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Department of Biochemistry profile

Emeritus Professor Warren Tate

PositionEmeritus Professor
DepartmentDepartment of Biochemistry
QualificationsMSc (Well) PhD (Otago) FNZIC FRSNZ MA-PIMBN
Research summaryProtein synthesis, genetic recoding, memory mechanisms, infectious disease

Research

My laboratory has had a long-term interest in understanding protein synthesis and, in particular, decoding and recoding mechanisms on the ribosome at stop signals. Important recent investigations have focused on how the decoding release factor as a molecular mimic of tRNA recognises the individual bases of the stop signal, and how alternative genetic codes like those found in vertebrate mitochondria can be accommodated into an integrated model. This has been helped considerably by the 2008 atomic resolution structures of the ribosome:factor complex.


The decoding release factor interacting with stop codon UAG.

From our chance discovery in the 1980s of recoding (frameshifting; a cellular mechanism for regulating gene expression during protein synthesis), we developed an interest in the frameshift mechanism of HIV-1 as a potential site of vulnerability in the virus. Now, our interest has extended to the only gene in the animal kingdom known to use this mechanism, human gene PEG10. The gene was relatively recently acquired as a retroelement insertion and has undergone molecular domestication to become expressed in placenta and amniotic membranes but not, as we have shown, in adult tissues. Significantly, it uses the same frameshifting expression strategy as HIV-1 to produce two proteins.


Morris water maze: testing memory in a rat.

A second long-standing interest has been the molecular mechanisms of mammalian memory and how they are impaired in human neurological diseases, particularly Alzheimer's. These investigations have focused on the molecular changes in neurons of the hippocampus when they receive electrical signals within in vivo models and more recently included behavioural studies. We have developed a simple recombinant production and purification strategy for a processed brain protein, secreted amyloid precursor protein-alpha, a protein that is neuroprotective but whose concentration is lowered in Alzheimer's patients. Remarkably, we have shown our recombinant protein alone can restore memory to rats impaired by drug treatment, not only in their electrophysiological responses but also in trials to determine memory of learned spatial tasks. We believe this external secreted protein is a signalling molecule that can switch on a signalling pathway and activate a range of gene responses to protect and enhance memory; an activity that may be critical as a counterbalance in the development of Alzheimer?s disease.

Professor Tate also researches the mechanisms underlying chronic fatigue syndrome

Publications

Peppercorn, K., Kleffmann, T., Hughes, S. M., & Tate, W. P. (2023). Secreted amyloid precursor protein alpha (sAPPα) regulates the cellular proteome and secretome of mouse primary astrocytes. International Journal of Molecular Sciences, 24, 7165. doi: 10.3390/ijms24087165

Tate, W. P., Walker, M. O. M., Peppercorn, K., Blair, A. L. H., & Edgar, C. D. (2023). Towards a better understanding of the complexities of myalgic encephalomyelitis/chronic fatigue syndrome and long COVID [Review]. International Journal of Molecular Sciences, 24(6), 5124. doi: 10.3390/ijms24065124

Peppercorn, K., Kleffmann, T., Jones, O., Hughes, S., & Tate, W. (2022). Secreted amyloid precursor protein alpha, a neuroprotective protein in the brain has widespread effects on the transcriptome and proteome of human inducible pluripotent stem cell-derived glutamatergic neurons related to memory mechanisms. Frontiers in Neuroscience, 16, 858524. doi: 10.3389/fnins.2022.858524

Helliwell, A. M., Stockwell, P. A., Edgar, C. D., Chatterjee, A., & Tate, W. P. (2022). Dynamic epigenetic changes during a relapse and recovery cycle in myalgic encephalomyelitis/chronic fatigue ayndrome. International Journal of Molecular Sciences, 23(19), 11852. doi: 10.3390/ijms231911852

Walker, M. O. M., Hall, K. H., Peppercorn, K., & Tate, W. P. (2022). The significance of oxidative stress in the pathophysiology of Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Medical Research Archives, 10(9), 3050. doi: 10.18103/mra.v10i9.3050

Poole, E. S., Major, L. L., Cridge, A. G., & Tate, W. P. (2004). The mechanism of recoding in pro- and eukaryotes. In K. H. Nierhaus & D. N. Wilson (Eds.), Protein synthesis and ribosome structure: Translating the genome. (pp. 397-428). Weinheim, Germany: Wiley-VCH.

Chapter in Book - Research

Tate, W. P., Dalphin, M. E., Pel, H. J., & Mannering, S. A. (1996). Decoding efficiencies of translational stop signals: a new facet of cellular regulation. In J. K. Setlow (Ed.), Genetic Engineering, Principles and Methods, Volume 18. (pp. 157-182). New York: Plenum Press.

