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Department of Biochemistry profile

Dr Tanya Major

PositionPostdoctoral Fellow
DepartmentDepartment of Biochemistry
Research summaryComplex human disease genetics

Research

I work in Professor Tony Merriman’s research group in the Biochemistry Department. My research is focused on the genetic and dietary factors influencing gout, a form of arthritis that affects ~3% of the adult New Zealand population

Publications

Emde, A.-K., Phipps-Green, A., Cadzow, M., Gallagher, C. S., Major, T. J., Merriman, M. E., Topless, R. K., Takei, R., Dalbeth, N., … Stamp, L. K., … Wilcox, P. L., … Merriman, T. R., & Castel, S. E. (2021). Mid-pass whole genome sequencing enables biomedical genetic studies of diverse populations. BMC Genomics, 22, 666. doi: 10.1186/s12864-021-07949-9

Wolyncewicz, B., Major, T. J., Delahunt, B., & Thunders, M. (2021). The epigenome: Key to understanding and predicting gout flares. Pathology. Advance online publication. doi: 10.1016/j.pathol.2021.09.001

Ji, A., Shaukat, A., Takei, R., Bixley, M., Cadzow, M., Topless, R. K., Major, T. J., Phipps-Green, A., Merriman, M. E., … Stamp, L. K., Dalbeth, N., … Merriman, T. R. (2021). Aotearoa New Zealand Māori and Pacific population-specific gout risk variants: CLNK is a separate risk gene at the SLC2A9 locus. Journal of Rheumatology. Advance online publication. doi: 10.3899/jrheum.201684

Topless, R. K. G., Major, T. J., Florez, J. C., Hirschhorn, J. N., Cadzow, M., Dalbeth, N., Stamp, L. K., Wilcox, P. L., … Merriman, T. R. (2021). The comparative effect of exposure to various risk factors on the risk of hyperuricaemia: Diet has a weak causal effect. Arthritis Research & Therapy, 23(1), 75. doi: 10.1186/s13075-021-02444-8

Takei, R., Cadzow, M., Markie, D., Bixley, M., Phipps-Green, A., Major, T. J., … Stamp, L. K., … Merriman, T. R., & Wei, W.-H. (2021). Trans-ancestral dissection of urate- and gout-associated major loci SLC2A9 and ABCG2 reveals primate-specific regulatory effects. Journal of Human Genetics, 66, 161-169. doi: 10.1038/s10038-020-0821-z

Merriman, T. R., & Flynn, T. J. (2013). Molecular genetics of hyperuricaemia and gout. In eLS. Chichester: John Wiley & Sons. doi: 10.1002/9780470015902.a0025153

Chapter in Book - Research

Emde, A.-K., Phipps-Green, A., Cadzow, M., Gallagher, C. S., Major, T. J., Merriman, M. E., Topless, R. K., Takei, R., Dalbeth, N., … Stamp, L. K., … Wilcox, P. L., … Merriman, T. R., & Castel, S. E. (2021). Mid-pass whole genome sequencing enables biomedical genetic studies of diverse populations. BMC Genomics, 22, 666. doi: 10.1186/s12864-021-07949-9

Journal - Research Article

Ji, A., Shaukat, A., Takei, R., Bixley, M., Cadzow, M., Topless, R. K., Major, T. J., Phipps-Green, A., Merriman, M. E., … Stamp, L. K., Dalbeth, N., … Merriman, T. R. (2021). Aotearoa New Zealand Māori and Pacific population-specific gout risk variants: CLNK is a separate risk gene at the SLC2A9 locus. Journal of Rheumatology. Advance online publication. doi: 10.3899/jrheum.201684

Journal - Research Article

Takei, R., Cadzow, M., Markie, D., Bixley, M., Phipps-Green, A., Major, T. J., … Stamp, L. K., … Merriman, T. R., & Wei, W.-H. (2021). Trans-ancestral dissection of urate- and gout-associated major loci SLC2A9 and ABCG2 reveals primate-specific regulatory effects. Journal of Human Genetics, 66, 161-169. doi: 10.1038/s10038-020-0821-z

