Accessibility Skip to Global Navigation Skip to Local Navigation Skip to Content Skip to Search Skip to Site Map Menu

Department of Biochemistry profile

Professor Tony Merriman

PositionResearch Professor
DepartmentDepartment of Biochemistry
QualificationsBSc(Hons) PhD(Otago)
Research summaryGenetic basis of gout and rheumatoid arthritis

Research

Our research group takes a genetic approach to understanding the biology of human disease. Currently we have four primary research projects:

  1. Gout – the genetic causes and how these genes interact with the environment
  2. Genetics of autoimmune disease (mainly gout and rheumatoid arthritis)
  3. A genetic relationship between rheumatoid arthritis and schizophrenia
  4. Copy number variable genes and disease

Publications

Ran, Z., Xue, X., Han, L., Terkeltaub, R., Merriman, T. R., Zhao, T., … Li, C. (2021). Decrease in serum urate level is associated with loss of visceral fat in male gout patients. Frontiers in Endocrinology, 12, 724822. doi: 10.3389/fendo.2021.724822

Burden, H. J., Adams, S., Kulatea, B., Wright-McNaughton, M. E., Sword, D., Ormsbee, J. J., … Merriman, T. R., … Krebs, J. D., Hall, R. M., … Merry, T. L. (2021). The CREBRF diabetes-protective rs373863828-A allele is associated with enhanced early insulin release in men of Māori and Pacific ancestry. Diabetologia. Advance online publication. doi: 10.1007/s00125-021-05552-x

Mandal, A. K., Leask, M. P., Estiverne, C., Choi, H. K., Merriman, T. R., & Mount, D. B. (2021). Genetic and physiological effects of insulin on human urate homeostasis. Frontiers in Physiology, 12, 713710. doi: 10.3389/fphys.2021.713710

Badii, M., Gaal, O. I., Cleophas, M. C., Klück, V., Davar, R., Habibi, E., … Stamp, L. K., … Phipps-Green, A. J., … Merriman, T. R., … Joosten, L. A. B. (2021). Urate-induced epigenetic modifications in myeloid cells. Arthritis Research & Therapy, 23, 202. doi: 10.1186/s13075-021-02580-1

Te Morenga, L., Kruimer, D., McLean, R., Sabadel, A. J. M., Van Hale, R., Tatin, X., … Mann, J., & Merriman, T. (2021). Associations between sugars intakes and urinary sugars excretion and carbon stable isotope ratios in red blood cells as biomarkers of sugars intake in a predominantly Māori population. Frontiers in Nutrition, 8, 637267. doi: 10.3389/fnut.2021.637267

Merriman, T. R., & Flynn, T. J. (2013). Molecular genetics of hyperuricaemia and gout. In eLS. Chichester: John Wiley & Sons. doi: 10.1002/9780470015902.a0025153

Chapter in Book - Research

Merriman, T. R., & McKinney, C. (2013). An update on the genetic causes of hyperuricemia and gout. In N. Dalbeth, F. Perez-Ruiz & N. Schlesinger (Eds.), Gout. (pp. 54-69). London, UK: Future Medicine. doi: 10.2217/ebo.12.256

Chapter in Book - Research

Al-Ani, A. H., Antoun, J. S., Thomson, W. M., Topless, R., Merriman, T. R., & Farella, M. (2021). Common variants of EDA are associated with non-syndromic hypodontia. Orthodontics & Craniofacial Research, 24, 155-163. doi: 10.1111/ocr.12419

Journal - Research Article

Badii, M., Gaal, O. I., Cleophas, M. C., Klück, V., Davar, R., Habibi, E., … Stamp, L. K., … Phipps-Green, A. J., … Merriman, T. R., … Joosten, L. A. B. (2021). Urate-induced epigenetic modifications in myeloid cells. Arthritis Research & Therapy, 23, 202. doi: 10.1186/s13075-021-02580-1

Journal - Research Article

Burden, H. J., Adams, S., Kulatea, B., Wright-McNaughton, M. E., Sword, D., Ormsbee, J. J., … Merriman, T. R., … Krebs, J. D., Hall, R. M., … Merry, T. L. (2021). The CREBRF diabetes-protective rs373863828-A allele is associated with enhanced early insulin release in men of Māori and Pacific ancestry. Diabetologia. Advance online publication. doi: 10.1007/s00125-021-05552-x

Journal - Research Article

Colantonio, L. D., Reynolds, R. J., Merriman, T. R., Gaffo, A., Singh, J. A., Plante, T. B., … Irvin, M. R. (2021). Higher serum urate levels are associated with an increased risk for sudden cardiac death. Journal of Rheumatology. Advance online publication. doi: 10.3899/jrheum.210139

Journal - Research Article

Dalbeth, N., Horne, A., Mihov, B., Stewart, A., Gamble, G. D., Merriman, T. R., Stamp, L. K., & Reid, I. R. (2021). Elevated urate does not alter bone turnover markers: Randomized controlled trial of inosine supplementation in post-menopausal women. Arthritis & Rheumatology. Advance online publication. doi: 10.1002/art.41691