Chapter in Book - Research

Tate, W. P., & Marshall, C. J. (2018). Post-dormancy transcription and translation in the brine shrimp. In R. A. Browne, P. Sorgeloos & C. N. A. Trotman (Eds.), Artemia biology. (pp. 21-36). Boca Raton, FL: Taylor & Francis. doi: 10.1201/9781351069892

Chapter in Book - Other

Peppercorn, K., Kleffmann, T., Hughes, S. M., & Tate, W. P. (2023). Secreted amyloid precursor protein alpha (sAPPα) regulates the cellular proteome and secretome of mouse primary astrocytes. International Journal of Molecular Sciences, 24, 7165. doi: 10.3390/ijms24087165

Journal - Research Article

Tate, W. P., Walker, M. O. M., Peppercorn, K., Blair, A. L. H., & Edgar, C. D. (2023). Towards a better understanding of the complexities of myalgic encephalomyelitis/chronic fatigue syndrome and long COVID [Review]. International Journal of Molecular Sciences, 24(6), 5124. doi: 10.3390/ijms24065124

Journal - Research Article

Guévremont, D., Tsui, H., Knight, R. G., Fowler, C. J., Masters, C. L., Martins, R. N., Abraham, W. C., Tate, W. P., Cutfield, N. J., & Williams, J. M. (2022). Plasma microRNA vary in association with the progression of Alzheimer's disease. Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 14, e12251. doi: 10.1002/dad2.12251

Journal - Research Article

Helliwell, A. M., Stockwell, P. A., Edgar, C. D., Chatterjee, A., & Tate, W. P. (2022). Dynamic epigenetic changes during a relapse and recovery cycle in myalgic encephalomyelitis/chronic fatigue ayndrome. International Journal of Molecular Sciences, 23(19), 11852. doi: 10.3390/ijms231911852

Journal - Research Article

Lam, P., Vinnakota, C., Calvo-Flores Guzmán, B., Newland, J., Peppercorn, K., Tate, W. P., … Kwakowsky, A. (2022). Beta-amyloid (Aβ1-42) increases the expression of NKCC1 in the mouse hippocampus. Molecules, 27, 2440. doi: 10.3390/molecules27082440

Journal - Research Article

Ohline, S. M., Chan, C., Schoderboeck, L., Wicky, H. E., Tate, W. P., Hughes, S. M., & Abraham, W. C. (2022). Effect of soluble amyloid precursor protein-alpha on adult hippocampal neurogenesis in a mouse model of Alzheimer's disease. Molecular Brain, 15, 5. doi: 10.1186/s13041-021-00889-1

Journal - Research Article

Peppercorn, K., Kleffmann, T., Jones, O., Hughes, S., & Tate, W. (2022). Secreted amyloid precursor protein alpha, a neuroprotective protein in the brain has widespread effects on the transcriptome and proteome of human inducible pluripotent stem cell-derived glutamatergic neurons related to memory mechanisms. Frontiers in Neuroscience, 16, 858524. doi: 10.3389/fnins.2022.858524

Journal - Research Article

Tate, W., Walker, M., Sweetman, E., Helliwell, A., Peppercorn, K., Edgar, C., Blair, A., & Chatterjee, A. (2022). Molecular mechanisms of neuroinflammation in ME/CFS and long COVID to sustain disease and promote relapses. Frontiers in Neurology, 13, 877772. doi: 10.3389/fneur.2022.877772

Journal - Research Article

Walker, M. O. M., Hall, K. H., Peppercorn, K., & Tate, W. P. (2022). The significance of oxidative stress in the pathophysiology of Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Medical Research Archives, 10(9), 3050. doi: 10.18103/mra.v10i9.3050

Journal - Research Article

Livingstone, R. W., Elder, M. K., Singh, A., Westlake, C. M., Tate, W. P., Abraham, W. C., & Williams, J. M. (2021). Secreted amyloid precursor protein-alpha enhances LTP through the synthesis and trafficking of Ca2+-permeable AMPA receptors. Frontiers in Molecular Neuroscience, 14, 660208. doi: 10.3389/fnmol.2021.660208

Journal - Research Article

Ryan, M., Tan, V. T. Y., Thompson, N., Guévremont, D., Mockett, B. G., Tate, W. P., Abraham, W. C., Hughes, S. M., & Williams, J. (2021). Lentivirus-mediated expression of human secreted amyloid precursor protein-alpha promotes long-term induction of neuroprotective genes and pathways in a mouse model of Alzheimer’s disease. Journal of Alzheimer's Disease, 79, 1075-1090. doi: 10.3233/JAD-200757

