Professor Bilkey received a PhD from the University of Otago in 1987. After working as a postdoctoral fellow at the University of Washington, in 1988 he returned to Otago as a lecturer. He is a past recipient of an Alexander von Humboldt Fellowship, has served on several major funding panels and is actively involved in promoting science in schools. Currently, he is the Director of the Brain Health Research Centre.
Recently, he has been using an animal model of schizophrenia to investigate how the function of the hippocampus is altered in this disorder. He is looking at the biological basis of memory by “tagging” episodic memories attached to particular moments and noting how the brain encodes an episodic memory. His lab has focused on the hippocampal region of the brain, which appears to process “where” information and the neighbouring perirhinal cortex, which appears to encode “what”. Given there is connectivity between the hippocampus and this neighbouring cortex, they have hypothesised that an episodic memory is created when hippocampal-based place information is combined with perirhinal-based object information.
How the brain combines information from different locations to form a coherent memory is a logical next step for research. Professor Bilkey proposes that the prefrontal cortex has a role in integrating this information with prior experience and motivation and he is currently testing this hypothesis using a variety of behavioral and electrophysiological techniques.
These projects will help clarify how the brain melds place and object information, which is distributed across different brain areas, into a coherent memory. At a higher level, it will inform us as to why place information seems to be such an important component of episodic memory. His research is funded by the Health Research Council and Marsden Fund.
Seo, S., Parr-Brownlie, L., Bilkey, D., Hughes, S., & Oorschot, D. (2023, June).
Opposite changes in midbrain dopamine microcircuitry in the repeated hypoxic rat model of ADHD-like hyperactivity/impulsivity versus the maternal immune activation rat model of schizophrenia: Potential bases for new therapies. Poster session presented at the International Basal Ganglia Society (IBAGS) XIV Meeting, Stockholm, Sweden.
Conference Contribution - Poster Presentation (not in published proceedings)
Speers, L. J., Chin, P., & Bilkey, D. K. (2023). No evidence that acute clozapine administration alters CA1 phase precession in rats.
Brain Research. Advance online publication.
doi: 10.1016/j.brainres.2023.148446
Journal - Research Article
Munn, R. G. K., Wolff, A., Speers, L. J., & Bilkey, D. K. (2023). Disrupted hippocampal synchrony following maternal immune activation in a rat model.
Hippocampus. Advance online publication.
doi: 10.1002/hipo.23545
Journal - Research Article
Speers, L. J., & Bilkey, D. K. (2023). Maladaptive explore/exploit trade-offs in schizophrenia [Opinion].
Trends in Neurosciences. Advance online publication.
doi: 10.1016/j.tins.2023.02.001
Journal - Research Other
Speers, L. J., Schmidt, R., & Bilkey, D. K. (2022). Aberrant phase precession of lateral septal cells in a maternal immune activation model of schizophrenia risk may disrupt the integration of location with reward.
Journal of Neuroscience,
42(20), 4187-4201.
doi: 10.1523/JNEUROSCI.0039-22.2022
Journal - Research Article
Bilkey, D. K. (2008). Neocortical influences on hippocampal place cells. In S. J. Y. Mizumori (Ed.),
Hippocampal place fields: Relevance to learning and memory. (pp. 253-270). Oxford University Press.
doi: 10.1093/acprof:oso/9780195323245.003.0019
Chapter in Book - Research
Dragunow, M., & Bilkey, D. (2002). Neuroanatomical and functional mapping using activation of transcription factors. In L. Kaczmarek & H. A. Robertson (Eds.),
The Handbook of Chemical Neuroanatomy, 19 - Immediate Early Genes and Inducible Transcription Factors in Mapping of the Central Nervous System Function and Dysfunction. (pp. 39-44). Amsterdam: Elsevier.
Chapter in Book - Research
Munn, R. G. K., Wolff, A., Speers, L. J., & Bilkey, D. K. (2023). Disrupted hippocampal synchrony following maternal immune activation in a rat model.
Hippocampus. Advance online publication.
doi: 10.1002/hipo.23545
Journal - Research Article
Speers, L. J., Chin, P., & Bilkey, D. K. (2023). No evidence that acute clozapine administration alters CA1 phase precession in rats.
Brain Research. Advance online publication.
doi: 10.1016/j.brainres.2023.148446
Journal - Research Article
Speers, L. J., Schmidt, R., & Bilkey, D. K. (2022). Aberrant phase precession of lateral septal cells in a maternal immune activation model of schizophrenia risk may disrupt the integration of location with reward.
Journal of Neuroscience,
42(20), 4187-4201.
doi: 10.1523/JNEUROSCI.0039-22.2022
Journal - Research Article
Bilkey, D. K., & Jensen, C. (2021). Neural markers of event boundaries.
Topics in Cognitive Science,
13(1), 128-141.
doi: 10.1111/tops.12470
Journal - Research Article
Butz, M. V., Achimova, A., Bilkey, D., & Knott, A. (2021). Event-predictive cognition: A root for conceptual human thought.
Topics in Cognitive Science,
13, 10-24.
doi: 10.1111/tops.12522
Journal - Research Article
Croy, E., Elston, T. W., & Bilkey, D. K. (2021). Anterior cingulate cortex and ventral tegmental area activity during cost-benefit decision-making following maternal immune activation.
