Contact Details
University Links
- Position
- Emeritus Professor
- Department
- Department of Biochemistry
- Qualifications
- MSc (Well) PhD (Otago) FNZIC FRSNZ MA-PIMBN
- Research summary
- Protein synthesis, genetic recoding, memory mechanisms, infectious disease
Research
My laboratory has had a long-term interest in understanding protein synthesis and, in particular, decoding and recoding mechanisms on the ribosome at stop signals. Important recent investigations have focused on how the decoding release factor as a molecular mimic of tRNA recognises the individual bases of the stop signal, and how alternative genetic codes like those found in vertebrate mitochondria can be accommodated into an integrated model. This has been helped considerably by the 2008 atomic resolution structures of the ribosome:factor complex.
The decoding release factor interacting with stop codon UAG.
From our chance discovery in the 1980s of recoding (frameshifting; a cellular mechanism for regulating gene expression during protein synthesis), we developed an interest in the frameshift mechanism of HIV-1 as a potential site of vulnerability in the virus. Now, our interest has extended to the only gene in the animal kingdom known to use this mechanism, human gene PEG10. The gene was relatively recently acquired as a retroelement insertion and has undergone molecular domestication to become expressed in placenta and amniotic membranes but not, as we have shown, in adult tissues. Significantly, it uses the same frameshifting expression strategy as HIV-1 to produce two proteins.
Morris water maze: testing memory in a rat.
A second long-standing interest has been the molecular mechanisms of mammalian memory and how they are impaired in human neurological diseases, particularly Alzheimer's. These investigations have focused on the molecular changes in neurons of the hippocampus when they receive electrical signals within in vivo models and more recently included behavioural studies. We have developed a simple recombinant production and purification strategy for a processed brain protein, secreted amyloid precursor protein-alpha, a protein that is neuroprotective but whose concentration is lowered in Alzheimer's patients. Remarkably, we have shown our recombinant protein alone can restore memory to rats impaired by drug treatment, not only in their electrophysiological responses but also in trials to determine memory of learned spatial tasks. We believe this external secreted protein is a signalling molecule that can switch on a signalling pathway and activate a range of gene responses to protect and enhance memory; an activity that may be critical as a counterbalance in the development of Alzheimer?s disease.
Professor Tate also researches the mechanisms underlying chronic fatigue syndrome
Publications
Peppercorn, K., Edgar, C. D., Kleffmann, T., & Tate, W. P. (2023). A pilot study on the immune cell proteome of long COVID patients shows changes to physiological pathways similar to those in myalgic encephalomyelitis/chronic fatigue syndrome. Scientific Reports, 13(1), 22068. doi: 10.1038/s41598-023-49402-9 Journal - Research Article
Stokes, C., Basak, I., Tate, W., & Hughes, S. (2023). Identifying superheroes in neurodegenerative disease. Proceedings of the Genetics Otago (GO) Annual Symposium & Workshops. Retrieved from https://blogs.otago.ac.nz/go Conference Contribution - Published proceedings: Abstract
Walker, M. O. M., Peppercorn, K., Kleffmann, T., Edgar, C. D., & Tate, W. P. (2023). An understanding of the immune dysfunction in susceptible people who develop the post-viral fatigue syndromes Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Long COVID. Medical Research Archives, 11(7). doi: 10.18103/mra.v11i7.1.4083 Journal - Research Article
Peppercorn, K., Kleffmann, T., Hughes, S. M., & Tate, W. P. (2023). Secreted amyloid precursor protein alpha (sAPPα) regulates the cellular proteome and secretome of mouse primary astrocytes. International Journal of Molecular Sciences, 24, 7165. doi: 10.3390/ijms24087165 Journal - Research Article
Tate, W. P., Walker, M. O. M., Peppercorn, K., Blair, A. L. H., & Edgar, C. D. (2023). Towards a better understanding of the complexities of myalgic encephalomyelitis/chronic fatigue syndrome and long COVID [Review]. International Journal of Molecular Sciences, 24(6), 5124. doi: 10.3390/ijms24065124 Journal - Research Article
2023
Journal - Research Article
Peppercorn, K., Edgar, C. D., Kleffmann, T., & Tate, W. P. (2023). A pilot study on the immune cell proteome of long COVID patients shows changes to physiological pathways similar to those in myalgic encephalomyelitis/chronic fatigue syndrome. Scientific Reports, 13(1), 22068. doi: 10.1038/s41598-023-49402-9
Walker, M. O. M., Peppercorn, K., Kleffmann, T., Edgar, C. D., & Tate, W. P. (2023). An understanding of the immune dysfunction in susceptible people who develop the post-viral fatigue syndromes Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Long COVID. Medical Research Archives, 11(7). doi: 10.18103/mra.v11i7.1.4083
Peppercorn, K., Kleffmann, T., Hughes, S. M., & Tate, W. P. (2023). Secreted amyloid precursor protein alpha (sAPPα) regulates the cellular proteome and secretome of mouse primary astrocytes. International Journal of Molecular Sciences, 24, 7165. doi: 10.3390/ijms24087165
Tate, W. P., Walker, M. O. M., Peppercorn, K., Blair, A. L. H., & Edgar, C. D. (2023). Towards a better understanding of the complexities of myalgic encephalomyelitis/chronic fatigue syndrome and long COVID [Review]. International Journal of Molecular Sciences, 24(6), 5124. doi: 10.3390/ijms24065124
Conference Contribution - Published proceedings: Abstract
Stokes, C., Basak, I., Tate, W., & Hughes, S. (2023). Identifying superheroes in neurodegenerative disease. Proceedings of the Genetics Otago (GO) Annual Symposium & Workshops. Retrieved from https://blogs.otago.ac.nz/go
2022
Journal - Research Article
Peppercorn, K., Kleffmann, T., Jones, O., Hughes, S., & Tate, W. (2022). Secreted amyloid precursor protein alpha, a neuroprotective protein in the brain has widespread effects on the transcriptome and proteome of human inducible pluripotent stem cell-derived glutamatergic neurons related to memory mechanisms. Frontiers in Neuroscience, 16, 858524. doi: 10.3389/fnins.2022.858524
Helliwell, A. M., Stockwell, P. A., Edgar, C. D., Chatterjee, A., & Tate, W. P. (2022). Dynamic epigenetic changes during a relapse and recovery cycle in myalgic encephalomyelitis/chronic fatigue ayndrome. International Journal of Molecular Sciences, 23(19), 11852. doi: 10.3390/ijms231911852
Walker, M. O. M., Hall, K. H., Peppercorn, K., & Tate, W. P. (2022). The significance of oxidative stress in the pathophysiology of Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Medical Research Archives, 10(9), 3050. doi: 10.18103/mra.v10i9.3050
Tate, W., Walker, M., Sweetman, E., Helliwell, A., Peppercorn, K., Edgar, C., Blair, A., & Chatterjee, A. (2022). Molecular mechanisms of neuroinflammation in ME/CFS and long COVID to sustain disease and promote relapses. Frontiers in Neurology, 13, 877772. doi: 10.3389/fneur.2022.877772
Lam, P., Vinnakota, C., Calvo-Flores Guzmán, B., Newland, J., Peppercorn, K., Tate, W. P., … Kwakowsky, A. (2022). Beta-amyloid (Aβ1-42) increases the expression of NKCC1 in the mouse hippocampus. Molecules, 27, 2440. doi: 10.3390/molecules27082440
Guévremont, D., Tsui, H., Knight, R. G., Fowler, C. J., Masters, C. L., Martins, R. N., Abraham, W. C., Tate, W. P., Cutfield, N. J., & Williams, J. M. (2022). Plasma microRNA vary in association with the progression of Alzheimer's disease. Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 14, e12251. doi: 10.1002/dad2.12251
Ohline, S. M., Chan, C., Schoderboeck, L., Wicky, H. E., Tate, W. P., Hughes, S. M., & Abraham, W. C. (2022). Effect of soluble amyloid precursor protein-alpha on adult hippocampal neurogenesis in a mouse model of Alzheimer's disease. Molecular Brain, 15, 5. doi: 10.1186/s13041-021-00889-1
Conference Contribution - Published proceedings: Abstract
Peppercorn, K., Kleffmann, T., Jones, O., Hughes, S., & Tate, W. (2022). Secreted amyloid precursor protein alpha has widespread effects on the transcriptome and proteome of human neurons related to memory mechanisms. In K. Horne (Ed.), Proceedings of the 38th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 64). Retrieved from https://www.queenstownresearchweek.org
Lam, P., Vinnakota, C., Calvo-Flores Guzmán, B., Newland, J., Peppercorn, K., Tate, W. P., … Kwakowsky, A. (2022). Investigating the expression of NKCC1 and KCC2 in Alzheimmer's disease mouse models. In K. Horne (Ed.), Proceedings of the 38th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 48). Retrieved from https://www.queenstownresearchweek.org
2021
Journal - Research Article
Livingstone, R. W., Elder, M. K., Singh, A., Westlake, C. M., Tate, W. P., Abraham, W. C., & Williams, J. M. (2021). Secreted amyloid precursor protein-alpha enhances LTP through the synthesis and trafficking of Ca2+-permeable AMPA receptors. Frontiers in Molecular Neuroscience, 14, 660208. doi: 10.3389/fnmol.2021.660208
Ryan, M., Tan, V. T. Y., Thompson, N., Guévremont, D., Mockett, B. G., Tate, W. P., Abraham, W. C., Hughes, S. M., & Williams, J. (2021). Lentivirus-mediated expression of human secreted amyloid precursor protein-alpha promotes long-term induction of neuroprotective genes and pathways in a mouse model of Alzheimer’s disease. Journal of Alzheimer's Disease, 79, 1075-1090. doi: 10.3233/JAD-200757
Journal - Research Other
Bernhardt, H. S., & Tate, W. P. (2021). A new perspective on the Maillard reaction and the origin of life. Journal of Molecular Evolution, 89, 594-597. doi: 10.1007/s00239-021-10030-4