Journal - Research Article

Topless, R. K. G., Major, T. J., Florez, J. C., Hirschhorn, J. N., Cadzow, M., Dalbeth, N., Stamp, L. K., Wilcox, P. L., … Merriman, T. R. (2021). The comparative effect of exposure to various risk factors on the risk of hyperuricaemia: Diet has a weak causal effect. Arthritis Research & Therapy, 23(1), 75. doi: 10.1186/s13075-021-02444-8

Journal - Research Article

Boocock, J., Leask, M., Okada, Y., Asian Genetic Epidemiology Network (AGEN) Consortium, Matsuo, H., Shi, Y., … Cadzow, M., Gosling, A. L., Major, T. J., Horsfield, J. A., … Merriman, T. R. (2020). Genomic dissection of 43 serum urate-associated loci provides multiple insights into molecular mechanisms of urate control. Human Molecular Genetics, 29(6), 923-943. doi: 10.1093/hmg/ddaa013

Journal - Research Article

Nakayama, A., Nakatochi, M., Kawamura, Y., Yamamoto, K., Nakaoka, H., Shimizu, S., … Major, T. J., Merriman, T. R., … on behalf of Japan Gout Genomics Consortium (Japan Gout). (2020). Subtype-specific gout susceptibility loci and enrichment of selection pressure on ABCG2 and ALDH2 identified by subtype genome-wide meta-analyses of clinically defined gout patients. Annals of the Rheumatic Diseases, 79, 657-665. doi: 10.1136/annrheumdis-2019-216644

Journal - Research Article

Wrigley, R., Phipps-Green, A. J., Topless, R. K., Major, T. J., Cadzow, M., Riches, P., … Stamp, L. K., … Merriman, T. R. (2020). Pleiotropic effect of the ABCG2 gene in gout: Involvement in serum urate levels and progression from hyperuricemia to gout. Arthritis Research & Therapy, 22, 45. doi: 10.1186/s13075-020-2136-z

Journal - Research Article

Fatima, T., McKinney, C., Major, T. J., Stamp, L. K., Dalbeth, N., Iverson, C., Merriman, T. R., & Miner, J. N. (2018). The relationship between ferritin and urate levels and risk of gout. Arthritis Research & Therapy, 20, 179. doi: 10.1186/s13075-018-1668-y

Journal - Research Article

Krishnan, M., Major, T. J., Topless, R. K., Dewes, O., Yu, L., Thompson, J. M. D., … Stamp, L. K., … Wilcox, P., Grattan, D., … Merriman, T. R. (2018). Discordant association of the CREBRF rs373863828 A allele with increased BMI and protection from type 2 diabetes in Māori and Pacific (Polynesian) people living in Aotearoa/New Zealand. Diabetologia, 61(7), 1603-1613. doi: 10.1007/s00125-018-4623-1

Journal - Research Article

Major, T. J., Topless, R. K., Dalbeth, N., & Merriman, T. R. (2018). Evaluation of the diet wide contribution to serum urate levels: Meta-analysis of population based cohorts. BMJ, 363, k3951. doi: 10.1136/bmj.k3951

Journal - Research Article

Dalbeth, N., Allan, J., Gamble, G. D., Phipps-Green, A., Flynn, T. J., Mihov, B., … Stamp, L. K., & Merriman, T. R. (2017). Influence of genetic variants on renal uric acid handling in response to frusemide: An acute intervention study. RMD Open, 3(1), e000424. doi: 10.1136/rmdopen-2016-000424

Journal - Research Article

Todd, A. S., Walker, R. J., MacGinley, R. J., Kelly, J., Merriman, T. R., Major, T. J., & Johnson, R. J. (2017). Dietary sodium modifies serum uric acid concentrations in humans. American Journal of Hypertension, 30(12), 1196-1202. doi: 10.1093/ajh/hpx123

Journal - Research Article

Wassenaar, M., & Major, T. (2017). Ties that bind. Junctures, 18, 48-52.