Journal - Research Article

Calvo-Flores Guzmán, B., Chaffey, T. E., Palpagama, T. H., Waters, S., Boix, J., Tate, W. P., Peppercorn, K., … Kwakowsky, A. (2020). The interplay between beta-amyloid 1-42 (Aβ1-42)-induced hippocampal inflammatory response, p-tau, vascular pathology, and their synergistic contributions to neuronal death and behavioral deficits. Frontiers in Molecular Neuroscience, 13, 522073. doi: 10.3389/fnmol.2020.552073

Journal - Research Article

Helliwell, A. M., Sweetman, E. C., Stockwell, P. A., Edgar, C. D., Chatterjee, A., & Tate, W. P. (2020). Changes in DNA methylation profiles of myalgic encephalomyelitis/chronic fatigue syndrome patients reflect systemic dysfunctions. Clinical Epigenetics, 12(1), 167. doi: 10.1186/s13148-020-00960-z

Journal - Research Article

Sweetman, E., Kleffmann, T., Edgar, C., de Lange, M., Vallings, R., & Tate, W. (2020). A SWATH-MS analysis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome peripheral blood mononuclear cell proteomes reveals mitochondrial dysfunction. Journal of Translational Medicine, 18, 365. doi: 10.1186/s12967-020-02533-3

Journal - Research Article

Vinnakota, C., Govindpani, K., Tate, W. P., Peppercorn, K., Anekal, P. V., Waldvogel, H. J., … Kwakowsky, A. (2020). An α5 GABAA receptor inverse agonist, α5IA, attenuates amyloid beta-induced neuronal death in mouse hippocampal cultures. International Journal of Molecular Sciences, 21(9), 3284. doi: 10.3390/ijms21093284

Journal - Research Article

Yeung, J. H. Y., Calvo-Flores Guzmán, B., Palpagama, H. T., Ethiraj, J., Zhai, Y., Tate, W. P., Peppercorn, K., … Kwakowsky, A. (2020). Amyloid-beta1-42 induced glutamatergic receptor and transporter expression changes in the mouse hippocampus. Journal of Neurochemistry, 155, 62-80. doi: 10.1111/jnc.15099

Journal - Research Article

Yeung, J. H. Y., Palpagama, T. H., Tate, W. P., Peppercorn, K., Waldvogel, H. J., Faull, R. L. M., & Kwakowsky, A. (2020). The acute effects of amyloid-Beta1–42 on glutamatergic receptor and transporter expression in the mouse hippocampus. Frontiers in Neuroscience, 13, 1427. doi: 10.3389/fnins.2019.01427

Journal - Research Article

Livingstone, R. W., Elder, M. K., Barrett, M. C., Westlake, C. M., Peppercorn, K., Tate, W. P., Abraham, W. C., & Williams, J. M. (2019). Secreted amyloid precursor protein-alpha promotes arc protein synthesis in hippocampal neurons. Frontiers in Molecular Neuroscience, 12, 198. doi: 10.3389/fnmol.2019.00198

Journal - Research Article

Mockett, B. G., Guévremont, D., Elder, M. K., Parfitt, K. D., Peppercorn, K., Morrissey, J., Singh, A., Hintz, T. J., … Tate, W. P., Williams, J. M., & Abraham, W. C. (2019). Glutamate receptor trafficking and protein synthesis mediate the facilitation of LTP by secreted amyloid precursor protein-alpha. Journal of Neuroscience, 39(17), 3188-3203. doi: 10.1523/jneurosci.1826-18.2019

Journal - Research Article

Morrissey, J. A., Bigus, E., Necarsulmer, J. C., Srinivasan, V., Peppercorn, K., O'Leary, D. J., Mockett, B. G., Tate, W. P., Hughes, S. M., … Abraham, W. C. (2019). The tripeptide RER mimics secreted amyloid precursor protein-alpha in upregulating LTP. Frontiers in Cellular Neuroscience, 13, 459. doi: 10.3389/fncel.2019.00459

Journal - Research Article

Morrissey, J. A., Mockett, B. G., Singh, A., Kweon, D., Ohline, S. M., Tate, W. P., Hughes, S. M., & Abraham, W. C. (2019). A C-terminal peptide from secreted amyloid precursor protein-α enhances long-term potentiation in rats and a transgenic mouse model of Alzheimer's disease. Neuropharmacology, 157, 107670. doi: 10.1016/j.neuropharm.2019.107670

Journal - Research Article

Sweetman, E., Ryan, M., Edgar, C., MacKay, A., Vallings, R., & Tate, W. (2019). Changes in the transcriptome of circulating immune cells of a New Zealand cohort with myalgic encephalomyelitis/chronic fatigue syndrome. International Journal of Immunopathology & Pharmacology, 33, 1-8. doi: 10.1177/2058738418820402