Wood, E., Hall, K. H., & Tate, W. (2021). Role of mitochondria, oxidative stress and the response to antioxidants in myalgic encephalomyelitis/chronic fatigue syndrome: A possible approach to SARS-CoV-2 ‘long-haulers’? Chronic Diseases & Translational Medicine, 7, 14-26. doi: 10.1016/j.cdtm.2020.11.002
Conference Contribution - Published proceedings: Abstract
Tate, W. (2021). The three macromolecules in the Central Dogma brought alive by over 60 years of biochemical and molecular studies assisted by visualisation and 'omic' technologies. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 160). Retrieved from https://www.faobmb2021.org
Westlake, C. M., Livingstone, R. W., Peppercorn, K., Tate, W. P., & Williams, J. M. (2021). Secreted amyloid precursor protein alpha (sAPPα) regulates surface expression of GluA1-containing glutamate receptors in primary hippocampal neurons. New Zealand Medical Journal, 134(1535), (pp. 98). Retrieved from https://www.nzma.org.nz/journal
2020
Journal - Research Article
Calvo-Flores Guzmán, B., Chaffey, T. E., Palpagama, T. H., Waters, S., Boix, J., Tate, W. P., Peppercorn, K., … Kwakowsky, A. (2020). The interplay between beta-amyloid 1-42 (Aβ1-42)-induced hippocampal inflammatory response, p-tau, vascular pathology, and their synergistic contributions to neuronal death and behavioral deficits. Frontiers in Molecular Neuroscience, 13, 522073. doi: 10.3389/fnmol.2020.552073
Helliwell, A. M., Sweetman, E. C., Stockwell, P. A., Edgar, C. D., Chatterjee, A., & Tate, W. P. (2020). Changes in DNA methylation profiles of myalgic encephalomyelitis/chronic fatigue syndrome patients reflect systemic dysfunctions. Clinical Epigenetics, 12(1), 167. doi: 10.1186/s13148-020-00960-z
Sweetman, E., Kleffmann, T., Edgar, C., de Lange, M., Vallings, R., & Tate, W. (2020). A SWATH-MS analysis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome peripheral blood mononuclear cell proteomes reveals mitochondrial dysfunction. Journal of Translational Medicine, 18, 365. doi: 10.1186/s12967-020-02533-3
Yeung, J. H. Y., Calvo-Flores Guzmán, B., Palpagama, H. T., Ethiraj, J., Zhai, Y., Tate, W. P., Peppercorn, K., … Kwakowsky, A. (2020). Amyloid-beta1-42 induced glutamatergic receptor and transporter expression changes in the mouse hippocampus. Journal of Neurochemistry, 155, 62-80. doi: 10.1111/jnc.15099
Vinnakota, C., Govindpani, K., Tate, W. P., Peppercorn, K., Anekal, P. V., Waldvogel, H. J., … Kwakowsky, A. (2020). An α5 GABAA receptor inverse agonist, α5IA, attenuates amyloid beta-induced neuronal death in mouse hippocampal cultures. International Journal of Molecular Sciences, 21(9), 3284. doi: 10.3390/ijms21093284
Yeung, J. H. Y., Palpagama, T. H., Tate, W. P., Peppercorn, K., Waldvogel, H. J., Faull, R. L. M., & Kwakowsky, A. (2020). The acute effects of amyloid-Beta1–42 on glutamatergic receptor and transporter expression in the mouse hippocampus. Frontiers in Neuroscience, 13, 1427. doi: 10.3389/fnins.2019.01427
Journal - Research Other
Calvo-Flores Guzmán, B., Kim, S., Chawdhary, B., Peppercorn, K., Tate, W. P., Waldvogel, H. J., … Kwakowsky, A. (2020). Amyloid-beta1-42 -induced increase in GABAergic tonic conductance in mouse hippocampal CA1 pyramidal cells [Communication]. Molecules, 25(3), 693. doi: 10.3390/molecules25030693
Conference Contribution - Published proceedings: Abstract
Guévremont, D., Tsui, H., Knight, R., Fowler, C. J., Masters, C. L., Martins, R. N., Abraham, W. C., Tate, W. P., Cutfield, N., & Williams, J. M. (2020). Plasma microRNA vary in association with the progression in Alzheimer's disease. Proceedings of the Alzheimer's Association International Conference (AAIC). ODO2-09-06. Retrieved from https://alz.confex.com/alz/20amsterdam/meetingapp.cgi/Home/0
Conference Contribution - Verbal presentation and other Conference outputs
Tate, W. (2020, November). Understanding the biological basis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and its sudden increase in public profile with COVID-19. Verbal presentation at the Brain Health Research Centre Lecture and Poster Session, Dunedin, New Zealand.
2019
Journal - Research Article
Morrissey, J. A., Bigus, E., Necarsulmer, J. C., Srinivasan, V., Peppercorn, K., O'Leary, D. J., Mockett, B. G., Tate, W. P., Hughes, S. M., … Abraham, W. C. (2019). The tripeptide RER mimics secreted amyloid precursor protein-alpha in upregulating LTP. Frontiers in Cellular Neuroscience, 13, 459. doi: 10.3389/fncel.2019.00459
Livingstone, R. W., Elder, M. K., Barrett, M. C., Westlake, C. M., Peppercorn, K., Tate, W. P., Abraham, W. C., & Williams, J. M. (2019). Secreted amyloid precursor protein-alpha promotes arc protein synthesis in hippocampal neurons. Frontiers in Molecular Neuroscience, 12, 198. doi: 10.3389/fnmol.2019.00198
Morrissey, J. A., Mockett, B. G., Singh, A., Kweon, D., Ohline, S. M., Tate, W. P., Hughes, S. M., & Abraham, W. C. (2019). A C-terminal peptide from secreted amyloid precursor protein-α enhances long-term potentiation in rats and a transgenic mouse model of Alzheimer's disease. Neuropharmacology, 157, 107670. doi: 10.1016/j.neuropharm.2019.107670
Mockett, B. G., Guévremont, D., Elder, M. K., Parfitt, K. D., Peppercorn, K., Morrissey, J., Singh, A., Hintz, T. J., … Tate, W. P., Williams, J. M., & Abraham, W. C. (2019). Glutamate receptor trafficking and protein synthesis mediate the facilitation of LTP by secreted amyloid precursor protein-alpha. Journal of Neuroscience, 39(17), 3188-3203. doi: 10.1523/jneurosci.1826-18.2019
Sweetman, E., Ryan, M., Edgar, C., MacKay, A., Vallings, R., & Tate, W. (2019). Changes in the transcriptome of circulating immune cells of a New Zealand cohort with myalgic encephalomyelitis/chronic fatigue syndrome. International Journal of Immunopathology & Pharmacology, 33, 1-8. doi: 10.1177/2058738418820402
Journal - Research Other
Sweetman, E., Noble, A., Edgar, C., Mackay, A., Helliwell, A., Vallings, R., Ryan, M., & Tate, W. (2019). Current research provides insight into the biological basis and diagnostic potential for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Diagnostics, 9(3), 73. doi: 10.3390/diagnostics9030073
Conference Contribution - Published proceedings: Abstract
Kleffmann, T., Tate, W., & Hughes, S. (2019). Does secreted amyloid precursor protein alpha affect the global proteome of astrocytes? Proceedings of the 39th Australasian Neuroscience Society (ANS) Annual Scientific Meeting. 13247. Retrieved from https://www.ans.org.au
Chu, A. J., Peppercorn, K., Tate, W. P., Erlandsson, A., & Williams, J. M. (2019). Secreted amyloid precursor protein-alpha enhances amyloid-beta protofibril degradation in primary murine astrocytes. Proceedings of the 39th Australasian Neuroscience Society (ANS) Annual Scientific Meeting. 12828. Retrieved from https://www.ans.org.au
Ohline, S. M., Chan, C. H., Whelan, J., Smith, H., Logan, B. J., Morrissey, J. A., Schoderboeck, L., Peppercorn, K., Tate, W. P., Hughes, S. M., & Abraham, W. C. (2019). Stimulation of neurogenesis by a potential therapeutic protein. In K. Hillman (Ed.), Proceedings of the 37th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 57). Retrieved from http://www.otago.ac.nz/awcbr
Livingstone, R., Elder, M. K., Barrett, M., Westlate, C., Peppercorn, K., Tate, W., Abraham, W. C., & Williams, J. M. (2019). Arc protein synthesis is promoted by secreted amyloid precursor protein-alpha in primary hippocampal neurons. Proceedings of the Society for Neuroscience Annual Meeting. 286.17/C27. SfN. Retrieved from https://www.sfn.org
Conference Contribution - Verbal presentation and other Conference outputs
Helliwell, A. M., Chatterjee, A., Stockwell, P. A., & Tate, W. P. (2019, August-September). DNA methylation changes in myalgic encephalomyelitis/chronic fatigue syndrome. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
2018
Chapter in Book - Other
Tate, W. P., & Marshall, C. J. (2018). Post-dormancy transcription and translation in the brine shrimp. In R. A. Browne, P. Sorgeloos & C. N. A. Trotman (Eds.), Artemia biology. (pp. 21-36). Boca Raton, FL: Taylor & Francis. doi: 10.1201/9781351069892
Journal - Research Article
Mackay, A., & Tate, W. P. (2018). A compromised paraventricular nucleus within a dysfunctional hypothalamus: A novel neuroinflammatory paradigm for ME/CFS. International Journal of Immunopathology & Pharmacology, 32, 1-8. doi: 10.1177/2058738418812342
Tan, V. T. Y., Mockett, B. G., Ohline, S. M., Parfitt, K. D., Wicky, H. E., Peppercorn, K., Schoderboeck, L., Yahaya, M. F. b., Tate, W. P., Hughes, S. M., & Abraham, W. C. (2018). Lentivirus-mediated expression of human secreted amyloid precursor protein-alpha prevents development of memory and plasticity deficits in a mouse model of Alzheimer's disease. Molecular Brain, 11, 7. doi: 10.1186/s13041-018-0348-9
Cridge, A. G., Crowe-McAuliffe, C., Mathew, S. F., & Tate, W. P. (2018). Eukaryotic translational termination efficiency is influenced by the 3' nucleotides within the ribosomal mRNA channel. Nucleic Acids Research, gkx1315. doi: 10.1093/nar/gkx1315
Journal - Research Other
Tate, W. P., Cridge, A. G., & Brown, C. M. (2018). 'Stop' in protein synthesis is modulated with exquisite subtlety by an extended RNA translation signal. Biochemical Society Transactions, 46(6), 1615-1625. doi: 10.1042/bst20180190
Conference Contribution - Published proceedings: Abstract
Elder, M. K., Tate, W. P., Abraham, W. C., Schman, E., & Williams, J. (2018). Secreted amyloid precursor protein alpha regulates AMPA receptor synthesis and trafficking. Proceedings of the 38th Australasian Neuroscience Society (ANS) Annual Scientific Meeting. 9274. Retrieved from https://www.ans.org.au
