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Department of Biochemistry profile

Dr Tanya Major

PositionPostdoctoral Fellow
DepartmentDepartment of Biochemistry
Research summaryComplex human disease genetics

Research

I work in Professor Tony Merriman’s research group in the Biochemistry Department. My research is focused on the genetic and dietary factors influencing gout, a form of arthritis that affects ~3% of the adult New Zealand population

Publications

Fatima, T., McKinney, C., Major, T. J., Stamp, L. K., Dalbeth, N., Iverson, C., Merriman, T. R., & Miner, J. N. (2018). The relationship between ferritin and urate levels and risk of gout. Arthritis Research & Therapy, 20, 179. doi: 10.1186/s13075-018-1668-y

Major, T. J., Topless, R. K., Dalbeth, N., & Merriman, T. R. (2018). Evaluation of the diet wide contribution to serum urate levels: Meta-analysis of population based cohorts. BMJ, 363, k3951. doi: 10.1136/bmj.k3951

Krishnan, M., Major, T. J., Topless, R. K., Dewes, O., Yu, L., Thompson, J. M. D., … Stamp, L. K., … Wilcox, P., Grattan, D., … Merriman, T. R. (2018). Discordant association of the CREBRF rs373863828 A allele with increased BMI and protection from type 2 diabetes in Māori and Pacific (Polynesian) people living in Aotearoa/New Zealand. Diabetologia. Advance online publication. doi: 10.1007/s00125-018-4623-1

Major, T. J., Krishnan, M., Topless, R. K., Dewes, O., Thompson, J., de Zoysa, J., Stamp, L. K., … Wilcox, P., Grattan, D., … Merriman, T. R. (2018). Re: "Widespread prevalence of a CREBRF variant among Māori and Pacific children is associated with weight and height in early childhood". International Journal of Obesity & Related Metabolic Disorders, 42, 1389-1391. doi: 10.1038/s41366-018-0025-1

Major, T. J., Dalbeth, N., Stahl, E. A., & Merriman, T. R. (2018). An update on the genetics of hyperuricaemia and gout. Nature Reviews Rheumatology. Advance online publication. doi: 10.1038/s41584-018-0004-x

Chapter in Book - Research

Merriman, T. R., & Flynn, T. J. (2013). Molecular genetics of hyperuricaemia and gout. In eLS. Chichester: John Wiley & Sons. doi: 10.1002/9780470015902.a0025153

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Journal - Research Article

Fatima, T., McKinney, C., Major, T. J., Stamp, L. K., Dalbeth, N., Iverson, C., Merriman, T. R., & Miner, J. N. (2018). The relationship between ferritin and urate levels and risk of gout. Arthritis Research & Therapy, 20, 179. doi: 10.1186/s13075-018-1668-y

Krishnan, M., Major, T. J., Topless, R. K., Dewes, O., Yu, L., Thompson, J. M. D., … Stamp, L. K., … Wilcox, P., Grattan, D., … Merriman, T. R. (2018). Discordant association of the CREBRF rs373863828 A allele with increased BMI and protection from type 2 diabetes in Māori and Pacific (Polynesian) people living in Aotearoa/New Zealand. Diabetologia. Advance online publication. doi: 10.1007/s00125-018-4623-1

Major, T. J., Topless, R. K., Dalbeth, N., & Merriman, T. R. (2018). Evaluation of the diet wide contribution to serum urate levels: Meta-analysis of population based cohorts. BMJ, 363, k3951. doi: 10.1136/bmj.k3951

Wassenaar, M., & Major, T. (2017). Ties that bind. Junctures, 18, 48-52.

