Recent genome-wide studies revealed that only 2% of the human genome encodes for proteins while as much as 80% of the genome can be transcribed.
Of these non-coding transcripts, long non-coding RNAs (lncRNAs) represent the largest and most diverse class. We identified 30 potentially oncogenic lncRNAs in breast cancer, termed Mammary Tumor Associated RNAs (MaTARs). Loss-of-function models revealed that MaTARs are drivers of tumor cell proliferation, migration and/or invasion.
Ongoing studies are investigating the molecular mechanism by which MaTARs function. Our results suggest that lncRNAs are likely important drivers of tumor progression and represent promising new therapeutic targets.
|Date||Friday, 13 April 2018|
|Time||1:00pm - 2:00pm|
|Event Category||Health Sciences|
|Department||Pathology (DSM), Biochemistry|
|Location||D'ath Lecture Theatre, Hercus Building|
|Contact Name||Euan Rodger|