Journal - Research Article

Cridge, A. G., Crowe-McAuliffe, C., Mathew, S. F., & Tate, W. P. (2018). Eukaryotic translational termination efficiency is influenced by the 3' nucleotides within the ribosomal mRNA channel. Nucleic Acids Research, gkx1315. doi: 10.1093/nar/gkx1315

Journal - Research Article

Mackay, A., & Tate, W. P. (2018). A compromised paraventricular nucleus within a dysfunctional hypothalamus: A novel neuroinflammatory paradigm for ME/CFS. International Journal of Immunopathology & Pharmacology, 32, 1-8. doi: 10.1177/2058738418812342

Journal - Research Article

Tan, V. T. Y., Mockett, B. G., Ohline, S. M., Parfitt, K. D., Wicky, H. E., Peppercorn, K., Schoderboeck, L., Yahaya, M. F. b., Tate, W. P., Hughes, S. M., & Abraham, W. C. (2018). Lentivirus-mediated expression of human secreted amyloid precursor protein-alpha prevents development of memory and plasticity deficits in a mouse model of Alzheimer's disease. Molecular Brain, 11, 7. doi: 10.1186/s13041-018-0348-9

Journal - Research Article

Xiong, M., Jones, O. D., Peppercorn, K., Ohline, S. M., Tate, W. P., & Abraham, W. C. (2017). Secreted amyloid precursor protein-alpha can restore novel object location memory and hippocampal LTP in aged rats. Neurobiology of Learning & Memory, 138, 291-299. doi: 10.1016/j.nlm.2016.08.002

Journal - Research Article

Kwakowsky, A., Potapov, K., Kim, S., Peppercorn, K., Tate, W. P., & Ábrahám, I. M. (2016). Treatment of beta amyloid 1-42 (Αβ1-42)-induced basal forebrain cholinergic damage by a non-classical estrogen signaling activator in vivo. Scientific Reports, 6, 21101. doi: 10.1038/srep21101

Journal - Research Article

Cardno, T. S., Shimaki, Y., Sleebs, B. E., Lackovic, K., Parisot, J. P., Moss, R. M., Crowe-McAuliffe, C., Mathew, S. F., Edgar, C. D., Kleffmann, T., & Tate, W. P. (2015). HIV-1 and human PEG10 frameshift elements are functionally distinct and distinguished by novel small molecule modulators. PLoS ONE, 10(10), e0139036. doi: 10.1371/journal.pone.0139036

Journal - Research Article

Mathew, S. F., Crowe-McAuliffe, C., Graves, R., Cardno, T. S., McKinney, C., Poole, E. S., & Tate, W. P. (2015). The highly conserved codon following the Slippery Sequence Supports -1 frameshift efficiency at the HIV-1 frameshift site. PLoS ONE, 10(3), e0122176. doi: 10.1371/journal.pone.0122176

Journal - Research Article

Ramsay, J. P., Tester, L. G. L., Major, A. S., Sullivan, J. T., Edgar, C. D., Kleffmann, T., … Tate, W. P., … Ronson, C. W. (2015). Ribosomal frameshifting and dual-target antiactivation restrict quorum-sensing–activated transfer of a mobile genetic element. PNAS, 112(3), 4104-4109. doi: 10.1073/pnas.1501574112

Journal - Research Article

Imhoff, F. M., Yang, D., Mathew, S. F., Clarkson, A. N., Kawagishi, Y., Tate, W. P., Koishi, K., & McLennan, I. S. (2013). The type 2 anti-Müllerian hormone receptor has splice variants that are dominant-negative inhibitors. FEBS Letters, 587(12), 1749-1753. doi: 10.1016/j.febslet.2013.04.014

Journal - Research Article

Ryan, M. M., Morris, G. P., Mockett, B. G., Bourne, K., Abraham, W. C., Tate, W. P., & Williams, J. M. (2013). Time-dependent changes in gene expression induced by secreted amyloid precursor protein-alpha in the rat hippocampus. BMC Genomics, 14, 376. doi: 10.1186/1471-2164-14-376

Journal - Research Article

Baratchi, S., Evans, J., Tate, W. P., Abraham, W. C., & Connor, B. (2012). Secreted amyloid precursor proteins promote proliferation and glial differentiation of adult hippocampal neural progenitor cells. Hippocampus, 22(7), 1517-1527. doi: 10.1002/hipo.20988

Journal - Research Article

Bernhardt, H. S., & Tate, W. P. (2012). Primordial soup or vinaigrette: Did the RNA world evolve at acidic pH? Biology Direct, 7(4). doi: 10.1186/1745-6150-7-4