Journal - Research Article

Gao, Q., Cheng, X., Merriman, T. R., Wang, C., Cui, L., Zhang, H., … Lu, J. (2021). Manifestations de la goutte chez 9754 patients d’un centre clinique chinois: étude observationnelle sur 10 ans. Revue du Rhumatisme. Advance online publication. doi: 10.1016/j.rhum.2021.07.002

Journal - Research Article

Gao, Q., Cheng, X., Merriman, T. R., Wang, C., Cui, L., Zhang, H., … Lu, J. (2021). Trends in the manifestations of 9754 gout patients in a Chinese clinical center: A 10-year observational study. Joint Bone Spine, 88, 105078. doi: 10.1016/j.jbspin.2020.09.010

Journal - Research Article

Ji, A., Shaukat, A., Takei, R., Bixley, M., Cadzow, M., Topless, R. K., Major, T. J., Phipps-Green, A., Merriman, M. E., … Stamp, L. K., Dalbeth, N., … Merriman, T. R. (2021). Aotearoa New Zealand Māori and Pacific population-specific gout risk variants: CLNK is a separate risk gene at the SLC2A9 locus. Journal of Rheumatology. Advance online publication. doi: 10.3899/jrheum.201684

Journal - Research Article

Li, X., Sun, W., Lu, J., He, Y., Chen, Y., Ren, W., … Merriman, T. R., & Li, C. (2021). Effects of fenofibrate therapy on renal function in primary gout patients. Rheumatology. Advance online publication. doi: 10.1093/rheumatology/keab231

Journal - Research Article

Lin, W., Farella, M., Antoun, J. S., Topless, R. K., Merriman, T. R., & Michelotti, A. (2021). Factors associated with orthodontic pain. Journal of Oral Rehabilitation. Advance online publication. doi: 10.1111/joor.13227

Journal - Research Article

Mandal, A. K., Leask, M. P., Estiverne, C., Choi, H. K., Merriman, T. R., & Mount, D. B. (2021). Genetic and physiological effects of insulin on human urate homeostasis. Frontiers in Physiology, 12, 713710. doi: 10.3389/fphys.2021.713710

Journal - Research Article

McCormick, N., O'Connor, M. J., Yokose, C., Merriman, T. R., Mount, D. B., Leong, A., & Choi, H. K. (2021). Assessing the causal relationships between insulin resistance and hyperuricemia and gout using bidirectional Mendelian randomization. Arthritis & Rheumatology. Advance online publication. doi: 10.1002/art.41779

Journal - Research Article

Narang, R. K., Gamble, G. G., Topless, R., Cadzow, M., Stamp, L. K., Merriman, T. R., & Dalbeth, N. (2021). Assessing the relationship between serum urate and urolithiasis using Mendelian randomization: An analysis of the UK Biobank. American Journal of Kidney Diseases. Advance online publication. doi: 10.1053/j.ajkd.2020.11.018

Journal - Research Article

Ran, Z., Xue, X., Han, L., Terkeltaub, R., Merriman, T. R., Zhao, T., … Li, C. (2021). Decrease in serum urate level is associated with loss of visceral fat in male gout patients. Frontiers in Endocrinology, 12, 724822. doi: 10.3389/fendo.2021.724822

Journal - Research Article

Reynolds, R. J., Irvin, M. R., Bridges, S. L., Kim, H., Merriman, T. R., Arnett, D. K., … Vazquez, A. I. (2021). Genetic correlations between traits associated with hyperuricemia, gout, and comorbidities. European Journal of Human Genetics. Advance online publication. doi: 10.1038/s41431-021-00830-z

Journal - Research Article

Shen, X., Wang, C., Liang, N., Liu, Z., Li, X., Zhu, Z.-J., … Merriman, T. R., … Yin, H. (2021). Serum metabolomics identifies dysregulated pathways and potential metabolic biomarkers for hyperuricemia and gout. Arthritis & Rheumatology. Advance online publication. doi: 10.1002/art.41733

Journal - Research Article

Takei, R., Cadzow, M., Markie, D., Bixley, M., Phipps-Green, A., Major, T. J., … Stamp, L. K., … Merriman, T. R., & Wei, W.-H. (2021). Trans-ancestral dissection of urate- and gout-associated major loci SLC2A9 and ABCG2 reveals primate-specific regulatory effects. Journal of Human Genetics, 66, 161-169. doi: 10.1038/s10038-020-0821-z

Journal - Research Article

Te Morenga, L., Kruimer, D., McLean, R., Sabadel, A. J. M., Van Hale, R., Tatin, X., … Mann, J., & Merriman, T. (2021). Associations between sugars intakes and urinary sugars excretion and carbon stable isotope ratios in red blood cells as biomarkers of sugars intake in a predominantly Māori population. Frontiers in Nutrition, 8, 637267. doi: 10.3389/fnut.2021.637267

Journal - Research Article

Topless, R. K. G., Major, T. J., Florez, J. C., Hirschhorn, J. N., Cadzow, M., Dalbeth, N., Stamp, L. K., Wilcox, P. L., … Merriman, T. R. (2021). The comparative effect of exposure to various risk factors on the risk of hyperuricaemia: Diet has a weak causal effect. Arthritis Research & Therapy, 23(1), 75. doi: 10.1186/s13075-021-02444-8

