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Biochemistry Seminar: Dr Liam Turk, Department of Biochemistry

This seminar was originally scheduled for 17 May but due to unforeseen circumstances has be postponed. The seminar will now take place on Tuesday 14 June 2022.

Dimeric conformation drives reelin's signaling pathway

Reelin is a secreted glycoprotein with well-characterized roles in the developing brain. This ~400 kDa protein forms a dimer and interacts with the very low-density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (ApoER2) to initiate signal transduction. A mutant reelin monomer binds to its receptors but does not activate its signaling pathway.

In this talk, I’ll present data from my PhD work – including the steps I took to address this apparent decoupling of binding and signaling. I’ll describe the in-solution structure of reelin, derived using cryo-electron tomography and small angle X-ray scattering, and how a manipulated reelin heterodimer can still activate the reelin signaling pathway. Overall, I constructed a model of reelin signaling that is reliant on its stable, dimeric conformation. I’ll also share the high-resolution structure of reelin’s most C-terminal domain, which has recently been reported to bind to the co-receptor, neuropilin‑1 and affect the protein’s activity.

Zoom

Zoom link for Dr Liam Turk's biochemistry seminar

Zoom password: bioc

Date Tuesday, 14 June 2022
Time 12:00pm - 1:00pm
Audience Undergraduate students,Postgraduate students,Staff
Event Category Sciences
Event Type Seminar
Academic
Online and in-person
CampusDunedin
DepartmentBiochemistry
LocationBiochemistry Seminar Room G.13 (BIG13), Dunedin and online via Zoom
CostFree
Contact NameDepartment of Biochemistry
Contact Emailbiochemistry@otago.ac.nz

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