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Department of Biochemistry profile

Dr Kate Powell

PositionPostdoctoral Fellow
DepartmentDepartment of Biochemistry
QualificationsPhD

Research

Originally from the United States, I received my PhD in Cancer Biology from Wayne State University School of Medicine in Detroit, Michigan. Following this, I studied cancer immunotherapy at Moffitt Cancer Center in Tampa, Florida. I joined the Cancer Genetics Laboratory in 2017 to study with Dr Anita Dunbier. Our research is focused on investigating the efficacy of immunotherapy treatments in oestrogen receptor-positive breast cancer, and to identify possible biomarkers that will help predict response to immunotherapies. Our main goal is to use immunotherapy treatments to redirect the body’s cytotoxic and killer immune cells towards an anti-tumour response while simultaneously inhibiting suppressive immune cells. In addition, we aim to determine if tumours that harbour a higher mutational burden will respond better to these treatments. Some of the immunotherapies we are studying include whole cell cancer vaccines and checkpoint inhibitors anti-CTLA-4 and anti-PD-1.

Publications

Powell, K., Semaan, L., Conley-LaComb, M. K., Asangani, I., Wu, Y.-M., Ginsburg, K. B., … Chinni, S. R. (2015). ERG/AKR1C3/AR constitutes a feed-forward loop for AR signaling in prostate cancer cells. Clinical Cancer Research, 21(11), 2569-2579. doi: 10.1158/1078-0432.CCR-14-2352

Singareddy, R., Semaan, L., Conley-LaComb, M. K., St John, J., Powell, K., Iyer, M., … Chinni, S. R. (2013). Transcriptional regulation of CXCR4 in prostate cancer: Significance of TMPRSS2-ERG fusions. Molecular Cancer Research, 11(11), 1349-1361. doi: 10.1158/1541-7786.MCR-12-0705

Herroon, M. K., Rajagurubandara, E., Hardaway, A. L., Powell, K., Turchick, A., Feldmann, D., & Podgorski, I. (2013). Bone marrow adipocytes promote tumor growth in bone via FABP4-dependent mechanisms. Oncotarget, 4(11), 2108-2123. doi: 10.18632/oncotarget.1482

Mueller, K. L., Powell, K., Madden, J. M., Eblen, S. T., & Boerner, J. L. (2012). EGFR tyrosine 845 phosphorylation-dependent proliferation and transformation of breast cancer cells require activation of p38 MAPK. Translational Oncology, 5(5), 327-334. doi: 10.1593/tlo.12163

St John, J., Powell, K., Conley-LaComb, M. K., & Chinni, S. R. (2012). TMPRSS2-ERG fusion gene expression in prostate tumor cells and its clinical and biological significance in prostate cancer progression. Journal of Cancer Science & Therapy, 4(4), 94-101. doi: 10.4172/1948-5956.1000119

Journal - Research Article

Powell, K., Semaan, L., Conley-LaComb, M. K., Asangani, I., Wu, Y.-M., Ginsburg, K. B., … Chinni, S. R. (2015). ERG/AKR1C3/AR constitutes a feed-forward loop for AR signaling in prostate cancer cells. Clinical Cancer Research, 21(11), 2569-2579. doi: 10.1158/1078-0432.CCR-14-2352

Singareddy, R., Semaan, L., Conley-LaComb, M. K., St John, J., Powell, K., Iyer, M., … Chinni, S. R. (2013). Transcriptional regulation of CXCR4 in prostate cancer: Significance of TMPRSS2-ERG fusions. Molecular Cancer Research, 11(11), 1349-1361. doi: 10.1158/1541-7786.MCR-12-0705

Herroon, M. K., Rajagurubandara, E., Hardaway, A. L., Powell, K., Turchick, A., Feldmann, D., & Podgorski, I. (2013). Bone marrow adipocytes promote tumor growth in bone via FABP4-dependent mechanisms. Oncotarget, 4(11), 2108-2123. doi: 10.18632/oncotarget.1482

Mueller, K. L., Powell, K., Madden, J. M., Eblen, S. T., & Boerner, J. L. (2012). EGFR tyrosine 845 phosphorylation-dependent proliferation and transformation of breast cancer cells require activation of p38 MAPK. Translational Oncology, 5(5), 327-334. doi: 10.1593/tlo.12163

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Journal - Research Other

St John, J., Powell, K., Conley-LaComb, M. K., & Chinni, S. R. (2012). TMPRSS2-ERG fusion gene expression in prostate tumor cells and its clinical and biological significance in prostate cancer progression. Journal of Cancer Science & Therapy, 4(4), 94-101. doi: 10.4172/1948-5956.1000119

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