Decoding the regulatory landscape that is linked to urate
High levels of serum urate are necessary but not sufficient for gout, a debilitating form of inflammatory arthritis.
Genome wide association studies (GWAS) have identified numerous single nucleotide polymorphisms (SNPs) that are strongly associated with serum urate levels and gout, however the majority of these genetic variants lie outside of coding regions and it is unclear how they could confer causation.
Nevertheless, the nature of the association means that these variants must be linked to or lie within regions of the genome that have biological consequences for serum urate control and the development of gout.
To assign causation to genetic variants in non-coding regions associated with serum urate levels and gout, it is important to 1) identify the function of the SNP-marked non-coding DNA regions; and 2) identify which gene(s) and pathways are under their control (if the function is regulatory). Using a suite of in silico, in vitro and in vivo techniques including novel zebrafish assays, we have assigned regulatory function to non coding regions of the genome that are associated with serum urate levels.
|Date||Tuesday, 19 June 2018|
|Time||12:00pm - 1:00pm|
|Event Category||Health Sciences|
|Location||Biochemistry Seminar Room 231|