Journal - Research Article

Fatima, T., Altaf, S., Phipps-Green, A., Topless, R., Flynn, T. J., Stamp, L. K., … Merriman, T. R. (2016). Association analysis of the beta-3 adrenergic receptor Trp64Arg (rs4994) polymorphism with urate and gout. Rheumatology International, 36(2), 255-261. doi: 10.1007/s00296-015-3370-6

Journal - Research Article

Flynn, T., Signal, B., Johnson, S. L., & Gemmell, N. J. (2016). Mitochondrial genome diversity among six laboratory zebrafish (Danio rerio) strains. Mitochondrial DNA, 27(6), 4364-4371. doi: 10.3109/19401736.2015.1089536

Journal - Research Article

Dalbeth, N., Topless, R., Flynn, T., Cadzow, M., Bolland, M. J., & Merriman, T. R. (2015). Mendelian randomization analysis to examine for a causal effect of urate on bone mineral density. Journal of Bone & Mineral Research, 30(6), 985-991. doi: 10.1002/jbmr.2434

Journal - Research Article

Flynn, T. J., Cadzow, M., Dalbeth, N., Jones, P. B., Stamp, L. K., Harré Hindmarsh, J., Todd, A. S., Walker, R. J., Topless, R., & Merriman, T. R. (2015). Positive association of tomato consumption with serum urate: Support for tomato consumption as an anecdotal trigger of gout flares. BMC Musculoskeletal Disorders, 16, 196. doi: 10.1186/s12891-015-0661-8

Journal - Research Article

Topless, R. K., Flynn, T. J., Cadzow, M., Stamp, L. K., Dalbeth, N., Black, M. A., & Merriman, T. R. (2015). Association of SLC2A9 genotype with phenotypic variability of serum urate in pre-menopausal women. Frontiers in Genetics, 6, 313. doi: 10.3389/fgene.2015.00313

Journal - Research Article

Hughes, K., Flynn, T., de Zoysa, J., Dalbeth, N., & Merriman, T. R. (2014). Mendelian randomization analysis associates increased serum urate, due to genetic variation in uric acid transporters, with improved renal function. Kidney International, 85(2), 344-351. doi: 10.1038/ki.2013.353

Journal - Research Article

Rasheed, H., Hughes, K., Flynn, T. J., & Merriman, T. R. (2014). Mendelian randomization provides no evidence for a causal role of serum urate in increasing serum triglyceride levels. Circulation: Cardiovascular Genetics, 7, 830-837. doi: 10.1161/circgenetics.114.000556

Journal - Research Article

Flynn, T. J., Phipps-Green, A., Hollis-Moffatt, J. E., Merriman, M. E., Topless, R., Montgomery, G., … Stamp, L. K., … Merriman, T. R. (2013). Association analysis of the SLC22A11 (organic anion transporter 4) and SLC22A12 (urate transporter 1) urate transporter locus with gout in New Zealand case-control sample sets reveals multiple ancestral-specific effects. Arthritis Research & Therapy, 15, R220. doi: 10.1186/ar4417

Journal - Research Article

Wolyncewicz, B., Major, T. J., Delahunt, B., & Thunders, M. (2021). The epigenome: Key to understanding and predicting gout flares. Pathology. Advance online publication. doi: 10.1016/j.pathol.2021.09.001

Journal - Research Other

Major, T. J., Dalbeth, N., Stahl, E. A., & Merriman, T. R. (2018). An update on the genetics of hyperuricaemia and gout. Nature Reviews Rheumatology, 14, 341-353. doi: 10.1038/s41584-018-0004-x

Journal - Research Other

Major, T. J., Krishnan, M., Topless, R. K., Dewes, O., Thompson, J., de Zoysa, J., Stamp, L. K., … Wilcox, P., Grattan, D., … Merriman, T. R. (2018). Re: "Widespread prevalence of a CREBRF variant among Māori and Pacific children is associated with weight and height in early childhood". International Journal of Obesity & Related Metabolic Disorders, 42, 1389-1391. doi: 10.1038/s41366-018-0025-1

Journal - Research Other

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