Journal - Research Article

Topless, R. K., Phipps-Green, A., Leask, M., Dalbeth, N., Stamp, L. K., Robinson, P. C., & Merriman, T. R. (2021). Gout, rheumatoid arthritis, and the risk of death related to coronavirus disease 2019: An analysis of the UK Biobank. ACR Open Rheumatology. Advance online publication. doi: 10.1002/acr2.11252

Journal - Research Article

Wiggins, G. A. R., Black, M. A., Dunbier, A., Merriman, T. R., Pearson, J. F., & Walker, L. C. (2021). Variable expression quantitative trait loci analysis of breast cancer risk variants. Scientific Reports, 11(1), 7192. doi: 10.1038/s41598-021-86690-5

Journal - Research Article

Zhang, H., Li, H., Phipps Green, A., Wang, M., Yan, F., Li, M., … Merriman, T. R., & Li, C. (2021). Association of low-level environmental exposure to cadmium and lead with gout flare using a cohort study design. Chemosphere, 280, 130648. doi: 10.1016/j.chemosphere.2021.130648

Journal - Research Article

Bodofsky, S., Merriman, T. R., Thomas, T. J., & Schlesinger, N. (2020). Advances in our understanding of gout as an auto-inflammatory disease. Seminars in Arthritis & Rheumatism, 50, 1089-1100. doi: 10.1016/j.semarthrit.2020.06.015

Journal - Research Article

Boocock, J., Leask, M., Okada, Y., Asian Genetic Epidemiology Network (AGEN) Consortium, Matsuo, H., Shi, Y., … Cadzow, M., Gosling, A. L., Major, T. J., Horsfield, J. A., … Merriman, T. R. (2020). Genomic dissection of 43 serum urate-associated loci provides multiple insights into molecular mechanisms of urate control. Human Molecular Genetics, 29(6), 923-943. doi: 10.1093/hmg/ddaa013

Journal - Research Article

Chen, H., Zhao, L., Liu, F., Chen, S., Hu, Z., Chen, L., … Merriman, T. R., & Min, J. Z. (2020). Urate in fingernail represents the deposition of urate burden in gout patients. Scientific Reports, 10, 15575. doi: 10.1038/s41598-020-72505-6

Journal - Research Article

Chung, P., Logge, W. B., Riordan, B. C., Haber, P. S., Merriman, M. E., Phipps-Green, A., Topless, R. K., Merriman, T. R., Conner, T., & Morley, K. C. (2020). Genetic polymorphisms on OPRM1, DRD2, DRD4, and COMT in young adults: Lack of association with alcohol consumption. Frontiers in Psychiatry, 11, 549429. doi: 10.3389/fpsyt.2020.549429

Journal - Research Article

Hoque, K. M., Dixon, E. E., Lewis, R. M., Allan, J., Gamble, G. D., Phipps-Green, A. J., … Stamp, L. K., Merriman, T. R., … Woodward, O. M. (2020). The ABCG2 Q141K hyperuricemia and gout associated variant illuminates the physiology of human urate excretion. Nature Communications, 11, 2767. doi: 10.1038/s41467-020-16525-w

Journal - Research Article

Klück, V., van Deuren, R. C., Cavalli, G., Shaukat, A., Arts, P., Cleophas, M. C., … Stamp, L. K., … Merriman, T. R., … Joosten, L. A. B. (2020). Rare genetic variants in interleukin-37 link this anti-inflammatory cytokine to the pathogenesis and treatment of gout. Annals of the Rheumatic Diseases, 79(4), 536-544. doi: 10.1136/annrheumdis-2019-216233

Journal - Research Article

Krishnan, M., Murphy, R., Okesene-Gafa, K. A. M., Ji, M., Thompson, J. M. D., Taylor, R. S., Merriman, T. R., … McKinlay, C. J. D. (2020). The Pacific-specific CREBRF rs373863828 allele protects against gestational diabetes mellitus in Māori and Pacific women with obesity. Diabetologia, 63(10), 2169-2176. doi: 10.1007/s00125-020-05202-8

Journal - Research Article

Leask, M. P., Sumpter, N. A., Lupi, A. S., Vazquez, A. I., Reynolds, R. J., Mount, D. B., & Merriman, T. R. (2020). The shared genetic basis of hyperuricemia, gout, and kidney function. Seminars in Nephrology, 40(6), 586-599. doi: 10.1016/j.semnephrol.2020.12.002

Journal - Research Article

Metcalfe, L. K., Krishnan, M., Turner, N., Yaghootkar, H., Merry, T. L., Dewes, O., … Stamp, L. K., Merriman, T. R., … Murphy, R. (2020). The Māori and Pacific specific CREBRF variant and adult height. International Journal of Obesity, 44, 748-752. doi: 10.1038/s41366-019-0437-6

Journal - Research Article

Morgan, B. M., Brown, A. N., Deo, N., Harrop, T. W. R., Taiaroa, G., Mace, P. D., Wilbanks, S. M., Merriman, T. R., Williams, M. J. A., & McCormick, S. P. A. (2020). Nonsynonymous SNPs in LPA homologous to plasminogen deficiency mutants represent novel null apo(a) alleles. Journal of Lipid Research, 61, 432-444. doi: 10.1194/jlr.M094540