Yeung, J. H. Y., Calvo-Flores Guzman, B., Tate, W. P., Waldvogel, H. J., Faull, R. L. M., & Kwakowsky, A. (2018). Alterations in glutamate receptor and transporter expression in the hippocampus of an in vivo alzheimers disease mouse model. Proceedings of the 38th Australasian Neuroscience Society (ANS) Annual Scientific Meeting. 9266. Retrieved from https://www.ans.org.au
Williams, J. M., Elder, M. K., & Tate, W. P. (2018). Cell surface expression of GluA1-containing AMPA receptors is enhanced by secreted amyloid precursor protein-alpha; visualized by BioPLAy. Proceedings of the Society for Neuroscience 48th Annual Meeting. 285.15/E44. SfN. Retrieved from https://www.sfn.org
Livingstone, R. W., Elder, M. K., Barrett, M., Westlake, C., Tate, W., Abraham, W., & Williams, J. M. (2018). Arc protein expression in response to secreted amyloid precursor protein-α in primary hippocampal cultures. In K. Hillman (Ed.), Proceedings of the 36th International Australasian Winter Conference on Brain Research. (pp. 60). AWCBR. Retrieved from https://www.otago.ac.nz/awcbr
Potemkin, N., Tate, W. P., & Williams, J. M. (2018). Amyloid-β increases SH-SY5y neuroblastoma cell viability. In K. Hillman (Ed.), Proceedings of the 36th International Australasian Winter Conference on Brain Research. (pp. 57). AWCBR. Retrieved from https://www.otago.ac.nz/awcbr
Vinnakota, C., Govindpani, K., Calvo-Flores Guzman, B., Tate, W. P., Waldvogel, H. J., Faull, R. L. M., & Kwakowsky, A. (2018). Extrasynaptic α5 type GABAA receptors as therapeutic targets for Alzheimer's disease. In K. Hillman (Ed.), Proceedings of the 36th International Australasian Winter Conference on Brain Research. (pp. 47). AWCBR. Retrieved from https://www.otago.ac.nz/awcbr
Conference Contribution - Poster Presentation (not in published proceedings)
Helliwell, A. M., & Tate, W. P. (2018, November). Insights from DNA methylation analysis into the aetiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, a disease predominantly affecting women. Poster session presented at the Women’s Wellbeing Symposium, Dunedin, New Zealand.
2017
Journal - Research Article
Xiong, M., Jones, O. D., Peppercorn, K., Ohline, S. M., Tate, W. P., & Abraham, W. C. (2017). Secreted amyloid precursor protein-alpha can restore novel object location memory and hippocampal LTP in aged rats. Neurobiology of Learning & Memory, 138, 291-299. doi: 10.1016/j.nlm.2016.08.002
Conference Contribution - Published proceedings: Abstract
Vinnakota, C., Govindpani, K., Calvo-Flores, G. B., Tate, W. P., Waldvogel, H. J., Faull, R. L. M., & Kwakowsky, A. (2017). Extrasynaptic alpha 5 type GABAA receptors as therapeutic targets for Alzheimer's disease. Proceedings of the Australasian Neuroscience Society 37th Annual Scientific Meeting. Retrieved from http://ans2017.aomevents.com.au
Calvo-Flores, G. B., Waters, S., Fuhrer, T., Palpagama, T., Tate, W. P., Dragunow, M., … Kwakowsky, A. (2017). Beta-amyloid (AB 1-42) -induced molecular and cellular changes in the hippocampus in an in vivo mouse model of Alzheimer's disease. Proceedings of the Australasian Neuroscience Society 37th Annual Scientific Meeting. Retrieved from http://ans2017.aomevents.com.au
Mockett, B. G., Guévremont, D., Parfitt, K., Elder, M., Peppercorn, K., Kochen, L., … Tate, W. P., Williams, J. M., & Abraham, W. C. (2017). Glutamate receptor trafficking and protein synthesis mediate the facilitation of LTP by secreted amyloid precursor protein-alpha. Proceedings of the Australasian Neuroscience Society 37th Annual Scientific Meeting. Retrieved from http://ans2017.aomevents.com.au
Sweetman, E. C., Tate, W. P., & Ryan, M. (2017). Investigating molecular diagnostic biomarkers for myalgic encephalomyelitis/chronic fatigue syndrome. New Zealand Medical Journal, 130(1467), (pp. 106). Retrieved from http://www.nzma.org.nz/journal
Elder, M., Peppercorn, K., Schuman, E. M., Tate, W. P., Abraham, W. C., & Williams, J. M. (2017). Secreted amyloid precursor protein alpha regulated AMPA receptor synthesis and trafficking. In B. Leitch (Ed.), Proceedings of the 35th International Australasian Winter Conference on Brain Research. (pp. 58). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr/index.html
2016
Journal - Research Article
Kwakowsky, A., Potapov, K., Kim, S., Peppercorn, K., Tate, W. P., & Ábrahám, I. M. (2016). Treatment of beta amyloid 1-42 (Αβ1-42)-induced basal forebrain cholinergic damage by a non-classical estrogen signaling activator in vivo. Scientific Reports, 6, 21101. doi: 10.1038/srep21101
Conference Contribution - Published proceedings: Full paper
Tate, W. P., Sweetman, E. C., Noble, A. J. K., Edgar, C. D., Bateman, G., MacKay, A., Ryan, M. M., … Vallings, R. (2016). Tackling ME/CFS in New Zealand by the principles of precision medicine. Journal of Iimer, 10(1), (pp. 46-55). Retrieved from http://publizr.com/investinmeresearch/journal-of-iime-vol-10-issue-1#/0
Conference Contribution - Published proceedings: Abstract
Parfitt, K. D., Mockett, B., Hintz, T. J., Bourne, K., Williams, J. M., Tate, W. P., & Abraham, W. C. (2016). Secreted amyloid precursor protein-alpha enhances long-term potentiation via protein synthesis- and protein trafficking-dependent mechanisms. Alzheimer's & Dementia, 12(7, Suppl.), (pp. P1040). doi: 10.1016/j.jalz.2016.06.2159
Williams, J. M., Guevremont, D., Mockett, B., Peppercorn, K., Tate, W. P., & Abraham, W. C. (2016). Secreted amyloid precursor protein-alpha regulates glutamate receptor trafficking in the hippocampus. Alzheimer's & Dementia, 12(7, Suppl.), (pp. P1040-P1041). doi: 10.1016/j.jalz.2016.06.2160
Morrissey, J., Mockett, B. G., Peppercorn, K., Tate, W. P., Hughes, S. M., & Abraham, W. C. (2016). Peptides of amyloid precursor protein alpha mimic the parent molecule's enhancement of hippocampal LTP. Proceedings of the Society for Neuroscience 46th Annual Meeting. 131.19/K17. SfN. Retrieved from https://www.sfn.org/
Elder, M. K., Peppercorn, K., tom Dieck, S., Kochen, L., Schuman, E., Tate, W., Abraham, C., & Williams, J. (2016). Secreted amyloid precursor protein-alpha regulates synthesis of the AMPA receptor subunit GluA1. Proceedings of the Society for Neuroscience 46th Annual Meeting. 397.08/E29. SfN. Retrieved from https://www.sfn.org/
Palpagama, T. H., Tate, W. P., Waldvogel, H. J., Faull, R. L., & Kwakowsky, A. (2016). Investigation of GABA signalling in an in-vivo Alzheimer’s disease mouse model. In B. Leitch (Ed.), Proceedings of the 34th International Australasian Winter Conference on Brain Research. (pp. 41). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr
2015
Journal - Research Article
Cardno, T. S., Shimaki, Y., Sleebs, B. E., Lackovic, K., Parisot, J. P., Moss, R. M., Crowe-McAuliffe, C., Mathew, S. F., Edgar, C. D., Kleffmann, T., & Tate, W. P. (2015). HIV-1 and human PEG10 frameshift elements are functionally distinct and distinguished by novel small molecule modulators. PLoS ONE, 10(10), e0139036. doi: 10.1371/journal.pone.0139036
Ramsay, J. P., Tester, L. G. L., Major, A. S., Sullivan, J. T., Edgar, C. D., Kleffmann, T., … Tate, W. P., … Ronson, C. W. (2015). Ribosomal frameshifting and dual-target antiactivation restrict quorum-sensing–activated transfer of a mobile genetic element. PNAS, 112(3), 4104-4109. doi: 10.1073/pnas.1501574112
Mathew, S. F., Crowe-McAuliffe, C., Graves, R., Cardno, T. S., McKinney, C., Poole, E. S., & Tate, W. P. (2015). The highly conserved codon following the Slippery Sequence Supports -1 frameshift efficiency at the HIV-1 frameshift site. PLoS ONE, 10(3), e0122176. doi: 10.1371/journal.pone.0122176
Conference Contribution - Published proceedings: Abstract
Kwakowsky, A., Waldvogel, H. J., Faull, R. L. M., Arasaratnam, C., Tate, W. P., & Peppercorn, K. (2015). Impaired GABAA receptor function in Alzheimer's disease. In B. Leitch (Ed.), Proceedings of the 33rd International Australasian Winter Conference on Brain Research. (pp. 70). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr
Morrissey, J., Mockett, B. G., Peppercorn, K., Tate, W. P., Hughes, S. M., & Abraham, W. C. (2015). Fragments of amyloid precursor protein enhance rat hippocampal LTP. In B. Leitch (Ed.), Proceedings of the 33rd International Australasian Winter Conference on Brain Research. (pp. 65). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr
Elder, M., Peppercorn, K., Schuman, E., Tate, W. P., Abraham, W. C., & Williams, J. M. (2015). Secreted amyloid precursor protein alpha regulates protein synthesis in primary hippocampal neuronal cultures. In B. Leitch (Ed.), Proceedings of the 33rd International Australasian Winter Conference on Brain Research. (pp. 28). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr
Elder, M., Peppercorn, K., Schuman, E., Tate, W., Abraham, C., & Williams, J. (2015). Secreted amyloid precursor protein alpha regulates protein synthesis in primary hippocampal neuronal cultures. Journal of Neurochemistry, 134(Suppl. 1), (pp. 302). doi: 10.1111/jnc.13189
Conference Contribution - Poster Presentation (not in published proceedings)
Sweetman, E. C., & Tate, W. P. (2015, August-September). Developing a diagnostic test for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome based on the anti-viral immune protein Protein Kinase R. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
2014
Conference Contribution - Published proceedings: Abstract
Kwakowsky, A., Potapov, K., Kim, S., Peppercorn, K., Tate, W. P., & Abraham, I. M. (2014). Effects and mechanism of action of estren on beta amyloid-induced cholinergic and behavioural deficits. Proceedings of the Society for Neuroscience 44th Annual Meeting. SfN. Retrieved from http://www.sfn.org/annual-meeting/neuroscience-2014/abstracts
