Dr Goebl is based in the Department of Pathology and Biomedical Science at the University of Otago, Christchurch.
Protein Amyloids in Cancer
Abstract: p16 is a small protein that plays critical roles in cell division by inhibiting cyclin-dependent kinases (CDKs) and it is therefore among the most frequently mutated proteins in cancer.
We recently reported that upon oxidation, p16 changes its structure and aggregates into amyloid fibril in cells. It thereby changes from a monomeric, all-alpha helical fold into a beta-sheet based polymer that loses it's ability to inhibit CDKs.
We are currently investigating this novel state by studying the mechanism and consequences of amyloid formation in cancer.
|Date||Tuesday, 4 August 2020|
|Time||12:00pm - 1:00pm|
|Event Category||Health Sciences|
|Location||Zoom meeting. Contact Biochemistry reception for login details|