Journal - Research Article

Nakayama, A., Nakatochi, M., Kawamura, Y., Yamamoto, K., Nakaoka, H., Shimizu, S., … Major, T. J., Merriman, T. R., … on behalf of Japan Gout Genomics Consortium (Japan Gout). (2020). Subtype-specific gout susceptibility loci and enrichment of selection pressure on ABCG2 and ALDH2 identified by subtype genome-wide meta-analyses of clinically defined gout patients. Annals of the Rheumatic Diseases, 79, 657-665. doi: 10.1136/annrheumdis-2019-216644

Journal - Research Article

Narang, R. K., Gamble, G., Phipps-Green, A. J., Topless, R., Cadzow, M., Stamp, L. K., Merriman, T. R., & Dalbeth, N. (2020). Do serum urate-associated genetic variants influence gout risk in people on diuretics? Analysis of the UK Biobank. Journal of Rheumatology, 47, 1704-1711. doi: 10.3899/jrheum.191005

Journal - Research Article

Stamp, L. K., Chapman, P. T., Barclay, M., Horne, A., Frampton, C., Merriman, T. R., Wright, D. F. B., … Dalbeth, N. (2020). Relationships between allopurinol dose, oxypurinol concentration and urate-lowering response: In search of a minimum effective oxypurinol concentration. Clinical & Translational Science, 13, 110-115. doi: 10.1111/cts.12686

Journal - Research Article

Tai, V., Narang, R. K., Gamble, G., Cadzow, M., Stamp, L. K., Merriman, T. R., & Dalbeth, N. (2020). Do serum urate-associated genetic variants differentially contribute to gout risk according to body mass index? Analysis of the UK Biobank. Arthritis & Rheumatology, 72(7), 1184-1191. doi: 10.1002/art.41219

Journal - Research Article

Wang, Z., Zhao, Y., Phipps-Green, A., Liu-Bryan, R., Ceponis, A., Boyle, D. L., … Merriman, T. R., … Terkeltaub, R. (2020). Differential DNA methylation of networked signaling, transcriptional, innate and adaptive immunity, and osteoclastogenesis genes and pathways in gout. Arthritis & Rheumatology, 72(5), 802-814. doi: 10.1002/art.41173

Journal - Research Article

Winbo, A., Earle, N., Marcondes, L., Crawford, J., Prosser, D. O., Love, D. R., Merriman, T. R., Cadzow, M., … Skinner, J. R. (2020). Genetic testing in Polynesian long QT syndrome probands reveals a lower diagnostic yield and an increased prevalence of rare variants. Heart Rhythm, 17(8), 1304-1311. doi: 10.1016/j.hrthm.2020.03.015

Journal - Research Article

Wrigley, R., Phipps-Green, A. J., Topless, R. K., Major, T. J., Cadzow, M., Riches, P., … Stamp, L. K., … Merriman, T. R. (2020). Pleiotropic effect of the ABCG2 gene in gout: Involvement in serum urate levels and progression from hyperuricemia to gout. Arthritis Research & Therapy, 22, 45. doi: 10.1186/s13075-020-2136-z

Journal - Research Article

Xue, X., Liu, Z., Li, X., Lu, J., Wang, C., Wang, X., … Merriman, T. R., … Cui, L. (2020). The efficacy and safety of citrate mixture vs sodium bicarbonate on urine alkalization in Chinese primary gout patients with benzbromarone: A prospective, randomized controlled study. Rheumatology. Advance online publication. doi: 10.1093/rheumatology/keaa668

Journal - Research Article

Zaidi, F., Narang, R. K., Phipps-Green, A., Gamble, G. G., Tausche, A.-K., So, A., … Stamp, L. K., Merriman, T. R., & Dalbeth, N. (2020). Systematic genetic analysis of early-onset gout: ABCG2 is the only associated locus. Rheumatology, 59, 2544-2549. doi: 10.1093/rheumatology/kez685

Journal - Research Article

Clark, D. W., Okada, Y., Moore, K. H. S., Mason, D., Pirastu, N., Gandin, I., … Bixley, M. J., … Merriman, T. R., … Wilson, J. F. (2019). Associations of autozygosity with a broad range of human phenotypes. Nature Communications, 10, 4957. doi: 10.1038/s41467-019-12283-6

Journal - Research Article

Jordan, D. M., Choi, H. K., Verbanck, M., Topless, R., Won, H.-H., Nadkarni, G., Merriman, T. R., & Do, R. (2019). No causal effects of serum urate levels on the risk of chronic kidney disease: A Mendelian randomization study. PLoS Medicine, 16(1), e1002725. doi: 10.1371/journal.pmed.1002725

Journal - Research Article

Kawamura, Y., Nakaoka, H., Nakayama, A., Okada, Y., Yamamoto, K., Higashino, T., … Merriman, T. R., … Matsuo, H. (2019). Genome-wide association study revealed novel loci which aggravate asymptomatic hyperuricaemia into gout. Annals of the Rheumatic Diseases, 78, 1430-1437. doi: 10.1136/annrheumdis-2019-215521