Yahaya, M. F., Parfitt, K. D., Mockett, B. G., Schoderböck, L., Peacock, H. E., Bourne, K., Tate, W. P., Hughes, S. M., & Abraham, W. C. (2014). Secreted amyloid precursor protein-α overexpression in vivo rescues the long-term potentiation deficit in a mouse model of Alzheimer’s disease. Proceedings of the Society for Neuroscience 44th Annual Meeting. SfN. Retrieved from http://www.sfn.org/annual-meeting/neuroscience-2014/abstracts
Parfitt, K. D., Mockett, B. G., Guevremont, D., Bourne, K., Tate, W. P., Williams, J. M., & Abraham, W. C. (2014). Secreted amyloid precursor protein-alpha (sAPPα) modulates long-term potentiation, induces metaplasticity and regulates glutamate receptor localization in rat hippocampus. Proceedings of the Society for Neuroscience 44th Annual Meeting. SfN. Retrieved from http://www.sfn.org/annual-meeting/neuroscience-2014/abstracts
Xiong, M., Jones, O., Peppercorn, K., Tate, W., & Abraham, W. (2014). Administration of secreted amyloid precursor protein-α rescues spatial memory and long-term potentiation deficits in aged rats. New Zealand Medical Journal, 127(1406). Retrieved from http://www.nzma.org.nz/journal
Elder, M., Mockett, B. G., Blok, J., Peppercorn, K., Tate, W. P., Abraham, W. C., & Williams, J. M. (2014). Secreted amyloid precursor protein-α attenuates apoptosis following amyloid-β insult and ischemic injury. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 32nd International Australasian Winter Conference on Brain Research. 32, (pp. 62). AWCBR. Retrieved from https://web.psy.otago.ac.nz/awcbr/proceedings.html
Xiong, M., Jones, O. D., Bourne, K., Tate, W. P., & Abraham, W. C. (2014). The effects of exogenous sAPPα on spatial memory and LTP in aging. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 32nd International Australasian Winter Conference on Brain Research. 32, (pp. 48). AWCBR. Retrieved from https://web.psy.otago.ac.nz/awcbr/proceedings.html
Kwakowsky, A., Potapov, K., Peppercorn, K., Kim, S., Tate, W. P., & Ábrahám, I. M. (2014). Effects and mechanism of action of estren on beta amyloid-induced cholinergic and behavioural deficits. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 32nd International Australasian Winter Conference on Brain Research. 32, (pp. 35). AWCBR. Retrieved from https://web.psy.otago.ac.nz/awcbr/proceedings.html
2013
Journal - Research Article
Ryan, M. M., Morris, G. P., Mockett, B. G., Bourne, K., Abraham, W. C., Tate, W. P., & Williams, J. M. (2013). Time-dependent changes in gene expression induced by secreted amyloid precursor protein-alpha in the rat hippocampus. BMC Genomics, 14, 376. doi: 10.1186/1471-2164-14-376
Imhoff, F. M., Yang, D., Mathew, S. F., Clarkson, A. N., Kawagishi, Y., Tate, W. P., Koishi, K., & McLennan, I. S. (2013). The type 2 anti-Müllerian hormone receptor has splice variants that are dominant-negative inhibitors. FEBS Letters, 587(12), 1749-1753. doi: 10.1016/j.febslet.2013.04.014
Conference Contribution - Published proceedings: Abstract
Parfitt, K. D., Bourne, K., Hintz, T. J., Tate, W. P., & Abraham, W. C. (2013). Secreted APPα rescues LTP deficits in APPswe/PS1ΔE9 transgenic mice. Proceedings of the Society for Neuroscience 43rd Annual Meeting. SfN. Retrieved from http://www.sfn.org/annual-meeting/neuroscience-2013/abstracts-and-sessions
Kwakowsky, A., Kim, S., Tate, W. P., & Abraham, I. M. (2013). Estren treatment attenuates beta amyloid-induced cholinergic and behavioural deficits. Proceedings of the Society for Neuroscience 43rd Annual Meeting. SfN. Retrieved from http://www.sfn.org/annual-meeting/neuroscience-2013/abstracts-and-sessions
Williams, J. M., Guévremont, D., Tsui, H., Logan, B., Knight, R., Abraham, W. C., Tate, W. P., & Cutfield, N. (2013). Altered expression of plasma microRNA in sporadic Alzheimer's disease. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 31st International Australasian Winter Conference on Brain Research. 31, (pp. 70). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2013copy.html
Conference Contribution - Verbal presentation and other Conference outputs
Kwakowsky, A., Kim, S. H., Tate, W. P., & Ábrahám, I. M. (2013, August). Estren treatment attenuates beta amyloid-induced cholinergic and behavioural deficits. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
2012
Journal - Research Article
Bernhardt, H. S., & Tate, W. P. (2012). Primordial soup or vinaigrette: Did the RNA world evolve at acidic pH? Biology Direct, 7(4). doi: 10.1186/1745-6150-7-4
Ryan, M. M., Ryan, B., Kyrke-Smith, M., Logan, B., Tate, W. P., Abraham, W. C., & Williams, J. M. (2012). Temporal profiling of gene networks associated with the late phase of long-term potentiation in vivo. PLoS ONE, 7(7), e40538. doi: 10.1371/journal.pone.0040538
Baratchi, S., Evans, J., Tate, W. P., Abraham, W. C., & Connor, B. (2012). Secreted amyloid precursor proteins promote proliferation and glial differentiation of adult hippocampal neural progenitor cells. Hippocampus, 22(7), 1517-1527. doi: 10.1002/hipo.20988
Conference Contribution - Published proceedings: Abstract
Overeem, K. A., Guévremont, D., Bilkey, D. K., Tate, W. P., Abraham, W. C., & Williams, J. M. (2012). Comparison of methods for the isolation of microRNA from rat and human plasma: Beginning the search for biomarkers of neurological disorders. Proceedings of the Australian Neuroscience Society (ANS) Annual Scientific Meeting. (pp. 124). Retrieved from http://www.ans.org.au/ans-annual-conference/
Conference Contribution - Poster Presentation (not in published proceedings)
MacKay, A., Tate, W., & Poole, E. (2012, August). Developing a blood test for myalgic encephalomyelitis (ME): miRNA as putative biomarkers. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Bernhardt, H. S., & Tate, W. P. (2012, August). Primordial soup or vinaigrette: Did the RNA world evolve at acidic pH? Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Tate, W. P. (2012, August). Old actors in a contemporary drama: Ancestral signatures of the RNA precursors to the modern ribosome. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
2011
Journal - Research Article
Morgan, N. V., Goddard, S., Cardno, T. S., McDonald, D., Rahman, F., Barge, D., Ciupek, A., … Tate, W. P., … Maher, E. R. (2011). Mutation in the TCRα subunit constant gene (TRAC) leads to a human immunodeficiency disorder characterized by a lack of TCRαβ+ T cells. Journal of Clinical Investigation, 121(2), 695-702. doi: 10.1172/JCI41931
Ryan, M. M., Mason-Parker, S. E., Tate, W. P., Abraham, W. C., & Williams, J. M. (2011). Rapidly induced gene networks following induction of long-term potentiation at perforant path synapses in vivo. Hippocampus, 21(5), 541-553. doi: 10.1002/hipo.20770
Conference Contribution - Published proceedings: Full paper
Tate, W. P., & Poole, E. S. (2011). Establishing a research base and clinical sample bank in New Zealand with emphasis on developing diagnostic biomarkers: RNase L cleavage, and PKR-mediated shutdown of protein synthesis through phosphorylation mechanisms. Proceedings of the International Science Symposium on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). (pp. 28-32). North Sydney, Australia: Alison Hunter Memorial Foundation. [Full Paper]
Conference Contribution - Published proceedings: Abstract
Ryan, M. M., Morris, G., Mockett, B. G., Bourne, K., Abraham, W. C., Tate, W. P., & Williams, J. M. (2011). Secreted amyloid precursor protein-alpha regulates hippocampal gene expression. Proceedings of the Australian Neuroscience Society (ANS) Annual Scientific Meeting. (pp. 163). Retrieved from http://www.ans.org.au/uploads/documents/2011%20Docs/conference%20abstracts/ANS%202011%20Poster%20Abstracts.pdf
Morris, G. P., Ryan, M. M., Bourne, K., & Tate, W. P. (2011). Understanding how secreted amyloid precursor protein-α (SAPPα) signals changes in gene expression in neurons. Proceedings of the Australian Neuroscience Society (ANS) Annual Scientific Meeting. (pp. 160). Retrieved from http://www.ans.org.au/uploads/documents/2011%20Docs/conference%20abstracts/ANS%202011%20Poster%20Abstracts.pdf
Claasen, A. M., Guévremont, D., Abraham, W. C., Tate, W. P., & Williams, J. M. (2011). Secreted amyloid precursor protein-alpha activates MAP kinase and CaM kinase signalling pathways at rat cortical synapses. Proceedings of the Australian Neuroscience Society (ANS) Annual Scientific Meeting. (pp. 91). Retrieved from http://www.ans.org.au/uploads/documents/2011%20Docs/conference%20abstracts/ANS%202011%20Poster%20Abstracts.pdf
Abraham, W. C., Baratchi, S., Evans, J., Tate, W. P., & Connor, B. (2011). Secreted amyloid precursor proteins promote proliferation and glial differentiation of adult hippocampal neural progenitor cells. In B. Leitch (Ed.), Proceedings of the 29th International Australasian Winter Conference on Brain Research. 29, 8.5. AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/abstracts/abstracts2011.html
Morris, G., Ryan, M., Bourne, K., & Tate, W. (2011). Secreted amyloid precursor protein-α mediates gene expression. New Zealand Medical Journal, 124(1346). Retrieved from http://journal.nzma.org.nz/journal/124-1346/4980/content.pdf
Conference Contribution - Poster Presentation (not in published proceedings)
Crowe-McAuliffe, C. T., Clark, M. B., Tate, W. P., & Poole, E. S. (2011, September). Analysis of the human retroviral-like PEG10 protease domain. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Bernhardt, H. S., & Tate, W. P. (2011, July). Small RNAs illuminate the dawn of coded protein synthesis. Poster session presented at the International Society for the Study of the Origin of Life (ISSOL) and Bioastronomy Joint International Conference, Montpellier, France.