Journal - Research Article

Ryan, M. M., Ryan, B., Kyrke-Smith, M., Logan, B., Tate, W. P., Abraham, W. C., & Williams, J. M. (2012). Temporal profiling of gene networks associated with the late phase of long-term potentiation in vivo. PLoS ONE, 7(7), e40538. doi: 10.1371/journal.pone.0040538

Journal - Research Article

Morgan, N. V., Goddard, S., Cardno, T. S., McDonald, D., Rahman, F., Barge, D., Ciupek, A., … Tate, W. P., … Maher, E. R. (2011). Mutation in the TCRα subunit constant gene (TRAC) leads to a human immunodeficiency disorder characterized by a lack of TCRαβ+ T cells. Journal of Clinical Investigation, 121(2), 695-702. doi: 10.1172/JCI41931

Journal - Research Article

Ryan, M. M., Mason-Parker, S. E., Tate, W. P., Abraham, W. C., & Williams, J. M. (2011). Rapidly induced gene networks following induction of long-term potentiation at perforant path synapses in vivo. Hippocampus, 21(5), 541-553. doi: 10.1002/hipo.20770

Journal - Research Article

Bernhardt, H. S., & Tate, W. P. (2010). The transition from noncoded to coded protein synthesis: Did coding mRNAs arise from stability-enhancing binding partners to tRNA? Biology Direct, 5, 16. doi: 10.1186/1745-6150-5-16

Journal - Research Article

Young, D. J., Edgar, C. D., Murphy, J., Fredebohm, J., Poole, E. S., & Tate, W. P. (2010). Bioinformatic, structural, and functional analyses support release factor-like MTRF1 as a protein able to decode nonstandard stop codons beginning with adenine in vertebrate mitochondria. RNA, 16(6), 1146-1155. doi: 10.1261/rna.1970310

Journal - Research Article

Young, D. J., Edgar, C. D., Poole, E. S., & Tate, W. P. (2010). The codon specificity of eubacterial release factors is determined by the sequence and size of the recognition loop. RNA, 16, 1623-1633. doi: 10.1261/rna.2117010

Journal - Research Article

Cardno, T. S., Poole, E. S., Mathew, S. F., Graves, R., & Tate, W. P. (2009). A homogeneous cell-based bicistronic fluorescence assay for high-throughput identification of drugs that perturb viral gene recoding and read-through of nonsense stop codons. RNA, 15(8), 1614-1621. doi: 10.1261/rna.1586709

Journal - Research Article

Claasen, A. M., Guévremont, D., Mason-Parker, S. E., Bourne, K., Tate, W. P., Abraham, W. C., & Williams, J. M. (2009). Secreted amyloid precursor protein-α upregulates synaptic protein synthesis by a protein kinase G-dependent mechanism. Neuroscience Letters, 460, 92-96. doi: 10.1016/j.neulet.2009.05.040

Journal - Research Article

Jacobs, G. H., Chen, A., Stevens, S. G., Stockwell, P. A., Black, M. A., Tate, W. P., & Brown, C. M. (2009). Transterm: A database to aid the analysis of regulatory sequences in mRNAs. Nucleic Acids Research, 37(Database issue), D72-D76. doi: 10.1093/nar/gkn763

Journal - Research Article

Bernhardt, H. S., & Tate, W. P. (2008). Evidence from glycine transfer RNA of a frozen accident at the dawn of the genetic code. Biology Direct, 3, 53. doi: 10.1186/1745-6150-3-53

Journal - Research Article

Bernhardt, H. S., & Tate, W. P. (2008). Self-assembling transfer RNA has potential for nanoparticle arrays. Current Applied Physics, 8(3-4), 380-382. doi: 10.1016/j.cap.2007.10.035

Journal - Research Article

Taylor, C. J., Ireland, D. R., Ballagh, I., Bourne, K., Marechal, N. M., Turner, P. R., Bilkey, D. K., Tate, W. P., & Abraham, W. C. (2008). Endogenous secreted amyloid precursor protein-α regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory. Neurobiology of Disease, 31(2), 250-260. doi: 10.1016/j.nbd.2008.04.011

Journal - Research Article

Clark, M. B., Jänicke, M., Gottesbühren, U., Kleffmann, T., Legge, M., Poole, E. S., & Tate, W. P. (2007). A mammalian gene PEG10 expresses two reading frames by high efficiency -1 frameshifting in embryonic-associated tissues. Journal of Biological Chemistry, 282(52), 37359-37369.

