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Department of Pathology Seminar Series - Dr Sarah Diermeier

Recent genome-wide studies revealed that only 2% of the human genome encodes for proteins while as much as 80% of the genome can be transcribed.

Of these non-coding transcripts, long non-coding RNAs (lncRNAs) represent the largest and most diverse class. We identified 30 potentially oncogenic lncRNAs in breast cancer, termed Mammary Tumor Associated RNAs (MaTARs). Loss-of-function models revealed that MaTARs are drivers of tumor cell proliferation, migration and/or invasion.

Ongoing studies are investigating the molecular mechanism by which MaTARs function. Our results suggest that lncRNAs are likely important drivers of tumor progression and represent promising new therapeutic targets.

Date Friday, 13 April 2018
Time 1:00pm - 2:00pm
Audience Public,All University
Event Category Health Sciences
Event Type Departmental Seminar
Open Seminar
DepartmentPathology (DSM), Biochemistry
LocationD'ath Lecture Theatre, Hercus Building
Contact NameEuan Rodger

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