Journal - Research Article

Leask, M., Dowdle, A., Salvesen, H., Topless, R., Fadason, T., Wei, W., … Marsman, J., Antony, J., … Merriman, T. R., & Horsfield, J. A. (2019). Functional urate-associated genetic variants influence expression of lincRNAs LINC01229 and MAFTRR. Frontiers in Genetics, 9, 733. doi: 10.3389/fgene.2018.00733

Journal - Research Article

Lu, J., Dalbeth, N., Yin, H., Li, C., Merriman, T. R., & Wei, W.-H. (2019). Mouse models for human hyperuricaemia: A critical review. Nature Reviews Rheumatology, 15, 413-426. doi: 10.1038/s41584-019-0222-x

Journal - Research Article

Lu, J., Sun, M., Wu, X., Yuan, X., Liu, Z., Qu, X., … Merriman, T. R., & Li, C. (2019). Urate-lowering therapy alleviates atherosclerosis inflammatory response factors and neointimal lesions in a mouse model of induced carotid atherosclerosis. FEBS Journal, 286, 1346-1359. doi: 10.1111/febs.14768

Journal - Research Article

Murphy, R., Gamble, G. D., House, M., Pool, B., Horne, A., Merriman, T. R., & Dalbeth, N. (2019). Greater insulin response to acute fructose ingestion among Māori and Pacific people compared to European people living in Aotearoa New Zealand. Internal Medicine Journal, 49, 196-202. doi: 10.1111/imj.14135

Journal - Research Article

Vazirpanah, N., Ottria, A., van der Linden, M., Wichers, C. G. K., Schuiveling, M., van Lochem, E., Phipps-Green, A., Merriman, T., … Broen, J. C. A. (2019). mTOR inhibition by metformin impacts monosodium urate crystal-induced inflammation and cell death in gout: A prelude to a new add-on therapy? Annals of the Rheumatic Diseases, 78, 663-671. doi: 10.1136/annrheumdis-2018-214656

Journal - Research Article

Conner, T. S., McFarlane, K. G., Choukri, M., Riordan, B. C., Flett, J. A. M., Phipps-Green, A. J., Topless, R. K., Merriman, M. E., & Merriman, T. R. (2018). The oxytocin receptor gene (OXTR) variant rs53576 is not related to emotional traits or states in young adults [Brief research report]. Frontiers in Psychology, 9, 2548. doi: 10.3389/fpsyg.2018.02548

Journal - Research Article

Fanning, N., Merriman, T. R., Dalbeth, N., & Stamp, L. K. (2018). An association of smoking with serum urate and gout: A health paradox. Seminars in Arthritis & Rheumatism, 47(6), 825-842. doi: 10.1016/j.semarthrit.2017.11.004

Journal - Research Article

Fatima, T., McKinney, C., Major, T. J., Stamp, L. K., Dalbeth, N., Iverson, C., Merriman, T. R., & Miner, J. N. (2018). The relationship between ferritin and urate levels and risk of gout. Arthritis Research & Therapy, 20, 179. doi: 10.1186/s13075-018-1668-y

Journal - Research Article

Gosling, A. L., Boocock, J., Dalbeth, N., Harré Hindmarsh, J., Stamp, L. K., Stahl, E. A., … Matisoo-Smith, E. A., & Merriman, T. R. (2018). Mitochondrial genetic variation and gout in Māori and Pacific people living in Aotearoa New Zealand. Annals of the Rheumatic Diseases, 77(4), 571-578. doi: 10.1136/annrheumdis-2017-212416

Journal - Research Article

Ketharnathan, S., Leask, M., Boocock, J., Phipps-Green, A. J., Antony, J., O'Sullivan, J. M., Merriman, T. R., & Horsfield, J. A. (2018). A non-coding genetic variant maximally associated with serum urate levels is functionally linked to HNF4A-dependent PDZK1 expression. Human Molecular Genetics, 27(22), 3964-3973. doi: 10.1093/hmg/ddy295

Journal - Research Article

Krishnan, M., Major, T. J., Topless, R. K., Dewes, O., Yu, L., Thompson, J. M. D., … Stamp, L. K., … Wilcox, P., Grattan, D., … Merriman, T. R. (2018). Discordant association of the CREBRF rs373863828 A allele with increased BMI and protection from type 2 diabetes in Māori and Pacific (Polynesian) people living in Aotearoa/New Zealand. Diabetologia, 61(7), 1603-1613. doi: 10.1007/s00125-018-4623-1

Journal - Research Article

Lacey, C. J., Doudney, K., Bridgman, P. G., George, P. M., Mulder, R. T., Zarifeh, J. J., Kimber, B., Cadzow, M. J., Black, M. A., Merriman, T. R., … Pearson, J. F., Cameron, V. A., & Kennedy, M. A. (2018). Copy number variants implicate cardiac function and development pathways in earthquake-induced stress cardiomyopathy. Scientific Reports, 8, 7548. doi: 10.1038/s41598-018-25827-5

Journal - Research Article

Major, T. J., Topless, R. K., Dalbeth, N., & Merriman, T. R. (2018). Evaluation of the diet wide contribution to serum urate levels: Meta-analysis of population based cohorts. BMJ, 363, k3951. doi: 10.1136/bmj.k3951