Schizophrenia Bulletin Open,
2(1), sgab023.
doi: 10.1093/schizbullopen/sgab023
Journal - Research Article
Meighan, W., Elston, T. W., Bilkey, D., & Ward, R. D. (2021). Impaired discrimination of a subanesthetic dose of ketamine in a maternal immune activation model of schizophrenia risk.
Journal of Psychopharmacology,
35(9), 1141-1151.
doi: 10.1177/02698811211029739
Journal - Research Article
Scott, K. J., Tashakori-Sabzevar, F., & Bilkey, D. K. (2021). Maternal immune activation alters the sequential structure of ultrasonic communications in male rats.
Brain, Behavior & Immunity: Health,
16, 100304.
doi: 10.1016/j.bbih.2021.100304
Journal - Research Article
Seo, S., Sizemore, R. J., Reader, K. L., Smither, R. A., Wicky, H. E., Hughes, S. M., Bilkey, D. K., Parr-Brownlie, L. C., & Oorschot, D. E. (2021). A schizophrenia risk factor induces marked anatomical deficits at GABAergic-dopaminergic synapses in the rat ventral tegmental area: Essential evidence for new targeted therapies.
Journal of Comparative Neurology,
529, 3946-3973.
doi: 10.1002/cne.25225
Journal - Research Article
Speers, L. J., Cheyne, K. R., Cavani, E., Hayward, T., Schmidt, R., & Bilkey, D. K. (2021). Hippocampal sequencing mechanisms are disrupted in a maternal immune activation model of schizophrenia risk.
Journal of Neuroscience,
41(32), 6954-6965.
doi: 10.1523/jneurosci.0730-21.2021
Journal - Research Article
Sutherland, C. J., & Bilkey, D. K. (2020). Hippocampal coding of conspecific position.
Brain Research,
1745, 146920.
doi: 10.1016/j.brainres.2020.146920
Journal - Research Article
Butz, M. V., Bilkey, D., Humaidan, D., Knott, A., & Otte, S. (2019). Learning, planning, and control in a monolithic neural event inference architecture.
Neural Networks,
117, 135-144.
doi: 10.1016/j.neunet.2019.05.001
Journal - Research Article
Elston, T. W., Croy, E., & Bilkey, D. K. (2019). Communication between the anterior cingulate cortex and ventral tegmental area during a cost-benefit reversal task.
Cell Reports,
26(9), 2353-2361.e3.
doi: 10.1016/j.celrep.2019.01.113
Journal - Research Article
Jackson, C. M., Jackson, J. C., Bilkey, D., Jong, J., & Halberstadt, J. (2019). The dynamic emergence of minimal groups.
Group Processes & Intergroup Relations,
22(7), 921-929.
doi: 10.1177/1368430218802636
Journal - Research Article
Porter, B. S., Hillman, K. L., & Bilkey, D. K. (2019). Anterior cingulate cortex encoding of effortful behavior.
Journal of Neurophysiology,
121, 701-714.
doi: 10.1152/jn.00654.2018
Journal - Research Article
Zhang, J., Jing, Y., Zhang, H., Bilkey, D. K., & Liu, P. (2019). Maternal immune activation altered microglial immunoreactivity in the brain of postnatal day 2 rat offspring.
Synapse,
73, e22072.
doi: 10.1002/syn.22072
Journal - Research Article
Bates, V., Maharajan, A., Millar, J., Bilkey, D. K., & Ward, R. D. (2018). Spared motivational modulation of cognitive effort in a maternal immune activation model of schizophrenia risk.
Behavioral Neuroscience,
132(1), 66-74.
doi: 10.1037/bne0000230
Journal - Research Article
Elston, T. W., Kalhan, S., & Bilkey, D. K. (2018). Conflict and adaptation signals in the anterior cingulate cortex and ventral tegmental area.
Scientific Reports,
8(1), 11732.
doi: 10.1038/s41598-018-30203-4
Journal - Research Article
Jackson, J. C., Jong, J., Bilkey, D., Whitehouse, H., Zollmann, S., McNaughton, C., & Halberstadt, J. (2018). Synchrony and physiological arousal Increase cohesion and cooperation in large naturalistic groups.
Scientific Reports,
8, 127.
doi: 10.1038/s41598-017-18023-4
Journal - Research Article
Porter, B. S., Schmidt, R., & Bilkey, D. K. (2018). Hippocampal place cell encoding of sloping terrain.
Hippocampus,
28(1), 767-782.
doi: 10.1002/hipo.22966
Journal - Research Article
Zhang, J., Jing, Y., Zhang, H., Bilkey, D. K., & Liu, P. (2018). Effects of maternal immune activation on brain arginine metabolism of postnatal day 2 rat offspring.
Schizophrenia Research,
192, 431-441.
doi: 10.1016/j.schres.2017.05.016
Journal - Research Article
Zhang, J., Jing, Y., Zhang, H., Bilkey, D. K., & Liu, P. (2018). Maternal immune activation leads to increased nNOS immunoreactivity in the brain of postnatal day 2 rat offspring.
Synapse,
72(1), e22011.
doi: 10.1002/syn.22011
Journal - Research Article
Bilkey, D. K., Cheyne, K. R., Eckert, M. J., Lu, X., Chowdhury, S., Worley, P. F., … Abraham, W. C. (2017). Exposure to complex environments results in more sparse representations of space in the hippocampus.
Hippocampus,
27(11), 1178-1191.
doi: 10.1002/hipo.22762
Journal - Research Article