Dalbeth, N., Allan, J., Gamble, G. D., Phipps-Green, A., Flynn, T. J., Mihov, B., … Stamp, L. K., & Merriman, T. R. (2017). Influence of genetic variants on renal uric acid handling in response to frusemide: An acute intervention study. RMD Open, 3(1), e000424. doi: 10.1136/rmdopen-2016-000424

Todd, A. S., Walker, R. J., MacGinley, R. J., Kelly, J., Merriman, T. R., Major, T. J., & Johnson, R. J. (2017). Dietary sodium modifies serum uric acid concentrations in humans. American Journal of Hypertension, 30(12), 1196-1202. doi: 10.1093/ajh/hpx123

Fatima, T., Altaf, S., Phipps-Green, A., Topless, R., Flynn, T. J., Stamp, L. K., … Merriman, T. R. (2016). Association analysis of the beta-3 adrenergic receptor Trp64Arg (rs4994) polymorphism with urate and gout. Rheumatology International, 36(2), 255-261. doi: 10.1007/s00296-015-3370-6

Flynn, T., Signal, B., Johnson, S. L., & Gemmell, N. J. (2016). Mitochondrial genome diversity among six laboratory zebrafish (Danio rerio) strains. Mitochondrial DNA, 27(6), 4364-4371. doi: 10.3109/19401736.2015.1089536

Topless, R. K., Flynn, T. J., Cadzow, M., Stamp, L. K., Dalbeth, N., Black, M. A., & Merriman, T. R. (2015). Association of SLC2A9 genotype with phenotypic variability of serum urate in pre-menopausal women. Frontiers in Genetics, 6, 313. doi: 10.3389/fgene.2015.00313

Flynn, T. J., Cadzow, M., Dalbeth, N., Jones, P. B., Stamp, L. K., Harré Hindmarsh, J., Todd, A. S., Walker, R. J., Topless, R., & Merriman, T. R. (2015). Positive association of tomato consumption with serum urate: Support for tomato consumption as an anecdotal trigger of gout flares. BMC Musculoskeletal Disorders, 16, 196. doi: 10.1186/s12891-015-0661-8

Dalbeth, N., Topless, R., Flynn, T., Cadzow, M., Bolland, M. J., & Merriman, T. R. (2015). Mendelian randomization analysis to examine for a causal effect of urate on bone mineral density. Journal of Bone & Mineral Research, 30(6), 985-991. doi: 10.1002/jbmr.2434

Hughes, K., Flynn, T., de Zoysa, J., Dalbeth, N., & Merriman, T. R. (2014). Mendelian randomization analysis associates increased serum urate, due to genetic variation in uric acid transporters, with improved renal function. Kidney International, 85(2), 344-351. doi: 10.1038/ki.2013.353

Rasheed, H., Hughes, K., Flynn, T. J., & Merriman, T. R. (2014). Mendelian randomization provides no evidence for a causal role of serum urate in increasing serum triglyceride levels. Circulation: Cardiovascular Genetics, 7, 830-837. doi: 10.1161/circgenetics.114.000556

Flynn, T. J., Phipps-Green, A., Hollis-Moffatt, J. E., Merriman, M. E., Topless, R., Montgomery, G., … Stamp, L. K., … Merriman, T. R. (2013). Association analysis of the SLC22A11 (organic anion transporter 4) and SLC22A12 (urate transporter 1) urate transporter locus with gout in New Zealand case-control sample sets reveals multiple ancestral-specific effects. Arthritis Research & Therapy, 15, R220. doi: 10.1186/ar4417

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Journal - Research Other

Major, T. J., Krishnan, M., Topless, R. K., Dewes, O., Thompson, J., de Zoysa, J., Stamp, L. K., … Wilcox, P., Grattan, D., … Merriman, T. R. (2018). Re: "Widespread prevalence of a CREBRF variant among Māori and Pacific children is associated with weight and height in early childhood". International Journal of Obesity & Related Metabolic Disorders, 42, 1389-1391. doi: 10.1038/s41366-018-0025-1

Major, T. J., Dalbeth, N., Stahl, E. A., & Merriman, T. R. (2018). An update on the genetics of hyperuricaemia and gout. Nature Reviews Rheumatology. Advance online publication. doi: 10.1038/s41584-018-0004-x

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