Journal - Research Article

Poole, E. S., Young, D. J., Askarian-Amiri, M. E., Scarlett, D.-J. G., & Tate, W. P. (2007). Accommodating the bacterial decoding release factor as an alien protein among the RNAs at the active site of the ribosome. Cell Research, 17, 591-607.

Journal - Research Article

Soleimanpour-Lichaei, H. R., Kühl, I., Gaisne, M., Passos, J. F., Wydro, M., Rorbach, J., … Tate, W., … Chrzanowska-Lightowlers, Z. (2007). mtRF1a is a human mitochondrial translation release factor decoding the major termination codons UAA and UAG. Molecular Cell, 27, 745-757.

Journal - Research Article

Turner, P. R., Bourne, K., Garama, D., Carne, A., Abraham, W. C., & Tate, W. P. (2007). Production, purification and functional validation of human secreted amyloid precursor proteins for use as neuropharmacological reagents. Journal of Neuroscience Methods, 164, 68-74.

Journal - Research Article

Williams, J. M., Guévremont, D., Mason-Parker, S. E., Luxmanan, C., Tate, W. P., & Abraham, W. C. (2007). Differential trafficking of AMPA and NMDA receptors during long-term potentiation in awake adult animals. Journal of Neuroscience, 27(51), 14171-14178.

Journal - Research Article

Cridge, A. G., Major, L. L., Mahagaonkar, A. A., Poole, E. S., Isaksson, L. A., & Tate, W. P. (2006). Comparison of characteristics and function of translation termination signals between and within prokaryotic and eukaryotic organisms. Nucleic Acids Research, 34(7), 1959-1973. doi: 10.1093/nar/gkl074

Journal - Research Article

Jacobs, G. H., Stockwell, P. A., Tate, W. P., & Brown, C. M. (2006). Transterm: Extended search facilities and improved integration with other databases. Nucleic Acids Research, 34(Database), D37-D40.

Journal - Research Article

Mockett, B. G., Brooks, W. M., Tate, W. P., & Abraham, W. C. (2004). Dopamine D1/D5 receptor activation fails to initiate an activity-independent late-phase LTP in rat hippocampus. Brain Research, 1021, 92-100.

Journal - Research Article

Tate, W. P., & Poole, E. S. (2004). The ribosome: Lifting the veil from a fascinating organelle. BioEssays, 26, 582-588.

Journal - Research Article

Cridge, A. G., Poole, E. S., & Tate, W. P. (2003). The signal for stop in protein synthesis in eukaryotes: Evidence for a sequence element rather than a simple stop codon. New Zealand BioScience, 12, 37-38.

Journal - Research Article

Poole, E. S., Askarian-Amiri, M. E., Major, L. L., McCaughan, K. K., Scarlett, D.-J. G., Wilson, D. N., & Tate, W. P. (2003). Molecular mimicry in the decoding of translational stop signals. Progress in Nucleic Acid Research & Molecular Biology, 74, 83-121.

Journal - Research Article

Scarlett, D.-J. G., McCaughan, K. K., Wilson, D. N., & Tate, W. P. (2003). Mapping functionally important motifs SPF and GGQ of the decoding release factor RF2 to the Escherichia coli ribosome by hydroxyl radical footprinting. Journal of Biological Chemistry, 278(17), 15095-15104.

Journal - Research Article

Turner, P. R., O'Connor, K., Tate, W. P., & Abraham, W. C. (2003). Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory. Progress in Neurobiology, 70, 1-32.

Journal - Research Article

Williams, J. M., Guévremont, D., Kennard, J. T. T., Mason-Parker, S. E., Tate, W. P., & Abraham, W. C. (2003). Long-term regulation of N-methyl-D-aspartate receptor subunits and associated synaptic proteins following hippocampal synaptic plasticity. Neuroscience, 118, 1003-1013.

Journal - Research Article

Jacobs, G. H., Rackham, O., Stockwell, P. A., Tate, W. P., & Brown, C. M. (2002). Transterm: a database of mRNAs and translational control elements. Nucleic Acids Research, 30, 310-311.

Journal - Research Article

Major, L. L., Edgar, C. D., Yip, P. Y., Isaksson, L. A., & Tate, W. P. (2002). Tandem termination signals: Myth or reality. FEBS Letters, 514, 84-89.

Journal - Research Article

Abraham, W. C., Mason-Parker, S. E., Bear, M. F., Webb, S. C., & Tate, W. P. (2001). Heterosynaptic metaplasticity in the hippocampus in vivo: A BCM-like modifiable threshold for LTP. PNAS, 98, 10924-10929.

