Accessibility Skip to Global Navigation Skip to Local Navigation Skip to Content Skip to Search Skip to Site Map Menu

Department of Biochemistry profile

Dr Lyvianne Decourtye

PositionPostdoctoral Fellow
DepartmentDepartment of Biochemistry
Research summaryDevelopmental biology and genetics

Research

I joined the Cancer Genetics Laboratory in Professor Parry Guilford team in September 2019. I am working on the development of chemoprevention and/or treatment for hereditary and sporadic diffuse gastric cancer, specifically cancer lacking E-cadherin expression. I am particularly focused on the impact of HDAC inhibitors on gastric and mammary cancer carrying CDH1 mutation, using 2D cellular culture and organoids.

Publications

Bougen-Zhukov, N., Decourtye-Espiard, L., Mitchell, W., Redpath, K., Perkinson, J., Godwin, T., Black, M. A., & Guilford, P. (2022). E-cadherin-deficient cells are sensitive to the multikinase inhibitor dasatinib. Cancers, 14, 1609. doi: 10.3390/cancers14071609

Decourtye, L., McCallum-Loudeac, J. A., Zellhuber-McMillan, S., Young, E., Sircombe, K. J., & Wilson, M. J. (2022). Characterization of a novel Lbx1 mouse loss of function strain. Differentiation, 123, 30-41. doi: 10.1016/j.diff.2021.12.001

Brew, T., Bougen-Zhukov, N., Mitchell, W., Decourtye, L., Schulpen, E., Nouri, Y., Godwin, T., & Guilford, P. (2021). Loss of E-cadherin leads to druggable vulnerabilities in sphingolipid metabolism and vesicle trafficking. Cancers, 14(1), 102. doi: 10.3390/ cancers14010102

Decourtye-Espiard, L., Bougen-Zhukov, N., Godwin, T., Brew, T., Schulpen, E., Black, M. A., & Guilford, P. (2021). E-cadherin-deficient epithelial cells are sensitive to HDAC inhibitors. Cancers, 14(1), 175. doi: 10.3390/ cancers14010102

Decourtye, L., Clemessy, M., Mire, E., Ledent, T., Périn, L., Robinson, I. C., … Kappeler, L. (2018). Impact of insulin on primary arcuate neurons culture is dependent on early-postnatal nutritional status and neuronal subpopulation. PLoS ONE, 13(2), e0193196. doi: 10.1371/journal. pone.0193196

Bougen-Zhukov, N., Decourtye-Espiard, L., Mitchell, W., Redpath, K., Perkinson, J., Godwin, T., Black, M. A., & Guilford, P. (2022). E-cadherin-deficient cells are sensitive to the multikinase inhibitor dasatinib. Cancers, 14, 1609. doi: 10.3390/cancers14071609

Journal - Research Article

Decourtye, L., McCallum-Loudeac, J. A., Zellhuber-McMillan, S., Young, E., Sircombe, K. J., & Wilson, M. J. (2022). Characterization of a novel Lbx1 mouse loss of function strain. Differentiation, 123, 30-41. doi: 10.1016/j.diff.2021.12.001

Journal - Research Article

Brew, T., Bougen-Zhukov, N., Mitchell, W., Decourtye, L., Schulpen, E., Nouri, Y., Godwin, T., & Guilford, P. (2021). Loss of E-cadherin leads to druggable vulnerabilities in sphingolipid metabolism and vesicle trafficking. Cancers, 14(1), 102. doi: 10.3390/ cancers14010102

Journal - Research Article

Decourtye-Espiard, L., Bougen-Zhukov, N., Godwin, T., Brew, T., Schulpen, E., Black, M. A., & Guilford, P. (2021). E-cadherin-deficient epithelial cells are sensitive to HDAC inhibitors. Cancers, 14(1), 175. doi: 10.3390/ cancers14010102

Journal - Research Article

Decourtye, L., Clemessy, M., Mire, E., Ledent, T., Périn, L., Robinson, I. C., … Kappeler, L. (2018). Impact of insulin on primary arcuate neurons culture is dependent on early-postnatal nutritional status and neuronal subpopulation. PLoS ONE, 13(2), e0193196. doi: 10.1371/journal. pone.0193196

Journal - Research Article

Decourtye, L., Mire, E., Clemessy, M., Heurtier, V., Ledent, T., Robinson, I. C., … Kappeler, L. (2017). IGF-1 induces GHRH neuronal axon elongation during early postnatal life in mice. PLoS ONE, 12(1), e0170083. doi: 10.1371/journal.pone.0170083

Journal - Research Article

Dumeige, L., Storey, C., Decourtye, L., Nehlich, M., Lhadj, C., Viengchareun, S., … Martinerie, L. (2017). Sex-specificity of mineralocorticoid target gene expression during renal development, and long-term consequences. International Journal of Molecular Sciences, 18(2), 457. doi: 10.3390/ijms18020457

Journal - Research Article

Kappeler, L., Clemessy, M., Saget, S., Decourtye, L., & Le Bouc, Y. (2017). Regulation of growth: Epigenetic mechanisms? [Régulation de la croissance: des mécanismes épigénétiques?]. Annales d'Endocrinologie, 78(2), 92-95. doi: 10.1016/j.ando.2017.04.004

Journal - Research Article

Lecoq, A.-L., Zizzari, P., Hage, M., Decourtye, L., Adam, C., Viengchareun, S., … Kamenický, P. (2016). Mild pituitary phenotype in 3- and 12-month-old Aip-deficient male mice. Journal of Endocrinology, 231(1), 59-69. doi: 10.1530/JOE-16-0190

Journal - Research Article

More publications...