A. H. (2018). Exploring neuronal function through advanced imaging techniques. Proceedings of the 38th Australasian Neuroscience Society (ANS) Annual Scientific Meeting. Retrieved from https://www.ans.org.au
Gumy, L. F., & Hoogenraad, C. C. (2018). Local mechanisms regulating selective cargo entry and long-range trafficking in axons. Current Opinion in Neurobiology, 51, 23-28. doi: 10.1016/j.conb.2018.02.007
Abil, Z., Gumy, L. F., Zhao, H., & Hoogenraad, C. C. (2017). Inducible control of mRNA transport using reprogrammable RNA-binding proteins. ACS Synthetic Biology, 6(6), 950-956. doi: 10.1021/acssynbio.7b00025
Malone, L. M., Warring, S. L., Jackson, S. A., Warnecke, C., Gardner, P. P., Gumy, L. F., & Fineran, P. C. (2020). A jumbo phage that forms a nucleus-like structure evades CRISPR-Cas DNA targeting but is vulnerable to type III RNA-based immunity. Nature Microbiology, 5, 48-55. doi: 10.1038/s41564-019-0612-5
Journal - Research Article
Gumy, L. F., & Hoogenraad, C. C. (2018). Local mechanisms regulating selective cargo entry and long-range trafficking in axons. Current Opinion in Neurobiology, 51, 23-28. doi: 10.1016/j.conb.2018.02.007
Journal - Research Article
Abil, Z., Gumy, L. F., Zhao, H., & Hoogenraad, C. C. (2017). Inducible control of mRNA transport using reprogrammable RNA-binding proteins. ACS Synthetic Biology, 6(6), 950-956. doi: 10.1021/acssynbio.7b00025
Journal - Research Article
Gumy, L. F., Katrukha, E. A., Grigoriev, I., Jaarsma, D., Kapitein, L. C., Akhmanova, A., & Hoogenraad, C. C. (2017). MAP2 defines a pre-axonal filtering zone to regulate KIF1-versus KIF5-dependent cargo transport in sensory neurons. Neuron, 94(2), 347-362. doi: 10.1016/j.neuron.2017.03.046
Journal - Research Article
Ruane, P. T., Gumy, L. F., Bola, B., Anderson, B., Wozniak, M. J., Hoogenraad, C. C., & Allan, V. J. (2016). Tumour suppressor adenomatous polyposis coli (APC) localisation is regulated by both kinesin-1 and kinesin-2. Scientific Reports, 6, 27456 . doi: 10.1038/srep27456
Journal - Research Article
Gumy, L. F., Katrukha, E. A., Kapitein, L. C., & Hoogenraad, C. C. (2014). New insights into mRNA trafficking in axons. Developmental Neurobiology, 74(3), 233-244. doi: 10.1002/dneu.22121
Journal - Research Article
Schlager, M. A., Serra-Marques, A., Grigoriev, I., Gumy, L. F., Esteves da Silva, M., Wulf, P. S., … Hoogenraad, C. C. (2014). Bicaudal D family adaptor proteins control the velocity of dynein-based movements. Cell Reports, 8(5), 1248-1256. doi: 10.1016/j.celrep.2014.07.052
Journal - Research Article
Gumy, L. F., Chew, D. J., Tortosa, E., Katrukha, E. A., Kapitein, L. C., Tolkovsky, A. M., … Fawcett, J. W. (2013). The kinesin-2 family member KIF3C regulates microtubule dynamics and is required for axon growth and regeneration. Journal of Neuroscience, 33(28), 11329-11345. doi: 10.1523/JNEUROSCI.5221-12.2013
Journal - Research Article
van Spronsen, M., van Battum, E. Y., Kuijpers, M., Vangoor, V. R., Rietman, M. L., Pothof, J., Gumy, L. F., … Hoogenraad, C. C. (2013). Developmental and activity-dependent miRNA expression profiling in primary hippocampal neuron cultures. PLoS ONE, 8(10), e74907. doi: 10.1371/journal.pone.0074907
Journal - Research Article
van der Vaart, B., van Riel, W. E., Doodhi, H., Kevenaar, J. T., Katrukha, E. A., Gumy, L., … Akhmanova, A. (2013). CFEOM1-associated kinesin KIF21A is a cortical microtubule growth inhibitor. Developmental Cell, 27(2), 145-160. doi: 10.1016/j.devcel.2013.09.010
Journal - Research Article
Tan, C. L., Andrews, M. R., Kwok, J. C. F., Heintz, T. G. P., Gumy, L. F., Fässler, R., & Fawcett, J. W. (2012). Kindlin-1 enhances axon growth on inhibitory chondroitin sulfate proteoglycans and promotes sensory axon regeneration. Journal of Neuroscience, 32(21), 7325-7335. doi: 10.1523/JNEUROSCI.5472-11.2012
Journal - Research Article
Gumy, L. F., & Hoogenraad, C. C. (2013). Off the rails: Axonal cargoes on the road to nowhere. EMBO Journal, 32(10). [Review].
Journal - Research Other
Gumy, L. (2018). Visualising intracellular transport in neurons. Proceedings of the 38th Australasian Neuroscience Society (ANS) Annual Scientific Meeting. Retrieved from https://www.ans.org.au
Conference Contribution - Published proceedings: Abstract
Mockett, B. G., Meunier, F. A., Gumy, L. F., Empson, R. M., & Micallef, A. H. (2018). Exploring neuronal function through advanced imaging techniques. Proceedings of the 38th Australasian Neuroscience Society (ANS) Annual Scientific Meeting. Retrieved from https://www.ans.org.au
Conference Contribution - Published proceedings: Abstract