Journal - Research Article

Manning, P. J., Grattan, D., Merriman, T., Manning, T., Williams, S., & Sutherland, W. (2018). Pharmaceutical interventions for weight-loss maintenance: No effect from cabergoline. International Journal of Obesity, 42, 1871-1879. doi: 10.1038/s41366-018-0165-3

Journal - Research Article

Pirro, M., Bianconi, V., Schiaroli, E., Francisci, D., Mannarino, M. R., Bagaglia, F., … Merriman, T., & Baldelli, F. (2018). Elevated serum uric acid levels are associated with endothelial dysfunction in HIV patients receiving highly-active antiretroviral therapy. Atherosclerosis, 272, 101-107. doi: 10.1016/j.atherosclerosis.2018.03.031

Journal - Research Article

Roberts, R. L., Wallace, M. C., Harrison, A. A., White, D., Dalbeth, N., Stamp, L. K., … Highton, J., Merriman, T. R., … Stebbings, S. M. (2018). Association of Crohn's disease-related chromosome 1q32 with ankylosing spondylitis is independent of bowel symptoms and faecal calprotectin. PeerJ, 6, e5088. doi: 10.7717/peerj.5088

Journal - Research Article

Sew Hoy, W., Antoun, J., Lin, W., Chandler, N., Merriman, T., & Farella, M. (2018). Ecological momentary assessment of pain in adolescents undergoing orthodontic treatment using a smartphone app. Seminars in Orthodontics, 24(2), 209-216. doi: 10.1053/j.sodo.2018.04.002

Journal - Research Article

Sun, M., Vazquez, A. I., Reynolds, R. J., Singh, J. A., Reeves, M., Merriman, T. R., … de los Campos, G. (2018). Untangling the complex relationships between incident gout risk, serum urate, and its comorbidities. Arthritis Research & Therapy, 20(1), 90. doi: 10.1186/s13075-018-1558-3

Journal - Research Article

Ton, K. N. T., Cree, S. L., Gronert-Sum, S. J., Merriman, T. R., Stamp, L. K., & Kennedy, M. A. (2018). Multiplexed nanopore sequencing of HLA-B locus in Māori and Pacific Island samples. Frontiers in Genetics, 9, 152. doi: 10.3389/fgene.2018.00152

Journal - Research Article

Wan Taib, W. R., Adanan, M., Yunus, N. M., Lin, T. H., Ghazali, W. S. W., Phipps-Green, A. J., & Merriman, T. R. (2018). Association of solute carrier family 2, member 9 (SLC2A9) genetic variant rs3733591 with gout in a Malay sample set. Medical Journal of Malaysia, 73(5), 307-310.

Journal - Research Article

Wright, D. F. B., Dalbeth, N., Phipps-Green, A. J., Merriman, T. R., Barclay, M. L., Drake, J., … Stamp, L. K. (2018). The impact of diuretic use and ABCG2 genotype on the predictive performance of a published allopurinol dosing tool. British Journal of Clinical Pharmacology, 84(5), 937-943. doi: 10.1111/bcp.13516

Journal - Research Article

Al-Ani, A. H., Antoun, J. S., Thomson, W. M., Merriman, T. R., & Farella, M. (2017). Maternal smoking during pregnancy is associated with offspring hypodontia. Journal of Dental Research, 96(9), 1014-1019. doi: 10.1177/0022034517711156

Journal - Research Article

Antoun, J. S., Thomson, W. M., Merriman, T. R., & Farella, M. (2017). Self-reported oral behaviour habits in hyperdivergent and normodivergent facial types. Journal of Oral Rehabilitation, 44(1), 16-21. doi: 10.1111/joor.12452

Journal - Research Article

Antoun, J. S., Thomson, W. M., Merriman, T. R., Rongo, R., & Farella, M. (2017). Impact of skeletal divergence on oral health-related quality of life and self-reported jaw function. Korean Journal of Orthodontics, 47(3), 186-194. doi: 10.4041/kjod.2017.47.3.186

Journal - Research Article

Cadzow, M., Merriman, T. R., & Dalbeth, N. (2017). Performance of gout definitions for genetic epidemiological studies: Analysis of UK Biobank. Arthritis Research & Therapy, 19(1), 181. doi: 10.1186/s13075-017-1390-1

Journal - Research Article

Cleophas, M. C., Joosten, L. A., Stamp, L. K., Dalbeth, N., Woodward, O. M., & Merriman, T. R. (2017). ABCG2 polymorphisms in gout: Insights into disease susceptibility and treatment approaches. Pharmacogenomics & Personalized Medicine, 10, 129-142. doi: 10.2147/pgpm.s105854

Journal - Research Article

Dalbeth, N., Allan, J., Gamble, G. D., Phipps-Green, A., Flynn, T. J., Mihov, B., … Stamp, L. K., & Merriman, T. R. (2017). Influence of genetic variants on renal uric acid handling in response to frusemide: An acute intervention study. RMD Open, 3(1), e000424. doi: 10.1136/rmdopen-2016-000424