Bernhardt, H. S., & Tate, W. P. (2011, July). The ribonucleic acid world: Did it evolve at low pH? Poster session presented at the International Society for the Study of the Origin of Life (ISSOL) and Bioastronomy Joint International Conference, Montpellier, France.
Conference Contribution - Verbal presentation and other Conference outputs
Tate, W. (2011, July). A slippery slope in HIV translating to lead compounds for a new class of antiviral drugs. Verbal presentation at the Brain Health Research Centre Conference, Dunedin, New Zealand.
2010
Journal - Research Article
Young, D. J., Edgar, C. D., Poole, E. S., & Tate, W. P. (2010). The codon specificity of eubacterial release factors is determined by the sequence and size of the recognition loop. RNA, 16, 1623-1633. doi: 10.1261/rna.2117010
Young, D. J., Edgar, C. D., Murphy, J., Fredebohm, J., Poole, E. S., & Tate, W. P. (2010). Bioinformatic, structural, and functional analyses support release factor-like MTRF1 as a protein able to decode nonstandard stop codons beginning with adenine in vertebrate mitochondria. RNA, 16(6), 1146-1155. doi: 10.1261/rna.1970310
Bernhardt, H. S., & Tate, W. P. (2010). The transition from noncoded to coded protein synthesis: Did coding mRNAs arise from stability-enhancing binding partners to tRNA? Biology Direct, 5, 16. doi: 10.1186/1745-6150-5-16
Conference Contribution - Published proceedings: Abstract
Mukadam, A., Bourne, K., & Tate, W. (2010). The unique C-terminal region of secreted amyloid precursor protein alpha is crucial for neuroprotection. Proceedings of the 30th Annual Meeting of the Australian Neuroscience Society, in conjunction with the 50th Anniversary Meeting of the Australian Physiological Society (ANS/AuPS). (pp. 181). Retrieved from http://www.sallyjayconferences.com.au/sydney2010/abstracts.html
Conference Contribution - Verbal presentation and other Conference outputs
Bernhardt, H., & Tate, W. P. (2010, January-February). The origin of genetic coding: Evolution of coded protein synthesis from a frozen accident, and serendipitous binding partners. Verbal presentation at the 23rd tRNA Workshop: From the origin of life to biomedicine, Aveiro, Portugal.
Intellectual Property
Cardno, T. S., & Tate, W. P. (2010). Dual-fluorescent reporter construct and assay for measuring translational recoding. (EP 1 929 015).
Other Research Output
Tate, W. (2010, July). Secreted amyloid precursor protein (sAPPalpha): Is this a lead compound to protect against Alzheimer's disease?. University of Otago Department of Pharmacology & Toxicology Seminar, Dunedin, New Zealand. [Department Seminar].
2009
Journal - Research Article
Cardno, T. S., Poole, E. S., Mathew, S. F., Graves, R., & Tate, W. P. (2009). A homogeneous cell-based bicistronic fluorescence assay for high-throughput identification of drugs that perturb viral gene recoding and read-through of nonsense stop codons. RNA, 15(8), 1614-1621. doi: 10.1261/rna.1586709
Jacobs, G. H., Chen, A., Stevens, S. G., Stockwell, P. A., Black, M. A., Tate, W. P., & Brown, C. M. (2009). Transterm: A database to aid the analysis of regulatory sequences in mRNAs. Nucleic Acids Research, 37(Database issue), D72-D76. doi: 10.1093/nar/gkn763
Claasen, A. M., Guévremont, D., Mason-Parker, S. E., Bourne, K., Tate, W. P., Abraham, W. C., & Williams, J. M. (2009). Secreted amyloid precursor protein-α upregulates synaptic protein synthesis by a protein kinase G-dependent mechanism. Neuroscience Letters, 460, 92-96. doi: 10.1016/j.neulet.2009.05.040
Conference Contribution - Published proceedings: Abstract
Morgan, N. V., Goddard, S., Cardno, T. S., Rahman, F., Ciupek, A., Straatman-Iwanowska, A., … Tate, W. P., & Maher, E. R. (2009). A novel human immunodeficiency disorder associated with a mutation in the T cell receptor α subunit constant gene (TRAC). Proceedings of the American Society of Human Genetics 59th Annual Meeting. (pp. 734). Retrieved from http://www.ashg.org/2009meeting/pdf/poster_4up.pdf
Tate, W. P., Young, D. J., Poole, E. S., & Edgar, C. D. (2009). Recognition of the RNA code of vertebrate mitochondria. Proceedings of the ComBio2009 Conference. [CD-ROM] [Abstract]
Bernhardt, H. S., & Tate, W. P. (2009). The RNA code: The origin of coded protein synthesis. Proceedings of the ComBio2009 Conference. [CD-ROM] [Abstract]
Poole, E. S., Saurat, N., Crowe-McAuliffe, C., Shimaki, Y., Clark, M., & Tate, W. P. (2009). RNA recoding and microRNAs regulate the expression of the human gene PEG10. Proceedings of the ComBio2009 Conference. [CD-ROM] [Abstract]
Morgan, N., Goddard, S., Cardno, T. S., Rahman, F., Ciupek, A., . . ., Tate, W. P., & et al (2009). A novel human immunodeficiency disorder associated with a mutation in the T cell receptor αsubunit constant gene (TRAC). Journal of Medical Genetics, 46(Suppl. 1), (pp. S15). [Abstract]
Ryan, M. M., Morris, G., Bourne, K., Mockett, B. G., Abraham, W. C., Tate, W. P., & Williams, J. M. (2009). Regulation of gene expression by sAPPα and RER derivative in differentiated neuroblastoma cells. Alzheimer's & Dementia, 5(4, Suppl. 1), (pp. P421). doi: 10.1016/j.jalz.2009.04.938
Cardno, T. S., Poole, E. S., Mathew, S. F., Graves, R., & Tate, W. P. (2009). A homogenous cell based bicistronic fluorescence assay for high-throughput sceening. Proceedings of the Webster Centre for Infectious Diseases Symposium. WCID. Retrieved from http://www.webstercentre.otago.ac.nz/WCIDSymposiumProgramme.pdf
Tate, W., Poole, E., Edgar, T., Cardno, T., Mathew, S., Shimaki, Y., James, S., Crowe-McAuliffe, C., Peat, J., & Saurat, N. (2009). The translational frameshift mechanism of HIV-1 as a drug target: Can damage to the same mechanism in human gene PEG10 be avoided? Proceedings of the Webster Centre for Infectious Diseases Symposium. WCID. Retrieved from http://www.webstercentre.otago.ac.nz/WCIDSymposiumProgramme.pdf
Conference Contribution - Poster Presentation (not in published proceedings)
Bernhardt, H. S., & Tate, W. P. (2009, May-June). The transition from noncoded to coded protein synthesis: Did mRNAs arise as binding partners to tRNAs? Poster session presented at the LXXIV Cold Spring Harbor Symposium on Quantitative Biology: Evolution: The Molecular Landscape, Cold Spring Harbor, USA.