Journal - Research Article

Mansell, J. B., Guevremont, D., Poole, E. S., & Tate, W. P. (2001). A dynamic competition between release factor 2 and the tRNASec decoding UGA at the recoding site of Escherichia coli formate dehydrogenase H. EMBO Journal, 20, 7284-7293.

Journal - Research Article

Stenstrom, M. C., Haining, J., Major, L. L., Tate, W. P., & Isaksson, L. A. (2001). Codon bias at the 3'-side of the initiation codon is correlated with translation initiation efficiency in Escherichia coli. Gene, 263, 273-284.

Journal - Research Article

Askarian-Amiri, M. E., Pel, H. J., Guevremont, D., McCaughan, K. K., Poole, E. S., Sumpter, V. G., & Tate, W. P. (2000). Functional characterization of yeast mitochondrial release factor 1. Journal of Biological Chemistry, 275, 17241-17248.

Journal - Research Article

Jacobs, G. H., Stockwell, P. A., Schreiber, M. J., Tate, W. P., & Brown, C. M. (2000). Transterm: A database of messenger RNA components and signals. Nucleic Acids Research, 28, 293-295.

Journal - Research Article

Poole, E., & Tate, W. (2000). Release factors and their role as decoding proteins: Specificity and fidelity for termination of protein synthesis. Biochimica et Biophysica Acta: Gene Structure & Expression, 1493, 1-11.

Journal - Research Article

Raymond, C., Thompson, V. L., Tate, W. P., & Abraham, W. C. (2000). Metabotropic glutamate receptors trigger homosynaptic protein synthesis to prolong long-term potentiation. Journal of Neuroscience, 20, 969-976.

Journal - Research Article

Williams, J. M., Beckmann, A. M., Mason-Parker, S. E., Abraham, W. C., Wilce, P. A., & Tate, W. P. (2000). Sequential increase in Egr-1 and AP-1 DNA binding activity in the dentate gyrus following the induction of long-term potentiation. Molecular Brain Research, 77, 258-266.

Journal - Research Article

Wilson, D. N., Dalphin, M. E., Pel, H. J., Major, L. L., Mansell, J. B., & Tate, W. P. (2000). Factor-mediated termination of protein synthesis: A welcome return to the mainstream of translation. The Ribosome: Structure, Function, Antibiotics & Cellular Interactions, 40, 495-508. Washington, D.C.: ASM Press.

Journal - Research Article

Wilson, D. N., Guevremont, D., & Tate, W. P. (2000). The ribosomal binding and peptidyl-tRNA hydrolysis functions of Escherichia coli release factor 2 are linked through residue 246. RNA, 6, 1-10.

Journal - Research Article

Brown, C. M., Jacobs, G. H., Schreiber, M. J. J., Magnum, J., McNaughton, J. C., Cambray, M., Futschik, M., Major, L. L., Rackham, O., Tate, W. P., … Stockwell, P. A., & Kasabov, N. K. (1999). Using bioinformatics to investigate post-transcriptional control of gene expression. New Zealand BioScience, 7, 11-12.

Journal - Research Article

Crawford, D.-J. G., Ito, K., Nakamura, Y., & Tate, W. P. (1999). Indirect regulation of translational termination efficiency at highly expressed genes and recoding sites by the factor recycling function of Escherichia coli release factor RF3. EMBO Journal, 18, 727-732.

Journal - Research Article

Dalphin, M. E., Stockwell, P. A., Tate, W. P., & Brown, C. M. (1999). TransTerm, the translational signal database, extended to include full coding sequences and untranslated regions. Nucleic Acids Research, 27, 293-294.

Journal - Research Article

Scrimshaw, B. J., Faed, J. M., Tate, W. P., & Yun, K. (1999). Rapid identification of a 1555 A to G mutation in human mitochronical DNA implicated in aminoglycoside-induced ototoxicity. Journal of Human Genetics, 44, 388-390.

Journal - Research Article

Scrimshaw, B. J., Faed, J. M., Tate, W. P., & Yun, K. (1999). The frequency in New Zealand of a mitochondrial DNA mutation (1555 A to G) associated with aminoglycoside-induced hearing loss. New Zealand Medical Journal, 112, 216-217.

Journal - Research Article

Tate, W. P., Mansell, J. B., Mannering, S. A., Irvine, J., Major, L. L., & Wilson, D. N. (1999). UGA: A dual signal for "stop" and for recoding in protein synthesis. Biochemistry (Moscow), 64, 1342-1353.

Journal - Research Article

Dalphin, M. E., Brown, C. M., Stockwell, P. A., & Tate, W. P. (1998). The translational signal database, TransTerm, is now a relational database. Nucleic Acids Research, 26, 335-337.