Journal - Research Article

De Smit, E., Clarke, L., Sanfilippo, P. G., Merriman, T. R., Brown, M. A., Hill, C. L., … Giant Cell Arteritis Pathology Network. (2017). Geo-epidemiology of temporal artery biopsy-positive giant cell arteritis in Australia and New Zealand: Is there a seasonal influence? RMD Open, 3(2), e000531. doi: 10.1136/rmdopen-2017-000531

Journal - Research Article

He, W., Phipps-Green, A., Stamp, L. K., Merriman, T. R., & Dalbeth, N. (2017). Population-specific association between ABCG2 variants and tophaceous disease in people with gout. Arthritis Research & Therapy, 19(1), 43. doi: 10.1186/s13075-017-1254-8

Journal - Research Article

Higashino, T., Takada, T., Nakaoka, H., Toyoda, Y., Stiburkova, B., Miyata, H., … Merriman, T. R., … Matsuo, H. (2017). Multiple common and rare variants of ABCG2 cause gout. RMD Open, 3(2), e000464. doi: 10.1136/rmdopen-2017-000464

Journal - Research Article

Jones, G. T., Tromp, G., Kuivaniemi, H., Gretarsdottir, S., Baas, A. F., Giusti, B., … Phillips, L. V., Williams, M. J. A., Wei, W., … Thomson, I. A., Krysa, J., Hill, G. B., Roake, J., Merriman, T. R., … van Rij, A., … Bown, M. J. (2017). Meta-analysis of genome-wide association studies for abdominal aortic aneurysm identifies four new disease-specific risk loci. Circulation Research, 120, 341-353. doi: 10.1161/circresaha.116.308765

Journal - Research Article

Merriman, T. (2017). Genomic Influences on hyperuricemia and gout. Rheumatic Disease Clinics of North America, 43(3), 389-399. doi: 10.1016/j.rdc.2017.04.004

Journal - Research Article

Morton, S. E., O'Hare, K. J. M., Maha, J. L. K., Nicolson, M. P., Machado, L., Topless, R., Merriman, T. R., & Linscott, R. J. (2017). Testing the validity of taxonic schizotypy using genetic and environmental risk variables. Schizophrenia Bulletin, 43(3), 633-643. doi: 10.1093/schbul/sbw108

Journal - Research Article

Nakayama, A., Nakaoka, H., Yamamoto, K., Sakiyama, M., Shaukat, A., Toyoda, Y., … Stamp, L. K., … Merriman, T. R., & Matsuo, H. (2017). GWAS of clinically defined gout and subtypes identifies multiple susceptibility loci that include urate transporter genes. Annals of the Rheumatic Diseases, 76(5), 869-877. doi: 10.1136/annrheumdis-2016-209632

Journal - Research Article

Pirro, M., Mannarino, M. R., Bianconi, V., De Vuono, S., Sahebkar, A., Bagaglia, F., … Merriman, T. (2017). Uric acid and bone mineral density in postmenopausal osteoporotic women: The link lies within the fat. Osteoporosis International, 28(3), 973-981. doi: 10.1007/s00198-016-3792-3

Journal - Research Article

Rasheed, H., Stamp, L. K., Dalbeth, N., & Merriman, T. R. (2017). Interaction of the GCKR and A1CF loci with alcohol consumption to influence the risk of gout. Arthritis Research & Therapy, 19, 161. doi: 10.1186/s13075-017-1369-y

Journal - Research Article

Roberts, R. L., Wallace, M. C., Phipps-Green, A. J., Topless, R., Drake, J. M., Tan, P., … Merriman, T. R., & Stamp, L. K. (2017). ABCG2 loss-of-function polymorphism predicts poor response to allopurinol in patients with gout. Pharmacogenomics Journal, 17, 201-203. doi: 10.1038/tpj.2015.101

Journal - Research Article

Stiburkova, B., Pavelcova, K., Zavada, J., Petru, L., Simek, P., Cepek, P., … Merriman, T. R., & Pavelka, K. (2017). Functional non-synonymous variants of ABCG2 and gout risk. Rheumatology, 56(11), 1982-1992. doi: 10.1093/rheumatology/kex295

Journal - Research Article

Tanner, C., Boocock, J., Stahl, E. A., Dobbyn, A., Mandal, A. K., Cadzow, M., Phipps-Green, A. J., Topless, R. K., … Stamp, L. K., … Merriman, T. R. (2017). Population specific resequencing associates the ATP binding cassette subfamily C member 4 (ABCC4) gene with gout in New Zealand Māori and Pacific men. Arthritis & Rheumatology, 69(7), 1461-1469. doi: 10.1002/art.40110

Journal - Research Article

Todd, A. S., Walker, R. J., MacGinley, R. J., Kelly, J., Merriman, T. R., Major, T. J., & Johnson, R. J. (2017). Dietary sodium modifies serum uric acid concentrations in humans. American Journal of Hypertension, 30(12), 1196-1202. doi: 10.1093/ajh/hpx123

Journal - Research Article

Vazirpanah, N., Kienhorst, L. B. E., Van Lochem, E., Wichers, C., Rossato, M., Shiels, P. G., … Stamp, L. K., Merriman, T. R., … Broen, J. C. A. (2017). Patients with gout have short telomeres compared with healthy participants: Association of telomere length with flare frequency and cardiovascular disease in gout. Annals of the Rheumatic Diseases, 76(7), 1309-1315. doi: 10.1136/annrheumdis-2016-210538