2008
Journal - Research Article
Bernhardt, H. S., & Tate, W. P. (2008). Evidence from glycine transfer RNA of a frozen accident at the dawn of the genetic code. Biology Direct, 3, 53. doi: 10.1186/1745-6150-3-53
Bernhardt, H. S., & Tate, W. P. (2008). Self-assembling transfer RNA has potential for nanoparticle arrays. Current Applied Physics, 8(3-4), 380-382. doi: 10.1016/j.cap.2007.10.035
Taylor, C. J., Ireland, D. R., Ballagh, I., Bourne, K., Marechal, N. M., Turner, P. R., Bilkey, D. K., Tate, W. P., & Abraham, W. C. (2008). Endogenous secreted amyloid precursor protein-α regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory. Neurobiology of Disease, 31(2), 250-260. doi: 10.1016/j.nbd.2008.04.011
Conference Contribution - Published proceedings: Abstract
Renshaw, J. A., Ryan, M., Williams, J., & Tate, W. (2008). Recombinant sAPPα causes specific changes in gene expression in neuroblastoma cells and rat hippocampal cell slices. New Zealand Medical Journal, 121(1274). Retrieved from http://journal.nzma.org.nz/journal/121-1274/3078/content.pdf
Claasen, A. M., Guévremont, D., Mason-Parker, S. E., Bourne, K., Tate, W. P., Abraham, W. C., & Williams, J. M. (2008). Secreted amyloid precursor protein alpha-dependent upregulation of synaptic protein synthesis is dose and protein kinase G-dependent. In J. G. Anson (Ed.), Proceedings of the 26th International Australasian Winter Conference on Brain Research. 26, (pp. 46). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/2008Abstracts.pdf
Abraham, W. C., Marechal, N. M., Logan, B. J., Bourne, K., & Tate, W. P. (2008). Regulation of spatial memory processing by endogenous secreted amyloid precursor protein-α. In J. G. Anson (Ed.), Proceedings of the 26th International Australasian Winter Conference on Brain Research. 26, (pp. 23). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/2008Abstracts.pdf
Conference Contribution - Poster Presentation (not in published proceedings)
Mukadam, A., & Tate, W. (2008, November-December). Characterisation of the function of the C-terminal 16 amino acids of sAPPα. Poster session presented at the New Zealand Institute of Chemistry, New Zealand Society for Biochemistry and Molecular Biology and the New Zealand Society of Plant Biologists Combined Conference, Dunedin, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Bernhardt, H. S., & Tate, W. P. (2008, November-December). Evidence from glycine transfer RNA of a 'frozen accident' at the dawn of the genetic code. Verbal presentation at the New Zealand Institute of Chemistry, New Zealand Society for Biochemistry and Molecular Biology and the New Zealand Society of Plant Biologists Combined Conference, Dunedin, New Zealand.
Tate, W., Bourne, K., Turner, P. R., Claasen, A., Ryan, M., Taylor, C., Ireland, D., Ballagh, I., Marechal, N., Bilkey, D., Williams, J., & Abraham, W. (2008, November-December). Secreted amyloid precursor protein alpha: A mammalian memory molecule. Verbal presentation at the New Zealand Institute of Chemistry, New Zealand Society for Biochemistry and Molecular Biology and the New Zealand Society of Plant Biologists Combined Conference, Dunedin, New Zealand.
2007
Journal - Research Article
Clark, M. B., Jänicke, M., Gottesbühren, U., Kleffmann, T., Legge, M., Poole, E. S., & Tate, W. P. (2007). A mammalian gene PEG10 expresses two reading frames by high efficiency -1 frameshifting in embryonic-associated tissues. Journal of Biological Chemistry, 282(52), 37359-37369.
Soleimanpour-Lichaei, H. R., Kühl, I., Gaisne, M., Passos, J. F., Wydro, M., Rorbach, J., … Tate, W., … Chrzanowska-Lightowlers, Z. (2007). mtRF1a is a human mitochondrial translation release factor decoding the major termination codons UAA and UAG. Molecular Cell, 27, 745-757.
Poole, E. S., Young, D. J., Askarian-Amiri, M. E., Scarlett, D.-J. G., & Tate, W. P. (2007). Accommodating the bacterial decoding release factor as an alien protein among the RNAs at the active site of the ribosome. Cell Research, 17, 591-607.
Turner, P. R., Bourne, K., Garama, D., Carne, A., Abraham, W. C., & Tate, W. P. (2007). Production, purification and functional validation of human secreted amyloid precursor proteins for use as neuropharmacological reagents. Journal of Neuroscience Methods, 164, 68-74.
Williams, J. M., Guévremont, D., Mason-Parker, S. E., Luxmanan, C., Tate, W. P., & Abraham, W. C. (2007). Differential trafficking of AMPA and NMDA receptors during long-term potentiation in awake adult animals. Journal of Neuroscience, 27(51), 14171-14178.
Conference Contribution - Published proceedings: Abstract
Young, G., Bourne, K., Tate, W. P., & Williams, J. M. (2007). Regulation of N-methyl-D-asparate receptor subunits NR1 and NR2A expression in vitro. In J. G. Anson (Ed.), Proceedings of the 25th International Australasian Winter Conference on Brain Research. 25, (pp. 43). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/2007Abstracts.pdf
Conference Contribution - Poster Presentation (not in published proceedings)
Bernhardt, H. S., & Tate, W. P. (2007, February). Transfer RNA building blocks for nanotechnology. Poster session presented at the Nano- and Bionano- Technology Quantum Transport and Quantum Functional Semiconductors (NBT-QT) Conference, Wellington, New Zealand.
Bernhardt, H. S., & Tate, W. P. (2007, February). Transfer RNA building blocks for nanotechnology. Poster session presented at the Third International Conference on Advanced Materials and Nanotechnology: AMN-3, Wellington, New Zealand.
Bernhardt, H. S., & Tate, W. P. (2007, March). Transfer RNA building blocks for nanotechnology. Poster session presented at the Supramolecular Chemistry and Nanoscience Conference, Dunedin, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Bernhardt, H., & Tate, W. P. (2007, August). Self-assembling transfer RNA has potential for nanoparticle arrays. Verbal presentation at the 17th Queenstown Molecular Biology Meeting, Queenstown, New Zealand.
Tate, W. (2007, April). Translational frameshifting: A vulnerable point in the biology of HIV-1 or a mechanism shared with the human genome? Verbal presentation at the Webster Centre for Molecular Research in Infectious Diseases Symposium, Dunedin, New Zealand.
Tate, W. (2007, March). Serendipity in science: Showing how a research area can develop strategically from a fundamental study and discovery. Keynote presentation at the Faculty of Dentistry 3M Research Day, Dunedin, New Zealand.
2006
Journal - Research Article
Cridge, A. G., Major, L. L., Mahagaonkar, A. A., Poole, E. S., Isaksson, L. A., & Tate, W. P. (2006). Comparison of characteristics and function of translation termination signals between and within prokaryotic and eukaryotic organisms. Nucleic Acids Research, 34(7), 1959-1973. doi: 10.1093/nar/gkl074
Jacobs, G. H., Stockwell, P. A., Tate, W. P., & Brown, C. M. (2006). Transterm: Extended search facilities and improved integration with other databases. Nucleic Acids Research, 34(Database), D37-D40.
Journal - Research Other
Bernhardt, H. S., & Tate, W. P. (2006). Transfer RNA as a potential building block for nanotechnology. Chemistry in New Zealand, 70(1), 7-11.
Conference Contribution - Published proceedings: Abstract
Ballagh, I., Ireland, D., Mockett, B., Bourne, K., Tate, W., Williams, J., & Abraham, W. (2006). The effect of secreted-amyloid precursor protein on NMDA receptors in cultured rat hippocampal slices. New Zealand Medical Journal, 119(1234). Retrieved from http://journal.nzma.org.nz/journal/119-1234/1991/content.pdf
Conference Contribution - Poster Presentation (not in published proceedings)
Garama, D. J., Carne, A., Abraham, W. C., & Tate, W. P. (2006, August). The purification and investigation of secreted amyloid precursor proteins. Poster session presented at the 16th Annual Queenstown Molecular Biology Meeting, Queenstown, New Zealand.
Taylor, C. J., Bourne, K., Tate, W. P., & Abraham, W. C. (2006, July). Secreted amyloid precursor protein-alpha regulates the induction of LTP in anesthetized rats. Poster session presented at the International Conference on Alzheimer's Disease and Related Disorders, Madrid, Spain.
Conference Contribution - Verbal presentation and other Conference outputs
Tate, W. P., Abraham, W. C., Turner, P. R., Bourne, K., Garama, D., Carne, A., Taylor, C., Ballagh, I., & Ireland, D. (2006, September). Production, purification and functional validation of human secreted amyloid precursor proteins as neuropharmacological agents. Verbal presentation at the 9th Asia Pacific International Molecular Biology Network Meeting, Kuala Lumpur, Malaysia.
2004
Chapter in Book - Research
Poole, E. S., Major, L. L., Cridge, A. G., & Tate, W. P. (2004). The mechanism of recoding in pro- and eukaryotes. In K. H. Nierhaus & D. N. Wilson (Eds.), Protein synthesis and ribosome structure: Translating the genome. (pp. 397-428). Weinheim, Germany: Wiley-VCH.
Journal - Research Article
Tate, W. P., & Poole, E. S. (2004). The ribosome: Lifting the veil from a fascinating organelle. BioEssays, 26, 582-588.
Mockett, B. G., Brooks, W. M., Tate, W. P., & Abraham, W. C. (2004). Dopamine D1/D5 receptor activation fails to initiate an activity-independent late-phase LTP in rat hippocampus. Brain Research, 1021, 92-100.
Conference Contribution - Poster Presentation (not in published proceedings)
Taylor, C. J., Turner, P. R., Tate, W. P., & Abraham, W. C. (2004, July). The contribution of secreted-amyloid precursor protein to the induction of long-term potentiation in anaesthetised rats. Poster session presented at the 9th International Conference on Alzheimer's Disease and Related Disorders, Philadelphia, Pennsylvania. Retrieved from http://www.nzma.org.nz/journal/116-1179/689/
2003
Journal - Research Article
Cridge, A. G., Poole, E. S., & Tate, W. P. (2003). The signal for stop in protein synthesis in eukaryotes: Evidence for a sequence element rather than a simple stop codon. New Zealand BioScience, 12, 37-38.