Journal - Research Article

Irvine, J., Horsfield, J. A., McKinney, C. Z., & Tate, W. P. (1998). A novel strategy to interfere with human immunodeficiency virus type 1 propagation. New Zealand Medical Journal, 111, 222-224.

Journal - Research Article

McCaughan, K. K., Poole, E. S., Pel, H. J., Mansell, J., Mannering, S. A., & Tate, W. P. (1998). Efficient in vitro translational termination in Escherichia coli is constrained by the orientations of the release factor, stop signal and peptidyl-tRNA within the termination complex. Biological Chemistry, 379(7), 857-866.

Journal - Research Article

Pel, H. J., Moffat, J. G., Ito, K., Nakamura, Y., & Tate, W. P. (1998). Escherichia coli release factor 3: Resolving the paradox of a typical G protein structure and atypical function with guanine nucleotides. RNA, 4, 47-54.

Journal - Research Article

Poole, E. S., Major, L. L., Mannering, S. A., & Tate, W. P. (1998). Translational termination in Escherichia coli: three bases following the stop codon crosslink to release factor 2 and affect the decoding efficiency of UGA-containing signals. Nucleic Acids Research, 26, 954-960.

Journal - Research Article

Trotman, C. N. A., Coleman, M., Jellie, A.-M., Shieffelbien, D. C., & Tate, W. P. (1998). Haemoglobin: a primordial role preserved in diapause? Archiv für Hydrobiologie, 52, 441-449.

Journal - Research Article

Williams, J. M., Mason-Parker, S. E., Abraham, W. C., & Tate, W. P. (1998). Biphasic changes in the levels of N-methyl-D-aspartate receptor-2 subunits correlate with the induction and persistence of long-term potentiation. Molecular Brain Research, 60, 21-27.

Journal - Research Article

Williams, J. M., Thompson, V. L., Mason-Parker, S. E., Abraham, W. C., & Tate, W. P. (1998). Synaptic activity-dependent modulation of mitochondrial gene expression in the rat hippocampus. Molecular Brain Research, 60, 50-56.

Journal - Research Article

Abraham, W. C., & Tate, W. P. (1997). Metaplasticity: A new vista across the field of synaptic plasticity. Progress in Neurobiology, 52, 303-323.

Journal - Research Article

Abraham, W. C., Logan, B., Thompson, V. L., Williams, J. M., & Tate, W. P. (1997). Sequence-independent effects of phosphorothioated oligonucleotides on synaptic transmission and excitability in the hippocampus in vivo. Neuropharmacology, 36, 345-352.

Journal - Research Article

Dalphin, M. E., Brown, C. M., Stockwell, P. A., & Tate, W. P. (1997). The translational signal database, TransTerm: more organisms, complete genomes. Nucleic Acids Research, 25, 246-247.

Journal - Research Article

Poole, E. S., Brimacombe, R., & Tate, W. P. (1997). Decoding the translational termination signal: the polypeptide chain release factor in Escherichia coli crosslinks to the base following the stop codon. RNA, 3, 974-982.

Journal - Research Article

Dalphin, M. E., Brown, C., Stockwell, P. A., & Tate, W. P. (1996). TransTerm: a database of translational signals. Nucleic Acids Research, 24, 216-218.

Journal - Research Article

Jellie, A. M., Tate, W. P., & Trotman, C. N. (1996). Evolutionary history of introns in a multi-domain globin gene. Journal of Molecular Evolution, 42, 641-647.

Journal - Research Article

Major, L. L., Poole, E., Dalphin, M. E., Mannering, S. A., & Tate, W. P. (1996). Is the in frame termination signal of the Escherichia coli release factor-2 frameshift site weakened by a particularly poor context? Nucleic Acids Research, 24, 2673-2678.

Journal - Research Article

Tate, W. P., & Mannering, S. A. (1996). Three, four or more: the translational stop signal at length. Molecular Microbiology, 21, 213-219.

Journal - Research Article

Tate, W. P., Poole, E., & Mannering, S. A. (1996). Hidden infidelities of the translational stop signal. Progress in Nucleic Acid Research & Molecular Biology, 52, 293-336.

Journal - Research Article

Tate, W. P., Poole, E., Dalphin, M. E., Major, L. L. M., Crawford, D.-J. G., & Mannering, S. A. (1996). The translational stop signal: Codon with a context, or extended factor recognition element? Biochimie, 78(11-12), 945-952.

Journal - Research Article

Curran, J. F., Poole, E., Tate, W. P., & Gross, B. L. (1995). Selection of aminoacyl-tRNAs at sense codons: the size of the tRNA variable loop determines whether the immediate 3' nucleotide to the codon has a context effect. Nucleic Acids Research, 23, 4104-4108.

Journal - Research Article

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