Journal - Research Article

Wei, W.-H., Viatte, S., Merriman, T. R., Barton, A., & Worthington, J. (2017). Genotypic variability based association identifies novel non-additive loci DHCR7 and IRF4 in sero-negative rheumatoid arthritis. Scientific Reports, 7(1), 5261. doi: 10.1038/s41598-017-05447-1

Journal - Research Article

Azevedo, P. M., Merriman, T. R., Topless, R. K., Wilson, N. J., Crengle, S., & Lennon, D. R. (2016). Association study involving polymorphisms in IL-6, IL-1RA, and CTLA4 genes and rheumatic heart disease in New Zealand population of Māori and Pacific ancestry. Cytokine, 85, 201-206. doi: 10.1016/j.cyto.2016.06.029

Journal - Research Article

Cadzow, M., Merriman, T. R., Boocock, J., Dalbeth, N., Stamp, L. K., Black, M. A., … Wilcox, P. L. (2016). Lack of direct evidence for natural selection at the candidate thrifty gene locus, PPARGC1A. BMC Medical Genetics, 17, 80. doi: 10.1186/s12881-016-0341-z

Journal - Research Article

Dalbeth, N., Merriman, T. R., & Stamp, L. K. (2016). Gout. Lancet, 388(10055), 2039-2052. doi: 10.1016/S0140-6736(16)00346-9

Journal - Research Article

Fatima, T., Altaf, S., Phipps-Green, A., Topless, R., Flynn, T. J., Stamp, L. K., … Merriman, T. R. (2016). Association analysis of the beta-3 adrenergic receptor Trp64Arg (rs4994) polymorphism with urate and gout. Rheumatology International, 36(2), 255-261. doi: 10.1007/s00296-015-3370-6

Journal - Research Article

Kannangara, D. R. W., Phipps-Green, A. J., Dalbeth, N., Stamp, L. K., Williams, K. M., Graham, G. G., … Merriman, T. R. (2016). Hyperuricaemia: Contributions of urate transporter ABCG2 and the fractional renal clearance of urate. Annals of the Rheumatic Diseases, 75, 1363-1366. doi: 10.1136/annrheumdis-2015-208111

Journal - Research Article

Mitnala, S., Phipps-Green, A., Franklin, C., Horne, A., Stamp, L. K., Merriman, T. R., & Dalbeth, N. (2016). Clinical and genetic features of diuretic-associated gout: A case-control study. Rheumatology, 55(7), 1172-1176. doi: 10.1093/rheumatology/kew018

Journal - Research Article

Nguyen, H. T., Boocock, J., Merriman, T. R., & Black, M. A. (2016). SRBreak: A read-depth and split-read framework to identify breakpoints of different events inside simple copy-number variable regions. Frontiers in Genetics, 7, 160. doi: 10.3389/fgene.2016.00160

Journal - Research Article

Phipps-Green, A. J., Merriman, M. E., Topless, R., Altaf, S., Montgomery, G. W., Franklin, C., Jones, G. T., van Rij, A. M., … Stamp, L. K., … Merriman, T. R. (2016). Twenty-eight loci that influence serum urate levels: Analysis of association with gout. Annals of the Rheumatic Diseases, 75, 124-130. doi: 10.1136/annrheumdis-2014-205877

Journal - Research Article

Rasheed, H., McKinney, C., Stamp, L. K., Dalbeth, N., Topless, R. K., Day, R., … Merriman, T. R. (2016). The toll-like receptor 4 (TLR4) variant rs2149356 and risk of gout in European and Polynesian sample sets. PLoS ONE, 11(1), e0147939. doi: 10.1371/journal.pone.0147939

Journal - Research Article

Rasheed, H., Phipps-Green, A. J., Topless, R., Smith, M. D., Hill, C., Lester, S., … van Rij, A., Jones, G. T., McCormick, S. P., Harrison, A. A., Stamp, L. K., … Merriman, T. R. (2016). Replication of association of the apolipoprotein A1-C3-A4 gene cluster with the risk of gout. Rheumatology, 55(8), 1421-1430. doi: 10.1093/rheumatology/kew057

Journal - Research Article

Robinson, P. C., Choi, H. K., Do, R., & Merriman, T. R. (2016). Insight into rheumatological cause and effect through the use of Mendelian randomization. Nature Reviews Rheumatology, 12, 486-496. doi: 10.1038/nrrheum.2016.102

Journal - Research Article

van 't Hof, F. N. G., Ruigrok, Y. M., Lee, C. H., Ripke, S., Anderson, G., de Andrade, M., … Jones, G. T., … van Rij, A. M., … Vascular Research Consortium of New Zealand, including Phillips, L. V., Hill, G. B., Williams, M. J. A., Thomson, I. A., Krysa, J., Wilkins, G. T., Merriman, T. R., Lewis, D. R., … de Bakker, P. I. W. (2016). Shared genetic risk factors of intracranial, abdominal, and thoracic aneurysms. Journal of the American Heart Association, 5(7), e002603. doi: 10.1161/jaha.115.002603

Journal - Research Article

More publications...