Turner, P. R., O'Connor, K., Tate, W. P., & Abraham, W. C. (2003). Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory. Progress in Neurobiology, 70, 1-32.
Scarlett, D.-J. G., McCaughan, K. K., Wilson, D. N., & Tate, W. P. (2003). Mapping functionally important motifs SPF and GGQ of the decoding release factor RF2 to the Escherichia coli ribosome by hydroxyl radical footprinting. Journal of Biological Chemistry, 278(17), 15095-15104.
Poole, E. S., Askarian-Amiri, M. E., Major, L. L., McCaughan, K. K., Scarlett, D.-J. G., Wilson, D. N., & Tate, W. P. (2003). Molecular mimicry in the decoding of translational stop signals. Progress in Nucleic Acid Research & Molecular Biology, 74, 83-121.
Williams, J. M., Guévremont, D., Kennard, J. T. T., Mason-Parker, S. E., Tate, W. P., & Abraham, W. C. (2003). Long-term regulation of N-methyl-D-aspartate receptor subunits and associated synaptic proteins following hippocampal synaptic plasticity. Neuroscience, 118, 1003-1013.
Conference Contribution - Published proceedings: Abstract
Taylor, C., Turner, P., Tate, W., & Abraham, W. (2003). The contribution of secreted-amyloid precursor protein to the induction of long-term potentiation in anaesthetised rats. New Zealand Medical Journal, 116(1186). Retrieved from http://journal.nzma.org.nz/journal/116-1186/689/content.pdf
2002
Journal - Research Article
Jacobs, G. H., Rackham, O., Stockwell, P. A., Tate, W. P., & Brown, C. M. (2002). Transterm: a database of mRNAs and translational control elements. Nucleic Acids Research, 30, 310-311.
Major, L. L., Edgar, C. D., Yip, P. Y., Isaksson, L. A., & Tate, W. P. (2002). Tandem termination signals: Myth or reality. FEBS Letters, 514, 84-89.
Conference Contribution - Published proceedings: Full paper
Watts, M., Major, L. L., & Tate, W. P. (2002). Evolutionary optimisation of multi-layer perceptions for modelling protein synthesis termination signal efficiency. In D. B. Fogel, M. A. El-Sharkawi, X. Yao, G. Greenwood, H. Iba, P. Marrow & M. Shackleton (Eds.), The Congress on Evolutionary Computation (CEC) 2002. 1, (pp. 193-198). Piscataway, NJ: IEEE Press. [Full Paper]
2001
Journal - Research Article
Mansell, J. B., Guevremont, D., Poole, E. S., & Tate, W. P. (2001). A dynamic competition between release factor 2 and the tRNASec decoding UGA at the recoding site of Escherichia coli formate dehydrogenase H. EMBO Journal, 20, 7284-7293.
Stenstrom, M. C., Haining, J., Major, L. L., Tate, W. P., & Isaksson, L. A. (2001). Codon bias at the 3'-side of the initiation codon is correlated with translation initiation efficiency in Escherichia coli. Gene, 263, 273-284.
Abraham, W. C., Mason-Parker, S. E., Bear, M. F., Webb, S. C., & Tate, W. P. (2001). Heterosynaptic metaplasticity in the hippocampus in vivo: A BCM-like modifiable threshold for LTP. PNAS, 98, 10924-10929.
Conference Contribution - Published proceedings: Full paper
Watts, M., Major, L. L., Kasabov, N. K., & Tate, W. P. (2001). Neural network analysis of protein termination signal efficiency. Proceedings of International Conference on Neural Information Processing. (pp. 975-980). China: ICONIP. [Full Paper]
Conference Contribution - Published proceedings: Abstract
Brooks, W. M., Abraham, W. C., & Tate, W. P. (2001). Hippocampal NMDA and dopamine receptors: Do they synergistically support synaptic strengthening? International Journal of Neuroscience. 108, (pp. 233). [Abstract]
Sun, Q., Wickens, J., & Tate, W. P. (2001). Dopamine and glutamate effects on protein phosphorylation and gene expression in the rat striatum, in vitro. Proceedings of the 7th Triennial Meeting, International Basal Ganglia Society. (pp. 90). [Abstract]
Williams, J. M., Guevremont, D., Mason-Parker, S. E., Abraham, W. C., & Tate, W. P. (2001). Regulation of NMDA receptor subunit NR1 folloing synaptic activity. Molecular Mechanisms of Synaptic Function. 2(42). [Abstract]
Williams, J. M., Thompson, V. L., Guevremont, D., Abraham, W. C., Tate, W. P., & Nairn, A. C. (2001). Presynaptic protein synthesis in axon terminals isolated from adult rat cortex. Proceedings of International Australasian Winter Conference on Brain Research. 19. [Abstract]
Thompson, V. L., Williams, J. M., & Tate, W. P. (2001). Synaptoneurosomes as a model for studying glutamate regulation of synaptic protein synthesis. International Journal of Neuroscience. 109, (pp. 201). [Abstract]
Williams, J. M., Thompson, V. L., Guevremont, D., Abraham, W. C., Tate, W. P., & Nairn, A. C. (2001). Protein synthesis in axon terminals isolated from adult rat cortex. 19th International Australasian Winter Conference on Brain and Research. 19, (pp. 40). Queenstown, New Zealand: Australasian Winter Conference on Brain and Research. [Abstract]
Williams, J. M., Mason-Parker, S. E., Abraham, W. C., & Tate, W. P. (2001). Regulation of NMDA receptor subunit NR1 following synaptic activity. 11th Neuropharmacology Conference Molecular Mechanisms of Synaptic Function. (pp. 2.42). United Kingdom: Elzevier Science. [Abstract]
Williams, J. M., Thompson, V. L., Guévremont, D., Abraham, W. C., Tate, W. P., & Nairn, A. C. (2001). Presynaptic protein synthesis in axon terminals isolated from adult rat cortex. Society for Neuroscience Abstract. 27, (pp. 275.9). San Diego, USA: Society for Neuroscience. [Abstract]
2000
Journal - Research Article
Raymond, C., Thompson, V. L., Tate, W. P., & Abraham, W. C. (2000). Metabotropic glutamate receptors trigger homosynaptic protein synthesis to prolong long-term potentiation. Journal of Neuroscience, 20, 969-976.
Wilson, D. N., Guevremont, D., & Tate, W. P. (2000). The ribosomal binding and peptidyl-tRNA hydrolysis functions of Escherichia coli release factor 2 are linked through residue 246. RNA, 6, 1-10.
Wilson, D. N., Dalphin, M. E., Pel, H. J., Major, L. L., Mansell, J. B., & Tate, W. P. (2000). Factor-mediated termination of protein synthesis: A welcome return to the mainstream of translation. The Ribosome: Structure, Function, Antibiotics & Cellular Interactions, 40, 495-508. Washington, D.C.: ASM Press.
Askarian-Amiri, M. E., Pel, H. J., Guevremont, D., McCaughan, K. K., Poole, E. S., Sumpter, V. G., & Tate, W. P. (2000). Functional characterization of yeast mitochondrial release factor 1. Journal of Biological Chemistry, 275, 17241-17248.
Williams, J. M., Beckmann, A. M., Mason-Parker, S. E., Abraham, W. C., Wilce, P. A., & Tate, W. P. (2000). Sequential increase in Egr-1 and AP-1 DNA binding activity in the dentate gyrus following the induction of long-term potentiation. Molecular Brain Research, 77, 258-266.
Jacobs, G. H., Stockwell, P. A., Schreiber, M. J., Tate, W. P., & Brown, C. M. (2000). Transterm: A database of messenger RNA components and signals. Nucleic Acids Research, 28, 293-295.
Poole, E., & Tate, W. (2000). Release factors and their role as decoding proteins: Specificity and fidelity for termination of protein synthesis. Biochimica et Biophysica Acta: Gene Structure & Expression, 1493, 1-11.
Conference Contribution - Published proceedings: Abstract
Webb, S. C., Williams, J. M., Tate, W. P., & Abraham, W. C. (2000). Involvement of the cAMP cascade in the printing of hippocampal LTP by metabotropic glutamate receptors. Society for Neuroscience Abstract. 26, (pp. 361). USA: Society fo Neuroscience. [Abstract]
Sun, Q., Wickens, J., & Tate, W. P. (2000). Differential regulation of protein phosphorylation and gene expression by dopamine and glutamate in at striatal slices. Society for Neuroscience Absracts. (pp. 1). [Abstract]
McKinney, C. Z., & Tate, W. P. (2000). Regulated translational frameshifting in HIV-1. Proceedings of the University of Otago Medical School. 78, (pp. 12). [Abstract]
1999
Journal - Research Article
Brown, C. M., Jacobs, G. H., Schreiber, M. J., Magnum, J., McNaughton, J. C., Cambray, M., Futschik, M., Major, L. L., Rackham, O., Tate, W. P., … Stockwell, P. A., & Kasabov, N. K. (1999). Using bioinformatics to investigate post-transcriptional control of gene expression. New Zealand BioScience, 7, 11-12.
Scrimshaw, B. J., Faed, J. M., Tate, W. P., & Yun, K. (1999). The frequency in New Zealand of a mitochondrial DNA mutation (1555 A to G) associated with aminoglycoside-induced hearing loss. New Zealand Medical Journal, 112, 216-217.
Scrimshaw, B. J., Faed, J. M., Tate, W. P., & Yun, K. (1999). Rapid identification of a 1555 A to G mutation in human mitochronical DNA implicated in aminoglycoside-induced ototoxicity. Journal of Human Genetics, 44, 388-390.
Crawford, D.-J. G., Ito, K., Nakamura, Y., & Tate, W. P. (1999). Indirect regulation of translational termination efficiency at highly expressed genes and recoding sites by the factor recycling function of Escherichia coli release factor RF3. EMBO Journal, 18, 727-732.
