Accessibility Skip to Global Navigation Skip to Local Navigation Skip to Content Skip to Search Skip to Site Map Menu

Department of Biochemistry profile

Dr Soledad Perez Santangelo

PositionResearch Fellow
DepartmentDepartment of Biochemistry
Research summaryPlant gene regulation


Legume crops such as peas, beans, lentils, and lucerne are an essential source of protein for both humans and livestock. Since climate change is altering the geographical range where crop plants can be grown, we need to understand how genetic variations in these plants allow them to grow in different places.

Our laboratory focuses on discovering and studying these genes in the model legume Medicago truncatula, specifically looking at the master regulator - the circadian clock. Our research will help produce legume varieties specifically tailored for local regions and conditions.

Leaf movement video

Timelapse of leaf growth.

Circadian clock

Circadian clock

<i>Medicago truncatula</i> plant

Medicago truncatula plant

Output data of leaf movement for 2 representative plants

Output data of leaf movement for 2 representative plants

On-Going projects:

Marsden Fast Start Fund:

Adjusting the clock: How naturally occurring variation in circadian clock genes maximises plant growth and fitness in different environments.

BMS Bequest Fund:

How a naturally longer circadian period modulates the development of the legume plant Medicago


Perez-Santángelo, S., Mancini, E., Francey, L. J., Schlaen, R. G., Chernomoretz, A., Hogenesch, J. B., & Yanovsky, M. J. (2014). Role for LSM genes in the regulation of circadian rhythms. PNAS, 111(42), 15166-15171. doi: 10.1073/pnas.1409791111

Schlaen, R. G., Mancini, E., Sanchez, S. E., Perez-Santángelo, S., Rugnone, M. L., Simpson, C. G., … Yanovsky, M. J. (2015). The spliceosome assembly factor GEMIN2 attenuates the effects of temperature on alternative splicing and circadian rhythms. PNAS, 112(30), 9382-9387. doi: 10.1073/pnas.1504541112

Perez-Santángelo, S., Schlaen, R. G., & Yanovsky, M. J. (2013). Genomic analysis reveals novel connections between alternative splicing and circadian regulatory networks. Briefings in Functional Genomics, 12(1), 13-24. doi: 10.1093/bfgp/els052