Dalphin, M. E., Stockwell, P. A., Tate, W. P., & Brown, C. M. (1999). TransTerm, the translational signal database, extended to include full coding sequences and untranslated regions. Nucleic Acids Research, 27, 293-294.
Tate, W. P., Mansell, J. B., Mannering, S. A., Irvine, J., Major, L. L., & Wilson, D. N. (1999). UGA: A dual signal for "stop" and for recoding in protein synthesis. Biochemistry (Moscow), 64, 1342-1353.
Conference Contribution - Published proceedings: Abstract
Sun, Q., Tate, W. P., & Wickens, J. (1999). Interactions of dopamine and glutamate signalling pathways for protein phosphorylation in the striatum: A possible explanation for the establishment of LTD or LDP. International Journal of Neuroscience. 97, (pp. 265). [Abstract]
1998
Journal - Research Article
McCaughan, K. K., Poole, E. S., Pel, H. J., Mansell, J., Mannering, S. A., & Tate, W. P. (1998). Efficient in vitro translational termination in Escherichia coli is constrained by the orientations of the release factor, stop signal and peptidyl-tRNA within the termination complex. Biological Chemistry, 379(7), 857-866.
Trotman, C. N. A., Coleman, M., Jellie, A.-M., Shieffelbien, D. C., & Tate, W. P. (1998). Haemoglobin: a primordial role preserved in diapause? Archiv für Hydrobiologie, 52, 441-449.
Irvine, J., Horsfield, J. A., McKinney, C. Z., & Tate, W. P. (1998). A novel strategy to interfere with human immunodeficiency virus type 1 propagation. New Zealand Medical Journal, 111, 222-224.
Pel, H. J., Moffat, J. G., Ito, K., Nakamura, Y., & Tate, W. P. (1998). Escherichia coli release factor 3: Resolving the paradox of a typical G protein structure and atypical function with guanine nucleotides. RNA, 4, 47-54.
Poole, E. S., Major, L. L., Mannering, S. A., & Tate, W. P. (1998). Translational termination in Escherichia coli: three bases following the stop codon crosslink to release factor 2 and affect the decoding efficiency of UGA-containing signals. Nucleic Acids Research, 26, 954-960.
Williams, J. M., Mason-Parker, S. E., Abraham, W. C., & Tate, W. P. (1998). Biphasic changes in the levels of N-methyl-D-aspartate receptor-2 subunits correlate with the induction and persistence of long-term potentiation. Molecular Brain Research, 60, 21-27.
Williams, J. M., Thompson, V. L., Mason-Parker, S. E., Abraham, W. C., & Tate, W. P. (1998). Synaptic activity-dependent modulation of mitochondrial gene expression in the rat hippocampus. Molecular Brain Research, 60, 50-56.
Dalphin, M. E., Brown, C. M., Stockwell, P. A., & Tate, W. P. (1998). The translational signal database, TransTerm, is now a relational database. Nucleic Acids Research, 26, 335-337.
Conference Contribution - Published proceedings: Abstract
Williams, J. M., Mason-Parker, S. E., Abraham, W. C., & Tate, W. P. (1998). Rapid increase in N-methyl-D-aspartate receptor subunit NR2B following long-term potentiation. International Journal of Neuroscience. 94, (pp. 108). [Abstract]
1997
Journal - Research Article
Abraham, W. C., Logan, B., Thompson, V. L., Williams, J. M., & Tate, W. P. (1997). Sequence-independent effects of phosphorothioated oligonucleotides on synaptic transmission and excitability in the hippocampus in vivo. Neuropharmacology, 36, 345-352.
Poole, E. S., Brimacombe, R., & Tate, W. P. (1997). Decoding the translational termination signal: the polypeptide chain release factor in Escherichia coli crosslinks to the base following the stop codon. RNA, 3, 974-982.
Dalphin, M. E., Brown, C. M., Stockwell, P. A., & Tate, W. P. (1997). The translational signal database, TransTerm: more organisms, complete genomes. Nucleic Acids Research, 25, 246-247.
Abraham, W. C., & Tate, W. P. (1997). Metaplasticity: A new vista across the field of synaptic plasticity. Progress in Neurobiology, 52, 303-323.
Conference Contribution - Published proceedings: Abstract
Trotman, C. N. A., Coleman, M., Jellie, A.-M., Matthews, C. M., Shieffelbien, D. C., Tate, W. P., & Vandenberg, C. J. (1997). Heamoglobin: A primordial role preserved in diapause? Proceedings of the Symposium on Diapause in the Crustacea. (pp. 35). [Abstract]
Matthews, C., Jellie, A.-M., Tate, W. P., & Trotman, C. N. A. (1997). Ancient and recent duplication events in Artemia provide a model for intron positional stability. Proceedings of the Symposium on Exon/Intron Structure. (pp. S19). [Abstract]
Williams, J. S., Mason-Parker, S. E., Abraham, W. C., & Tate, W. P. (1997). Rapid and persistent elevation in the N-methyl-D-aspartate receptor subunit NR2B folowing long-term potentiation. Society for Neuroscience Abstracs. 23, (pp. 1175). [Abstract]
Williams, J. M., Mason-Parker, S. E., Abraham, W. C., & Tate, W. P. (1997). Rapid and persistent elevation in N-methyl-D-aspartate receptor subunit NR2B following long-term potentiation. Society for Neuroscience Abstract. 23, (pp. 1175). San Diego, USA: Society for Neuroscience. [Abstract]
Webb, S. C., Williams, J. M., Tate, W. P., Mason-Parker, S. E., & Abraham, W. C. (1997). Expression of elongation factor-2 during the maintenance of long-term potentiation. International Journal of Neuroscience. 89, (pp. 92). [Abstract]
Williams, J. M., Mason-Parker, S. E., Abraham, W. C., & Tate, W. P. (1997). NMDA receptor subunit composition and phosphorylation following long-term potentiation. International Journal of Neuroscience. 89, (pp. 91). [Abstract]
Cheesman, E. T., Pel, H. J., & Tate, W. P. (1997). Isolation and characterisation of the human mitochondrial release factor, a potential deafness locus on chromosome 4. Proceedings of the University of Otago Medical School. 75(1), (pp. 10). Dunedin: University of Otago. [Abstract]
Matthews, C. M., Jellie, A.-M., Tate, W. P., & Trotman, C. N. A. (1997). Evolutionary history of the T and C polymer introns of Artemia haemoglobin genes. Proceedings of the University of Otago Medical School. 75, (pp. 5-6). Dunedin. [Abstract]
Major, L. L. M., & Tate, W. P. (1997). Tandem translational termination signals in E coli: Are two stops better than one? Proceedings of the University of Otago Medical School. 75, (pp. 16). Dunedin: University of Otago. [Abstract]
Ross, M. F., Pel, H. J., & Tate, W. P. (1997). Cloning and expression of the yeast cytosolic and mitochondrial release factors. Proceedings of the University of Otago Medical School. 75, (pp. 25). Dunedin: University of Otago. [Abstract]
1996
Chapter in Book - Research
Tate, W. P., Dalphin, M. E., Pel, H. J., & Mannering, S. A. (1996). Decoding efficiencies of translational stop signals: a new facet of cellular regulation. In J. K. Setlow (Ed.), Genetic Engineering, Principles and Methods, Volume 18. (pp. 157-182). New York: Plenum Press.
Journal - Research Article
Tate, W. P., Poole, E., Dalphin, M. E., Major, L. L. M., Crawford, D.-J. G., & Mannering, S. A. (1996). The translational stop signal: Codon with a context, or extended factor recognition element? Biochimie, 78(11-12), 945-952.
Dalphin, M. E., Brown, C., Stockwell, P. A., & Tate, W. P. (1996). TransTerm: a database of translational signals. Nucleic Acids Research, 24, 216-218.
Jellie, A. M., Tate, W. P., & Trotman, C. N. (1996). Evolutionary history of introns in a multi-domain globin gene. Journal of Molecular Evolution, 42, 641-647.
Major, L. L., Poole, E., Dalphin, M. E., Mannering, S. A., & Tate, W. P. (1996). Is the in frame termination signal of the Escherichia coli release factor-2 frameshift site weakened by a particularly poor context? Nucleic Acids Research, 24, 2673-2678.
Tate, W. P., & Mannering, S. A. (1996). Three, four or more: the translational stop signal at length. Molecular Microbiology, 21, 213-219.
Tate, W. P., Poole, E., & Mannering, S. A. (1996). Hidden infidelities of the translational stop signal. Progress in Nucleic Acid Research & Molecular Biology, 52, 293-336.
Conference Contribution - Published proceedings: Abstract
Irvine, J., Horsfield, J. A., & Tate, W. P. (1996). Factors influencing +1 and -1 frameshifting on mammalian ribosomes. Proceedings of the University of Otago Medical School. 74(1), (pp. 8). Dunedin: University of Otago. [Abstract]
Pel, H. J., Bolotin-Fukuhara, M., & Tate, W. P. (1996). From yeast to man: A yeast model system for the study of human aminoglycoside induced deafness. Proceedings of the University of Otago Medical School. 74(3), (pp. 44). Dunedin: University of Otago. [Abstract]
1995
Journal - Research Article
Curran, J. F., Poole, E., Tate, W. P., & Gross, B. L. (1995). Selection of aminoacyl-tRNAs at sense codons: the size of the tRNA variable loop determines whether the immediate 3' nucleotide to the codon has a context effect. Nucleic Acids Research, 23, 4104-4108.
Tate, W. P. (1995). Genetic code revisited: a substratum of cellular regulation revealed. New Zealand BioScience, 3, 22-25.
Tate, W. P., Poole, E. S., Horsfield, J. A., Mannering, S. A., Brown, C. M., Moffat, J. G., Dalphin, M. E., … Major, L. L., & Wilson, D. N. (1995). Translational termination efficiency in both bacteria and mammals is regulated by the base following the stop codon. Biochemistry & Cell Biology, 73, 1095-1103. doi: 10.1139/o95-118